EP3908244B1 - Dispositif et procédé de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire - Google Patents
Dispositif et procédé de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire Download PDFInfo
- Publication number
- EP3908244B1 EP3908244B1 EP19835604.0A EP19835604A EP3908244B1 EP 3908244 B1 EP3908244 B1 EP 3908244B1 EP 19835604 A EP19835604 A EP 19835604A EP 3908244 B1 EP3908244 B1 EP 3908244B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- magazine
- die
- die chamber
- active ingredient
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000004480 active ingredient Substances 0.000 title claims description 120
- 238000000034 method Methods 0.000 title claims description 32
- 239000000203 mixture Substances 0.000 title claims description 28
- 239000007788 liquid Substances 0.000 title claims description 17
- 235000011837 pasties Nutrition 0.000 title claims description 6
- 239000012876 carrier material Substances 0.000 claims description 30
- 239000013543 active substance Substances 0.000 claims description 18
- 239000011230 binding agent Substances 0.000 claims description 13
- 230000005484 gravity Effects 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000012790 confirmation Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 description 54
- 239000011159 matrix material Substances 0.000 description 34
- 239000010410 layer Substances 0.000 description 16
- 238000004806 packaging method and process Methods 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 238000003825 pressing Methods 0.000 description 13
- 239000003814 drug Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 235000013305 food Nutrition 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000010146 3D printing Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 235000019219 chocolate Nutrition 0.000 description 4
- 238000005056 compaction Methods 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 241001631457 Cannula Species 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000002346 layers by function Substances 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 244000198134 Agave sisalana Species 0.000 description 1
- 235000011624 Agave sisalana Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- KEUKAQNPUBYCIC-UHFFFAOYSA-N ethaneperoxoic acid;hydrogen peroxide Chemical compound OO.CC(=O)OO KEUKAQNPUBYCIC-UHFFFAOYSA-N 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005428 food component Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 240000004308 marijuana Species 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/46—Shape or structure of electric heating means
- A24F40/465—Shape or structure of electric heating means specially adapted for induction heating
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/50—Control or monitoring
- A24F40/51—Arrangement of sensors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/50—Control or monitoring
- A24F40/57—Temperature control
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F47/00—Smokers' requisites not otherwise provided for
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F7/00—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders
- A24F7/04—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders with smoke filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/04—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with a fixed mould
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/30—Feeding material to presses
- B30B15/302—Feeding material in particulate or plastic state to moulding presses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/10—Devices with chemical heating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
- A61M2202/066—Powder made from a compacted product by abrading
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0211—Ceramics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0227—Materials having sensing or indicating function, e.g. indicating a pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/362—General characteristics of the apparatus related to heating or cooling by gas flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3633—General characteristics of the apparatus related to heating or cooling thermally insulated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/364—General characteristics of the apparatus related to heating or cooling by chemical reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
- A61M2205/3686—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6054—Magnetic identification systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6063—Optical identification systems
- A61M2205/6072—Bar codes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/609—Biometric patient identification means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8237—Charging means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/20—Flow characteristics having means for promoting or enhancing the flow, actively or passively
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/06—Packaging for specific medical equipment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0835—Ampoules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
Definitions
- the invention relates to a device and a method for tableting a powdery, liquid, pasty, encapsulated or granular active ingredient composition.
- a device and a method are described for the production of a powdery, liquid, pasty, encapsulated or granular single-dose active ingredient form, where at least a portion of the composition can contain active ingredients from the hemp plant (cannabis).
- Such a device according to the preamble of claim 1 and a corresponding method are from WO 01/87272 A2 known. Similar objects also describe the WO 2017/175057 A1 and the EP 2 532 349 A1 .
- Tablets are manufactured under pressure from powders, granules or other active ingredient precursor products on tablet presses. Tablets can have different shapes. The biconvex shape is particularly common when it comes to oral tablets. Tablets for medicinal use are medicines with other health-related uses and are classified as medical devices or dietary supplements. Tablets are also used in other areas. Among the dosage forms, tablets play a special role with a share of almost 50%.
- 3D printers are also known for use in food technology, for example. This often involves bringing a food component in a flowable state into a desired three-dimensional shape and then hardening it. Such processes have so far been used, for example, in the production of chocolate molds and the like. For example, this describes WO 2011/117012 A1 the selective application of nutritional supplements to food products.
- the US 2013/0034633 A1 describes a system for producing a free-form three-dimensional food product. Furthermore, a process is described that can be used to vary certain properties of a manufactured food product.
- the EP 2 937 206 A1 describes a process for the production of chocolate-based foods in which the chocolate is hardened after the dispensing process to serve as a crystallization initiator for a subsequent layer.
- the solid chocolate is intended to form a complete internal and external three-dimensional structure of the food into which liquid or gaseous substances can be incorporated in internal chambers of the structure with solid walls.
- the WO 2010/151302 A1 discloses a method for printing food in which small drops of a liquid food and a liquid binder, preferably consisting of a gelling agent that solidifies when pressurized, are processed.
- the US 2013/0034633 A1 shows a manufacturing process for a three-dimensional food product in which local solidification is brought about in a powder layer by locally limited application of liquid drops using liquid and powder. By applying additional layers of powder and structures of liquid droplets, a three-dimensional food structure is formed after the removal of unsolidified powder components.
- a device for tabletting a powdery, liquid, pasty, encapsulated or granular active ingredient composition with at least one matrix chamber and a magazine which has a plurality of active ingredient containers, each with an individually controllable dosing device and a nozzle for the active ingredient outlet.
- the magazine can be adjusted between a plurality of positioning positions relative to the at least one die chamber, with at least one of the nozzles facing an opening in the die chamber in each of the positioning positions.
- the magazine is spherical and the active ingredient containers extend in the radial direction of the magazine and open with their respective nozzles into a spherical surface of the magazine. It can be provided that the active ingredient(s) held in the active ingredient container are stored in the active ingredient container fluidly separated from the environment of the device.
- the active ingredient containers can at least partially have a temperature control device in order to keep an active ingredient stored in one of the active ingredient containers at a predetermined temperature or to bring it to a certain temperature before dosing into the matrix chamber, which promotes a chemical conversion of the active ingredient or a physical property of the active ingredient changed.
- the at least one die chamber can be accommodated in a base plate which has a concave recess in which the spherical magazine is accommodated.
- the at least one die chamber can be arranged at the lowest point of the recess.
- the magazine can be adjustable relative to the base plate about at least one axis extending parallel to the base plate.
- the spherical magazine can have a cavity in its center in which a spherical actuating element is accommodated in a freely movable and form-fitting or at least approximately form-fitting manner.
