CN113873903A - 用于定性和/或定量地检测大麻植物中所含物质的方法及其中使用的套件 - Google Patents

用于定性和/或定量地检测大麻植物中所含物质的方法及其中使用的套件 Download PDF

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CN113873903A
CN113873903A CN201980093775.9A CN201980093775A CN113873903A CN 113873903 A CN113873903 A CN 113873903A CN 201980093775 A CN201980093775 A CN 201980093775A CN 113873903 A CN113873903 A CN 113873903A
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ampoule
cannabis
color indicator
color
kit according
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CN201980093775.9A
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CN113873903B (zh
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弗里茨·施密特
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Luxkan Innovation Pte Ltd
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Fu LiciShimite
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Abstract

本发明涉及一种套件以及一种用于使用该套件定性和/或定量地检测大麻植物中所含的一种或多种物质的方法，该套件包括：a)安瓿；b)包含大麻植物或其部分的材料；和c)颜色指示剂，其适合通过与大麻植物和/或其至少一部分接触而发生反应，改变所述颜色指示剂的颜色，其中，所述材料和所述颜色指示剂布置在所述安瓿中。

Description

用于定性和/或定量地检测大麻植物中所含物质的方法及其 中使用的套件
技术领域
本发明涉及一种用于定性和/或定量地检测大麻植物中所含物质的方法。本发明还涉及一种用于该方法中的套件。
背景技术
大麻合法化及其作为药物的使用引发了生产商和分销商尤其是药剂师和医生的许多质量保证问题。特别是，必须由药剂师保证，并根据制药规则以可验证的方式记录投放市场的产品具有多大的活性成分含量。
关于THC和CBD含量的信息尤其成问题。就这些铅物质的含量而言，没有固定的上下限，但应该是已知的或能够确定的。一个批次的含量应处于在包装上声明的含量的+/-10％范围内。这是因为，各个品种的四氢大麻酚(THC)和大麻二酚(CBD)部分地含量差异很大。在此没有考虑到的是，即使在一个品种内，不同的收获物之间也可能存在相当大的差异。从制药的角度来看，这是不能令人满意的，尤其是在预计未来会发生变化的更严格的要求的背景下。
在EP 1 32 313 A2中描述了基于重氮试剂的用于药物测试包的大麻素检测方法。反应在滤纸上进行，试剂在此以液体形式或作为喷雾施用。这些方法和类似的方法执行起来比较麻烦。此外，需要采用诸如干燥、萃取、过滤和蒸发的措施来制备样品材料，以便能够进行相应的测定。这需要耗费大量的工作和时间，有时还会导致样品材料的材料成分发生变化。此外，这些方法通常需要使用有毒的或高腐蚀性的化学品，这对于外行的广泛应用来说是有问题的。
