CN113557001A - 用于将粉末状、液体状、糊状、包封的或颗粒状活性成分组合物压片的装置 - Google Patents

用于将粉末状、液体状、糊状、包封的或颗粒状活性成分组合物压片的装置 Download PDF

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Publication number
CN113557001A
CN113557001A CN201980093710.4A CN201980093710A CN113557001A CN 113557001 A CN113557001 A CN 113557001A CN 201980093710 A CN201980093710 A CN 201980093710A CN 113557001 A CN113557001 A CN 113557001A
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active ingredient
mould cavity
plunger
mould
reservoir
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Granted
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CN201980093710.4A
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CN113557001B (zh
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弗里茨·施密特
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Luxkan Innovation Pte Ltd
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Fu LiciShimite
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Abstract

本发明涉及一种用于将粉末状、液体状、糊状、包封的或粒状的活性成分组合物压片的装置，带有存放部(1)，该存放部具有多个活性成分容器(2)，这些活性成分容器各自具有可单独控制的配给机构(3)和用于输出活性成分的喷嘴(4)，其中，所述存放部(1)可相对于至少一个型模腔(5)在多个设定位置之间移调，其中，在每个所述设定位置，至少一个所述喷嘴(4)面向所述型模腔(5)的开口(6)。还介绍一种相应的方法。

Description

用于将粉末状、液体状、糊状、包封的或颗粒状活性成分组合 物压片的装置
技术领域
本发明涉及用于将粉末状、液体状、糊状、包封的或颗粒状的活性成分组合物压片的装置以及方法。特别地介绍用于生产粉末状、液体状、糊状、包封的或颗粒状的单剂量活性成分形式的装置以及方法，其中，所述组合物的至少一部分可以包含来自大麻植物(大麻)的活性成分。
背景技术
片剂是已知的，其在压片机上由粉末、颗粒或其他活性成分前体产品在压力下制造。片剂可以具有不同的形状。对于要服用的片剂，尤其双凸面形状广为采用。药用片剂属于其他与健康有关的用途的药物，应归入医疗产品或膳食补充剂。片剂也用于其他领域。在药物形式中，片剂扮演着特殊的角色，其份额接近50％。
每年有大量片剂未使用，因为它们由于过度包装而无法在有效期前使用。据估计，所有处方药中有30％未使用就被丢弃。
此外，今天仍在开处方药，就好像所有患者对治疗都有相同的生物学要求。然而，为了获得更好的治疗成功，医学进步越来越需要在开药时考虑患者的个体特征，并提供量身定制的治疗方法。同样，在许多情况下，与标准药物相比更经济的药物剂量就足够了，这也降低了副作用的风险。因此非常需要尤其是片剂形式的个体药物。
