EE04398B1 - Asendatud 1,2,3,4,5,6-heksahüdro-2,6-metano-3-bensasotsiin-10-oolid, nende valmistamise meetod ja kasutamine ravimitena - Google Patents
Asendatud 1,2,3,4,5,6-heksahüdro-2,6-metano-3-bensasotsiin-10-oolid, nende valmistamise meetod ja kasutamine ravimitenaInfo
- Publication number
- EE04398B1 EE04398B1 EEP200000129A EEP200000129A EE04398B1 EE 04398 B1 EE04398 B1 EE 04398B1 EE P200000129 A EEP200000129 A EE P200000129A EE P200000129 A EEP200000129 A EE P200000129A EE 04398 B1 EE04398 B1 EE 04398B1
- Authority
- EE
- Estonia
- Prior art keywords
- benzazocin
- methano
- hexahydro
- pharmaceuticals
- substituted
- Prior art date
Links
- LKSFMIVSEZLAPD-UHFFFAOYSA-N 10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-6-ol Chemical class C1C2CCNC1CC1=C2C=CC=C1O LKSFMIVSEZLAPD-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19740110A DE19740110A1 (de) | 1997-09-12 | 1997-09-12 | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1998/005734 WO1999014199A1 (de) | 1997-09-12 | 1998-09-09 | Substituierte 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000129A EE200000129A (et) | 2001-02-15 |
| EE04398B1 true EE04398B1 (et) | 2004-12-15 |
Family
ID=7842134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000129A EE04398B1 (et) | 1997-09-12 | 1998-09-09 | Asendatud 1,2,3,4,5,6-heksahüdro-2,6-metano-3-bensasotsiin-10-oolid, nende valmistamise meetod ja kasutamine ravimitena |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6455538B1 (et) |
| EP (1) | EP1015433B1 (et) |
| JP (1) | JP3827528B2 (et) |
| KR (1) | KR100601008B1 (et) |
| CN (1) | CN1166640C (et) |
| AR (1) | AR017095A1 (et) |
| AT (1) | ATE267811T1 (et) |
| AU (1) | AU751036B2 (et) |
| BG (1) | BG64418B1 (et) |
| BR (1) | BR9812443A (et) |
| CA (1) | CA2302347C (et) |
| CO (1) | CO5011117A1 (et) |
| CZ (1) | CZ296909B6 (et) |
| DE (2) | DE19740110A1 (et) |
| DK (1) | DK1015433T3 (et) |
| EE (1) | EE04398B1 (et) |
| ES (1) | ES2222612T3 (et) |
| HR (1) | HRP980502B1 (et) |
| HU (1) | HUP0004588A3 (et) |
| ID (1) | ID24173A (et) |
| IL (1) | IL134572A (et) |
| MY (1) | MY120550A (et) |
| NO (1) | NO315650B1 (et) |
| NZ (1) | NZ503710A (et) |
| PE (1) | PE122899A1 (et) |
| PL (1) | PL198486B1 (et) |
| PT (1) | PT1015433E (et) |
| RS (1) | RS49888B (et) |
| RU (1) | RU2218334C2 (et) |
| SA (1) | SA98190765B1 (et) |
| SK (1) | SK284670B6 (et) |
| TR (1) | TR200000697T2 (et) |
| TW (1) | TW505645B (et) |
| UA (1) | UA61973C2 (et) |
| UY (2) | UY25175A1 (et) |
| WO (1) | WO1999014199A1 (et) |
| YU (1) | YU12000A (et) |
| ZA (1) | ZA988285B (et) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19826365A1 (de) * | 1998-06-12 | 1999-12-16 | Gruenenthal Gmbh | Verwendung von Benzomorphanderivaten als Analgetikum |
| DE19957156A1 (de) * | 1999-11-27 | 2001-05-31 | Boehringer Ingelheim Pharma | Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
| US6355652B1 (en) | 1999-11-27 | 2002-03-12 | Boehringer Ingelheim Pharma Kg | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions |
| US6683089B2 (en) | 2002-02-02 | 2004-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols |
| DE10204276A1 (de) * | 2002-02-02 | 2003-08-07 | Boehringer Ingelheim Pharma | N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel |
| DE10223783A1 (de) * | 2002-05-29 | 2003-12-11 | Boehringer Ingelheim Pharma | Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers |
| US6828311B2 (en) | 2002-05-29 | 2004-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Formulation for the parenteral application of a sodium channel blocker |
| US20040019075A1 (en) * | 2002-05-29 | 2004-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New formulation for the parenteral application of crobenetine |
| DE10226814A1 (de) * | 2002-06-15 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände |
| US20030235576A1 (en) * | 2002-06-15 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New drug combinations for the treatment of ischaemic conditions |
