EE9500049A - Bensoksasolüül- ja bensotiasolüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimitena ja nimetatud ühendeid sisaldavad ravimid - Google Patents

Bensoksasolüül- ja bensotiasolüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimitena ja nimetatud ühendeid sisaldavad ravimid

Info

Publication number
EE9500049A
EE9500049A EE9500049A EE9500049A EE9500049A EE 9500049 A EE9500049 A EE 9500049A EE 9500049 A EE9500049 A EE 9500049A EE 9500049 A EE9500049 A EE 9500049A EE 9500049 A EE9500049 A EE 9500049A
Authority
EE
Estonia
Prior art keywords
alkyl
substd
opt
alkoxy
acyl
Prior art date
Application number
EE9500049A
Other languages
English (en)
Estonian (et)
Inventor
H�bich Dieter
Riedl Bernd
Ruppelt Martin
Stolle Andreas
Wild Hanno
Endermann Rainer
Bremm Klaus-Dieter
Kroll Hein-Peter
Labischinski Harald
Schaller Klaus
Werling Hans-Otto
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of EE9500049A publication Critical patent/EE9500049A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EE9500049A 1994-08-03 1995-08-02 Bensoksasolüül- ja bensotiasolüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimitena ja nimetatud ühendeid sisaldavad ravimid EE9500049A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4427475 1994-08-03
DE19514313A DE19514313A1 (de) 1994-08-03 1995-04-18 Benzoxazolyl- und Benzothiazolyloxazolidinone

Publications (1)

Publication Number Publication Date
EE9500049A true EE9500049A (et) 1996-02-15

Family

ID=25938925

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9500049A EE9500049A (et) 1994-08-03 1995-08-02 Bensoksasolüül- ja bensotiasolüüloksasolidinoonid, nende valmistamismeetod, kasutamine ravimitena ja nimetatud ühendeid sisaldavad ravimid

Country Status (30)

Country Link
US (1) US5529998A (fr)
EP (1) EP0697412B1 (fr)
JP (1) JPH0881463A (fr)
KR (1) KR960007585A (fr)
CN (1) CN1122803A (fr)
AT (1) ATE188698T1 (fr)
AU (1) AU698939B2 (fr)
BG (1) BG62404B1 (fr)
CA (1) CA2155092A1 (fr)
CO (1) CO4410392A1 (fr)
CZ (1) CZ198895A3 (fr)
DE (2) DE19514313A1 (fr)
DZ (1) DZ1920A1 (fr)
EE (1) EE9500049A (fr)
FI (1) FI953665A (fr)
HR (1) HRP950428A2 (fr)
HU (1) HUT75037A (fr)
IL (1) IL114784A (fr)
MA (1) MA23638A1 (fr)
NO (1) NO305701B1 (fr)
NZ (1) NZ272674A (fr)
PE (1) PE2796A1 (fr)
PL (1) PL309848A1 (fr)
RO (1) RO115263B1 (fr)
SK (1) SK97495A3 (fr)
SV (1) SV1995000045A (fr)
TN (1) TNSN95088A1 (fr)
TW (1) TW352386B (fr)
YU (1) YU51095A (fr)
ZA (1) ZA956445B (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) * 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
NZ505902A (en) 1998-01-23 2003-08-29 Upjohn Co Oxazolidinone compounds useful as antimicrobial agents and combinatorial libraries
CN1311787A (zh) 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
AU1045300A (en) * 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel heterocyclyl-substituted oxazolidone derivatives
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) * 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
WO2002002095A2 (fr) 2000-06-30 2002-01-10 Pharmacia & Upjohn Company Composition et techniques de traitement d'infections bacteriennes
KR100944645B1 (ko) * 2000-12-15 2010-03-04 버텍스 파마슈티칼스 인코포레이티드 자이라제 억제제 및 이를 포함하는 약제학적 조성물
WO2002059116A2 (fr) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Derives antimicrobiens de la quinolone et leur utilisation pour le traitement d'infections bacteriennes
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
NZ535648A (en) * 2002-03-29 2007-05-31 Pharmacia & Upjohn Co Llc Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
KR101052433B1 (ko) 2002-06-13 2011-07-29 버텍스 파마슈티칼스 인코포레이티드 자이라제 및/또는 토포이소머라제 ⅳ 억제제로서의 2-우레이도-6-헤테로아릴-3ｈ-벤조이미다졸-4-카복실산 유도체 및 이를 포함하는 세균 감염 치료용 약제학적 조성물
CA2491287A1 (fr) * 2002-08-12 2004-02-19 Pharmacia & Upjohn Company N-aryl-2-oxazolidinones et leurs derives
WO2004026848A1 (fr) * 2002-09-20 2004-04-01 Lupin Limited Derives d'oxazolidinone, leur procede de preparation et leur utilisation comme agents antimycobacterients
ES2271660T3 (es) * 2002-11-21 2007-04-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
US7582641B2 (en) 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) * 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) * 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7618974B2 (en) * 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
JP2006516991A (ja) * 2003-02-07 2006-07-13 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 抗菌剤
MXPA05007937A (es) * 2003-02-07 2005-09-30 Warner Lambert Co Agentes antibacterianos.
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2536480A1 (fr) * 2003-08-25 2005-03-03 Warner-Lambert Company Llc Nouveaux composes d'aryloxazolidinone antimicrobiens
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US20060004090A1 (en) * 2004-07-01 2006-01-05 Roberts William J Forskolin compositions and methods for administration
CA2637811A1 (fr) * 2006-02-01 2007-08-09 Pfizer Products Inc. Agents antibacteriens
TW200804358A (en) 2006-03-31 2008-01-16 Res Found Itsuu Lab Novel compound having heterocycle
CA2685121A1 (fr) * 2007-04-27 2008-11-06 Purdue Pharma L.P. Agents therapeutiques utiles pour traiter la douleur
CA2833209C (fr) * 2007-04-27 2016-06-28 Purdue Pharma L.P. Composes de piperidine et piperazine en tant qu'antagonistes de trpv1
JPWO2009044777A1 (ja) * 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
EP2254887B9 (fr) * 2008-02-22 2013-05-29 Actelion Pharmaceuticals Ltd. Dérivés d'oxazolidinone
US8703962B2 (en) * 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
CA2824403C (fr) 2011-01-14 2019-09-24 Vertex Pharmaceuticals Incorporated Formes solides d'inhibiteur de gyrase (r)-1-ethyle-3-[6-fluoro-5-[2-(1-hydroxy-1-methyle-ethyle) pyrimidine-5-yl]-7-(tetrahydrofurane-2-yl)-1h-benzimidazol-2-yl]uree
EP2663558A1 (fr) 2011-01-14 2013-11-20 Vertex Pharmaceuticals Incorporated Formes solides de l'inhibiteur de gyrase, la (r)-1-éthyl-3-[5-[2-{1-hydroxy-1-méthyl-éthyl}pyrimidin-5-yl]-7-(tétrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urée
JP6006235B2 (ja) 2011-01-14 2016-10-12 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ジャイレースおよびトポイソメラーゼｉｖ阻害剤を作製するプロセス
WO2012097269A1 (fr) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Inhibiteurs de pyrimidine gyrase et topoïsomérase iv
CN103702994B (zh) 2011-06-20 2016-03-23 沃泰克斯药物股份有限公司 旋转酶和拓扑异构酶抑制剂的磷酸酯
EP2723732B1 (fr) 2011-06-22 2017-01-18 Purdue Pharma LP Antagonistes de trpv1 comprenant un substituant dihydroxy et leurs utilisations
WO2013021276A1 (fr) 2011-08-10 2013-02-14 Purdue Pharma L.P. Antagonistes du trpv1 comprenant un substituant dihydroxy et leurs utilisations
TWI595002B (zh) 2012-07-18 2017-08-11 思沛羅三南公司 （Ｒ）－２－（５－（２－（３－乙基脲基）－６－氟－７－（四氫呋喃－２－基）－１Ｈ－苯并［ｄ］咪唑－５－基）嘧啶－２－基）丙烷－２－基磷酸二氫鹽之固體形式及其鹽
US9572809B2 (en) 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases

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US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
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US4801600A (en) 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (fr) 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Derives d'aminomethyloxooxazolidinylaroylbenzene, agents antibacteriens
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
JP2865211B2 (ja) * 1988-09-15 1999-03-08 ファルマシア・アンド・アップジョン・カンパニー ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
JP2669579B2 (ja) * 1991-10-23 1997-10-29 エーザイ株式会社 オキサゾリドン誘導体
EP0610265B1 (fr) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Aryl- et heteroarylphenyloxazolidinones substituees, utilisees comme agents antibacteriens

Also Published As

Publication number Publication date
CZ198895A3 (en) 1996-02-14
JPH0881463A (ja) 1996-03-26
NO953045L (no) 1996-02-05
YU51095A (sh) 1998-07-10
SK97495A3 (en) 1996-06-05
SV1995000045A (es) 1996-06-17
NZ272674A (en) 1997-02-24
BG62404B1 (bg) 1999-10-29
CA2155092A1 (fr) 1996-02-04
BG99833A (bg) 1996-02-28
TW352386B (en) 1999-02-11
PL309848A1 (en) 1996-02-05
EP0697412A1 (fr) 1996-02-21
PE2796A1 (es) 1996-03-23
US5529998A (en) 1996-06-25
NO953045D0 (no) 1995-08-02
CN1122803A (zh) 1996-05-22
IL114784A (en) 1999-10-28
EP0697412B1 (fr) 2000-01-12
NO305701B1 (no) 1999-07-12
FI953665A (fi) 1996-02-04
DE19514313A1 (de) 1996-02-08
AU2723095A (en) 1996-02-15
CO4410392A1 (es) 1997-01-09
DZ1920A1 (fr) 2002-02-17
AU698939B2 (en) 1998-11-12
HRP950428A2 (en) 1997-08-31
HU9502295D0 (en) 1995-09-28
TNSN95088A1 (fr) 1996-02-06
HUT75037A (en) 1997-03-28
KR960007585A (ko) 1996-03-22
IL114784A0 (en) 1995-11-27
ZA956445B (en) 1996-03-22
ATE188698T1 (de) 2000-01-15
MA23638A1 (fr) 1996-04-01
FI953665A0 (fi) 1995-08-01
DE59507595D1 (de) 2000-02-17
RO115263B1 (ro) 1999-12-30

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