MA27125A1 - Composes de thienodibenzoazulene comme inhibiteurs de facteurs de tumeur de necrose - Google Patents
Composes de thienodibenzoazulene comme inhibiteurs de facteurs de tumeur de necroseInfo
- Publication number
- MA27125A1 MA27125A1 MA26901A MA26901A MA27125A1 MA 27125 A1 MA27125 A1 MA 27125A1 MA 26901 A MA26901 A MA 26901A MA 26901 A MA26901 A MA 26901A MA 27125 A1 MA27125 A1 MA 27125A1
- Authority
- MA
- Morocco
- Prior art keywords
- thienodibenzoazulene
- compounds
- factor inhibitors
- tumor factor
- necrosis tumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
ABSTRACT La présente invention a trait aux compositions de dibenzoazulene représentées par la formule I ainsi que leurs préparations pharmaceutiques pour l'inhibition du facteur de nécrose de tumeurs alpha (TNF-a) et interleukine I (IL-I) chez les mammifères dans toutes les maladies et conditions oé ces médiateurs sont excessivement sécrétés. Les compositions de la présente invention démontrent également une action anlgétique et peuvent être utilisées pour soulager la douleur.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20000310A HRP20000310A2 (en) | 2000-05-17 | 2000-05-17 | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27125A1 true MA27125A1 (fr) | 2005-01-03 |
Family
ID=10947110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA26901A MA27125A1 (fr) | 2000-05-17 | 2002-11-11 | Composes de thienodibenzoazulene comme inhibiteurs de facteurs de tumeur de necrose |
Country Status (37)
Country | Link |
---|---|
US (2) | US6897211B2 (fr) |
EP (1) | EP1284977B1 (fr) |
JP (1) | JP2003533528A (fr) |
KR (1) | KR100823064B1 (fr) |
CN (1) | CN1194976C (fr) |
AR (1) | AR030562A1 (fr) |
AT (1) | ATE434619T1 (fr) |
AU (2) | AU2001256560B2 (fr) |
BG (1) | BG65967B1 (fr) |
BR (1) | BR0111202A (fr) |
CA (1) | CA2409090C (fr) |
CR (1) | CR6860A (fr) |
CY (1) | CY1109328T1 (fr) |
CZ (1) | CZ301770B6 (fr) |
DE (1) | DE60139070D1 (fr) |
DK (1) | DK1284977T3 (fr) |
DZ (1) | DZ3357A1 (fr) |
EA (1) | EA006069B1 (fr) |
EE (1) | EE200200636A (fr) |
ES (1) | ES2328335T3 (fr) |
GE (1) | GEP20043304B (fr) |
HK (1) | HK1056719A1 (fr) |
HR (1) | HRP20000310A2 (fr) |
HU (1) | HUP0302295A3 (fr) |
IL (1) | IL152809A0 (fr) |
IS (1) | IS6621A (fr) |
MA (1) | MA27125A1 (fr) |
MX (1) | MXPA02011269A (fr) |
NO (1) | NO20025510L (fr) |
NZ (1) | NZ522553A (fr) |
PL (1) | PL204849B1 (fr) |
PT (1) | PT1284977E (fr) |
RS (1) | RS50893B (fr) |
SI (1) | SI1284977T1 (fr) |
SK (1) | SK17702002A3 (fr) |
WO (1) | WO2001087890A1 (fr) |
ZA (1) | ZA200209180B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020303B8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020440B1 (en) * | 2002-05-21 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20020451A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
HRP20020452A2 (en) * | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
HRP20020453A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
WO2005047274A1 (fr) * | 2003-11-12 | 2005-05-26 | Dr. Reddy's Laboratories, Inc. | Preparation d'escitaloprame |
HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
US20090048221A1 (en) | 2004-10-27 | 2009-02-19 | Mladen Mercep | Conjugates with Anti-Inflammatory Activity |
WO2006061392A2 (fr) * | 2004-12-07 | 2006-06-15 | Janssen Pharmaceutica N.V. | Nouveaux derives insatures tetracycliques de tetrahydrofurane, pyrrolidine et tetrahydrothiophene |
JP2008532927A (ja) * | 2005-01-13 | 2008-08-21 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 抗炎症マクロライド接合体 |
JP2009529057A (ja) | 2006-03-08 | 2009-08-13 | コートリア・コーポレーシヨン | Cox−関連胃損傷を予防するための非−選択的cox阻害剤との組み合わせ療法 |
