CN113677225A - 用于产生气态活性成分或气态活性成分混合物的装置 - Google Patents

用于产生气态活性成分或气态活性成分混合物的装置 Download PDF

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Publication number
CN113677225A
CN113677225A CN201980093719.5A CN201980093719A CN113677225A CN 113677225 A CN113677225 A CN 113677225A CN 201980093719 A CN201980093719 A CN 201980093719A CN 113677225 A CN113677225 A CN 113677225A
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Prior art keywords
active ingredient
gaseous
mixture
cannabis
precursor
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CN201980093719.5A
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Inventor
弗里茨·施密特
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Luxkan innovation Pte. Ltd.
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Fu LiciShimite
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Publication of CN113677225A publication Critical patent/CN113677225A/zh
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Abstract

本发明涉及一种套件、一种用于产生气态活性成分或气态活性成分混合物的方法以及一种可采用所述方法获得的气态组合物，该套件包括：a)带有出口的袋子，其中，所述出口可封闭和打开；b)固体的和/或液体的活性成分前体；和c)用于从所述活性成分前体中释放气态活性成分或气态活性成分混合物的机构，该方法包括以下步骤：a)提供所述套件；b)提供在袋子中的固体的和/或液体的活性成分前体；c)借助用于释放气态活性成分或气态活性成分混合物的机构，从固体的和/或液体的所述活性成分前体中释放所述气态活性成分或气态活性成分混合物。

Description

用于产生气态活性成分或气态活性成分混合物的装置
技术领域
本发明涉及一种用于产生气态活性成分或气态活性成分混合物的方法、一种应用于该方法中的套件以及一种可以通过该方法获得的气态组合物。
背景技术
由现有技术已知大量不同的设备，这些设备试图使用热空气、加热板或灼热丝在特定温度下加热物质、草药或液体，以便有所需的活性成分可供吸入之用。大多数已知装置根据“加热板原理”工作。也就是说，含有活性成分的植物部分散布在被加热的表面上，希望成分在这种情况下蒸发。这种方法的效果并不理想，因为与加热表面直接接触的物质比在位于其上面的层中的物质被加热的程度要大得多，由此无法实现成分的均匀蒸发。
在另一个功能原理中，植物的某些部分被加热到一定温度范围的空气流过。然后植物部分—在必要的最低温度前提下—使得它们的成分蒸发，这些成分然后可以在冷却后吸入。特别是在医疗领域使用时，这些设备无法保证设备安全。医疗设备的所有前提都缺失了，因为该设备无法灭菌。然而，如果考虑到加热板(“烤架”)上的预期的燃烧残留物，则这是迫切需要的。
发明内容
因此，本发明的目的是，提供一种用于利用符合医学标准的机构从相应的前体混合物中释放活性成分的方法，该方法克服了现有技术的缺点，特别适用于从相应的前体混合物中以温和的方式释放活性成分。