由现有技术已知例如也应用于食品技术中的3D打印机。在这种情况下，流动状态的食品成分通常被制成所需的三维形状，然后硬化。迄今为止，此类方法例如已用于由巧克力等制造模具。例如，WO 2011/117012 A1描述了将膳食补充剂选择性地应用于食品。US2013/0034633 A1描述了一种用于生产自由成形的三维食品的系统。此外，描述了一种方法，借助该方法可以改变制成的食品的某些特性。
EP 2 937 206 A1描述了一种用于生产基于巧克力的食品的方法，其中，巧克力在配给过程之后硬化，以便用作后续层的结晶引发剂。固体巧克力应形成完整的食品内外三维结构，在具有实心壁的结构的内腔中的液态的或气态的物质可以嵌入到该三维结构中。
WO 2010/151302 A1公开了一种用于打印食品的方法，其中，处理液体食品的和液体粘合剂的小滴，所述粘合剂优选由在施加压力时固化的胶凝剂组成。
US 2013/0034633 A1公开了一种三维食品的制造方法，其中，通过使用液体和粉末，局部限制地施加液滴，在一个粉末层中引起局部固化。通过应用其它粉末层和液滴结构，在去除未固化的粉末成分后形成三维食物结构。
发明内容
因此，本发明的目的是，提供用于将活性成分组合物压片的装置和方法，其能够高度灵活地适应变化的活性成分组合物并且是可扩展的。
该目的通过一种具有权利要求1的特征的装置来实现。并列独立权利要求16涉及一种相应的方法。有利的实施方式分别是从属权利要求的主题。
因此，提出了一种用于将粉末状、液体状、糊状、包封的或粒状的活性成分组合物压片的装置，其带有存放部，该存放部具有多个活性成分容器，这些活性成分容器各自具有可单独控制的配给机构和用于输出活性成分的喷嘴。存放部可相对于至少一个型模腔在多个设定位置之间移调，其中，在每个设定位置，至少一个喷嘴面向型模腔的开口。
存放部可以球形地构造。在这种情况下，活性成分容器可以在存放部的径向方向上延伸，并且以它们各自的喷嘴通入到存放部的球形表面中。可以规定，预备在活性成分容器中的活性成分在流体上与装置的周围分离地储存在活性成分容器中。活性成分容器可以至少部分地具有调温机构，以便将预备在活性成分容器之一中的活性成分保持在规定的温度，或在配给到型模腔中之前使其达到一定的温度，该温度促进了活性成分的化学转变，或改变了活性成分的物理特性。
至少一个型模腔可以容纳在基板中，该基板具有凹入的凹部，球形存放部容纳在该凹部中。在这种情况下，至少一个型模腔可以布置在凹部的最深点处。
存放部可以相对于基板围绕至少一个平行于基板延伸的轴线移调。
球形存放部可以在其中心具有空腔，球形触动部件可自由移动地且形状配合地或至少近似形状配合地容纳在该空腔中。在这种情况下，触动部件可以具有执行件，该执行件可在触动位置与松开位置之间移调。触动部件可以具有偏心的重心，该重心沿着执行件的直线移调方向布置在触动位置与松开位置之间。
球形触动部件可以具有穿过其中心延伸的通道，在该通道中设置了磁性线圈，该磁性线圈具有可沿线圈轴线移动的线圈芯。
通道可以相对于球形触动部件的重心适当布置，使得通道竖直地朝向，而与存放部的朝向无关。
存放部可以具有可直线移调的柱塞，在存放部的设定位置之一或另一设定位置，该柱塞相对于型模腔面向型模腔的开口。
柱塞可以在自由端具有柱塞型模，柱塞通过该柱塞型模在伸出的位置经由开口伸入到型模腔中，并且在松开位置通过该柱塞型模脱离与型模腔的接合。
至少一个活性成分容器可以具有用于活性成分的处理机构。该处理机构可以是用于加热活性成分的加热部件和/或用于冷却活性成分的冷却部件，或具有这样的部件。
除了具有多个活性成分容器之外，存放部还可以具有至少一个载体材料容器，该载体材料容器带有可单独控制的配给机构和用于输出载体材料的喷嘴。在此，在存放部的另一设定位置，载体材料容器的喷嘴可以面向型模腔的开口和/或装置的基板，该基板具有片剂包装部的型模。