- the actuating element can have an actuator that is adjustable between an actuation position and a release position.
- the actuating element can have an eccentric center of gravity, which is arranged along a linear adjustment direction of the actuator between the actuating position and the release position.
- the spherical actuating element can have a passage extending through its center, in which a magnetic coil with a coil core movable along the coil axis is arranged.
- the passage may be arranged with respect to the center of gravity of the spherical confirmation element such that the passage is vertically oriented regardless of the orientation of the magazine.
- the magazine can have a linearly adjustable stamp, which faces the opening of the die chamber in one of the positioning positions or in a further positioning position of the magazine relative to the die chamber.
- the stamp can have a stamp die at a free end, with which the stamp projects into the die chamber via the opening in an extended position and with which the stamp is disengaged from the die chamber in a release position.
- At least one of the active ingredient containers can have a processing device for an active ingredient.
- the processing device can be a heating element for heating and/or a cooling element for cooling an active ingredient or can have such an element.
- the magazine can have at least one carrier material container with an individually controllable metering device and a nozzle for the carrier material outlet.
- the nozzle of the carrier material container can have an opening in the Be facing the matrix chamber and / or a base plate of the device, which has the matrix of a tablet packaging.
- the die can have a plurality of die chambers, which are preferably arranged in a regular grid.
- Dosing the carrier material into the matrix chamber can involve the formation of an active ingredient capsule. Dosing the carrier material into the matrix of the base plate can result in the formation of a tablet packaging.
- the method described can be used to produce a child-resistant blister pack or an all-round packaging for an active ingredient or an active ingredient tablet.
- the method makes it possible for the production of the tablet, the production of the packaging and any necessary labeling of the packaging and possibly the addition of a data carrier to the packaging to provide information on the contents and the like to all be provided in a single operation.
- the previously described device and the method for tabletting active ingredients can make use of the principles of additive manufacturing known from the prior art, for example 3D printing.
- This refers to all manufacturing processes in which solid bodies are layer by layer applied and three-dimensional objects can subsequently be created.
- the layer-by-layer construction is usually carried out under computer control using at least one liquid or solid material.
- the active ingredient containers can be designed in the manner of printer cartridges and each have a dosing device that can be individually controlled. In this way it is ensured that contact between the different active ingredients in the device is excluded.
- the nozzles of the active ingredient containers can, for example, be interchangeable in the same way as disposable cannulas and can be replaced after each use of the device according to the invention or application of the method according to the invention.
- the applied active ingredient doses or active ingredient layers are compacted or compressed after all the individual doses or individual layers have been dosed.
- the die is formed by the die chamber.
- the stamp can be kept in the magazine and for compression or compacting, the magazine can be brought into a position in which the stamp is aligned with the die chamber, so that the stamp can be extended from the magazine and inserted into the die chamber, for example by linear adjustment .
- an underside of the matrix chamber is also designed as a movable stamp, so that when the dosed active ingredients are compacted or compressed in the matrix chamber, the two stamps are brought closer to one another, with homogeneous compaction being achieved.
- Known automatic devices for compacting tablets have a lower punch, arranged vertically one above the other, which runs in a die and an upper punch which is inserted into the die only for pressing.
- the tablet blank is dosed or printed directly into the die chamber and, if necessary, only an upper punch, which is kept in the magazine, is inserted into the die for further compression.
- the thickness, strength and pressed gloss of the tablet depend solely on the upper punch and its pressing pressure.
- the insertion depth and the pressure strength of the upper punch into the die chamber and the pressure strength can be adjusted with the shape of the in the die chamber regulate the separated or dosed blank.
- the lower punch can be arranged in the die and limit the filling space of the die chamber downwards. During the compaction process, it forms the counter bearing for the upper punch held in the magazine. After the pressing process is completed, the lower punch is moved upwards, which moves the tablet onto the edge of the die, where it can be pushed aside. In an optional next work cycle, the tableted active ingredient can be soaked with an active ingredient or covered with a protective or functional layer.
- the active ingredient containers can be designed as replaceable cartridges.
- a carrier material for the production of a tablet packaging can be kept in one of the active ingredient containers or in one of the cartridges, for example for the formation of a blister pack, for which purpose a biodegradable material can be provided, for example silicone.
- the method according to the invention can be carried out under clean room conditions, for which purpose the device according to the invention can have a circulating air system with HEPA filters.
- the sterilizability of the device can be ensured by a UV or ozone system or by another system.
- the device and the method according to the invention can be used to control individual compositions of active ingredients and shapes of tablets. Using patient-related data, tablets can be produced cost-effectively, even in small quantities, within just a few minutes.
- FIGS. 1 and 2 each show exemplary embodiments of a device according to the invention for tableting an active ingredient composition.
- the features of the two embodiments shown can also be implemented in a single embodiment.
- the individual active ingredients of the active ingredient composition can be separated from one another in the magazine 1 of the device, in particular fluidly separated from one another, for example as powdery, liquid, pasty, encapsulated or granular active ingredients in each active ingredient container 2.
- the magazine 1 has a plurality of active ingredient containers 2, each of which contains an active ingredient or a defined active ingredient mixture, each of the active ingredient containers 2 having a separately controllable dosing device 3.
- the active ingredient containers 2 can also have a nozzle 4 for the active ingredient outlet.
- the magazine 1 is spherical, so that the active ingredient containers 2 extend in the radial direction of the magazine 1 and open with their respective nozzle 4 into a spherical surface of the magazine 1.
- the spherical magazine 1 can be adjustable between a plurality of positioning positions relative to at least one matrix chamber 5 in the base plate 7, with at least one of the active substance containers 2, in particular the respective nozzle 4 of the active substance container 2 in question, facing an opening 6 of the matrix chamber 5 in each of the positioning positions , so that when the dosing device 3 is actuated, the active ingredient held in the respective active ingredient container 2 can be dosed into the matrix chamber 5.
- the dosing device 3 can have suitable means for reliably dispensing a predetermined dose into the chamber 5, for example a flow meter, a weight sensor or the like.
- the magazine 1 can have further functional elements which can come into contact with the matrix chamber 5 or an active ingredient composition held therein via the spherical surface of the magazine 1.
- one of the functional elements can be a means for compacting the active ingredient composition in the matrix chamber 5, for example a stamp with a matrix.
- the magazine 1 can have at least one carrier material container 19, in which at least one carrier material 22 is kept, which can be applied into the matrix chamber 5 if necessary, for example to form an active ingredient capsule containing the active ingredient composition.
- the at least one die chamber 5, which is accommodated in the base plate 7, can be arranged in a concave recess 8 in the base plate 7, preferably at a deepest point in the recess 8, with the spherical magazine 1 in the concave recess 8 is held.