该目的首先通过一种套件得以实现，该套件包括：a)带有出口的袋子，其中，出口可封闭和打开；b)固体的和/或液体的活性成分前体；和c)用于从活性成分前体中释放气态活性成分或气态活性成分混合物的机构。
根据本发明的套件能够以简单且温和的方式从固体的和/或液体的活性成分前体中释放气态活性成分。在此可以规定，活性成分是药理活性成分。释放后，气态活性成分或气态活性成分混合物可以吸入或被吸入用于医疗目的。众所周知，吸入活性成分是特别有效的，因为由此省去了通过胃(在口服给药时)或门静脉循环(在注射时)的途径。此外，活性成分的吸收是通过口腔粘膜吸收来得到支持的。根据本发明的套件和根据本发明的方法(如下文进一步描述)使患者能够在肺中摄取药理活性成分，该活性成分在肺中局部有限地起作用，或通过肺泡快速进入血液循环并在那里系统地起作用。在局部治疗情况下，可以减少在其余组织中的副作用，并且需要更低的剂量，因为与口服施用相比，更大比例的剂量到达作用部位。但即使活性成分要进入血液循环以产生系统性效果，通常也需要较低的剂量，因为绕过了在肝脏中的首过效应。由于肺的吸收面积大(约70-100平方米)和薄的上皮层，活性成分进入体内更快，可以比口服更早地发挥作用。
根据本发明的套件的另一个优点是它的灵活性。根据患者及其需要，活性成分前体可以单独制备并由药剂师为患者量身定制，然后在套件中予以提供用于施用。
在一种实施方式中可以规定，活性成分前体被布置在袋子中。活性成分前体的量可以根据患者进行调节，使得从活性成分前体释放的气态活性成分的量大约对应于患者的肺容积(例如肺容积+/-10％体积)。在这方面可以规定，释放的气态活性成分的量为袋子总容积的10倍，优选20倍，特别优选30倍。由此可以实现针对患者定制的对气态活性成分的特别有效的施用。
在一个实施方式中可以规定，活性成分前体包括大麻花、大麻叶、大麻膏、大麻油、至少一种大麻素或其混合物。
大麻(大麻)与葎草属(Humulus)一起属于大麻科，但葎草属植物不含大麻素。在大麻属内，存在植物学和化学分类学上的差异，确切地说，分为物种大麻苜蓿林奈(Cannabissativa Linnaeus)、印度大麻(Cannabis indica)LAM和莠草大麻(Cannabis ruderalis)，或分为“集体物种”大麻(Cannabis sativa L.)，其由亚种Cannabis sativa ssp.sativa和ssp.indica组成。此外，大麻分为药物大麻和纤维大麻，其中，根据主要大麻素大麻二酚(CBD)和Δ9-四氢大麻酚(Δ9-THC)(INN：屈大麻酚)的数量比进行区分。纤维大麻(又作：工业大麻)主要用于工业纤维生产，可以具有最多0.2％的Δ9-THC含量(如德国等)，而药物类型可以具有约5-15％的Δ9-THC含量(大麻叶、大麻膏)。Cannabis sativa L.包含400多种不同的成分，其中的60多种化合物属于大麻素类。主要大麻素如下所示：
o大麻酚类(CBG)：大麻酚((E)-CBG-C5)、大麻酚单甲醚((E)-CBGM-C5 A)、大麻酚酸A((Z)-CBGA-C5 A)、大麻二酚((E))-CBGV-C3)、大麻二酚酸A((E)-CBGA-C5 A)、大麻二酚酸A单甲醚((E)-CBGAM-C5 A)、大麻二酚酸A((E)-CBGVA-C3 A)；
o大麻素类(CBC)：大麻素(CBC-C5)、大麻素酸A(CBCA-C5 A)、大麻色素(CBCV-C3)、大麻色素酸A(CBCVA-C3 A)；
o大麻二酚类(CBD)：大麻二酚(CBD-C5)、大麻二酚单甲醚(CBDM-C5)、大麻二酚-C4(CBD-C4)、大麻二酚(CBDV-C3)、大麻二酚(CBD-C1)、大麻二酚酸(CBDA-C5)、大麻二酸(CBDVA-C3)；
o大麻二酚类(CBND)：大麻二酚(CBND-C5)、大麻二酚(CBND-C3)；