型模可以具有多个型模腔，这些型模腔优选地布置成规则的网格。
用于利用上述类型的装置将活性成分压片的方法可以具有以下步骤：
a)指定要压片的活性成分组合物；
b)相对于型模腔移调存放部，直到存放部处于设定位置，在该设定位置，存放部的活性成分容器以其喷嘴面向型模腔，在该型模腔中预备有活性成分组合物的活性成分；
c)将由活性成分组合物预先确定的剂量的第一活性成分配给到型模腔中；和
d)如果活性成分组合物具有多于一种的活性成分，则针对于活性成分组合物中的任何其它的活性成分，任选地重复步骤b)和c)。
该方法可以具有以下其它的步骤：
e)相对于型模腔移调存放部，直到存放部处于设定位置，在该设定位置，存放部的粘合剂储备容器以其喷嘴面向型模腔，粘合剂预备在该粘合剂储备容器中；
f)将由活性成分组合物预先确定的剂量的粘合剂配给到型模腔中。
此外，该方法可以具有以下步骤：
g)相对于型模腔移调存放部，直到存放部处于设定位置，在该设定位置，存放部的可直线移调的柱塞面向型模腔的开口，该柱塞在一个自由端具有柱塞型模；
h)将柱塞从松开位置移动到伸出位置，在该松开位置，柱塞以其柱塞型模脱离与型模腔的接合，在该伸出位置，柱塞以其柱塞型模经由开口伸入到型模腔中，其中，将至少一种配给到型模腔中的活性成分且必要时将粘合剂压实。
同样，该方法还可以具有以下步骤：
i)相对于型模腔移调存放部，直到存放部处于设定位置，在该设定位置，存放部的载体材料容器以其喷嘴面向型模腔和/或基板，该基板具有片剂包装部的型模，在该载体材料容器中预备了载体材料；
j)将载体材料配给到型模腔和/或基板的型模中。
将载体材料配给到型模腔中可以包括：形成活性成分胶囊。将载体材料配给到基板的型模中可以包括：形成片剂包装部。
所描述的方法可以用来生产用于活性成分或活性成分片剂的儿童防护泡罩包装部或全方位包装部。特别地，该方法能实现可以生产片剂、生产包装部以及包装部的有时需要的标签和可能给包装部添加数据载体，以便提供关于内容物的信息，等等，全部都在一个唯一的工步中提供。
上述装置以及用于将活性成分压片的方法可以采用由现有技术已知的增材制造例如3D打印的原理。这意味着在所有制造过程中都可以逐层地敷设固体，从而可以创建三维对象。逐层构造通常在计算机的控制下使用至少一种液体的或固体的材料进行。活性成分容器可以按照打印机墨盒的方式设计，并且分别具有可单独控制的配给机构。以这种方式确保避免在装置中的不同活性成分之间的接触。活性成分容器的喷嘴例如可以与一次性插管类似地可更换，并且可以在每次使用根据本发明的装置或应用根据本发明的方法之后更换。
有利地，在所有单独剂量或单独层已配给之后，将所施用的活性成分剂量或活性成分层压紧或压实。这可以类似于由现有技术已知的压制，使用柱塞和型模来进行。在此，型模由型模腔形成。柱塞可以预备在存放部中，并且为了压实或压紧，存放部可以被带到一个设定位置，在这个设定位置，柱塞与型模腔对齐，使得柱塞例如可以通过直线移调而从存放部中伸出并插入到型模腔中。有利地，型模腔的下侧也设计为可移动的柱塞，从而当压紧或压实在型模腔中的配给的活性成分时，使两个柱塞彼此靠近，其中，实现了均匀的压实。已知的用于压紧片剂的自动装置具有竖直朝向地上下叠置的下柱塞和上柱塞，下柱塞在型模中伸展，上柱塞仅仅为了压制而插入到型模中。相比之下，在根据本发明的装置中可以规定，将片剂坯料直接配给或打印到型模腔中，并且必要时仅将保持在存放部中的上柱塞插入型模中以用于进一步压实。片剂的厚度、强度和压制光泽由此仅取决于上柱塞及其压制压力。