- the spherical magazine 1 can be accommodated at least partially in a form-fitting manner in the recess 8, so that the magazine 1 is guided in the recess 8 when it changes its orientation.
- the Figure 2 further shows that the spherical magazine 1 has a cavity 9 in its center, in which an actuating element 10 is freely accommodated.
- the actuating element 10 can in particular be designed as a rotatably mounted cam, with an axis of rotation x of the actuating element 10 being located outside the center of gravity of the actuating element 10. Since the actuating element 10 is accommodated in the cavity 9 in a freely rotating manner, it can always be located with its center of gravity at a lowest point regardless of the orientation of the magazine 1 in relation to the base plate 7 and, for example, be brought into engagement with a metering device 3, which is brought into alignment with the die chamber 5 in a lowest point of the spherical magazine 1.
- the dosing device is designed in the manner of a stamp, which is driven further into the active ingredient container 2 by the actuating element when the magazine 1 is relocated in the manner described above, whereby the active ingredient 21 reserved in the container 2 via the nozzle 4 opening into the matrix chamber 5 of the active ingredient container 2 is metered into the matrix chamber 5.
- the Figure 3 shows a further embodiment of a magazine 1 according to the invention, wherein the magazine 1 is aligned with respect to the die chamber 5 in the base plate 7 in such a way that a stamp 15 with a stamp die 16 arranged at the end can be brought into engagement with the die chamber 5, for example by one To achieve compression, compaction, shaping or other mechanical solidification of the active ingredient 21 contained in the matrix chamber 5.
- the stamp 15 can be used, for example, for further tableting of the active ingredient 21.
- stamping the active ingredient 21 with the stamp 15 is only a variant for tableting the active ingredient 21.
- the active ingredient 21 can also take on the contour of the matrix chamber 5 and can therefore be tabletted by dosing the active ingredient 21 or the active ingredients 21 into the matrix chamber 5.
- a binder can be added to the active ingredient 21, as is basically known from the prior art.
- the binder can be kept in a separate active ingredient container 2 of the magazine 1 and added to the active ingredient composition 21 in the matrix chamber 5 in a separate metering step or can already be added to the active ingredients 21 or at least some of the active ingredients 21 in the active ingredient containers 2 of the magazine 1.
- the Figure 3 also shows a further embodiment of an actuating element 10, which is arranged in the cavity 9 in the center of the spherical magazine 1.
- This embodiment differs from the embodiment according to Figure 2 the actuating element 10 is also spherical and accommodated essentially in a form-fitting manner, but again freely movable in the cavity 9.
- the actuating element 10 has a linearly adjustable actuator 11, which is shown in the illustration Figure 3 is adjustable in the vertical direction between an actuation position and a release position.
- the actuating element 10 has a passage 12 extending through its center, in which a magnetic coil 13 with a coil core 14 movable along the coil axis is located.
- the coil core 14 is rod-shaped and extends through the center of both the magazine 1 and the actuating element 10.
- the rod-shaped coil core 14 can, for example, be a permanent magnet, which can be displaced along the coil axis by applying current to the coil.
- the coil core 14 is shown in its release position, in which the coil core 14 is not engaged with the stamp 15. By applying current, the coil core 14 can be removed from the in Figure 3 shown position can be shifted into an actuating position in which it is shifted vertically downwards relative to the release position and is in engagement with the stamp 15.
- the coil core can enter into the linear guide 27 of the stamp 15, whereby the stamp 15 with its end die 16 is driven further into the die chamber 5 in order to contain the active ingredient 21 located in the die chamber 5 or an active ingredient mixture, which may optionally be in addition to at least one active ingredient also has a binder, to be tableted.
- the coil core 14 can then be returned to the in. by reversing the current flow Figure 3 shown release position.
- the Figure 4 shows an exemplary embodiment of a die 17, as is intended for the formation of a large number of tablets, and at the same time a tablet packaging in which the tablets produced are packaged.
- the die 17 has a plurality of die chambers 5 arranged in a regular grid, so that in addition to the production of the tablets in the die chambers 5 with the aid of the device according to the invention, for example one of the ones in the Figures 1 to 3 Device shown, in addition to the tablets 24, carrier material can also be introduced into the die 17, so that packaged tablets 24 can be produced.
- the Figure 5 shows a cross section through an exemplary embodiment of a tablet packaging 23 with tablets 24 accommodated therein, which are prepared with the aid of, for example, those in the Figures 1 to 4 shown device has been produced.
- the tablet packaging 23 has a layer sequence in cross section, consisting of a lower carrier material layer 22, on which, in addition to the tablets 24, the tablets 24 separating elements 28 are arranged.
- a further carrier material layer 22 is formed over the tablets 24 and the separating elements 28 with closures 25 embedded therein above each tablet 24.
- All of the in Figure 5 Elements 22, 23, 24, 25, 28 shown can be produced using the device according to the invention in a corresponding printing process.
- the carrier material 22 can be, for example, a plastic material.
- the tablets 24 can be formed in the matrix chambers 5 and above the carrier material layer 22 that has already hardened therein, as required by the patient, using the same device 1, for example with reference to the previous figures were explained.
- the separating elements 28 can be deposited between the tablets 24.
- closures 25 are then formed above the tablets 24 and, in a final step, the die 17 around the closures 25 is completely filled with carrier material 22. All applications of the aforementioned active ingredients and other materials, including the carrier materials 22, the materials for the closures 25 and the separating elements 28, can be carried out using one of the Figures 1 to 3 shown devices are produced.
- the active ingredients and other substances can be dosed using the principle of 3D printing.
- the invention can therefore be implemented as an automatic device for producing tablets based on the principle of 3D printing, also known under the names additive manufacturing, additive manufacturing, generative manufacturing or rapid technologies.
- the layered structure can be carried out under computer control from one or more liquid or solid active ingredients and at least one binder.
- the active ingredients and the binder are stored in active ingredient containers designed as printer cartridges, each of which has a dosing device and can be controlled individually. This ensures that contact between the active ingredients is excluded.
- the nozzles on the printer cartridges can be interchangeable, similar to disposable cannulas, and are replaced after each printing process.
- a special embodiment provides that the tablet material is pressed into a tablet after 3D printing using the same device using a single pressing process.
- two movable stamps can be provided as pressing tools.
- Known automatic devices for producing tablets have a vertically aligned lower punch that runs in a die and an upper die that is inserted into the die only for pressing.
- the tablet blank is printed directly in the die chamber and then the upper punch slides into the die and presses the tablet.
- the thickness, strength and pressed gloss of the tablet depend on its geometry and its pressing pressure.