o四氢大麻酚类(THC)：Δ9-四氢大麻酚(Δ9-THC-C5)、Δ9-四氢大麻酚-C4(Δ9-THC-C4)、Δ9-四氢大麻酚(Δ9-THCV-C3)、Δ9-四氢大麻酚(Δ9(Δ9-THC-C4)-C1)、Δ9-四氢大麻酚酸(Δ9-THCA-C5 A)、Δ9-四氢大麻酚酸B(Δ9-THCA-C5 B)、Δ9-四氢大麻酚酸-C4(Δ9-THCA-C4 A和/或B)、Δ9-四氢大麻酸A(Δ9-THCVA-C3 A)、Δ9-四氢大麻二酚酸(Δ9-THCOA-C1 A和/或B)、(-)-Δ8-反式-(6aR,10aR))-Δ8-四氢大麻酚(Δ8-THC-C5),(-)-Δ8-反式-(6aR,10aR)-四氢大麻酚酸A(Δ8-THCA-C5 A)；(-)-(6aS,10aR)-Δ9-四氢大麻酚((-)-cis-Δ9-THC-C5)；
o大麻酚类(CBN)：大麻酚CBN-C5、大麻酚-C4(CBN-C4)、大麻酚(CBN-C3)、大麻酚C2(CBN-C2)、大麻酚(CBN-C1)、大麻酚酸A(CBNA)-C5 A)、大麻酚甲醚(CBNM-C5)
o大麻三醇类(CBT)：(-)-(9R,10R)-反式-大麻三醇((-)-反式CBT-C5),(+)-(9S,10S)-大麻三醇((+)-反式-CBT-C5),(±)-(9R,10S/9S,10R)-大麻三醇((±)-cis-CBT-C5),(-)-(9R,10R)-反式[10-0-乙基-大麻三醇]((-)-反式-CBT-OEt-C5),(±)-(9R,10R/9S,10S)-大麻三醇-C3((±)-反式-CBT-C3),8,9-二羟基-Δ6a(10a)四氢大麻酚(8,9-Di-OH-CBT-C5),大麻二酚酸A(CBDA-C5 9-OH-CBT-C5酯),(-)-(6aR,9S,10S,10aR)-9,10-二羟基-六氢大麻,大麻酚大麻酚-C5,(-)-6a,7,10a-三羟基-Δ9-四氢大麻酚((-)-大麻二酚),10-oxo-Δ6a(10a)四氢大麻酚(OTHC)；
o大麻素(Cannabielsoin)类(CBE):(5aS,6S,9R,9aR)-C5-大麻素(CBE-C5),(5aS,6S,9R,9aR)-C3-大麻素(CBE-C3),(5aS,6S),9R,9aR)-大麻二酚酸A(CBEA-C5 A),(5aS,6S,9R,9aR)-大麻二酚酸B(CBEA-C5 B),(5aS,6S,9R,9aR)-C3-大麻二酚酸B(CBEA-C3 B)、大麻二酚-C3(OH-iso-HHCV-C3)、脱氢大麻呋喃(DCBF-C5)、大麻呋喃(CBF-C5)；
o异大麻素：(-)-Δ7-反式-(1R,3R,6R)-异四氢大麻酚，(±)-Δ7-1,2-cis-(1R,3R,6S/1S,3S,6R)-异四氢大麻素，(-)-Δ7-反式-(1R,3R,6R)-异四氢大麻素；
o大麻二酚(Cannabicyclol)类(CBL):(±)-(1aS,3aR,8bR,8cR-大麻二酚(CBL-C5),(±)-(1aS,3aR,8bR,8cR-大麻二酚酸A(CBLA-C5 A)),(±)-(1aS,3aR,8bR,8cR-大麻二酚(CBLV-C3)；
o大麻素类(CBT)：大麻素(CBT-C5)；
o大麻色满酮类(CBCN)：大麻色满酮(CBCN-C5)、大麻色满酮-C3(CBCN-C3)、大麻色满酮(CBCON-C5)。
除了上面提到的大麻素，它们的相关羧酸存在于原料药中。这些羧酸是生物合成的前体。
大麻制剂具有多种治疗作用，包括抗痉挛、镇痛、止吐、神经保护、抗炎以及对精神疾病的作用(Grotenhermen F、Müller-Vahl K：The therapeutic potential of cannabisand cannabinoids(大麻和大麻素的治疗潜力))。
在德国，一种含有比例为1:1的THC(屈大麻酚)和CBD(萘酚)的大麻提取物自2011年以来根据制药法已被批准作为舌下喷雾剂(Sativex)，用于治疗多发性硬化症(MS)的中度至重度、难治性痉挛。
大麻二酚(CBD,CBD-C5)是大麻属中最重要的非精神性大麻素，CBD不是大麻素受体激动剂。
图1：CBD(结构式)
Figure GDA0003308318200000041
CBD可以合成生产(Michoulam R,Shvo Y.,Hashish.I.The structure ofcannabidiol,Tetrahedron(大麻二酚的结构，四面体).1963,19(12),2073)。
