DK1284977T3 - Thienodibenzoazulenforbindelser som tumornekrosefaktorhæmmere - Google Patents

Thienodibenzoazulenforbindelser som tumornekrosefaktorhæmmere

Info

Publication number
DK1284977T3
DK1284977T3 DK01929882T DK01929882T DK1284977T3 DK 1284977 T3 DK1284977 T3 DK 1284977T3 DK 01929882 T DK01929882 T DK 01929882T DK 01929882 T DK01929882 T DK 01929882T DK 1284977 T3 DK1284977 T3 DK 1284977T3
Authority
DK
Denmark
Prior art keywords
compounds
necrosis factor
tumor necrosis
thienodibenzoazulen
factor inhibitors
Prior art date
Application number
DK01929882T
Other languages
Danish (da)
English (en)
Inventor
Mladen Mercep
Milan Mesic
Zeljko Zupanovic
Boska Hrvacic
Dijana Pesic
Original Assignee
Glaxosmithkline Zagreb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
Application granted granted Critical
Publication of DK1284977T3 publication Critical patent/DK1284977T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK01929882T 2000-05-17 2001-05-16 Thienodibenzoazulenforbindelser som tumornekrosefaktorhæmmere DK1284977T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20000310A HRP20000310A2 (en) 2000-05-17 2000-05-17 New dibenzoazulene compounds as tumor necrosis factor inhibitors
PCT/HR2001/000027 WO2001087890A1 (en) 2000-05-17 2001-05-16 Thienodibenzoazulene compounds as tumor necrosis factor inhibitors

Publications (1)

Publication Number Publication Date
DK1284977T3 true DK1284977T3 (da) 2009-09-14

Family

ID=10947110

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01929882T DK1284977T3 (da) 2000-05-17 2001-05-16 Thienodibenzoazulenforbindelser som tumornekrosefaktorhæmmere

Country Status (36)

