EE200200636A - Dibensoasuleeni derivaadid, nende valmistamismeetodid ja kasutamine - Google Patents

Dibensoasuleeni derivaadid, nende valmistamismeetodid ja kasutamine

Info

Publication number
EE200200636A
EE200200636A EEP200200636A EEP200200636A EE200200636A EE 200200636 A EE200200636 A EE 200200636A EE P200200636 A EEP200200636 A EE P200200636A EE P200200636 A EEP200200636 A EE P200200636A EE 200200636 A EE200200636 A EE 200200636A
Authority
EE
Estonia
Prior art keywords
dibenzo
processes
preparation
azulene derivatives
present
Prior art date
Application number
EEP200200636A
Other languages
English (en)
Estonian (et)
Inventor
Mercep Mladen
Mesic Milan
Pe�ic Dijana
Zupanovic Zeljko
Hrvacic Bo�ka
Original Assignee
PLIVA, farmaceutska industrija, dionicko dru�tvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PLIVA, farmaceutska industrija, dionicko dru�tvo filed Critical PLIVA, farmaceutska industrija, dionicko dru�tvo
Publication of EE200200636A publication Critical patent/EE200200636A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EEP200200636A 2000-05-17 2001-05-16 Dibensoasuleeni derivaadid, nende valmistamismeetodid ja kasutamine EE200200636A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20000310A HRP20000310A2 (en) 2000-05-17 2000-05-17 New dibenzoazulene compounds as tumor necrosis factor inhibitors
PCT/HR2001/000027 WO2001087890A1 (en) 2000-05-17 2001-05-16 Thienodibenzoazulene compounds as tumor necrosis factor inhibitors

Publications (1)

Publication Number Publication Date
EE200200636A true EE200200636A (et) 2004-04-15

Family

ID=10947110

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200636A EE200200636A (et) 2000-05-17 2001-05-16 Dibensoasuleeni derivaadid, nende valmistamismeetodid ja kasutamine

Country Status (36)