- the insertion depth and pressure strength can be regulated by the shape of the 3D blank.
- the lower punch can be arranged within the die. It limits the filling space at the bottom. During the pressing process it usually forms the counter bearing. After the compression has been completed, it can be guided upwards and thereby brings the tablet onto the edge of the die, where it can be pushed aside.
- the blank if it is made of absorbent material, can be soaked with active ingredients or covered with a protective or functional layer.
- the layer can have the following properties.
- the magazine can have several replaceable cartridges and in a special embodiment of the invention it is intended to replace the usual blistering of tablets with the same magazine and the same device.
- a biodegradable material can be provided for this, for example silicone.
- the entire process can be carried out in an installation space of the device that is hermetically sealed.
- a recirculation system with HEPA filters ensures clean room conditions.
- the device can be sterilized by UV or ozone treatment, or by other suitable systems.
- the greatest advantage of the invention lies in the individually controllable composition of the active ingredients and the shape of the tablets. Thanks to the controllability of the device and the feeding of patient-related data, tablets can be produced cost-effectively, even in small quantities, within just a few minutes.
- the base plate can have a pressing device with a further die in the form of a tablet and/or holding devices for tablet blanks, cartridges, ampoules, or syringe bodies.
- the active ingredient containers of the magazine can be designed as printer cartridges or cartridges, which, for example, can not only contain and dose active ingredients, but can also be set up to be able to press them into a die with up to 80 kN / cm 3 , for example by have a stamp with an end die.
- One embodiment of the invention relates to a 3D medication dispensing device which consists of a replaceable unit and a permanently installed unit.
- the replaceable unit has active ingredients and possibly other substances in the form of powder, particles, fluid or the like in a suitable reservoir, which can be provided in the form of a pressurized printer cartridge to hold the active ingredient or other substance.
- the magazine In contrast to the known, standard tablet machines, the magazine cannot be designed as a fixed pressing device, but can be aligned vertically and horizontally and movable in the X, Y and Z directions. This measure also allows 3D moldings to be produced from carrier material for active ingredients without press molding.
- the blanks can also be shaped using pressing tools.
- the dosing devices can also only be used to fill the pressing tools or hollow bodies that were previously printed in the same system.
- the hollow bodies can consist of absorbent sponge/foam material that is very absorbent, e.g. silica, hyaluronic acid or substances that readily combine with the active ingredients.
- the dosing device can have a sensor for detecting the flow rate of a liquid active ingredient or binder, one provided with a flow resistance, have a fluid channel fluidly connected to the active ingredient reservoir and at least one nozzle connected to the fluid channel.
- Concave matrices can be attached to a spherical surface of the magazine, which can bring active ingredients into a desired shape. It has proven to be particularly advantageous to mount the spherical magazine in a partially or hemispherically-like holder in a freely movable manner.
- the holder in turn can be movable in the X, Y and Z directions.
- the holder can have at least four rotatable drives that can rotate the magazine in all directions. This makes it possible to use all the cartridges or tools in the sphere at any level in the room. Contact areas on the surfaces and electromagnets that can be activated guarantee secure adjustment.
- a liquid active ingredient contained in the active ingredient container can preferably be pressurized using a constant pressure transmitter.
- the device can have at least one pressure sensor to detect the pressure of the liquid medication in front of a flow resistance of the active ingredient container. Furthermore, a further pressure sensor can be provided after the flow resistance, with a control device being set up to control the flow rate of a liquid active ingredient.
- the dosing system can work according to the overpressure principle and preferably uses a micromechanically manufactured optical sensor and thus offers the possibility of externally influencing the dosing rate via the control device to compensate for any defects in the printed tablet.
- the dosing system can have a pinch valve that is controlled in a timed manner by the control device in order to enable or prevent a flow through a hose of the dosing system.
- This pinch valve engages the tubing from the outside and squeezes it to prevent flow of the liquid medication. This means that the valve does not come into contact with the medication.
- the valve can be part of the permanent device.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (15)
- Dispositif pour le pastillage d'une composition d'agents actifs pulvérulente, liquide, pâteuse, en capsulée ou granulaire, avec au moins une chambre de matrice (5) et un magasin (1), qui comprend une pluralité de récipients d'agents actifs (2) avec chacun un dispositif de dosage (3) pouvant être contrôlé individuellement et une buse (4) pour la sortie de l'agent actif, dans lequel le magasin (1) peut être réglé entre une pluralité de positions de réglage par rapport à l'au moins une chambre de matrice (5), dans lequel, dans chacune des positions de réglage, au moins une des buses (4) est orientée vers une ouverture (6) de la chambre de matrice (5), caractérisé en ce que le magasin (1) présente une forme sphérique, dans lequel les récipients d'agents actifs (2) s'étendent dans la direction radiale du magasin (1) et débouchent, avec leur buse (4) respective, dans une surface sphérique du magasin (1).
- Dispositif selon la revendication 1, dans lequel l'au moins une chambre de matrice (5) est logée dans une plaque de base (7) qui présente un évidement concave (8) dans laquelle est logé le magasin sphérique (1).
- Dispositif selon la revendication 2, dans lequel, au niveau de l'endroit le plus bas de l'évidement (8), est disposée l'au moins une chambre de matrice (5).
- Dispositif selon la revendication 2 ou 3, dans lequel le magasin (1) peut être réglé par rapport à la plaque de base (7) autour d'au moins un axe s'étendant parallèlement à la plaque de base (7).
- Dispositif selon l'une des revendications précédentes, dans lequel le magasin sphérique (1) présente, en son centre, une cavité (9) dans laquelle un élément d'actionnement (10) est logé de façon à pouvoir se déplacer librement, dans lequel l'élément d'actionnement (10) comprend un organe de réglage (11) qui peut être réglé entre une position d'actionnement et une position de libération.
- Dispositif selon la revendication 5, dans lequel soit l'élément d'actionnement (10) présente une forme sphérique et est logé par complémentarité de forme dans la cavité (9) soit l'élément d'actionnement (10) est une came logée de manière rotative avec un centre de gravité se trouvant hors de l'axe de rotation (x), dans lequel l'organe de réglage (11) est une saillie de la came.
- Dispositif selon la revendication 5 ou 6, dans lequel l'élément d'actionnement (10) comprend un passage (12) s'étendant à travers son centre, dans lequel est disposée une bobine magnétique (13) avec un noyau de bobine (14) mobile le long de l'axe de la bobine.
- Dispositif selon l'une des revendications précédentes, dans lequel le magasin (1) comprend un poinçon réglable de manière linéaire (15) qui est orienté, dans une des positions de réglage ou dans une autre position de réglage du magasin (1) par rapport à la chambre de matrice (5), vers l'ouverture (6) de la chambre de matrice (5).