上柱塞的插入到型模腔中的深度和压力大小可以利用沉积在或配给在型模腔中的坯料的造型进行调节。在这种情况下，下柱塞可以布置在型模内部，并且向下限制了型模腔的填充空间。在压实过程期间，该下柱塞形成用于保持在存放部中的上柱塞的垫座。在压制过程结束后，该下柱塞可以移动，由此使得片剂移位到型模边缘上，在那里，片剂可以被推到一边。在任选的下一个工作循环中，可以用活性成分浸泡被压片的活性成分，或者敷上保护层或功能层。
活性成分容器可以设计为可更换的药筒。在本发明的一个实施方式中，可以在活性成分容器之一或药筒之一内预备用于生产片剂包装部的载体材料，例如用于形成泡罩包装部，为此例如可以规定可生物降解的材料，例如硅树脂。
根据本发明的方法可以在洁净室条件下进行，为此，根据本发明的装置可以具有带HEPA过滤器的循环空气系统。可以通过紫外线系统或臭氧系统或另一种系统来确保装置的可消毒性。根据本发明的装置和方法可以用于控制活性成分的各个组成和片剂的形状。使用与患者相关的数据，即使是小批量，也可以在几分钟内经济高效地制造片剂。
附图说明
本发明的其它细节将借助以下附图来介绍。其中：
图1是根据本发明的装置的示例性实施方式的立体示意图；
图2以示意性横剖视图示出了根据本发明的装置的另一实施方式；
图3以示意性横剖视图示出了根据本发明的装置的另一实施方式的细节；
图4以立体示意图示出了根据本发明实施方式的基板；和
图5以示意性横剖视图示出了片剂包装的一个实施方式。
具体实施方式
图1和2分别示出了根据本发明的用于将活性成分组合物压片的装置的示例性实施方式。所示的两个实施方式的特征也可以在一个唯一的实施方式中实施。
活性成分组合物的各种活性成分可以在装置的存放部1中彼此分离，特别是彼此流体分离，例如作为粉末状、液体状、糊状、包封的或颗粒状的活性成分在各自的活性成分容器2中提供。因此，存放部1具有多个活性成分容器2，在每个活性成分容器中都预备有活性成分或规定的活性成分混合物，其中，每个活性成分容器2都具有可单独控制的配给机构3。活性成分容器2还可以具有用于活性成分出口的喷嘴4。
存放部1球形地构造，从而活性成分容器2沿存放部1的径向方向延伸，并以其相应的喷嘴4通至存放部1的球形表面。球形存放部1可以相对于在基板7中的至少一个型模腔5在多个设定位置之间移调，其中，在每个设定位置，至少一个活性成分容器2，特别是相关活性成分容器2的相应喷嘴4，面向型模腔5的开口6，从而在触动配给机构3时，预备在相应活性成分容器2中的活性成分可以被配给到型模腔5中。
配给机构3可以具有用于过程可靠地将预定剂量输送到腔5中的合适机构，例如流量计、重量传感器等。
除了多个活性成分容器2之外，存放部1还可以具有其他功能部件，这些功能部件可以通过存放部1的球形表面与型模腔5或预备在其中的活性成分组合物接触。例如，这些功能部件之一可以是用于压实在型模腔5中的活性成分组合物的机构，例如带有型模的柱塞。此外，存放部1可以具有至少一个载体材料容器19，在该载体材料容器中预备了至少一种载体材料22，可以根据需要将该载体材料施加到型模腔5中，例如用来形成包含活性成分组合物的活性成分胶囊。
如由图2还可看出，容置在基板7中的至少一个型模腔5可以布置在基板7的凹入的凹部8中，优选地在凹部8的最深点处，其中，球形存放部1被保持在凹入的凹部8中。球形存放部1可以至少部分地形状配合地容纳在凹部8中，从而当存放部1改变其取向时该存放部在凹部8中被引导。
图2还示出，球形存放部1在其中心具有空腔9，触动部件10自由地容纳在该空腔中。触动部件10可以特别地设计为可旋转地安置的凸轮，其中，触动部件10的旋转轴线x位于触动部件10的重心之外。由于触动部件10自由旋转地被容纳在空腔9中，因此无论存放部1相对于基板7的取向如何，它总是可以以其重心位于最低点，并且例如被带动至与配给机构3接合，该配给机构在球形存放部1的最低点与型模腔5对齐。由此可以实现，随着存放部1的旋转，其中预备了一定的活性成分21的某个活性成分容器2被带到最低位置，相关活性成分容器2的配给机构3由于受重力驱动的触动部件10而被触动。