发明内容
因此，本发明的目的是，提供一种克服现有技术的缺点的用于对大麻植物中所含物质进行定性和/或定量检测的方法，特别是提供一种允许特别是由那些在化学分析方面缺乏经验的人，例如本领域技术人员、药剂师、医生、临床工作人员等，简单且廉价地分析在大麻植物或其他基于大麻的产品中可能含有的物质的方法。根据本发明的方法尤其还应当允许在分析上缺乏经验的人例如药剂师，以符合当前要求的准确度来确定在基于大麻的产品中的活性成分含量。
该目的是通过一种套件实现的，该套件包括：a)安瓿；b)包含大麻植物或其部分的材料；c)颜色指示剂，其适合通过与大麻植物和/或其至少一部分接触而发生反应，改变颜色指示剂的颜色，其中，材料和颜色指示剂布置在安瓿中。
根据本发明的方法允许在大麻或基于大麻的材料投放市场之前对其进行简单的定性和定量的质量检查。这种测试也可以由没有经验的人例如药剂师以简单且安全的方式进行，于是他可以保证和证明他销售的产品的质量。
该材料包括大麻植物或其一部分。从大麻植物中分离的单一化合物，优选药物活性化合物，也可以理解为大麻植物的一部分。
大麻(大麻)与葎草属(Humulus)一起属于大麻科，但葎草属植物不含大麻素。在大麻属内，存在植物学和化学分类学上的差异，确切地说，分为物种大麻苜蓿林奈(Cannabissativa Linnaeus)、印度大麻(Cannabis indica)LAM和莠草大麻(Cannabis ruderalis)，或分为“集体物种”大麻(Cannabis sativa L.)，其由亚种Cannabis sativa ssp.sativa和ssp.indica组成。此外，大麻分为药物大麻和纤维大麻，其中，根据主要大麻素大麻二酚(CBD)和Δ9-四氢大麻酚(Δ9-THC)(INN：屈大麻酚)的数量比进行区分。纤维大麻(又作：工业大麻)主要用于工业纤维生产，可以具有最多0.2％的Δ9-THC含量(如德国等)，而药物类型可以具有约5-15％的Δ9-THC含量(大麻叶、大麻膏)。Cannabis sativa L.包含400多种不同的成分，其中的60多种化合物属于大麻素类。主要大麻素如下所示：
o大麻酚类(CBG)：大麻酚((E)-CBG-C5)、大麻酚单甲醚((E)-CBGM-C5 A)、大麻酚酸A((Z)-CBGA-C5 A)、大麻二酚((E))-CBGV-C3)、大麻二酚酸A((E)-CBGA-C5 A)、大麻二酚酸A单甲醚((E)-CBGAM-C5 A)、大麻二酚酸A((E)-CBGVA-C3 A)；
o大麻素类(CBC)：大麻素(CBC-C5)、大麻素酸A(CBCA-C5 A)、大麻色素(CBCV-C3)、大麻色素酸A(CBCVA-C3 A)；
o大麻二酚类(CBD)：大麻二酚(CBD-C5)、大麻二酚单甲醚(CBDM-C5)、大麻二酚-C4(CBD-C4)、大麻二酚(CBDV-C3)、大麻二酚(CBD-C1)、大麻二酚酸(CBDA-C5)、大麻二酸(CBDVA-C3)；
o大麻二酚类(CBND)：大麻二酚(CBND-C5)、大麻二酚(CBND-C3)；
o四氢大麻酚类(THC)：Δ9-四氢大麻酚(Δ9-THC-C5)、Δ9-四氢大麻酚-C4(Δ9-THC-C4)、Δ9-四氢大麻酚(Δ9-THCV-C3)、Δ9-四氢大麻酚(Δ9(Δ9-THC-C4)-C1)、Δ9-四氢大麻酚酸(Δ9-THCA-C5 A)、Δ9-四氢大麻酚酸B(Δ9-THCA-C5 B)、Δ9-四氢大麻酚酸-C4(Δ9-THCA-C4 A和/或B)、Δ9-四氢大麻酸A(Δ9-THCVA-C3 A)、Δ9-四氢大麻二酚酸(Δ9-THCOA-C1 A和/或B)、(-)-Δ8-反式-(6aR,10aR))-Δ8-四氢大麻酚(Δ8-THC-C5),(-)-Δ8-反式-(6aR,10aR)-四氢大麻酚酸A(Δ8-THCA-C5 A)；(-)-(6aS,10aR)-Δ9-四氢大麻酚((-)-cis-Δ9-THC-C5)；
o大麻酚类(CBN)：大麻酚CBN-C5、大麻酚-C4(CBN-C4)、大麻酚(CBN-C3)、大麻酚C2(CBN-C2)、大麻酚(CBN-C1)、大麻酚酸A(CBNA)-C5 A)、大麻酚甲醚(CBNM-C5)
o大麻三醇类(CBT)：(-)-(9R,10R)-反式-大麻三醇((-)-反式CBT-C5),(+)-(9S,10S)-大麻三醇((+)-反式-CBT-C5),(±)-(9R,10S/9S,10R)-大麻三醇((±)-cis-CBT-C5),(-)-(9R,10R)-反式[10-0-乙基-大麻三醇]((-)-反式-CBT-OEt-C5),(±)-(9R,10R/9S,10S)-大麻三醇-C3((±)-反式-CBT-C3),8,9-二羟基-Δ6a(10a)四氢大麻酚(8,9-Di-OH-CBT-C5),大麻二酚酸A(CBDA-C5 9-OH-CBT-C5酯),(-)-(6aR,9S,10S,10aR)-9,10-二羟基-六氢大麻,大麻酚大麻酚-C5,(-)-6a,7,10a-三羟基-Δ9-四氢大麻酚((-)-大麻二酚),10-oxo-Δ6a(10a)四氢大麻酚(OTHC)；
o大麻素(Cannabielsoin)类(CBE):(5aS,6S,9R,9aR)-C5-大麻素(CBE-C5),(5aS,6S,9R,9aR)-C3-大麻素(CBE-C3),(5aS,6S),9R,9aR)-大麻二酚酸A(CBEA-C5 A),(5aS,6S,9R,9aR)-大麻二酚酸B(CBEA-C5 B),(5aS,6S,9R,9aR)-C3-大麻二酚酸B(CBEA -C3 B)、大麻二酚-C3(OH-iso-HHCV-C3)、脱氢大麻呋喃(DCBF-C5)、大麻呋喃(CBF-C5)；
o异大麻素：(-)-Δ7-反式-(1R,3R,6R)-异四氢大麻酚，(±)-Δ7-1,2-cis-(1R,3R,6S/1S,3S,6R)-异四氢大麻素，(-)-Δ7-反式-(1R,3R,6R)-异四氢大麻素；
o大麻二酚(Cannabicyclol)类(CBL):(±)-(1aS,3aR,8bR,8cR-大麻二酚(CBL-C5),(±)-(1aS,3aR,8bR,8cR-大麻二酚酸A (CBLA-C5 A)),(±)-(1aS,3aR,8bR,8cR-大麻二酚(CBLV-C3)；
o大麻素类(CBT)：大麻素(CBT-C5)；
o大麻色满酮类(CBCN)：大麻色满酮(CBCN-C5)、大麻色满酮-C3(CBCN-C3)、大麻色满酮(CBCON-C5)。
除了上面提到的大麻素，它们的相关羧酸存在于原料药中。这些羧酸是生物合成的前体。
大麻制剂具有多种治疗作用，包括抗痉挛、镇痛、止吐、神经保护、抗炎以及对精神疾病的作用(Grotenhermen F、Müller-Vahl K：The therapeutic potential of cannabisand cannabinoids(大麻和大麻素的治疗潜力))。
在德国，一种含有比例为1:1的THC(屈大麻酚)和CBD(萘酚)的大麻提取物自2011年以来根据制药法已被批准作为舌下喷雾剂(Sativex)，用于治疗多发性硬化症(MS)的中度至重度、难治性痉挛。
大麻二酚(CBD,CBD-C5)是大麻属中最重要的非精神性大麻素，CBD不是大麻素受体激动剂。
图1：CBD(结构式)
Figure BDA0003249786630000041