Country Link
US (2) US6897211B2 (cs)
EP (1) EP1284977B1 (cs)
JP (1) JP2003533528A (cs)
KR (1) KR100823064B1 (cs)
CN (1) CN1194976C (cs)
AR (1) AR030562A1 (cs)
AT (1) ATE434619T1 (cs)
AU (2) AU2001256560B2 (cs)
BG (1) BG65967B1 (cs)
BR (1) BR0111202A (cs)
CA (1) CA2409090C (cs)
CR (1) CR6860A (cs)
CY (1) CY1109328T1 (cs)
CZ (1) CZ301770B6 (cs)
DE (1) DE60139070D1 (cs)
DK (1) DK1284977T3 (cs)
DZ (1) DZ3357A1 (cs)
EA (1) EA006069B1 (cs)
EE (1) EE200200636A (cs)
ES (1) ES2328335T3 (cs)
GE (1) GEP20043304B (cs)
HR (1) HRP20000310A2 (cs)
HU (1) HUP0302295A3 (cs)
IL (1) IL152809A0 (cs)
IS (1) IS6621A (cs)
MA (1) MA27125A1 (cs)
MX (1) MXPA02011269A (cs)
NO (1) NO20025510L (cs)
NZ (1) NZ522553A (cs)
PL (1) PL204849B1 (cs)
PT (1) PT1284977E (cs)
RS (1) RS50893B (cs)
SI (1) SI1284977T1 (cs)
SK (1) SK17702002A3 (cs)
WO (1) WO2001087890A1 (cs)
ZA (1) ZA200209180B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020303A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020304B1 (en) * 2002-04-10 2008-04-30 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20020440B1 (en) * 2002-05-21 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020451A2 (en) * 2002-05-23 2003-12-31 Pliva D D 1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020452A2 (en) 2002-05-23 2004-02-29 Pliva D D 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020453A2 (en) 2002-05-23 2003-12-31 Pliva D D 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
EP1706394B1 (en) * 2003-11-12 2014-12-17 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
JP2008517993A (ja) 2004-10-27 2008-05-29 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗炎症作用を有するコンジュゲート
AU2005313325C1 (en) * 2004-12-07 2011-11-10 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
EP1844053A2 (en) * 2005-01-13 2007-10-17 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Anti-inflammatory macrolide conjugates
EP2026651B1 (en) 2006-03-08 2013-04-17 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
US8389482B2 (en) 2007-01-30 2013-03-05 New York University Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
WO2008096755A1 (ja) * 2007-02-07 2008-08-14 Nippon Suisan Kaisha, Ltd. バニロイド受容体（ｖｒ１）阻害剤及びその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711489A (en) * 1971-03-31 1973-01-16 Pfizer Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
JPS53116385A (en) * 1977-03-19 1978-10-11 Hokuriku Pharmaceutical Pyrazin derivative and method for its production
US4198421A (en) * 1978-11-30 1980-04-15 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
CZ288865B6 (cs) * 1996-04-12 2001-09-12 Janssen Pharmaceutica N. V. Substituované tetracyklické deriváty tetrahydrofuranu, způsob jejich výroby, kompozice obsahující tyto deriváty a použití těchto derivátů jako léčiva
GB9713368D0 (en) * 1997-06-25 1997-08-27 Weston Medical Ltd Flame control
EP0887339A1 (de) * 1997-06-27 1998-12-30 Roche Diagnostics GmbH Neue Azulenderivate und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
HUP0302295A2 (hu) 2003-10-28
CZ20024090A3 (cs) 2003-05-14
DZ3357A1 (fr) 2001-11-22
BR0111202A (pt) 2003-04-01
CA2409090C (en) 2010-06-29
SK17702002A3 (sk) 2003-10-07
EA006069B1 (ru) 2005-08-25
RS50893B (sr) 2010-08-31
DK1284977T3 (da) 2009-09-14
DE60139070D1 (de) 2009-08-06
US20050171091A1 (en) 2005-08-04
IS6621A (is) 2002-11-14
PL365054A1 (en) 2004-12-27
KR100823064B1 (ko) 2008-04-18
AU2001256560B2 (en) 2005-10-06
CN1437605A (zh) 2003-08-20
EP1284977A1 (en) 2003-02-26
CY1109328T1 (el) 2012-05-23
MA27125A1 (fr) 2005-01-03
KR20030010625A (ko) 2003-02-05
GEP20043304B (en) 2004-02-10
CZ301770B6 (cs) 2010-06-16
HUP0302295A3 (en) 2007-03-28
CA2409090A1 (en) 2001-11-22
AR030562A1 (es) 2003-08-27
AU5656001A (en) 2001-11-26
BG65967B1 (bg) 2010-07-30
YU84102A (sh) 2006-01-16
ES2328335T3 (es) 2009-11-12
MXPA02011269A (es) 2003-06-06
EA200201223A1 (ru) 2003-06-26
HK1056719A1 (en) 2004-02-27
PT1284977E (pt) 2009-09-09
US20030153750A1 (en) 2003-08-14
WO2001087890A1 (en) 2001-11-22
ATE434619T1 (de) 2009-07-15
CN1194976C (zh) 2005-03-30
EP1284977B1 (en) 2009-06-24
US6897211B2 (en) 2005-05-24
CR6860A (es) 2008-06-02
ZA200209180B (en) 2003-11-12
BG107399A (bg) 2003-09-30
SI1284977T1 (sl) 2009-10-31
HRP20000310A2 (en) 2002-02-28
NO20025510D0 (no) 2002-11-15
IL152809A0 (en) 2003-06-24
NZ522553A (en) 2005-04-29
PL204849B1 (pl) 2010-02-26
NO20025510L (no) 2003-01-14
JP2003533528A (ja) 2003-11-11

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Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner