EE04750B1 - HIV-proteaasi inhibiitorite valmistamismeetod - Google Patents
HIV-proteaasi inhibiitorite valmistamismeetodInfo
- Publication number
- EE04750B1 EE04750B1 EEP200000568A EEP200000568A EE04750B1 EE 04750 B1 EE04750 B1 EE 04750B1 EE P200000568 A EEP200000568 A EE P200000568A EE P200000568 A EEP200000568 A EE P200000568A EE 04750 B1 EE04750 B1 EE 04750B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- protease inhibitors
- hiv protease
- hiv
- inhibitors
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805898.5A GB9805898D0 (en) | 1998-03-20 | 1998-03-20 | Process for the sythesis of hiv protease inhibitors |
| PCT/GB1999/000852 WO1999048885A1 (en) | 1998-03-20 | 1999-03-18 | Process for the synthesis of hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000568A EE200000568A (et) | 2002-02-15 |
| EE04750B1 true EE04750B1 (et) | 2006-12-15 |
Family
ID=10828884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000568A EE04750B1 (et) | 1998-03-20 | 1999-03-18 | HIV-proteaasi inhibiitorite valmistamismeetod |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6281367B1 (cs) |
| EP (1) | EP1066276B1 (cs) |
| JP (1) | JP3363439B2 (cs) |
| KR (1) | KR100555278B1 (cs) |
| CN (1) | CN1308319C (cs) |
| AP (1) | AP1226A (cs) |
| AT (1) | ATE242772T1 (cs) |
| AU (1) | AU751534B2 (cs) |
| BR (1) | BR9908970A (cs) |
| CA (1) | CA2324217C (cs) |
| CZ (1) | CZ299193B6 (cs) |
| DE (1) | DE69908761T2 (cs) |
| DK (1) | DK1066276T3 (cs) |
| EA (1) | EA003022B1 (cs) |
| EE (1) | EE04750B1 (cs) |
| ES (1) | ES2203090T3 (cs) |
| GB (1) | GB9805898D0 (cs) |
| HR (1) | HRP20000609B1 (cs) |
| HU (1) | HUP0105439A3 (cs) |
| ID (1) | ID26587A (cs) |
| IL (1) | IL138127A (cs) |
| IS (1) | IS2273B (cs) |
| NO (1) | NO317648B1 (cs) |
| NZ (1) | NZ506563A (cs) |
| PL (1) | PL201810B1 (cs) |
| PT (1) | PT1066276E (cs) |
| RS (1) | RS49954B (cs) |
| SK (1) | SK283939B6 (cs) |
| TR (1) | TR200002698T2 (cs) |
| WO (1) | WO1999048885A1 (cs) |
| ZA (1) | ZA200004482B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994004492A1 (en) | 1992-08-25 | 1994-03-03 | G.D. Searle & Co. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US6548706B2 (en) * | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| WO2001046120A1 (en) * | 1999-12-23 | 2001-06-28 | Aerojet Fine Chemicals Llc | Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| HUE034389T2 (en) | 2002-05-16 | 2018-02-28 | Janssen Sciences Ireland Uc | Pseudopolymorphic forms of an HIV protease inhibitor |
| ATE433982T1 (de) * | 2003-12-23 | 2009-07-15 | Tibotec Pharm Ltd | Verfahren zur herstellung von (1s,2r)-3-ää(4- aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl- - hydroxypropylcarbamidsäure-(3r,3as,6ar)- hexahydrofuroä2,3-büfuran-3-ylester |
| RS51073B (sr) | 2003-12-23 | 2010-10-31 | Tibotec Pharmaceuticals Ltd. | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| ME03058B (me) | 2010-01-27 | 2019-01-20 | Viiv Healthcare Co | Antivirusna terapija |
| EP2614055A2 (en) | 2010-09-10 | 2013-07-17 | Lupin Limited | Process for preparation of substantially pure fosamprenavir calcium and its intermediates |
| CN111233794A (zh) * | 2020-03-27 | 2020-06-05 | 江巨东 | 一种安普那韦的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| WO1994004492A1 (en) * | 1992-08-25 | 1994-03-03 | G.D. Searle & Co. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
-
1998
- 1998-03-20 GB GBGB9805898.5A patent/GB9805898D0/en not_active Ceased
-
1999
- 1999-03-18 TR TR2000/02698T patent/TR200002698T2/xx unknown
- 1999-03-18 ID IDW20001857A patent/ID26587A/id unknown
- 1999-03-18 AP APAP/P/2000/001911A patent/AP1226A/en active
- 1999-03-18 EA EA200000859A patent/EA003022B1/ru unknown