CBD可以合成生产(Michoulam R,Shvo Y.,Hashish.I.The structure ofcannabidiol,Tetrahedron(大麻二酚的结构，四面体).1963,19(12),2073)。
在一个实施方式中可以规定，材料包含大麻花、大麻叶(marijuana)、大麻膏(hashish)、大麻油、至少一种大麻素或其混合物。
在各种不同的实施方式中，根据本发明的套件(以及根据本发明的下述方法)可以用于大麻制品例如大麻叶、大麻膏、大麻油和其他含大麻素的材料的鉴定和质量测定，用于确定大麻植物的成熟程度，以及用于区分药物—即使对于新鲜或干燥形式的年轻大麻植物。
特别地可以规定，根据本发明的套件/方法用于各种不同的酚类化合物、精油、树脂类、新鲜植物、植物药物、植物提取物和萃取物及气味物质的化学检测，以及用于它们的鉴定和表征以及质量测定。
在另一实施方式中可以规定，颜色指示剂包含成色物质，该成色物质优选地选自于由以下组成的组：真黑、真蓝盐、二溴醌氯酰亚胺、二氯醌氯酰亚胺、香草醛、水杨醛、甲醛、乙醛、对二甲氨基苯甲醛、二乙氨基苯甲醛、三氯化铁、氨基苯酚、氨基安替比林、六氰基铁酸钾及其两种或多种的混合物。
同样可以规定，颜色指示剂包含至少一种优选地选自于由水和一元醇或多元醇构成的组的溶剂。
特别地可以规定，作为溶剂，单独使用一元醇或多元醇或使用其混合物，其一方面保证从材料中最佳地提取活性成分，但另一方面也为所用的成色物质以及必要时颜色指示剂的其它组成部分提供了良好的溶解性能，并且保证了无干扰的颜色反应。
在另一实施方式中可以规定，颜色指示剂还包含支持材料与成色物质反应的试剂，其中，该试剂优选为碱性化合物，特别优选地选自于由碱金属氢氧化物、碱金属碳酸盐、有机酸的铵盐或碱金属盐及其两种或多种的混合物构成的组。
此外可以规定，颜色指示剂还包括载体材料，优选吸收性的中性载体材料。载体材料可以是开孔或闭孔的。颜色指示剂的各个组成部分，例如着色物质或试剂，可以包含在孔中。
在一个实施方式中可以规定，颜色指示剂由成色物质在水中和/或伯醇、仲醇和/或叔醇中的第一溶液和碱例如碱金属氢氧化物在水或醇中的第二溶液或它们的混合物组成。
根据本发明规定，在颜色指示剂中含有的组成部分，单独地或与颜色指示剂的颜色变化一起对包含在根据本发明的材料中的物质的存在状态做出反应。
在另一实施方式中可以规定，安瓿是可分开的安瓿，它由两个或多个部分组成，这些部分可以相互连接，以便形成安瓿，其中，颜色指示剂布置在这些部分之一的内壁的至少一部分上，这些部分可以相互连接，以便形成安瓿。
根据本发明可以规定，安瓿是气密的和/或可气密地封闭。
例如可以规定，安瓿由三个不同的气密地相互连接的部分组成。安瓿的各个部分的连接可以通过不同的方式实现，例如将各部分相互拧紧。可以规定，颜色指示剂设置在可分开的安瓿的一部分(或几个部分)的内壁(或其一部分)上。在此，该内壁是在各部分组装和连接后朝向安瓿内部布置的部分。在此可以规定，载体例如通过在载体和内壁之间的粘合连接而布置在安瓿的内壁或其一部分上。颜色指示剂的其余组成部分，特别是成色物质，然后被布置在载体上，朝向安瓿的内侧，以便与材料或者从该材料释放出来的组成部分接触，例如与从大麻植物中释放出来的物质接触。
在一个实施方式中可以规定，在其内壁上至少部分地布置有颜色指示器的部分是间隔盘，该间隔盘可以通过拧紧与可分开的安瓿的一个或多个其它的部分连接。
在一个实施方式中可以规定，可分开的安瓿的各个组成部分包括盘形的、可旋拧的环，这些环可以在两侧相互连接。
在另一实施方式中可以规定，安瓿，特别是安瓿的内部，是耐腐蚀的，尤其是耐酸和碱的。
在另一实施方式中规定，安瓿是透明的。在此尤其可以规定，安瓿由硼硅玻璃构成。安瓿的透明度允许可以容易地光学评估颜色指示剂的颜色变化，必要时附加地相应存储，并与作为参照存储在数据库中的数据进行比较。