- Dispositif selon la revendication 8, dans lequel le poinçon (15) comprend, au niveau de son extrémité libre, une matrice de poinçon (16) avec laquelle le poinçon (15), dans une position déployée, pénètre, par l'ouverture (6), dans la chambre de matrice (5) et avec laquelle le poinçon (15) est déboîté avec la chambre de matrice (5) dans une position de libération.
- Dispositif selon l'une des revendications précédentes, dans lequel au moins un des récipients d'agents actifs (2) comprend un dispositif de traitement (18) pour un agent actif.
- Dispositif selon la revendication 10, dans lequel le dispositif de traitement (18) est ou comprend un élément chauffant pour le chauffage et/ou un élément de refroidissement pour le refroidissement d'un agent actif.
- Dispositif selon l'une des revendications précédentes, dans lequel le magasin (1) comprend, en plus de la pluralité de récipients d'agents actifs (2), au moins un récipient d'excipient (19) avec un dispositif de dosage (3) pouvant être contrôlé individuellement et une buse (4) pour la sortie de l'excipient, dans lequel, dans une autre position de réglage du magasin (1), la buse (4) du récipient d'excipient (19) est orientée vers une ouverture (6) de la chambre de matrice (5).
- Procédé de pastillage d'un agent actif avec un dispositif selon l'une des revendications précédentes, qui comprend les étapes suivantes :a. indication d'une composition d'agents actifs à pastiller ;b. réglage du magasin (1) par rapport à la chambre de matrice (5) jusqu'à ce que le magasin (1) soit dans une position de réglage dans laquelle le récipient d'agent actif (2) du magasin (1), dans lequel est contenu un agent actif de la composition d'agents actifs, est orienté, avec sa buse (4), vers la chambre de matrice (5) ;c. dosage d'une dose du premier agent actif prédéterminée par la composition d'agents actifs, dans la chambre de matrice (5) ; etd. répétition optionnelle des étapes b. et c. pour chaque agent actif supplémentaire de la composition d'agents actifs, lorsque la composition d'agents actifs comprend plusieurs agents actifs.
- Procédé selon la revendication 13, qui comprend les étapes supplémentaires suivantes :e. réglage du magasin (1) par rapport à la chambre de matrice (5) jusqu'à ce que le magasin (1) soit dans une position de réglage dans laquelle un poinçon à déplacement linéaire (15) du magasin (1), qui comprend, au niveau d'une extrémité libre, une matrice de poinçon (16), est orienté vers une ouverture (6) de la chambre de matrice (5) ;f. déplacement du poinçon (15) de la position de libération, dans laquelle le poinçon (15), avec sa matrice de poinçon (16), est déboîtée de la chambre de matrice (5), vers une position déployée dans laquelle le poinçon (15) pénètre, avec sa matrice de poinçon (16), par l'ouverture (6), dans la chambre de matrice (5), dans lequel l'au moins un agent actif dosé dans la chambre de matrice (5) et, le cas échéant un liant, sont comprimés.
- Procédé selon la revendication 13 ou 14, qui comprend les étapes supplémentaires suivantes :g. réglage du magasin (1) par rapport à la chambre de matrice (5) jusqu'à ce que le magasin (1) soit dans une position de réglage dans laquelle un récipient d'excipient (19) du magasin (1), dans lequel un excipient est contenu, est orienté, avec sa buse (4), vers la chambre de matrice (5) ; eth. dosage de l'excipient dans la chambre de matrice (5).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP24154965.8A EP4338722A3 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé de fabrication de comprimés d'une composition de principe actif pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102019000016 | 2019-01-07 | ||
DE102019000018 | 2019-01-07 | ||
DE102019000199 | 2019-01-15 | ||
PCT/DE2019/101067 WO2020143864A1 (fr) | 2019-01-07 | 2019-12-10 | Dispositif de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP24154965.8A Division EP4338722A3 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé de fabrication de comprimés d'une composition de principe actif pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3908244A1 EP3908244A1 (fr) | 2021-11-17 |
EP3908244C0 EP3908244C0 (fr) | 2024-02-07 |
EP3908244B1 true EP3908244B1 (fr) | 2024-02-07 |
Family
ID=69005183
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19836461.4A Active EP3908133B1 (fr) | 2019-01-07 | 2019-12-10 | Dispositif pour l'extraction et l'aspiration de substances actives, en particulier de cannabis |
EP19827605.7A Active EP3908131B8 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé pour l'extraction et l'aspiration de substances actives, en particulier de cannabis |
EP19835604.0A Active EP3908244B1 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
EP24154965.8A Pending EP4338722A3 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé de fabrication de comprimés d'une composition de principe actif pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
EP19836460.6A Pending EP3908132A1 (fr) | 2019-01-07 | 2019-12-10 | Procédé de détection qualitative et/ou quantitative de substances présentes dans une plante de chanvre et kit pour une utilisation dans ce procédé |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19836461.4A Active EP3908133B1 (fr) | 2019-01-07 | 2019-12-10 | Dispositif pour l'extraction et l'aspiration de substances actives, en particulier de cannabis |
EP19827605.7A Active EP3908131B8 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé pour l'extraction et l'aspiration de substances actives, en particulier de cannabis |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP24154965.8A Pending EP4338722A3 (fr) | 2019-01-07 | 2019-12-10 | Dispositif et procédé de fabrication de comprimés d'une composition de principe actif pulvérulente, liquide, pâteuse, encapsulée ou granulaire |