出口可封闭和打开。这意味着，出口可以例如通过施加负压(抽吸)或通过机械器具而打开，以使气态活性成分或气态活性成分混合物从袋子中逸出以供施用，然后可以再次关闭，以便将剩余的气态活性成分或剩余的气态活性成分混合物储存在袋子中。
在一个实施方式中可以规定，出口包括咬嘴。替代地可以规定，出口包括用于使得出口与咬嘴连接的机构。咬嘴在此是管状构件，气体可以例如通过负压(抽吸)被输送经过该构件。以此方式，便于施用释放的气态活性成分。
在这方面可以规定，咬嘴是出口的一部分，也就是说，出口连同咬嘴一起是一个与袋子连接的整体构件。同样可以规定，出口和咬嘴是两个不同的部分，它们可以例如通过将咬嘴拧到出口上、卡扣等而彼此连接。此外可以规定，出口和咬嘴的组合包括其它构件，例如可转动的套环、插塞连接部、铰链和用于连接的其它构件。尤其可以规定，如果出口不整体地包括咬嘴，则出口还包括咬嘴支架。可以规定，咬嘴和/或出口由多个部分构成，其中，形成咬嘴和/或出口的各个部分可相互连接。
在另一实施方式中可以规定，咬嘴包括进气口。此外可以规定，咬嘴附加地包括进气调节部。以此方式，可以按简单的方式调节环境空气和来自袋子的气态活性成分的量的浓度。
在一种实施方式中可以规定，出口包括穿刺插管和/或穿刺膜。由此可以特别有效地确保没有活性成分(在施用气态活性成分或气态活性成分混合物之前)无意中逸出。
用于从活性成分前体中释放气态活性成分或气态活性成分混合物的机构可以布置在袋子外或袋子内。同样可以规定，用于从活性成分前体中释放气态活性成分或气态活性成分混合物的机构与袋子连接，或形成袋子的一部分。在一个实施方式中可以规定，用于释放气态活性成分或气态活性成分混合物的机构布置在袋子中和/或与袋子连接。
原则上，用于从活性成分前体中释放气态活性成分或气态活性成分混合物的机构不受限制，只要它们允许从固体的和/或液体的活性成分前体中释放相关药理学活性成分。下列机构或允许执行以下一个或多个方法步骤的机构是合适的：
-提取
-蒸馏
-按压
-分馏
-清洁
-富集
-发酵
-温度
-超声波
-电磁波
-细菌
-真菌
在一个实施方式中可以规定，用于释放气态活性成分或气态活性成分混合物的机构包括加热部件，优选化学加热部件。
加热部件例如可以包括优选由铂或金箔制成的加热线圈。金属箔的作用类似于灯泡中的电热丝，但不会烧坏。放置在袋子中的加热线圈可以通过蓄电池供应能量，通常使用锂离子电池。
化学加热部件是一种加热部件，其中，通过在加热部件中所含的一种或多种化合物(发热组合物；发热反应物)的放热反应而产生热量。例如可以规定，作为反应物，使用酸酐或酸盐和碱性酐或碱性盐，其中，碱性盐可以选自于由乙酸钠、苯甲酸钠和抗坏血酸钾构成的组。还可以包括选自于由油、蜡、表面活性剂构成的组的惰性材料。
如果在化学加热部件中含有两种不同的在放热反应中彼此反应的化合物，则可以规定，在活化之前，这些化合物存在于不同的储存器中，这些储存器防止了那些化合物意外地混合和反应。通过触动打开部件，储存器被打开，使得两种反应物接触并发生反应，并释放热量。两种材料之间的接触导致放热的化学反应。替代地，第一个储存器也可以包含燃料，例如酒精，而第二个储存器可以包含氧化剂，例如高锰酸盐化合物，从而在两种材料接触时同样会发生发热的化学反应。对化学加热部件的使用允许独立于电源地使用根据本发明的套件。
在一个实施方式中可以规定，袋子包括优选由一种或多种塑料制成的薄膜，该塑料优选地选自于由下述构成的组：聚对苯二甲酸乙二醇酯、聚对苯二甲酸乙二醇酯与间苯二甲酸和二甘醇的共聚酯、聚萘二甲酸乙二醇酯、聚乙烯呋喃酸酯、聚丙交酯和它们的混合物。由此可以实现可靠且简单地制造袋子。
在另一实施方式中可以规定，袋子包括第一腔室和第二腔室，其中，第一腔室包含固体的和/或液体的活性成分前体并且与第二腔室连接；出口布置在第二腔室处。由此可以防止活性成分前体的固体的和/或液体的部分以不希望的方式到达出口。
第一腔室在此可以由热塑性薄膜制成，特别是PET、具有间苯二甲酸和二甘醇的PET共聚酯、PET、PEN、PEF、PLA。第二腔室可以由具有一层、两层或甚至多层的箔或铝箔、铝箔、必要时在一侧或两侧涂层的箔等制成。