在另一实施方式中可以规定，安瓿被抽真空。
该目的还通过一种用于定性和/或定量地检测大麻植物中所含的一种或多种物质的方法来实现，该方法包括如下步骤：a)提供根据本发明的套件；b)使材料或其部分与颜色指示剂接触；c)探测颜色指示剂的颜色变化。
在此可以规定，使材料或其部分与颜色指示剂接触包括，加热安瓿中的材料或其部分。在这方面可以规定，加热包括感应加热。
在另一实施方式中可以规定，使用比色标尺、光学传感器、化学传感器或它们中的两个或更多个进行探测。
同样可以规定，该方法还包括在探测之后的步骤，包括将通过探测获得的信息与存储在数据库中的数据进行比较。
附图说明
下面借助具体实施方式，参照附图对本发明进行说明。在此应理解，对具体实施方式的引用仅用于说明本发明。具体实施方式的特征并不一定是对本发明的限制，但能够特别是与上述实施方式相组合地有助于本发明的有利实施。
图1：根据本发明的一个实施方式的安瓿的示意图；
图2：根据本发明的另一实施方式的安瓿的示意图；和
图3：根据本发明的另一实施方式的安瓿的示意图。
具体实施方式
本发明涉及一种药用大麻的质量测试方法，其中，材料如大麻花或其部分位于安瓿中，该安瓿可以经过设计，从而可以确保药剂师对安瓿本身或通过与附加部件相组合来进行相应的测试，以便投放市场，并且可以根据制药规则可验证地记录和制作测试证书。
根据本发明的方法可以规定，大麻花或其部分在收获后立即密封包装，并封闭在优选由硼硅玻璃制成的特殊透明安瓿中，使得活性成分只能通过破坏安瓿才能取出。可以使用这里介绍的各种不同的辅助工具在安瓿内进行化学分析检查。结果可以作为数据置于相应的条形码或类似物上。其它相应的相关信息是：例如种植、收获、加工、质量检测、储存、包装，当然也防篡改地存在。这可以通过把激光码烤入表面来实现。数据可以在扩展坞中读出。
使用在权利要求中更详细描述的该新方法，即使在植物生长期间也可以进行质量测试。可考虑的是，安瓿中的大麻花是在生长期间予以检查的。
化学检查在安瓿中进行或利用安瓿进行。安瓿可以这样设计，即带有相应试剂的测试元件形成安瓿的一部分，或者可以拧紧在安瓿上。
通过在权利要求书中描述的套件确保符合通常的要求，特别是：
·始终如一的产品质量
·所含物质
·活性成分浓度的信息
·避免任何类型的污染
·可追溯性
根据本发明的套件和根据本发明的方法使专业人员、药剂师、医生或临床人员能够化学检测酚类物质，特别是大麻素和含有此类物质的材料。
样品可以直接地即例如以预处理的或未处理的形式，即使没有预先干燥，也能直接添加成色试剂。这可以通过如下方式来实现：如图1所示的多部件式的安瓿100包括可拧上的环形适配器110。环形适配器110在其填充了环的面上含有对于分析材料120所必需的颜色指示剂。
颜色指示剂可以作为成色物质和试剂的溶液使用，添加或不添加有机溶剂。
成色物质优选以成色物质在水和/或伯醇、仲醇和叔醇中的稀溶液形式存在，添加或不添加有机溶剂，例如饱和与不饱和的烃、卤代烃、醚、酮、羧酸酯和/或芳香烃。
试剂优选为碱，例如碱金属氢氧化物和/或碱金属碳酸盐，有机酸的必要时由一个或多个有机基团例如烷基取代的铵盐或碱金属盐或其混合物，并且可以与成色物质一起在水和/或伯醇、仲醇和叔醇或其混合物中以稀溶液形式存在。必要时可以使用有机酸的铵盐或碱金属盐，例如乙酸、丙酸、丁酸、苹果酸、山梨酸、富马酸、苯甲酸、苯乙酸、邻苯二甲酸、萘乙酸或其混合物。
令人惊讶的是，已经可以开发出一种方法，在该方法中，特定选择的颜色反应经过如下修改：把与颜色反应相关的组成部分直接添加到用作萃取剂的溶剂中，并直接应用在化学检测反应中。在图2所示的安瓿200中，这是通过如下方式来实现的：将测试材料(未示出)，在这种情况下是大麻花，在安瓿200中压入第一间隔环210和第二间隔环220之间。在图2a中示出安瓿处于未压缩状态，而图2b示出相同的安瓿处于压缩状态。