在根据图2的实施方式中，配给机构以柱塞的方式设计，在存放部1移位时，该柱塞以上述方式被触动部件进一步推入到活性成分容器2中，由此把预备在容器2中的活性成分21经由活性成分容器2的通入到型模腔5中的喷嘴4配给到型模腔5中。
图3示出了根据本发明的存放部1的另一实施方式，其中，该存放部1相对于在基板7中的型模腔5适当地取向，从而柱塞15可以利用设置在端部的柱塞型模16与型模腔5接合，以便例如实现使得包含在型模腔5中的活性成分21压实、压紧、成形或以其他方式机械地固化。柱塞15例如可以用于将活性成分21进一步压片。但根据本发明，用柱塞15压制活性成分21仅仅是将活性成分21压片的一种变体。如已经参考图1和2所述，也可以通过把一种活性成分21或多种活性成分21配给到型模腔5中，使得活性成分21呈现型模腔5的轮廓，因此被压片。
为了固化型模腔中的活性成分，无论是使用用于压紧的柱塞15还是使用另一机械的辅助机构，都可以将粘合剂添加到活性成分21中，如由现有技术基本上已知。粘合剂可以预备在存放部1的单独的活性成分容器2中，并在单独的配给步骤中添加给型模腔5中的活性成分组合物21中，或者可以已经混入到在存放部1的活性成分容器2内的活性成分21中或活性成分21的至少一部分中。
图3还示出了触动部件10的另一实施方式，该触动部件布置在处于球形存放部1的中心的空腔9中。在该实施方式中，不同于根据图2的实施方式，触动部件10同样球形地设计，并且基本上形状配合地但又可自由移动地容纳在空腔9中。触动部件10具有可直线地移调的执行件11，该执行件在根据图3的视图中可沿竖直方向在触动位置与松开位置之间移调。
触动部件10具有延伸穿过其中心的通道12，在该通道中存在磁性线圈13，该磁性线圈具有可沿线圈轴线移动的线圈芯14。线圈芯14棒状地设计，并且既延伸穿过存放部1的中心，又穿过触动部件10的中心。棒状线圈芯14例如可以是永磁体，其可以通过对线圈施加电流而沿线圈轴线移位。在图3中示出，线圈芯14处在其松开位置，在该松开位置，线圈芯14不与柱塞15接合。通过施加电流，线圈芯14可以从图3中所示的位置移位到触动位置，在该触动位置，线圈芯相对于松开位置垂直向下移位并且与柱塞15接合。特别地，线圈芯为此可以进入到柱塞15的直线引导部27中，由此使得柱塞15以其端侧的型模16被进一步推入到型模腔5中，以便将位于型模腔5中的活性成分21或者将活性成分混合物压片，该活性成分混合物除了具有至少一种活性成分外，必要时还具有粘合剂。随后，可以通过使电流反向，线圈芯14又转移至图3中所示的松开位置。
图4示出了型模17的示例性实施方式，其比如被设置用于形成多个片剂并且同时用于形成片剂包装部，所产生的片剂被包装在该片剂包装部中。为此，型模17具有多个布置成规则网格的型模腔5，从而除了借助根据本发明的装置例如图1～3所示的装置之一生产在型模腔5中的片剂之外，除了片剂24外，还可以把载体材料引入型模17中，从而可以生产包装的片剂24。
图5所示为片剂包装部23的示例性实施方式的横剖视图，该片剂包装部带有容纳于其中的片剂24，该片剂包装部例如已借助在图1～4中所示的装置制造。因此，片剂包装部23在横截面中具有层序列，该层序列由下面的载体材料层22组成，在该下面的载体材料层上除了布置有片剂24之外，还布置有将各片剂24彼此分开的分隔部件28。在片剂24和分隔部件28上方构造了另一载体材料层22，其带有嵌入其中的在每个片剂24上方的封闭件25。
