EE04917B1 - Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine - Google Patents

Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine

Info

Publication number
EE04917B1
EE04917B1 EEP200100328A EEP200100328A EE04917B1 EE 04917 B1 EE04917 B1 EE 04917B1 EE P200100328 A EEP200100328 A EE P200100328A EE P200100328 A EEP200100328 A EE P200100328A EE 04917 B1 EE04917 B1 EE 04917B1
Authority
EE
Estonia
Prior art keywords
antihistamine
spirits
intermediates
preparation
methods
Prior art date
Application number
EEP200100328A
Other languages
English (en)
Estonian (et)
Inventor
Eduard Janssens Frans
Elisabeth Leenaerts Joseph
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100328A publication Critical patent/EE200100328A/xx
Publication of EE04917B1 publication Critical patent/EE04917B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200100328A 1998-12-19 1999-12-15 Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine EE04917B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204347 1998-12-19
PCT/EP1999/010176 WO2000037470A1 (en) 1998-12-19 1999-12-15 Antihistaminic spiro compounds

Publications (2)

Publication Number Publication Date
EE200100328A EE200100328A (et) 2002-08-15
EE04917B1 true EE04917B1 (et) 2007-10-15

Family

ID=8234498

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100328A EE04917B1 (et) 1998-12-19 1999-12-15 Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine

Country Status (37)

Country Link
US (2) US7148214B1 (id)
EP (1) EP1144411B1 (id)
JP (1) JP4601175B2 (id)
KR (1) KR100598725B1 (id)
CN (1) CN1258533C (id)
AR (1) AR021888A1 (id)
AT (1) ATE294178T1 (id)
AU (1) AU764820C (id)
BG (1) BG65133B1 (id)
BR (1) BR9916371A (id)
CA (1) CA2355939C (id)
CO (1) CO5140116A1 (id)
CZ (1) CZ301953B6 (id)
DE (1) DE69925036T2 (id)
DK (1) DK1144411T3 (id)
EA (1) EA004500B1 (id)
EE (1) EE04917B1 (id)
EG (1) EG24605A (id)
ES (1) ES2242443T3 (id)
HK (1) HK1043128B (id)
HR (1) HRP20010453B1 (id)
HU (1) HU229406B1 (id)
ID (1) ID29268A (id)
IL (1) IL143767A0 (id)
MY (1) MY129663A (id)
NO (1) NO318891B1 (id)
NZ (1) NZ512870A (id)
PL (1) PL196262B1 (id)
PT (1) PT1144411E (id)
SA (1) SA00210113B1 (id)
SI (1) SI1144411T1 (id)
SK (1) SK286158B6 (id)
TR (1) TR200101711T2 (id)
TW (1) TWI250981B (id)
UA (1) UA74537C2 (id)
WO (1) WO2000037470A1 (id)
ZA (1) ZA200104977B (id)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA76224C2 (en) 2001-10-15 2006-07-17 Janssen Pharmaceutica Nv Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists
BR0213325A (pt) * 2001-10-15 2004-10-13 Janssen Pharmaceutica Nv Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico
WO2005110685A2 (en) * 2004-05-11 2005-11-24 Alliss George E Vegetation trimmer apparatus
AU2005280921B2 (en) * 2004-09-07 2011-05-19 Msd K.K. Carbamoyl-substituted spiro derivative
BRPI0911577B8 (pt) 2008-04-29 2021-05-25 Novartis Ag derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2016004340A (es) 2013-10-04 2016-08-08 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
CA2959208C (en) 2014-08-29 2023-09-19 Tes Pharma S.R.L. Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
WO2017088080A1 (es) 2015-11-25 2017-06-01 Natural Response S.A. Método para la obtención de saponinas a partir de plantas
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20240052355A (ko) 2022-10-14 2024-04-23 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. 여과 장치용 커버
KR20240052354A (ko) 2022-10-14 2024-04-23 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. 여과 장치
CN117624052B (zh) * 2024-01-26 2024-04-12 四川益能康生环保科技有限公司 一种用于捕集二氧化碳的离子液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464380A (en) 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
PH30434A (en) 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
EP0552292B1 (en) * 1990-10-10 1995-06-21 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them
IL101851A (en) 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
US5106844A (en) * 1991-09-10 1992-04-21 Sterling Drug Inc. Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives

Also Published As

Publication number Publication date
BG65133B1 (bg) 2007-03-30
ID29268A (id) 2001-08-16
CZ301953B6 (cs) 2010-08-11
DE69925036T2 (de) 2006-01-26
US7087595B2 (en) 2006-08-08
EP1144411B1 (en) 2005-04-27
ZA200104977B (en) 2002-06-18
NO20012710L (no) 2001-06-01
HRP20010453A2 (en) 2002-06-30
NZ512870A (en) 2003-11-28
BR9916371A (pt) 2001-09-18
PT1144411E (pt) 2005-09-30
AU764820C (en) 2004-11-18
HUP0104779A3 (en) 2003-12-29
US7148214B1 (en) 2006-12-12
BG105546A (en) 2001-12-29
JP2002533344A (ja) 2002-10-08
SA00210113B1 (ar) 2006-09-13
WO2000037470A8 (en) 2000-08-24
NO318891B1 (no) 2005-05-18
CN1331694A (zh) 2002-01-16
PL196262B1 (pl) 2007-12-31
CA2355939C (en) 2010-12-14
IL143767A0 (en) 2002-04-21
AU3041200A (en) 2000-07-12
HK1043128A1 (en) 2002-09-06
US20050026901A1 (en) 2005-02-03
UA74537C2 (uk) 2006-01-16
CZ20012069A3 (cs) 2002-02-13
SI1144411T1 (en) 2005-10-31
HU229406B1 (en) 2013-12-30
WO2000037470A1 (en) 2000-06-29
KR20010075655A (ko) 2001-08-09
SK8142001A3 (en) 2002-04-04
KR100598725B1 (ko) 2006-07-11
PL348295A1 (en) 2002-05-20
SK286158B6 (sk) 2008-04-07
JP4601175B2 (ja) 2010-12-22
DE69925036D1 (de) 2005-06-02
ATE294178T1 (de) 2005-05-15
ES2242443T3 (es) 2005-11-01
NO20012710D0 (no) 2001-06-01
EE200100328A (et) 2002-08-15
CA2355939A1 (en) 2000-06-29
EG24605A (en) 2010-01-10
DK1144411T3 (da) 2005-09-19
HRP20010453B1 (en) 2010-07-31
AR021888A1 (es) 2002-08-07
EP1144411A1 (en) 2001-10-17
EA200100681A1 (ru) 2001-12-24
CO5140116A1 (es) 2002-03-22
TR200101711T2 (tr) 2001-12-21
MY129663A (en) 2007-04-30
HK1043128B (zh) 2007-01-19
HUP0104779A2 (hu) 2002-04-29
EA004500B1 (ru) 2004-04-29
TWI250981B (en) 2006-03-11
CN1258533C (zh) 2006-06-07
AU764820B2 (en) 2003-08-28

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KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

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Effective date: 20101231