- 1999-03-18 CN CNB998042242A patent/CN1308319C/zh not_active Expired - Fee Related
- 1999-03-18 HU HU0105439A patent/HUP0105439A3/hu unknown
- 1999-03-18 RS YUP-559/00A patent/RS49954B/sr unknown
- 1999-03-18 NZ NZ506563A patent/NZ506563A/en unknown
- 1999-03-18 AT AT99910543T patent/ATE242772T1/de not_active IP Right Cessation
- 1999-03-18 DE DE69908761T patent/DE69908761T2/de not_active Expired - Lifetime
- 1999-03-18 IL IL13812799A patent/IL138127A/xx not_active IP Right Cessation
- 1999-03-18 ES ES99910543T patent/ES2203090T3/es not_active Expired - Lifetime
- 1999-03-18 WO PCT/GB1999/000852 patent/WO1999048885A1/en active IP Right Grant
- 1999-03-18 AU AU29475/99A patent/AU751534B2/en not_active Ceased
- 1999-03-18 DK DK99910543T patent/DK1066276T3/da active
- 1999-03-18 CZ CZ20003457A patent/CZ299193B6/cs not_active IP Right Cessation
- 1999-03-18 PL PL342602A patent/PL201810B1/pl not_active IP Right Cessation
- 1999-03-18 EE EEP200000568A patent/EE04750B1/xx not_active IP Right Cessation
- 1999-03-18 PT PT99910543T patent/PT1066276E/pt unknown
- 1999-03-18 US US09/646,277 patent/US6281367B1/en not_active Expired - Lifetime
- 1999-03-18 SK SK1373-2000A patent/SK283939B6/sk not_active IP Right Cessation
- 1999-03-18 EP EP99910543A patent/EP1066276B1/en not_active Expired - Lifetime
- 1999-03-18 BR BR9908970-0A patent/BR9908970A/pt not_active Application Discontinuation
- 1999-03-18 KR KR1020007010359A patent/KR100555278B1/ko not_active Expired - Fee Related
- 1999-03-18 CA CA002324217A patent/CA2324217C/en not_active Expired - Fee Related
- 1999-03-18 HR HR20000609A patent/HRP20000609B1/xx not_active IP Right Cessation
- 1999-03-18 JP JP2000537868A patent/JP3363439B2/ja not_active Expired - Lifetime
-
2000
- 2000-08-29 ZA ZA200004482A patent/ZA200004482B/en unknown
- 2000-08-29 IS IS5605A patent/IS2273B/is unknown
- 2000-09-19 NO NO20004664A patent/NO317648B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20012980D0 (no) | Proteaseinhibitorer | |
| CY2007029I2 (el) | Μεθοδος για την παρασκευη υποκατεστημενων οκτανοϋλ-αμιδιων | |
| AR028253A1 (es) | Inhibidores de la glucogeno fosforilasa | |
| NO995433D0 (no) | Protease-inhibitorer | |
| PT1086076E (pt) | Inibidores de sulfonamida de aspartil protease | |
| ATE264339T1 (de) | Serine protease inhibitoren | |
| DK1085981T3 (da) | Fremgangsmåde til emballering | |
| IT1315269B1 (it) | Metodo per la preparazione di 5-cianoftalide | |
| NO20004696L (no) | Kinoloner som serinproteaseinhibitorer | |
| NO995434D0 (no) | Proteaseinhibitorer | |
| NO995268D0 (no) | Proteaseinhibitorer | |
| EE04234B1 (et) | L-fenüülefriinvesinikkloriidi valmistamise meetod | |
| DE59806475D1 (de) | Urokinase-inhibitoren | |
| EE04750B1 (et) | HIV-proteaasi inhibiitorite valmistamismeetod | |
| IT1298096B1 (it) | Procedimento per la produzione di gamma-butirrolattone | |
| FI20000553L (fi) | Proteaasi-inhibiittoreina käyttökelpoisten 4-hydroksi-2-oksopyraanijohdannaisten valmistusmenetelmä | |
| FI963054L (fi) | Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi | |
| DK0987356T3 (da) | Fremgangsmåde til trækning | |
| FI960184L (fi) | Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi | |
| FI960206L (fi) | Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi | |
| TR199800403A3 (tr) | a-Bromo-laktam türevlerinin hazirlanmasi için yöntem. | |
| DZ2815A1 (fr) | Inhibiteurs de protéase. | |
| FI20002262A0 (fi) | Menetelmä proteiinin rakenteen muuttamiseksi | |
| DK1077945T3 (da) | Isoquinoliner som urokinaseinhibitorer | |
| EE9900404A (et) | Arüülaminotriasolopüridiinide valmistamise meetod |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HK1A | Erratum in gazette | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20100318 |