颜色指示剂及其颜色变化可以利用相应的光学的和化学的传感器进行评估。
根据孔径测量方法，主要的酚醛体通过形成特定的、清晰可辨的颜色而单独被肉眼可见，因此能够以一种以前未知的简单快速的方式直接检测。由于所采用的方法发生在安瓿内部，因此排除了外部影响。通过在电子光学传感器的帮助下改进该方法，可以进行数据收集和数据存储。由此实现了额外最佳的、特别易于阅读的渐变，以及对所产生的色调的永久、持久的存储。通过这种方式，首次也可行的是，新鲜的、未处理的样品材料，甚至是新鲜植物以预处理或未处理的形式，即使没有预先干燥，例如在现场，直接受到检查，并且针对酚类或大麻素成分予以分析。由此可以在生长过程中比较所记录的数据。根据本发明的方法已表明特别适用于检测大麻素。由此第一次可以从两周大开始，区分年轻或成年、雄性或雌性植物中的药物大麻和工业大麻。此外，甚至可以直接在新鲜植物上，以快速且简单的方式确定大麻植物的成熟度。根据本发明的方法的应用领域包括大麻研究和医药、大麻消费(质量控制)和对药剂师、医生等的监管要求。此外，该方法可以用于检测生物样品材料中的大麻制剂。通过对试剂和程序的特殊修改，可以找到用于选择性检测单个特定大麻素的新方法。
由于该方法设计简单，所需试剂也很简单，因此该方法特别适用于可直接在现场使用的分析包。通过受软件支持地对显色色调的主要吸收最大值进行光度测量，该方法还可用于定量地测定所检测的酚醛体。数据存储和能比较扩展了在医用大麻的处理中的安全性。
在试剂溶液中，优选单独地或作为混合物使用一元醇或多元醇作为溶剂，这一方面保证了对活性成分的最佳提取，但另一方面也保证了捆扎纸板的负责化合的所用组成部分的良好溶解性能，并保证无干扰的颜色反应。显色器的对于显色所需的组成部分经过设计，使得它们只需以液滴形式添加到试剂混合物中，旨在尽量简单且有效的处理。通过向试剂溶液中添加有机酸的盐，可以实现显色色调的更好的可读性及其改进的耐久性。
在相应地存储色调时，可以创建一个数据库，其允许根据位置和来源分配大麻植物。
将借助以下例子解释和说明本发明，但不限于这些例子。
颜色表示的例子：
-新鲜大麻植物，未成熟的药大麻，紫色，微红色，成熟，蓝绿色
-成熟的欧盟工业大麻，紫红色
-百里酚，深蓝色
-大麻二酚(CBD)，紫粉色
-四氢大麻酚，绿蓝色
-大麻酚(CBN)，蓝色
为了确定成熟度，使用新鲜、未干燥的植物材料，因为在干燥过程中大麻素含量会发生变化(例如，大麻二酚转化为THC)。为了将其与工业大麻或药用大麻区分开来，使用植物的完全发育的手指状正常叶子(新鲜的或干燥的)，而不是花序或果实簇。通过测试至少两周大的某种年轻植物的正常手指状叶子，可以确定其未来可实现的最大大麻素谱。如果显色的色调太强烈而难以阅读，则应减少样本量，重新进行测试。样品量太少又会导致苍白、模糊的色调转变为黄色。在这种情况下，应使用大量样品重复测试。
进行测试：
将少量样品放置在图3所示的可分割的安瓿300的一部分的浸有试剂的环形表面310上。带有着色物质溶液的间隔件320用带有试剂溶液的间隔件330利用塑料盖340封闭，并在约1分钟内摇动数次。上清液中的所产生的颜色可以在一分钟内读出。在透亮的日光或明亮的表面上可以看到最佳效果。借助光谱仪进行受软件控制的评估自然会提供非常精确的结果。
在前述说明书和所附权利要求中公开的特性可以单独地或组合地形成用于以不同形式实现在独立权利要求中的公开内容的方面的主题。

Claims (16)

1.一种套件，包括：
a)安瓿；
b)包含大麻植物或其部分的材料；和