EP19836460.6A Pending EP3908132A1 (fr) | 2019-01-07 | 2019-12-10 | Procédé de détection qualitative et/ou quantitative de substances présentes dans une plante de chanvre et kit pour une utilisation dans ce procédé |
Country Status (7)
Country | Link |
---|---|
US (4) | US20220054769A1 (fr) |
EP (5) | EP3908133B1 (fr) |
CN (4) | CN113873903A (fr) |
CA (4) | CA3125798A1 (fr) |
DE (4) | DE112019006596A5 (fr) |
WO (4) | WO2020143862A1 (fr) |
ZA (4) | ZA202105146B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113205958B (zh) * | 2021-04-26 | 2023-01-31 | 骏日科技(深圳)有限公司 | 球面线圈的绕制装置及方法 |
CN113287787A (zh) * | 2021-05-26 | 2021-08-24 | 深圳市吉迩科技有限公司 | 气溶胶生成装置 |
USD1031140S1 (en) * | 2022-03-07 | 2024-06-11 | Oomlaut Inc. | Pipe |
DE102022123319A1 (de) | 2022-09-13 | 2024-03-14 | HaLu Pharmatechnologies GmbH | Mikrodosiervorrichtung und Verfahren zur Befüllung von Kapseln mit medikamenthaltigem Fluid |
DE102022126605A1 (de) | 2022-10-12 | 2024-04-18 | Wessling Gmbh | Verfahren zum Behandeln von phenolartigen Verbindungen mittels Aryldiazoniumverbindungen |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3715189A (en) * | 1970-06-15 | 1973-02-06 | Secretary Of The Treasury | Qualitative analysis device |
FR2239174A5 (en) * | 1973-07-23 | 1975-02-21 | Pm Labs Of Nevada Inc | Narcotics and drugs detection - appts. permits analysis on the spot under laboratory conditions permissible as evidence |
US4104027A (en) * | 1977-11-21 | 1978-08-01 | Carroll Robert B | Process for the presumptive identification of narcotics and drugs of abuse |
US4196167A (en) * | 1978-12-26 | 1980-04-01 | California Medical Developments, Inc. | Drug detection device |
DE3933978A1 (de) * | 1989-10-11 | 1991-05-02 | Eisenmann Siegfried A | Sauggeregelte zahnringpumpe |
US5865186A (en) * | 1997-05-21 | 1999-02-02 | Volsey, Ii; Jack J | Simulated heated cigarette |
WO2001087272A2 (fr) * | 2000-05-18 | 2001-11-22 | Therics, Inc. | Procede et forme d'un dispositif d'administration de medicament, par exemple enrober un noyau toxique a l'interieur d'une zone non toxique en forme posologique orale |
EP1386251A4 (fr) * | 2001-03-02 | 2005-11-23 | Euro Celtique Sa | Procede et appareil permettant de preparer des melanges pour des formes posologiques personnalisees |
US20030051728A1 (en) * | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
GB2381450B (en) * | 2001-10-31 | 2006-05-31 | Gw Pharma Ltd | Compositions for administration of natural or synthetic cannabinoids by vaporisation |
US7013888B2 (en) * | 2002-12-19 | 2006-03-21 | Scadds Incorporated | Self contained aerosol dual delivery system (SCADDS) |
IES20060065A2 (en) * | 2005-02-02 | 2006-10-18 | Oglesby & Butler Res & Dev Ltd | A device for vaporising vaporisable matter |
JP2008104966A (ja) * | 2006-10-26 | 2008-05-08 | Seiko Epson Corp | 霧化装置、吸引装置 |
US9376704B2 (en) * | 2007-02-12 | 2016-06-28 | Charm Sciences, Inc. | Test kit and method for detecting bacteriophage |
EP2708256A3 (fr) * | 2007-03-30 | 2014-04-02 | Philip Morris Products S.A. | Dispositif et procédé pour administrer un médicament |
WO2008152980A1 (fr) * | 2007-06-12 | 2008-12-18 | Olympus Corporation | Récipients pour mélanger un échantillon biologique avec un réactif et procédé de mélange d'un échantillon biologique avec un réactif |
GB0714134D0 (en) * | 2007-07-19 | 2007-08-29 | Norton Healthcare Ltd | Dry-powder medicament |
EP2408494B1 (fr) * | 2009-03-17 | 2021-05-05 | Philip Morris Products S.A. | Système de génération d'aérosol de nicotine à base de tabac |
BRPI0925048B8 (pt) * | 2009-05-07 | 2021-06-22 | Gea Pharma Systems Ltd | módulo para produção de comprimidos e método para a produção contínua de comprimidos |
CN102458541A (zh) * | 2009-06-25 | 2012-05-16 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 吸入器 |
US8124797B2 (en) | 2009-06-26 | 2012-02-28 | Lyondell Chemical Technology, Lp | Epoxidation process |
US8647285B2 (en) * | 2009-07-17 | 2014-02-11 | Biophor Diagnostics, Inc. | Fluid sample collection system |
FR2951989B1 (fr) * | 2009-10-30 | 2012-02-03 | Medelpharm | Installation pour la realisation d'un produit solide a partir d'un ou de plusieurs materiaux pulverulents |
WO2011117012A1 (fr) | 2010-03-23 | 2011-09-29 | Nestec S.A. | Amélioration de la valeur nutritionnelle de produits alimentaires |
US20170368273A1 (en) * | 2010-08-23 | 2017-12-28 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
US9180264B2 (en) * | 2010-11-29 | 2015-11-10 | Sanofi-Aventis Deutschland Gmbh | Medicated module for an inhaler |
US9709580B2 (en) * | 2011-05-12 | 2017-07-18 | William Marsh Rice University | Bio-nano-chips for on-site drug screening |
PL2714162T3 (pl) * | 2011-05-27 | 2020-08-24 | Boehringer Ingelheim International Gmbh | Inhalator i kapsułka do inhalatora |
US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
US20130014755A1 (en) * | 2011-07-11 | 2013-01-17 | Jay Kumar | Vaporization device |
US20130034633A1 (en) | 2011-08-02 | 2013-02-07 | Von Hasseln Kyle William | Apparatus and Method for Producing a Three-Dimensional Food Product |
US20130220314A1 (en) * | 2012-02-29 | 2013-08-29 | General Electric Company | Medical vaporizer with porous vaporization element |
US9445971B2 (en) * | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
GB201211305D0 (en) * | 2012-06-26 | 2012-08-08 | Gamlen Michael | Tablet press |
US10034988B2 (en) * | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
EP2925273A4 (fr) * | 2012-11-28 | 2016-08-31 | Jaleva Pharmaceuticals Llc | Applicateur à deux chambres |
CA3237942A1 (fr) * | 2013-03-01 | 2014-09-04 | Compassionate Analytics Inc. | Procedes de quantification de cannabinoide |
US20140261486A1 (en) * | 2013-03-12 | 2014-09-18 | R.J. Reynolds Tobacco Company | Electronic smoking article having a vapor-enhancing apparatus and associated method |
WO2014150826A1 (fr) * | 2013-03-15 | 2014-09-25 | Aerodesigns, Inc. | Distributeur d'aérosol ayant une cartouche comestible |