在另一实施方式中可以规定，袋子还包括适合于将附加罐与袋子连接的接头。在该附加罐中例如可以储存氧气或其他气态物质。该接头能够以简单的方式将这些附加物质引入到袋子中。
在另一实施方式中可以规定，袋子对二氧化碳的渗透性大于1.0*10-2ml/(cm2*atm*天)，优选大于2.0*10-2m)/(cm2*atm*天)。同样可以规定，袋子对于气态活性成分或气态活性成分混合物的透气性小于10*10-2ml/(cm2*atm*天)。
此外，很多其它的实施方式可以有助于本发明的有利设计。
可以规定，袋子，特别是其出口，包括儿童安全部。
可以规定，袋子由织物特别是使用碳纤维制成。
可以规定，袋子由薄膜构成。
可以规定，袋子由一种材料制成，该材料随着颜色的变化对温度的变化起反应。
可以规定，该套件还包括温度计，该温度计指示袋子内部的温度。
可以规定，加热部件使用汞蒸汽制造。
可以规定，在加热部件中特别是在化学加热部件中通过催化作用产生热量。
可以规定，固体活性成分前体包含磨碎的大麻花，优选呈面粉状设计。可以规定，固体的和/或液体的活性成分前体至少部分地以涂层的形式布置在袋子的内侧上。特别地可以规定，袋子的内侧涂有磨碎的大麻花，特别是呈面粉状设计。由此实现了活性成分前体的特别高的比表面积，进而实现了便于气体的释放。
可以规定，气态活性成分或气态活性成分混合物是药物和/或疫苗。由此例如可以实现自然的过程。
可以规定，该套件包含呈加热单元、营养液和微生物或草药和花卉形式的推进剂组合物。
在另一实施方式中可以规定，第一腔室由无障碍的热塑性薄膜制成，在该第一腔室中容纳了草药、花卉和植物成分或营养液和微生物，其中，微生物能够通过发酵释放活性成分，并且，第二容器布置在出口处并且用于容纳和混合待输出的组合物，和/或，彼此嵌套地设置了多个例如可以具有球体形状的第二容器。
可以规定，袋子是气密的。
可以规定，将固体的和/或液体的活性成分前体与功能部件一起放置在袋子中(其中，功能部件可以包括用于释放气态活性成分或气态活性成分混合物的机构，但并非必须局限于此)，并且可以从外部控制功能部件，以便用于释放气态活性成分或释放气态活性成分混合物。
可以规定，袋子的内侧设有涂层，该涂层适合于使得不是气态活性成分或不包含在气态活性成分混合物中的气态物质结合。
该目的还通过一种用于产生气态活性成分或气态活性成分混合物的方法得以实现，该方法包括以下步骤：a)提供根据前述权利要求中任一项的套件；b)提供在袋子中的固体的和/或液体的活性成分前体；c)借助用于释放气态活性成分或气态活性成分混合物的机构，从固体的和/或液体的活性成分前体中释放气态活性成分或气态活性成分混合物。
在此可以规定，释放包括加热固体的和/或液体的活性成分前体。
在这方面可以规定，在加热期间将固体的和/或液体的活性成分前体加热至在170℃～220℃，优选180℃～210℃，特别优选185℃～210℃范围内的温度。
那些以药用为目的摄入大麻的人希望从大麻植物中提取尽可能多的大麻素(尤其是THC和CBD)。这些大麻素在大麻植物中并非以其有效的纯形式存在，而是作为所谓的羧酸(THCA和CBDA)存在。这些羧酸需要转化为THC和CBD。这是通过所谓的脱羧来实现的。在此过程中，从羧酸THCA和CBDA中分别分离出来一分子的二氧化碳。剩下的是所需的化合物THC和CBD。
脱羧可以用热引发。因此，在采用本发明蒸发大麻时，通过电子调节来确保设定正确的蒸发温度。这应优选在180和210摄氏度之间。
可以采用以下工艺步骤：首先用电磁波将大麻加热到恰好180℃，传感器将温度控制到1°的精度。可以将温度提高到210℃，以便尽可能多地溶解大麻素。当然，也可以使用大麻油或提取物。
根据本发明的方法的另一个优点：居所保持无味。任何在其居所里吸食大麻的人都必须预料到在未来几天内都能闻到烟味。蒸发时没有这种风险。
加热过程是在没有氧气的情况下进行的，由此可以防止花朵燃烧。
大麻花可以在使用前碎化。借助于磁铁能够移动的研磨球适用于此。通过感应地加热金属球可以实现增强效果。
根据本发明，大麻可以与其他药用植物结合，这取决于疗法。这用本方法很容易实现，因为袋子可以与不同的腔室多次组合。在这种情况下，由于随行效应，可以支持大麻的效果。