| RS54522B1 (en) | 2005-12-22 | 2016-06-30 | Newron Pharmaceuticals S.P.A. | 2-Phenylethylamino Derivatives as Modulators of Calcium and (or Sodium) Channels |
| ES2655704T3 (es) | 2007-06-15 | 2018-02-21 | Newron Pharmaceuticals S.P.A. | Derivados de 2-[2-(fenil)etilamino]alcanoamida sustituidos y su uso como moduladores de canales de calcio y/o sodio |
| WO2013000651A1 (en) | 2011-06-27 | 2013-01-03 | Newron Pharmaceuticals S.P.A. | Fluorinated arylalkylaminocarboxamide derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2828039A1 (de) | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung |
| US4208523A (en) | 1978-11-30 | 1980-06-17 | Sterling Drug Inc. | 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines |
| DE4121821A1 (de) | 1991-07-02 | 1993-01-14 | Boehringer Ingelheim Kg | Neue benzomorphane und ihre verwendung als arzneimittel |
| US5607941A (en) * | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| DE19528472A1 (de) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
-
1997
- 1997-09-12 DE DE19740110A patent/DE19740110A1/de not_active Ceased
-
1998
- 1998-09-08 PE PE1998000847A patent/PE122899A1/es not_active Application Discontinuation
- 1998-09-09 UY UY25175A patent/UY25175A1/es not_active IP Right Cessation
- 1998-09-09 CZ CZ20000894A patent/CZ296909B6/cs not_active IP Right Cessation
- 1998-09-09 DK DK98950009T patent/DK1015433T3/da active
- 1998-09-09 RU RU2000109358/04A patent/RU2218334C2/ru not_active IP Right Cessation
- 1998-09-09 ID IDW20000461A patent/ID24173A/id unknown
- 1998-09-09 AT AT98950009T patent/ATE267811T1/de not_active IP Right Cessation
- 1998-09-09 EE EEP200000129A patent/EE04398B1/et not_active IP Right Cessation
- 1998-09-09 HU HU0004588A patent/HUP0004588A3/hu unknown
- 1998-09-09 IL IL13457298A patent/IL134572A/xx not_active IP Right Cessation
- 1998-09-09 SK SK334-2000A patent/SK284670B6/sk not_active IP Right Cessation
- 1998-09-09 BR BR9812443-9A patent/BR9812443A/pt not_active Application Discontinuation
- 1998-09-09 AU AU96242/98A patent/AU751036B2/en not_active Ceased
- 1998-09-09 NZ NZ503710A patent/NZ503710A/xx unknown
- 1998-09-09 CA CA002302347A patent/CA2302347C/en not_active Expired - Fee Related
- 1998-09-09 EP EP98950009A patent/EP1015433B1/de not_active Expired - Lifetime
- 1998-09-09 CN CNB988090155A patent/CN1166640C/zh not_active Expired - Fee Related
- 1998-09-09 ES ES98950009T patent/ES2222612T3/es not_active Expired - Lifetime
- 1998-09-09 PT PT98950009T patent/PT1015433E/pt unknown
- 1998-09-09 JP JP2000511750A patent/JP3827528B2/ja not_active Expired - Fee Related
- 1998-09-09 WO PCT/EP1998/005734 patent/WO1999014199A1/de active IP Right Grant
- 1998-09-09 TR TR2000/00697T patent/TR200000697T2/xx unknown
- 1998-09-09 RS YUP-120/00A patent/RS49888B/sr unknown
- 1998-09-09 DE DE59811477T patent/DE59811477D1/de not_active Expired - Fee Related
- 1998-09-09 PL PL339061A patent/PL198486B1/pl not_active IP Right Cessation
- 1998-09-09 UA UA2000042088A patent/UA61973C2/uk unknown
- 1998-09-09 KR KR1020007002562A patent/KR100601008B1/ko not_active IP Right Cessation
- 1998-09-10 TW TW087115042A patent/TW505645B/zh active
- 1998-09-10 CO CO98052134A patent/CO5011117A1/es unknown
- 1998-09-10 ZA ZA988285A patent/ZA988285B/xx unknown
- 1998-09-10 MY MYPI98004142A patent/MY120550A/en unknown
- 1998-09-11 HR HR980502A patent/HRP980502B1/xx not_active IP Right Cessation
- 1998-09-11 AR ARP980104530A patent/AR017095A1/es active Pending
- 1998-11-16 SA SA98190765A patent/SA98190765B1/ar unknown
-
1999
- 1999-03-22 UY UY25439A patent/UY25439A1/es not_active IP Right Cessation
-
2000
- 2000-03-02 YU YU12000A patent/YU12000A/sh unknown
- 2000-03-09 BG BG104232A patent/BG64418B1/bg active Active
- 2000-03-10 NO NO20001288A patent/NO315650B1/no not_active IP Right Cessation
- 2000-03-10 US US09/523,473 patent/US6455538B1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC1A | Change of owner name | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20090909 |