CN105473012B (zh) * | 2013-06-14 | 2020-06-19 | 尤尔实验室有限公司 | 电子汽化设备中的具有单独的可汽化材料的多个加热元件 |
WO2015006720A1 (fr) * | 2013-07-12 | 2015-01-15 | Wisys Technology Foundation | Procédé colorimétrique et trousse pour détecter des drogues illicites |
US10292424B2 (en) * | 2013-10-31 | 2019-05-21 | Rai Strategic Holdings, Inc. | Aerosol delivery device including a pressure-based aerosol delivery mechanism |
US9339975B2 (en) * | 2013-12-31 | 2016-05-17 | Nike, Inc. | 3D printer with native spherical control |
EP3099363A4 (fr) * | 2014-01-31 | 2018-03-28 | Cannakorp, Inc. | Procédés et appareil de production de vapeur à base d'herbes |
US20150245632A1 (en) | 2014-02-28 | 2015-09-03 | Xerox Corporation | Printed chocolate structures |
US20170064997A1 (en) * | 2014-02-28 | 2017-03-09 | Beyond Twenty Ltd. | Electronic vaporiser system |
TWI669072B (zh) * | 2014-05-21 | 2019-08-21 | 瑞士商菲利浦莫里斯製品股份有限公司 | 電熱式霧劑產生系統及用於此系統中之匣筒 |
GB201500582D0 (en) * | 2015-01-14 | 2015-02-25 | British American Tobacco Co | Apparatus for heating or cooling a material contained therein |
US10300228B2 (en) * | 2014-08-26 | 2019-05-28 | Innovosciences, Llc | Thermal modulation of an inhalable medicament |
GB201418817D0 (en) * | 2014-10-22 | 2014-12-03 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
CN106999972B (zh) * | 2014-12-17 | 2020-03-24 | 阿甘芳香和精细化工有限公司 | 用于释放香味的系统和方法 |
US9814271B2 (en) * | 2015-01-13 | 2017-11-14 | Haiden Goggin | Multiple chamber vaporizer |
US9765000B2 (en) * | 2015-01-22 | 2017-09-19 | Phytoplant Research S.L. | Methods of purifying cannabinoids, compositions and kits thereof |
CN107404950B (zh) * | 2015-03-27 | 2022-02-08 | 菲利普莫里斯生产公司 | 包括一体化穿刺元件的气溶胶生成系统 |
GB2541719B (en) * | 2015-08-27 | 2019-06-12 | Nerudia Ltd | An inhaler |
US20170055574A1 (en) * | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Cartridge for use with apparatus for heating smokable material |
US9907930B2 (en) * | 2015-10-06 | 2018-03-06 | Michael Alexander Trzecieski | Aromatherapy vaporization device |
WO2017075096A1 (fr) * | 2015-10-26 | 2017-05-04 | Blaesi Aron H | Forme galénique solide à libération immédiate de médicament et appareil et procédé de fabrication associés |
US10412995B2 (en) * | 2015-12-01 | 2019-09-17 | Altria Client Services Llc | E-vapor device including puncture device and sealed packet of pre-vapor formulation |
MX2018007311A (es) * | 2015-12-22 | 2018-09-11 | Philip Morris Products Sa | Un cartucho para un sistema generador de aerosol y un sistema generador de aerosol que comprende un cartucho. |
CA3009441A1 (fr) * | 2016-01-25 | 2017-08-03 | Philip Morris Products S.A. | Ensemble cartouche possedant un corps de cartouche coulissant |
GB201602831D0 (en) * | 2016-02-18 | 2016-04-06 | British American Tobacco Co | Flavour delivery device |
US11285082B2 (en) | 2016-04-05 | 2022-03-29 | Jan Franck | Device and method for the dosing of active substances for the preparation of medicaments |
CN205648930U (zh) * | 2016-05-17 | 2016-10-19 | 深圳市博迪科技开发有限公司 | 具有气流散热功能的电子烟烟嘴及烧草式电子烟 |
WO2017207674A1 (fr) * | 2016-05-31 | 2017-12-07 | Philip Morris Products S.A. | Système générateur d'aérosol à commande électrique avec article tubulaire générateur d'aérosol à écoulement d'air amélioré |
US10791760B2 (en) * | 2016-07-29 | 2020-10-06 | Altria Client Services Llc | Aerosol-generating system including a cartridge containing a gel |
WO2018019738A1 (fr) * | 2016-07-29 | 2018-02-01 | Philip Morris Products S.A. | Système producteur d'aérosol comprenant une cartouche contenant un gel et un dispositif pour chauffer la cartouche |
US10440993B2 (en) * | 2016-10-10 | 2019-10-15 | Innovosciences Llc | Hand-held inhalable vapor producing device and method |
JP7399711B2 (ja) * | 2016-11-14 | 2023-12-18 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 可変気流を有するエアロゾル発生システム |
US10092039B2 (en) * | 2016-12-14 | 2018-10-09 | Rai Strategic Holdings, Inc. | Smoking article for on-demand delivery of an increased quantity of an aerosol precursor composition, a cartridge, and a related method |
KR102558187B1 (ko) * | 2017-02-17 | 2023-07-24 | 메사추세츠 인스티튜트 오브 테크놀로지 | 제약 정제를 비롯한 정제의 제작을 위한 시스템 및 방법 |
US10219544B2 (en) * | 2017-03-24 | 2019-03-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device and a related method |
GB201705693D0 (en) * | 2017-04-07 | 2017-05-24 | Sensus Invest Ltd | Carrier, apparatus and method |
WO2018216019A1 (fr) * | 2017-05-25 | 2018-11-29 | Ian Solomon | Appareil permettant de distribuer un aérosol liquide à des surfaces de cavité buccale |
WO2018224677A2 (fr) * | 2017-06-09 | 2018-12-13 | Philip Morris Products S.A. | Système de génération d'aérosol adaptable |
CA3061895A1 (fr) * | 2017-06-28 | 2019-01-03 | Philip Morris Products S.A. | Recipient avec des particules destinees a etre utilisees avec un inhalateur |
CN208193372U (zh) * | 2017-07-04 | 2018-12-07 | 湖南凯利医疗科技有限公司 | 一种全气囊引流管 |
EP3706833B1 (fr) | 2017-11-10 | 2023-08-16 | Conzima GmbH | Procédé et dispositif d'injection sans aiguille d'un liquide dans un substrat et récipient de liquide destiné à être utilisé dans le procédé et le dispositif |
JP7206274B2 (ja) * | 2017-11-30 | 2023-01-17 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 内表面サセプタ材料を有するカートリッジ |
US10201503B1 (en) * | 2018-01-09 | 2019-02-12 | Triastek, Inc. | Precision pharmaceutical 3D printing device |
WO2020023535A1 (fr) * | 2018-07-23 | 2020-01-30 | Juul Labs, Inc. | Gestion de flux d'air pour dispositif vaporisateur |
US11001799B2 (en) * | 2018-10-18 | 2021-05-11 | Terragene Llc | Biological disinfection or sterilization indicator |
EP3876760B1 (fr) * | 2018-11-08 | 2024-05-15 | Juul Labs, Inc. | Cartouches pour dispositifs vaporisateurs |
KR20230016618A (ko) * | 2020-05-28 | 2023-02-02 | 제이티 인터내셔널 소시에떼 아노님 | 히터를 갖는 홀더 및 액체 캡슐을 포함하는 에어로졸 발생 시스템 및 장치 |
