EE04500B1 - Trombiini inhibiitorid, nende saamine ja kasutamine - Google Patents

Trombiini inhibiitorid, nende saamine ja kasutamine

Info

Publication number
EE04500B1
EE04500B1 EE9700354A EE9700354A EE04500B1 EE 04500 B1 EE04500 B1 EE 04500B1 EE 9700354 A EE9700354 A EE 9700354A EE 9700354 A EE9700354 A EE 9700354A EE 04500 B1 EE04500 B1 EE 04500B1
Authority
EE
Estonia
Prior art keywords
preparation
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
EE9700354A
Other languages
English (en)
Estonian (et)
Other versions
EE9700354A (et
Inventor
Gustafsson David
Nystr�m Jan-Erik
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9502487A external-priority patent/SE9502487D0/xx
Priority claimed from SE9502504A external-priority patent/SE9502504D0/xx
Priority claimed from SE9502505A external-priority patent/SE9502505D0/xx
Priority claimed from SE9503923A external-priority patent/SE9503923D0/xx
Priority claimed from SE9504349A external-priority patent/SE9504349D0/xx
Priority claimed from GBGB9526411.5A external-priority patent/GB9526411D0/en
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of EE9700354A publication Critical patent/EE9700354A/xx
Publication of EE04500B1 publication Critical patent/EE04500B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
EE9700354A 1995-07-06 1996-07-02 Trombiini inhibiitorid, nende saamine ja kasutamine EE04500B1 (et)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
SE9502487A SE9502487D0 (sv) 1995-07-06 1995-07-06 New amino acid derivatives
SE9502504A SE9502504D0 (sv) 1995-07-07 1995-07-07 New amino acid derivatives
SE9502505A SE9502505D0 (sv) 1995-07-07 1995-07-07 New amino acid derivatives
SE9503923A SE9503923D0 (sv) 1995-11-07 1995-11-07 New amino acid derivatives
SE9504349A SE9504349D0 (sv) 1995-12-05 1995-12-05 New amino acid derivatives
GBGB9526411.5A GB9526411D0 (en) 1995-12-22 1995-12-22 Compounds
PCT/SE1996/000878 WO1997002284A1 (en) 1995-07-06 1996-07-02 New thrombin inhibitors, their preparation and use

Publications (2)

Publication Number Publication Date
EE9700354A EE9700354A (et) 1998-06-15
EE04500B1 true EE04500B1 (et) 2005-06-15

Family

ID=27547251

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700354A EE04500B1 (et) 1995-07-06 1996-07-02 Trombiini inhibiitorid, nende saamine ja kasutamine

Country Status (30)

Country Link
US (4) US6051568A (cs)
EP (1) EP0836615B1 (cs)
JP (1) JP4107682B2 (cs)
KR (1) KR100435008B1 (cs)
CN (1) CN1147504C (cs)
AR (1) AR003440A1 (cs)
AT (1) ATE238342T1 (cs)
AU (1) AU709710B2 (cs)
BR (1) BR9609447A (cs)
CA (1) CA2226256C (cs)
CZ (1) CZ298487B6 (cs)
DE (1) DE69627659T2 (cs)
DK (1) DK0836615T3 (cs)
EE (1) EE04500B1 (cs)
ES (1) ES2197240T3 (cs)
HU (1) HUP9802315A3 (cs)
IL (1) IL122813A0 (cs)
IS (1) IS2081B (cs)
MX (1) MX9800146A (cs)
MY (1) MY116539A (cs)
NO (1) NO324092B1 (cs)
NZ (2) NZ509474A (cs)
PL (1) PL185606B1 (cs)
PT (1) PT836615E (cs)
RU (1) RU2176645C2 (cs)
SA (1) SA96170106A (cs)
SI (1) SI0836615T1 (cs)
SK (1) SK284695B6 (cs)
TR (1) TR199800009T1 (cs)
WO (1) WO1997002284A1 (cs)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
AU3496297A (en) * 1996-06-25 1998-01-14 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds
JP2003529528A (ja) 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
WO2000031078A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 1-acetylazetidine
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
DE60037183T2 (de) 1999-01-13 2008-10-09 Astrazeneca Ab Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
ATE407116T1 (de) * 2000-08-16 2008-09-15 Astrazeneca Ab Neue amidino-derivate und deren verwendung als thrombin-inhibitoren
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
SE0102921D0 (sv) 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
RU2300521C2 (ru) * 2000-12-01 2007-06-10 Астразенека Аб Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US6528503B2 (en) * 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
US7144899B2 (en) * 2001-02-09 2006-12-05 Merck & Co., Inc. Thrombin inhibitors
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