c)颜色指示剂，其适合通过与大麻植物和/或其至少一部分接触而发生反应，改变所述颜色指示剂的颜色，
其中，所述材料和所述颜色指示剂布置在所述安瓿中。
2.如权利要求1所述的套件，其中，所述材料包含大麻花、大麻叶、大麻膏、大麻油、至少一种大麻素或其混合物。
3.如权利要求1或2所述的套件，其中，所述颜色指示剂包含成色物质，该成色物质优选地选自于由以下组成的组：真黑、真蓝盐、二溴醌氯酰亚胺、二氯醌氯酰亚胺、香草醛、水杨醛、甲醛、乙醛、对二甲氨基苯甲醛、二乙氨基苯甲醛、三氯化铁、氨基苯酚、氨基安替比林、六氰基铁酸钾及其两种或多种的混合物。
4.如前述权利要求中任一项所述的套件，其中，所述颜色指示剂包含至少一种优选地选自于由水和一元醇或多元醇构成的组的溶剂。
5.如权利要求3或4中任一项所述的套件，其中，所述颜色指示剂还包含支持所述材料与所述成色物质反应的试剂，其中，所述试剂优选为碱性化合物，特别优选地选自于由碱金属氢氧化物、碱金属碳酸盐、有机酸的铵盐或碱金属盐及其两种或多种的混合物构成的组。
6.如权利要求3～5中任一项所述的套件，其中，所述颜色指示剂还包括载体材料，优选吸收性的中性载体材料。
7.如前述权利要求中任一项所述的套件，其中，所述安瓿是可分开的安瓿，它由两个或多个可以相互连接以便形成所述安瓿的部分组成，其中，所述颜色指示剂布置在可以相互连接以便形成所述安瓿的所述部分之一的内壁的至少一部分上。
8.如权利要求7所述的套件，其中，在其内壁上至少部分地布置有所述颜色指示器的部分是间隔盘，该间隔盘可以通过拧紧与可分开的所述安瓿的一个或多个其它的部分连接。
9.如前述权利要求中任一项所述的套件，其中，所述安瓿是透明的。
10.如权利要求9所述的套件，其中，所述安瓿至少部分地由硼硅玻璃构成。
11.如前述权利要求中任一项所述的套件，其中，所述安瓿被抽真空。
12.一种用于定性和/或定量地检测大麻植物中所含的一种或多种物质的方法，该方法包括如下步骤：
a)提供根据权利要求1～11中任一项所述的套件；
b)使材料或其部分与颜色指示剂接触；和
c)探测所述颜色指示剂的颜色变化。
13.如权利要求12所述的方法，其中，使所述材料或其部分与所述颜色指示剂接触包括：加热安瓿中的材料或其部分。
14.如权利要求13所述的方法，其中，所述加热包括感应加热。
15.如权利要求12～14中任一项所述的方法，其中，使用比色标尺、光学传感器、化学传感器或它们中的两个或更多个进行所述探测。
16.如权利要求12～15中任一项所述的方法，还包括在所述探测之后的步骤，包括将通过所述探测获得的信息与存储在数据库中的数据进行比较。
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US20220054769A1 (en) 2022-02-24
WO2020143863A1 (de) 2020-07-16
CN113873903B (zh) 2024-09-24
CN113557001A (zh) 2021-10-26
US20220057417A1 (en) 2022-02-24
WO2020143862A1 (de) 2020-07-16
WO2020143864A1 (de) 2020-07-16
EP3908133B1 (de) 2023-10-11
CN113543663A (zh) 2021-10-22
DE112019006596A5 (de) 2021-12-23
EP3908131B1 (de) 2024-04-17
DE112019006578A5 (de) 2022-01-13
WO2020143865A1 (de) 2020-07-16

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