US11832651B2 (en) * | 2020-12-16 | 2023-12-05 | Flume Sarl | Hookah bowl thermal vaporizer |
-
2019
- 2019-12-10 CN CN201980093775.9A patent/CN113873903A/zh active Pending
- 2019-12-10 CA CA3125798A patent/CA3125798A1/fr active Pending
- 2019-12-10 EP EP19836461.4A patent/EP3908133B1/fr active Active
- 2019-12-10 DE DE112019006596.3T patent/DE112019006596A5/de not_active Withdrawn
- 2019-12-10 WO PCT/DE2019/101064 patent/WO2020143862A1/fr unknown
- 2019-12-10 DE DE112019006582.3T patent/DE112019006582A5/de not_active Withdrawn
- 2019-12-10 DE DE112019006577.7T patent/DE112019006577A5/de not_active Withdrawn
- 2019-12-10 WO PCT/DE2019/101068 patent/WO2020143865A1/fr unknown
- 2019-12-10 CA CA3125792A patent/CA3125792C/fr active Active
- 2019-12-10 CN CN201980093719.5A patent/CN113677225A/zh active Pending
- 2019-12-10 US US17/421,058 patent/US20220054769A1/en active Pending
- 2019-12-10 EP EP19827605.7A patent/EP3908131B8/fr active Active
- 2019-12-10 WO PCT/DE2019/101067 patent/WO2020143864A1/fr unknown
- 2019-12-10 US US17/421,068 patent/US20220095681A1/en active Pending
- 2019-12-10 EP EP19835604.0A patent/EP3908244B1/fr active Active
- 2019-12-10 CA CA3125791A patent/CA3125791A1/fr active Pending
- 2019-12-10 DE DE112019006578.5T patent/DE112019006578A5/de not_active Withdrawn
- 2019-12-10 CN CN201980093726.5A patent/CN113543663A/zh active Pending
- 2019-12-10 CN CN201980093710.4A patent/CN113557001B/zh active Active
- 2019-12-10 US US17/421,046 patent/US20220057417A1/en active Pending
- 2019-12-10 EP EP24154965.8A patent/EP4338722A3/fr active Pending
- 2019-12-10 WO PCT/DE2019/101065 patent/WO2020143863A1/fr unknown
- 2019-12-10 US US17/421,062 patent/US11946942B2/en active Active
- 2019-12-10 EP EP19836460.6A patent/EP3908132A1/fr active Pending
- 2019-12-10 CA CA3125779A patent/CA3125779A1/fr active Pending
-
2021
- 2021-07-21 ZA ZA2021/05146A patent/ZA202105146B/en unknown
- 2021-07-21 ZA ZA2021/05141A patent/ZA202105141B/en unknown
- 2021-07-21 ZA ZA2021/05142A patent/ZA202105142B/en unknown
- 2021-07-21 ZA ZA2021/05145A patent/ZA202105145B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3908244B1 (fr) | Dispositif et procédé de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire | |
EP0049909B1 (fr) | Compositions pharmaceutiques en forme d'unités de dosage solides ainsi que méthode pour leur préparation | |
DD147203A5 (de) | Verfahren zur herstellung von arzneimitteln mit aufgepunktetem wirkstoff | |
DD219729A5 (de) | Verfahren und vorrichtungen zum bepunkten von werkzeugen | |
EP2902327B1 (fr) | Dispositif de dosage pour poudre et procédé de dosage de poudre | |
EP2081758A2 (fr) | Procédé et dispositif de moulage d'ébauches à partir d'une matière malléable | |
DE102017003662A1 (de) | Beschichtungsvorrichtung mit Schieber und Verfahren zur Herstellung von dreidimensionalen Bauteilen | |
DE2604791A1 (de) | Verfahren zur herstellung einer mehrbezirkstablette und tablette, hergestellt nach diesem verfahren | |
DE202016000442U1 (de) | Fülleinrichtung für das Befüllen von Zielbehältern mit einem Pulverprodukt | |
DE2834226A1 (de) | Presskoerper und verfahren sowie vorrichtung zu ihrer herstellung | |
EP2281683B1 (fr) | Procédé de production d'un élément de poudre comprimé et dispositif correspondant | |
EP3900923B1 (fr) | Procédé de fabrication automatisée de comprimés individualisés et presse à comprimés destinée à la fabrication automatisée de comprimés individualisés | |
EP1212191A1 (fr) | Procede et dispositif de production de comprimes | |
EP3650212B1 (fr) | Procédé de fabrication automatisée de comprimés individualisés et presse à comprimés destinée à la fabrication automatisée de comprimés individualisés | |
EP1702843A1 (fr) | Dispositif pour remplir des quantités prédéterminées de poudre | |
EP3369409B1 (fr) | Dispositif et procédé de dosage de matériaux de remplissage pulvérulents | |
EP4072519A1 (fr) | Procédé et dispositif d'impression par points pour la fabrication additive de formes galéniques contenant des principes actifs | |
EP2977195A1 (fr) | dispositif et procédé de fabrication de comprimés multi-couches | |
EP3975987A1 (fr) | Formes galéniques pharmaceutiques et procédé pour les produire | |
DE10246659A1 (de) | Verfahren und Vorrichtung zum dosierten Befüllen von Behältnissen mit mikronisiertem Pulver | |
DE102019134284A1 (de) | Vorrichtung und Verfahren zum Drucken von 3D Medikamenten in Form von Tabletten und biologischem Material | |
EP2081759B1 (fr) | Procédé et dispositif de moulage à cycles de rotation à haut rendement | |
EP3492394B1 (fr) | Dispositif de remplissage dosé d'une paille pour boisson avec un produit de remplissage | |
EP3492395B1 (fr) | Dispositif et procédé destinés au remplissage dosé de récipients à l'aide d'un produit de remplissage | |
EP4391986A1 (fr) | Dispositif de préparation d'un produit pharmaceutique, d'un complément alimentaire ou d'un produit cosmétique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20210709 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: LUXCAN INNOVATION S.A. |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: LUXCAN INNOVATION S.A. |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RAP3 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: LUXCAN INNOVATION S.A. |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: LUXCAN INNOVATION S.A. |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
INTG | Intention to grant announced |
Effective date: 20231128 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SCHMITT, FRITZ |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502019010563 Country of ref document: DE |
|
U01 | Request for unitary effect filed |
Effective date: 20240207 |
|
U07 | Unitary effect registered |
Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI Effective date: 20240212 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240607 |