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HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
ZA883953B (en) * 1987-06-05 1990-02-28 Du Pont Peptide boronic acid inhibitors of trypsin-like proteases
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) * 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
CA2024697A1 (en) * 1989-09-07 1991-03-08 George P. Vlasuk Protein having anticoagulant properties
TW201303B (cs) * 1990-07-05 1993-03-01 Hoffmann La Roche
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
RU2048719C1 (ru) * 1991-11-06 1995-11-27 Гкн Вальтершайд Гмбх Устройство для соединения сельскохозяйственного орудия с трактором
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
CZ333492A3 (en) * 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ATE159030T1 (de) * 1992-03-04 1997-10-15 Gyogyszerkutato Intezet Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
TW223629B (cs) 1992-03-06 1994-05-11 Hoffmann La Roche
FR2695562B1 (fr) * 1992-09-11 1994-10-14 Synthelabo Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.
US5519193A (en) 1992-10-27 1996-05-21 International Business Machines Corporation Method and apparatus for stressing, burning in and reducing leakage current of electronic devices using microwave radiation
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US5780631A (en) * 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
DE4321444A1 (de) * 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) * 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
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US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
JPH10509712A (ja) * 1994-11-24 1998-09-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ルベルゾール静脈用水剤
CZ245797A3 (cs) * 1995-02-17 1998-06-17 Basf Aktiengesellschaft Derivát amidinu dipeptidu jako inhibitor thrombinu
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5629324A (en) * 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives

Also Published As

Publication number Publication date
SI0836615T1 (en) 2003-10-31
MX9800146A (es) 1998-03-31
PL185606B1 (pl) 2003-06-30
US6617320B2 (en) 2003-09-09
IS2081B (is) 2006-02-15
NO980015L (no) 1998-02-25
IS4639A (is) 1997-12-22
EP0836615B1 (en) 2003-04-23
US6337343B1 (en) 2002-01-08
NZ509474A (en) 2005-08-26
PL324483A1 (en) 1998-05-25
HUP9802315A2 (hu) 1999-01-28
KR19990028755A (ko) 1999-04-15
CN1195354A (zh) 1998-10-07
NO980015D0 (no) 1998-01-02
SA96170106A (ar) 2005-12-03
SK284695B6 (sk) 2005-09-08
ES2197240T3 (es) 2004-01-01
US20020042396A1 (en) 2002-04-11
EE9700354A (et) 1998-06-15
RU2176645C2 (ru) 2001-12-10
SK180497A3 (en) 1998-11-04
DK0836615T3 (da) 2003-08-11
CZ421297A3 (cs) 1998-06-17
IL122813A0 (en) 1998-08-16
JP4107682B2 (ja) 2008-06-25
US6921758B2 (en) 2005-07-26
CA2226256A1 (en) 1997-01-23
US20040087647A1 (en) 2004-05-06
HK1008995A1 (en) 1999-05-21
NO324092B1 (no) 2007-08-13
DE69627659T2 (de) 2004-03-04
ATE238342T1 (de) 2003-05-15
PT836615E (pt) 2003-09-30
HUP9802315A3 (en) 1999-03-01
CN1147504C (zh) 2004-04-28
CA2226256C (en) 2008-12-30
AU709710B2 (en) 1999-09-02
AU6325396A (en) 1997-02-05
EP0836615A1 (en) 1998-04-22
TR199800009T1 (xx) 1998-05-21
KR100435008B1 (ko) 2004-07-16
NZ311854A (en) 2000-06-23
JPH11508591A (ja) 1999-07-27
US6051568A (en) 2000-04-18
DE69627659D1 (de) 2003-05-28
MY116539A (en) 2004-02-28
WO1997002284A1 (en) 1997-01-23
AR003440A1 (es) 1998-08-05
BR9609447A (pt) 1999-03-02
CZ298487B6 (cs) 2007-10-17

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