US8389482B2 (en) | 2007-01-30 | 2013-03-05 | New York University | Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species |
WO2008096755A1 (fr) * | 2007-02-07 | 2008-08-14 | Nippon Suisan Kaisha, Ltd. | Inhibiteur du récepteur vanilloïde (vr1) et son utilisation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
JPS53116385A (en) * | 1977-03-19 | 1978-10-11 | Hokuriku Pharmaceutical | Pyrazin derivative and method for its production |
US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
TR199801164T2 (xx) * | 1996-04-12 | 1998-10-21 | Janssen Pharmaceutica N.V. | S�bstit�e edilmi� tetrasiklik tetrahidrofuran t�revleri. |
GB9713368D0 (en) * | 1997-06-25 | 1997-08-27 | Weston Medical Ltd | Flame control |
EP0887339A1 (fr) * | 1997-06-27 | 1998-12-30 | Roche Diagnostics GmbH | Dérivés de l'azulène et médicaments les contenant |
-
2000
- 2000-05-17 HR HR20000310A patent/HRP20000310A2/hr not_active Application Discontinuation
-
2001
- 2001-05-16 JP JP2001584284A patent/JP2003533528A/ja active Pending
- 2001-05-16 SK SK1770-2002A patent/SK17702002A3/sk unknown
- 2001-05-16 DZ DZ013357A patent/DZ3357A1/fr active
- 2001-05-16 DE DE60139070T patent/DE60139070D1/de not_active Expired - Lifetime
- 2001-05-16 PT PT01929882T patent/PT1284977E/pt unknown
- 2001-05-16 CZ CZ20024090A patent/CZ301770B6/cs not_active IP Right Cessation
- 2001-05-16 RS YUP-841/02A patent/RS50893B/sr unknown
- 2001-05-16 NZ NZ522553A patent/NZ522553A/en unknown
- 2001-05-16 CA CA2409090A patent/CA2409090C/fr not_active Expired - Fee Related
- 2001-05-16 MX MXPA02011269A patent/MXPA02011269A/es active IP Right Grant
- 2001-05-16 IL IL15280901A patent/IL152809A0/xx unknown
- 2001-05-16 DK DK01929882T patent/DK1284977T3/da active
- 2001-05-16 KR KR1020027015567A patent/KR100823064B1/ko not_active IP Right Cessation
- 2001-05-16 BR BR0111202-3A patent/BR0111202A/pt not_active Application Discontinuation
- 2001-05-16 GE GE5019A patent/GEP20043304B/en unknown
- 2001-05-16 EA EA200201223A patent/EA006069B1/ru not_active IP Right Cessation
- 2001-05-16 EE EEP200200636A patent/EE200200636A/xx unknown
- 2001-05-16 WO PCT/HR2001/000027 patent/WO2001087890A1/fr active IP Right Grant
- 2001-05-16 CN CNB018115896A patent/CN1194976C/zh not_active Expired - Fee Related
- 2001-05-16 HU HU0302295A patent/HUP0302295A3/hu unknown
- 2001-05-16 ES ES01929882T patent/ES2328335T3/es not_active Expired - Lifetime
- 2001-05-16 EP EP01929882A patent/EP1284977B1/fr not_active Expired - Lifetime
- 2001-05-16 AU AU2001256560A patent/AU2001256560B2/en not_active Ceased
- 2001-05-16 AT AT01929882T patent/ATE434619T1/de not_active IP Right Cessation
- 2001-05-16 SI SI200130930T patent/SI1284977T1/sl unknown
- 2001-05-16 PL PL365054A patent/PL204849B1/pl not_active IP Right Cessation
- 2001-05-16 AU AU5656001A patent/AU5656001A/xx active Pending
- 2001-05-17 AR ARP010102339A patent/AR030562A1/es active IP Right Grant
-
2002
- 2002-11-11 MA MA26901A patent/MA27125A1/fr unknown
- 2002-11-12 ZA ZA200209180A patent/ZA200209180B/en unknown
- 2002-11-14 IS IS6621A patent/IS6621A/is unknown
- 2002-11-15 NO NO20025510A patent/NO20025510L/no not_active Application Discontinuation
- 2002-11-18 US US10/298,217 patent/US6897211B2/en not_active Expired - Fee Related
- 2002-12-17 CR CR6860A patent/CR6860A/es not_active Application Discontinuation
- 2002-12-17 BG BG107399A patent/BG65967B1/bg unknown
-
2003
- 2003-12-11 HK HK03109004A patent/HK1056719A1/xx not_active IP Right Cessation
-
2005
- 2005-03-25 US US11/090,743 patent/US20050171091A1/en not_active Abandoned
-
2009
- 2009-08-20 CY CY20091100888T patent/CY1109328T1/el unknown
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