可以规定，套件包括其它的功能部件。此处示范性地提及以下功能部件。
-用于结合液体的材料
-过滤材料
-加热部件
-机械的研磨机
-产生化学反应或机械反应的所有材料
-带静电的部件
-离心机
-催化器
-紫外线过滤器
最后，该目的通过一种可采用根据本发明的方法获得的气态组合物实现，其中，活性成分前体包括大麻花、大麻叶、大麻膏、大麻油、至少一种大麻素或其混合物；并且在加热期间将固体的和/或液体的活性成分前体加热至在170℃-220℃，优选180℃-210℃，特别优选185℃-210℃范围内的温度。
附图说明
下面借助具体实施方式，参照附图对本发明进行说明。在此应理解，对具体实施方式的引用仅用于说明本发明。具体实施方式的特征并不一定是对本发明的限制，但能够特别是与上述实施方式相组合地有助于本发明的有利实施。
图1：根据本发明的一个实施方式的套件的示意图。
在图1中，参考标号具有以下含义：
1 咬嘴
2 进气口
3 进气调节部
4 套环，可转动
5 咬嘴支架
6 附加罐
7 插塞连接部
8 穿刺插管
9 连接部件
10 穿刺膜
11 铰链
12 出口
13 用于花或其他生物材料的细网篮
14 化学加热部件
15 加热部件
16 液体活性成分
17 并入袋子中的活性成分
18 外部的能量产生器
19 弯曲部件，引发化学反应
20 套件
21 袋子套
23 用于外部填充的接头
24 加热部件
25 用于弯曲的金属小片，引发化学反应
26 带活性炭过滤器的有害物抽吸器
27 生物材料，如大麻花
28 过滤器
29 液体活性成分
具体实施方式
在图1所示的实施方式中，同时示出了可以有助于本发明的有利实施的多个特征和部件。本领域技术人员将理解，为了实现根据本发明的装置，图1中所示的所有特征(构件等)不一定必须同时存在。
图1中示出了根据本发明的套件20。该套件包括袋子21和各种不同的机构14、15、18、19、24、25，袋子具有出口12，这些机构用于从活性成分前体中释放气态活性成分或气态活性成分混合物。在袋子21中含有固体活性成分前体27和液体活性成分前体16、29。如果固体活性成分前体27是细碎的材料，例如粉末状材料，则其可以存在于细网篮13中。将另一种固体活性成分前体并入到袋子17的一部分中。通过对袋子17的该部分的机械作用，可以释放包含在其中的活性成分前体。
图1中所示的出口12包括穿刺膜10和铰链11，铰链11使得穿刺膜10与出口12按适当的方式连接，从而该穿刺膜可移动地布置。出口12被设计用来可以与咬嘴1和其他部分即套环4、咬嘴支架5和插塞连接部7连接。咬嘴1包括进气口2以及过滤器28。利用套环4，在咬嘴1和出口12之间布置进气调节部3。与插塞连接部7一起，在出口12和咬嘴支架5之间设置了连接部件9和穿刺插管8。
图1中示出了用于从活性成分前体释放气态活性成分或气态活性成分混合物的各种不同的机构。例如示出了外部的能量产生器18，其可以是布置在袋子外部的加热器。还示出了化学加热部件14、其它的加热部件15、可以引发放热化学反应的弯曲部件19、另一个加热部件24以及可以弯曲以便引发放热化学反应的金属小片25。
此外，袋子21包括设置有活性炭过滤器的有害物抽吸器26。最后，袋子具有接头23，该接头允许给袋子21填充来自附加罐6的材料。
在前述说明书和所附权利要求中公开的特性可以单独地或组合地形成用于以不同形式实现在独立权利要求中的公开内容的方面的主题。

Claims (11)

1.一种套件，包括：
a.带有出口的袋子，其中，所述出口可封闭和可打开；
b.固体的和/或液体的活性成分前体；和
c.用于从所述活性成分前体中释放气态活性成分或气态活性成分混合物的机构。
2.如权利要求1所述的套件，其中，所述活性成分前体被布置在所述袋子中。
3.如权利要求1或2所述的套件，其中，所述活性成分前体包括大麻花、大麻叶、大麻膏、大麻油、至少一种大麻素或其混合物。
4.如前述权利要求中任一项所述的套件，其中，所述出口包括咬嘴。
5.如权利要求1～3中任一项所述的套件，其中，所述出口包括用于使得所述出口与咬嘴连接的机构。
6.如前述权利要求中任一项所述的套件，其中，用于释放气态活性成分或气态活性成分混合物的所述机构包括加热部件，优选化学加热部件。
7.如前述权利要求中任一项所述的套件，其中，所述袋子包括第一腔室和第二腔室，其中，
所述第一腔室包含固体的和/或液体的活性成分前体并且与所述第二腔室连接；
所述出口布置在所述第二腔室处。
8.一种用于产生气态活性成分或气态活性成分混合物的方法，包括以下步骤：
a.提供根据前述权利要求中任一项的套件；
b.提供在袋子中的固体的和/或液体的活性成分前体；
c.借助用于释放气态活性成分或气态活性成分混合物的机构，从固体的和/或液体的所述活性成分前体中释放所述气态活性成分或气态活性成分混合物。
9.如权利要求8所述的方法，其中，所述释放包括加热固体的和/或液体的所述活性成分前体。
10.如权利要求9所述的方法，其中，在所述加热期间将固体的和/或液体的所述活性成分前体加热至在170℃～220℃，优选185℃～210℃范围内的温度。
11.一种可采用根据权利要求8～10中任一项所述的方法获得的气态组合物，其中，
活性成分前体包括大麻花、大麻叶、大麻膏、大麻油、至少一种大麻素或其混合物；并且
在加热期间将固体的和/或液体的活性成分前体加热至在170℃～220℃，优选185℃～210℃范围内的温度。
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CN113873903A (zh) 2021-12-31
ZA202105146B (en) 2022-07-27
EP4338722A3 (de) 2024-05-29
CA3125791A1 (en) 2020-07-16
DE112019006577A5 (de) 2022-01-13
CA3125798A1 (en) 2020-07-16
EP3908244C0 (de) 2024-02-07
EP3908131A1 (de) 2021-11-17
WO2020143862A1 (de) 2020-07-16
US20220062108A1 (en) 2022-03-03
US20220054769A1 (en) 2022-02-24
WO2020143863A1 (de) 2020-07-16
CA3125792A1 (en) 2020-07-16
ZA202105145B (en) 2022-07-27
EP3908132A1 (de) 2021-11-17
EP3908131C0 (de) 2024-04-17
ZA202105141B (en) 2022-07-27
WO2020143865A1 (de) 2020-07-16
EP3908244A1 (de) 2021-11-17
WO2020143864A1 (de) 2020-07-16
EP3908133B1 (de) 2023-10-11
EP3908133A1 (de) 2021-11-17
CA3125792C (en) 2024-05-14
DE112019006582A5 (de) 2022-01-13
CA3125779A1 (en) 2020-07-16
EP3908244B1 (de) 2024-02-07
EP3908133C0 (de) 2023-10-11
US20220095681A1 (en) 2022-03-31
EP3908131B1 (de) 2024-04-17
DE112019006578A5 (de) 2022-01-13
EP4338722A2 (de) 2024-03-20
ZA202105142B (en) 2022-07-27
DE112019006596A5 (de) 2021-12-23
CN113557001B (zh) 2023-10-20
US20220057417A1 (en) 2022-02-24
CN113543663A (zh) 2021-10-22
US11946942B2 (en) 2024-04-02
CN113557001A (zh) 2021-10-26

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