图5中所示的所有部件22、23、24、25、28都可以借助根据本发明的装置采用相应的打印工艺制造。例如，可以利用图1中所示的装置，使用图4中所示的型模，在第一方法步骤中将连续的、即不间断的载体材料层22引入到型模17中，载体材料22例如可以是塑料材料。在载体材料层22已经被引入型模17中并且必要时硬化之后，可以在下一步骤中使用同一个装置1，根据病人需要，使得片剂24在型模腔5中并且在这些型模腔中已经硬化的载体材料层22上方成型，如参照前面的附图所述。类似于载体材料层22，可以在各片剂24之间沉积分隔部件28。然后在片剂24上方构造封闭件25，并且在最后步骤中，在封闭件25周围给型模17完全填充载体材料22。上述活性成分和其他材料—包括载体材料22、封闭件25的以及分隔部件28的材料在内—的所有应用，都可以借助图1～3中所示的装置之一进行。
对活性成分和其他物质的配给可以根据3D打印的原理进行。因此，根据一个实施方式，本发明可以实施为用来基于3D打印原理生产片剂的自动装置，也称为增材生产、增材制造、衍生式制造或快速技术。
可以在计算机的控制下，由一种或多种液体的或固体的活性成分和至少一种粘合剂进行逐层构造。在这种情况下，活性成分和粘合剂被储备到设计成打印机墨盒的活性成分容器中，这些活性成分容器分别具有配给机构且可以独自地控制。由此确保避免各种活性成分相互接触。
打印机墨盒上的喷嘴可以类似于一次性插管可更换，并在每次打印过程后更换。一个特殊的实施方式规定，在3D打印后，利用同一个装置，通过单次压制过程将压片产物压制成片剂。为此可以设置两个可移动的柱塞作为压制工具。已知的用于生产片剂的自动装置具有竖直朝向的下柱塞和上柱塞，下柱塞在型模中伸展，上柱塞仅仅为了压制而插入到型模中。在本发明的一个实施方式中，片剂坯料直接打印在型模腔中，然后上柱塞滑入型模中并压制片剂。片剂的厚度、强度和压制光泽取决于上柱塞的几何形状和压制压力。插入深度和压力大小可以利用3D坯料的造型进行调节。在这种情况下，下柱塞可以布置在型模内部。该下柱塞向下限制了填充空间。在压制过程中，该下柱塞通常形成垫座。压制完成后，该下柱塞可以向上移动，由此将片剂带到型模边缘，在那里，片剂可以被推到一边。在下一个循环中，如果坯料是由吸收性材料构成，则可以用活性成分浸泡坯料，或者给坯料敷上保护层或功能层。该层可以具有以下特性。
存放部可以具有多个可更换的药筒，并且在本发明的一个特殊实施方式中规定，利用同一个存放部和同一个装置来代替否则常见的片剂起泡。为此可以规定可生物降解的材料，例如硅树脂。整个过程可以在装置的密闭地锁定的安装空间内进行。带有HEPA过滤器的循环空气系统负责洁净室条件。该装置可以通过紫外线处理或臭氧处理或通过其他合适的系统进行消毒。
本发明的最大优点在于，可单独控制活性成分的组分和片剂的形状。由于装置的可控性和对患者相关数据的输入，还可以在几分钟内经济高效地小批量生产片剂。
除了具有至少一个型模腔之外，基板还可以具有压制装置和/或用于片剂坯料、卡普耳、安瓿或注射器主体的保持装置，压制装置带有片剂形状的另一型模。同样，存放部的活性成分容器可以设计为打印机墨盒或药筒，其例如不仅可以包含和配给活性成分，而且还可以被设计用于能够将它们压入高达80kN/cm3的型模中，其方式例如为，它们具有带端侧型模的柱塞。
本发明的一个实施方式涉及一种3D药剂配给装置，其由可更换单元和永久安装单元组成。可更换单元具有活性成分，有时具有粉末、颗粒、流体等形式的其它物质，分别都在合适的储存器中，该储存器可以提供为处于压力下的打印机墨盒的形式，用于容纳活性成分或其他物质。
与在结构上常见的已知压片机不同，存放部不能设计为固定的压制机构，而是可以竖直和水平地朝向，并可在X、Y和Z方向上移动。通过这种措施，3D成型品也可以由活性成分的载体材料制得，无需压制成型。坯料也可以使用压制工具成型。配给机构也只能用于填充先前在同一系统中打印的压制工具或空心体。中空体可以由吸收性很强的海绵/泡沫材料构成，例如硅酸、透明质酸或喜欢与活性成分结合的物质。
配给机构可以具有用于检测液体活性成分或粘合剂的流量的传感器、设置有流动阻力的与活性成分储存器流体连接的流体通道和至少一个与流体通道连接的喷嘴。