Country Link
US (2) US6897211B2 (cs)
EP (1) EP1284977B1 (cs)
JP (1) JP2003533528A (cs)
KR (1) KR100823064B1 (cs)
CN (1) CN1194976C (cs)
AR (1) AR030562A1 (cs)
AT (1) ATE434619T1 (cs)
AU (2) AU5656001A (cs)
BG (1) BG65967B1 (cs)
BR (1) BR0111202A (cs)
CA (1) CA2409090C (cs)
CR (1) CR6860A (cs)
CY (1) CY1109328T1 (cs)
CZ (1) CZ301770B6 (cs)
DE (1) DE60139070D1 (cs)
DK (1) DK1284977T3 (cs)
DZ (1) DZ3357A1 (cs)
EA (1) EA006069B1 (cs)
EE (1) EE200200636A (cs)
ES (1) ES2328335T3 (cs)
GE (1) GEP20043304B (cs)
HR (1) HRP20000310A2 (cs)
HU (1) HUP0302295A3 (cs)
IL (1) IL152809A0 (cs)
IS (1) IS6621A (cs)
MA (1) MA27125A1 (cs)
MX (1) MXPA02011269A (cs)
NO (1) NO20025510L (cs)
NZ (1) NZ522553A (cs)
PL (1) PL204849B1 (cs)
PT (1) PT1284977E (cs)
RS (1) RS50893B (cs)
SI (1) SI1284977T1 (cs)
SK (1) SK17702002A3 (cs)
WO (1) WO2001087890A1 (cs)
ZA (1) ZA200209180B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020303B8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020304B1 (en) * 2002-04-10 2008-04-30 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020440B1 (en) * 2002-05-21 2008-02-29 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
HRP20020451A2 (en) 2002-05-23 2003-12-31 Pliva D D 1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020453A2 (en) 2002-05-23 2003-12-31 Pliva D D 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020452A2 (en) 2002-05-23 2004-02-29 Pliva D D 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US20090018351A1 (en) * 2003-11-12 2009-01-15 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
JP2008517993A (ja) 2004-10-27 2008-05-29 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗炎症作用を有するコンジュゲート
CN101115719B (zh) * 2004-12-07 2011-08-31 詹森药业有限公司 取代的四环四氢吡喃、吡咯烷和四氢噻吩衍生物
EP1844053A2 (en) * 2005-01-13 2007-10-17 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Anti-inflammatory macrolide conjugates
EP2026651B1 (en) 2006-03-08 2013-04-17 Cortria Corporation Combination therapy with non-selective cox inhibitors to prevent cox-related gastric injuries
US8389482B2 (en) 2007-01-30 2013-03-05 New York University Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
WO2008096755A1 (ja) * 2007-02-07 2008-08-14 Nippon Suisan Kaisha, Ltd. バニロイド受容体（ｖｒ１）阻害剤及びその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711489A (en) * 1971-03-31 1973-01-16 Pfizer Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
JPS53116385A (en) * 1977-03-19 1978-10-11 Hokuriku Pharmaceutical Pyrazin derivative and method for its production
US4198421A (en) * 1978-11-30 1980-04-15 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
IL123655A (en) * 1996-04-12 2001-03-19 Janssen Pharmaceutica Nv Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them
GB9713368D0 (en) * 1997-06-25 1997-08-27 Weston Medical Ltd Flame control
EP0887339A1 (de) * 1997-06-27 1998-12-30 Roche Diagnostics GmbH Neue Azulenderivate und diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
AU5656001A (en) 2001-11-26
BG65967B1 (bg) 2010-07-30
IL152809A0 (en) 2003-06-24
DE60139070D1 (de) 2009-08-06
SK17702002A3 (sk) 2003-10-07
SI1284977T1 (sl) 2009-10-31
CR6860A (es) 2008-06-02
HRP20000310A2 (en) 2002-02-28
CA2409090A1 (en) 2001-11-22
BR0111202A (pt) 2003-04-01
IS6621A (is) 2002-11-14
US20030153750A1 (en) 2003-08-14
CA2409090C (en) 2010-06-29
RS50893B (sr) 2010-08-31
PT1284977E (pt) 2009-09-09
CZ301770B6 (cs) 2010-06-16
US20050171091A1 (en) 2005-08-04
NO20025510D0 (no) 2002-11-15
EP1284977B1 (en) 2009-06-24
AR030562A1 (es) 2003-08-27
HK1056719A1 (en) 2004-02-27
US6897211B2 (en) 2005-05-24
MA27125A1 (fr) 2005-01-03
GEP20043304B (en) 2004-02-10
KR100823064B1 (ko) 2008-04-18
AU2001256560B2 (en) 2005-10-06
EA200201223A1 (ru) 2003-06-26
PL204849B1 (pl) 2010-02-26
NZ522553A (en) 2005-04-29
EE200200636A (et) 2004-04-15
PL365054A1 (en) 2004-12-27
KR20030010625A (ko) 2003-02-05
CZ20024090A3 (cs) 2003-05-14
EA006069B1 (ru) 2005-08-25
WO2001087890A1 (en) 2001-11-22
BG107399A (bg) 2003-09-30
EP1284977A1 (en) 2003-02-26
CN1194976C (zh) 2005-03-30
NO20025510L (no) 2003-01-14
ES2328335T3 (es) 2009-11-12
CN1437605A (zh) 2003-08-20
CY1109328T1 (el) 2012-05-23
HUP0302295A3 (en) 2007-03-28
ZA200209180B (en) 2003-11-12
DZ3357A1 (fr) 2001-11-22
YU84102A (sh) 2006-01-16
HUP0302295A2 (hu) 2003-10-28
MXPA02011269A (es) 2003-06-06
JP2003533528A (ja) 2003-11-11
ATE434619T1 (de) 2009-07-15

Similar Documents

Publication Publication Date Title
DK1284977T3 (da) Thienodibenzoazulenforbindelser som tumornekrosefaktorhæmmere
NO20025601D0 (no) Arylmetylaminderivater for anvendelse som tryptaseinhibitorer
TR200102072T2 (tr) İltihap karşıtı maddeler olarak aromatik çok döngülü bileşimler
NO20050851L (no) Kaspase-inhibitorer og anvendelser derav
EA200400595A1 (ru) Бензимидазолы, применяемые в качестве ингибиторов протеинкиназы
DK0752987T3 (da) Pyrimidinylderivater som interleukininhibitorer
EA200201276A1 (ru) Производные арилметиламина для использования в качестве ингибиторов триптазы
MXPA05010958A (es) Derivados indazol como inhibidores jnk.
EA200400689A1 (ru) Фармацевтические и косметические композиции, содержащие ароматические альдегиды, содержащие оксигруппу
ATE329909T1 (de) 1,2,3-triazolamid-derivate als cytokininhibitoren
DE60332717D1 (de) Heterocyclische amid-derivate als cytokin-inhibitoren
EA199900057A1 (ru) Ингибиторы матриксных металлопротеиназ
DE60230155D1 (de) Verwendung von verzweigtkettigen fettsäuren und ihrer derivate zur schmerzbehandlung
UY26895A1 (es) Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2
ITMI20042475A1 (it) Uso di derivati tiazolidinonici come agenti terapeutici
SE0004101D0 (sv) New use
FI974444A0 (fi) N-hydroksiureayhdisteitä anti-inflammatorisina aineina
ATE320797T1 (de) Verwendung von 6-dimethylaminomethyl-1-phenyl- cyclohexanverbindungen zur therapie der harninkontinenz