在存放部的球形表面上可以安置凹面的型模，这些型模可以将活性成分制成所需的形状。已表明特别有利的是，球形存放部可自由移动地安置在部分球形或半球形的支架中。支架又可以在X、Y和Z方向上移动。支架可以具有至少四个可旋转的驱动器，这些驱动器可以使得存放部在所有方向上旋转。由此可行的是，在空间的每个层级使用位于球体中的所有药筒或工具。表面上的接触面和待激活的电磁体保证了可靠的调节。
包含在活性成分容器中的液体活性成分可以优选借助于恒压产生器予以施加压力。该装置可以具有至少一个压力传感器，以便在活性成分容器的流动阻力之前检测液体药物的压力。此外，可以在流动阻力之后设置另一个压力传感器，其中，控制机构被设计用来控制液体活性成分的流速。
配给系统可以根据超压原理工作，并且优选使用微机械制造的光学传感器，因此提供了如下可能性：通过控制装置从外部影响配给速率，以便补偿在打印的片剂上的可能的缺陷。
配给系统可以具有夹管阀，该夹管阀由控制机构节拍式地致动，以便允许或阻止流过配给系统的软管。该夹管阀从外部夹住并挤压管道，以便防止液体药物流过。由此使得阀门不与药物接触。因此，阀门可以是永久性装置的一部分。
本发明的在以上说明、附图以及权利要求中公开的各特征，无论单独地还是任意组合地，对于实现本发明来说都是重要的。
附图标记清单
1 存放部
2 有效成分容器
3 配给机构
4 喷嘴
5 型模腔
6 开口
7 基板
8 凹部
9 空腔
10 触动部件
11 执行件
12 通道
13 磁性线圈
14 线圈芯
15 柱塞
16 柱塞型模
17 型模
18 处理机构
19 载体材料容器
20 粘合剂储备容器
21 活性成分
22 载体材料
23 片剂包装部
24 片剂
25 封闭件
26 运动机构
27 直线引导部
28 分隔部件
X 旋转轴线

Claims (20)

1.一种用于将粉末状、液体状、糊状、包封的或粒状的活性成分组合物压片的装置，带有存放部(1)，该存放部具有多个活性成分容器(2)，这些活性成分容器各自具有可单独控制的配给机构(3)和用于输出活性成分的喷嘴(4)，其中，所述存放部(1)可相对于至少一个型模腔(5)在多个设定位置之间移调，其中，在每个所述设定位置，至少一个所述喷嘴(4)面向所述型模腔(5)的开口(6)。
2.如权利要求1所述的装置，其中，所述存放部(1)球形地构造，其中，所述活性成分容器(2)在所述存放部(1)的径向方向上延伸，并且以它们各自的喷嘴(4)通入到所述存放部(1)的球形表面中。
3.如权利要求1或2所述的装置，其中，至少一个所述型模腔(5)容纳在基板(7)中，该基板具有凹入的凹部(8)，球形的所述存放部(1)容纳在该凹部中。
4.如权利要求3所述的装置，其中，至少一个所述型模腔(5)布置在所述凹部(8)的最深点处。
5.如权利要求3或4所述的装置，其中，所述存放部(1)可相对于所述基板(7)围绕至少一个平行于所述基板(7)延伸的轴线移调。
6.如前述权利要求中任一项所述的装置，其中，球形的所述存放部(1)在其中心具有空腔(9)，触动部件(10)可自由移动地容纳在该空腔中，其中，所述触动部件(10)具有执行件(11)，该执行件可在触动位置与松开位置之间移调。
7.如权利要求6所述的装置，其中，要么所述触动部件(10)球形地构造并且形状配合地容纳在所述空腔(9)中，要么所述触动部件(10)是可转动地安置的凸轮，该凸轮带有位于旋转轴线(x)之外的重心，其中，所述执行件(11)是凸轮凸起。
8.如权利要求6或7所述的装置，其中，所述触动部件(10)具有穿过其中心延伸的通道(12)，在该通道中设置了磁性线圈(13)，该磁性线圈具有可沿线圈轴线移动的线圈芯(14)。
9.如权利要求8所述的装置，其中，所述通道(12)相对于所述触动部件(10)的重心适当布置，使得所述通道(12)竖直地朝向，而与所述存放部(1)的朝向无关。
10.如前述权利要求中任一项所述的装置，其中，所述存放部(1)具有可直线移调的柱塞(15)，在所述存放部(1)的设定位置之一或另一设定位置，该柱塞相对于所述型模腔(5)面向所述型模腔(5)的开口(6)。
11.如权利要求10所述的装置，其中，所述柱塞(15)在自由端具有柱塞型模(16)，所述柱塞(15)通过该柱塞型模在伸出的位置经由所述开口(6)伸入到所述型模腔(5)中，并且所述柱塞(15)在松开位置通过该柱塞型模脱离与所述型模腔(5)的接合。
12.如前述权利要求中任一项所述的装置，其中，至少一个所述活性成分容器(2)具有用于活性成分的处理机构(18)。
13.如权利要求12所述的装置，其中，所述处理机构(18)是或具有用于加热活性成分的加热部件和/或用于冷却活性成分的冷却部件。
14.如前述权利要求中任一项所述的装置，其中，除了具有多个所述活性成分容器(2)之外，所述存放部(1)还具有至少一个载体材料容器(19)，该载体材料容器带有可单独控制的配给机构(3)和用于输出载体材料的喷嘴(4)，其中，在所述存放部(1)的另一设定位置，所述载体材料容器(19)的喷嘴(4)面向所述型模腔(5)的开口(6)和/或所述装置的基板(7)，该基板具有片剂包装部(23)的型模(17)。
15.如权利要求14所述的装置，其中，所述型模(17)具有多个所述型模腔(5)，这些型模腔优选地布置成规则的网格。
16.一种用于利用根据前述权利要求中任一项所述的装置将活性成分压片的方法，具有以下步骤：
a.指定要压片的活性成分组合物；
b.相对于型模腔(5)移调存放部(1)，直到所述存放部(1)处于设定位置，在该设定位置，所述存放部(1)的活性成分容器(2)以其喷嘴(4)面向型模腔(5)，在该型模腔中预备有所述活性成分组合物的活性成分；
c.将由所述活性成分组合物预先确定的剂量的第一活性成分配给到所述型模腔(5)中；和
d.如果所述活性成分组合物具有多于一种的活性成分，则针对于所述活性成分组合物中的任何其它的活性成分，任选地重复步骤b.和c.。
17.如权利要求16所述的方法，其具有以下其它的步骤：
e.相对于所述型模腔(5)移调所述存放部(1)，直到所述存放部(1)处于设定位置，在该设定位置，所述存放部(1)的粘合剂储备容器(20)以其喷嘴(4)面向所述型模腔(5)，粘合剂预备在该粘合剂储备容器中；
f.将由所述活性成分组合物预先确定的剂量的所述粘合剂配给到所述型模腔(5)中。
18.如权利要求16或17所述的方法，其具有以下其它的步骤：
g.相对于所述型模腔(5)移调所述存放部(1)，直到所述存放部(1)处于设定位置，在该设定位置，所述存放部(1)的可直线移调的柱塞(15)面向所述型模腔(5)的开口(6)，该柱塞在一个自由端具有柱塞型模(16)；
h.将所述柱塞(15)从松开位置移动到伸出位置，在该松开位置，所述柱塞(15)以其柱塞型模(16)脱离与所述型模腔(5)的接合，在该伸出位置，所述柱塞(15)以其柱塞型模(16)经由所述开口(6)伸入到所述型模腔(5)中，其中，将至少一种配给到所述型模腔(5)中的活性成分且必要时将粘合剂压实。
19.如权利要求16～18中任一项所述的方法，其具有以下其它的步骤：
i.相对于所述型模腔(5)移调所述存放部(1)，直到所述存放部(1)处于设定位置，在该设定位置，所述存放部(1)的载体材料容器(19)以其喷嘴(4)面向所述型模腔(5)和/或基板(7)，该基板具有片剂包装部(23)的型模(17)，在该载体材料容器中预备了载体材料；
j.将所述载体材料配给到所述型模腔(5)和/或所述基板(7)的型模(17)中。
20.如权利要求19所述的方法，其中，将所述载体材料配给到所述型模腔(5)中包括：形成活性成分胶囊；和/或，将所述载体材料配给到所述基板(7)的型模(17)中包括：形成片剂包装部(23)。
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