EE04060B1 - Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised - Google Patents

Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Info

Publication number
EE04060B1
EE04060B1 EEP200000315A EEP200000315A EE04060B1 EE 04060 B1 EE04060 B1 EE 04060B1 EE P200000315 A EEP200000315 A EE P200000315A EE P200000315 A EEP200000315 A EE P200000315A EE 04060 B1 EE04060 B1 EE 04060B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
heterocyclic compounds
gastric acid
acid secretion
Prior art date
Application number
EEP200000315A
Other languages
English (en)
Estonian (et)
Inventor
Amin Kosrat
Dahlstr�m Mikael
Nordberg Peter
Starke Ingemar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200000315A publication Critical patent/EE200000315A/xx
Publication of EE04060B1 publication Critical patent/EE04060B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000315A 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised EE04060B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (fr) 1997-11-28 1998-11-18 Composes heterocycliques permettant d'inhiber la secretion d'acide gastrique, leurs procedes de preparation et leurs compositions pharmaceutiques

Publications (2)

Publication Number Publication Date
EE200000315A EE200000315A (et) 2001-10-15
EE04060B1 true EE04060B1 (et) 2003-06-16

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000315A EE04060B1 (et) 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Country Status (33)

Country Link
US (1) US6518270B1 (fr)
EP (1) EP1042324B1 (fr)
JP (1) JP2001525322A (fr)
KR (1) KR20010032559A (fr)
CN (1) CN1142933C (fr)
AR (1) AR016972A1 (fr)
AT (1) ATE233263T1 (fr)
AU (1) AU752187C (fr)
BR (1) BR9814755A (fr)
CA (1) CA2311798A1 (fr)
CZ (1) CZ292349B6 (fr)
DE (1) DE69811735T2 (fr)
DK (1) DK1042324T3 (fr)
EE (1) EE04060B1 (fr)
ES (1) ES2191356T3 (fr)
HK (1) HK1030216A1 (fr)
HU (1) HUP0100601A3 (fr)
ID (1) ID24730A (fr)
IL (1) IL136145A0 (fr)
IS (1) IS5486A (fr)
MY (1) MY121032A (fr)
NO (1) NO315704B1 (fr)
NZ (1) NZ504355A (fr)
PL (1) PL340920A1 (fr)
PT (1) PT1042324E (fr)
RU (1) RU2241000C2 (fr)
SE (1) SE9704404D0 (fr)
SK (1) SK283904B6 (fr)
TR (1) TR200001530T2 (fr)
TW (1) TW515798B (fr)
UA (1) UA70932C2 (fr)
WO (1) WO1999028322A1 (fr)
ZA (1) ZA9810468B (fr)

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WO1997025429A1 (fr) 1996-01-04 1997-07-17 Rican Limited Bacterioferritine de helicobacter pilori
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
JP4803935B2 (ja) 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
ATE420640T1 (de) * 2001-04-06 2009-01-15 Affinium Pharm Inc Fab-i-inhibitoren
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
BR0309398A (pt) 2002-04-19 2005-02-01 Cellular Genomics Inc Composto ou um seu sal, hidrato, solvato, forma cristalina, diastereÈmero, prodroga farmaceuticamente aceitável, ou misturas deles, composição farmacêutica, e, métodos para tratar uma condição envolvida com a cinase em um mamìfero, para tratar câncer, e para identificar uma cinase
WO2004022562A1 (fr) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-arykl-imidazo[1,2-a]pyrazin-8-ylamines, procede de preparation et procede d'utilisation correspondants
AU2003266622A1 (en) * 2002-09-25 2004-04-19 Sankyo Company, Limited Medicinal composition for inhibiting increase in blood gastrin concentration
WO2004029057A1 (fr) * 2002-09-25 2004-04-08 Sankyo Company, Limited Composition medicale permettant de traiter ou de prevenir une douleur viscerale
US7790709B2 (en) * 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
CA2519429C (fr) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Compositions pharmaceutiques comportant des inhibiteurs de fab i et autres antibiotiques
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (fr) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certaines imidazo[1,2-a]pyrazin-8-ylamines substituees heterocycliques et methodes d'inhibition de la tyrosine kinase de bruton utilisant ces composes
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
CN1874772A (zh) 2003-11-03 2006-12-06 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物
DK1828167T3 (da) 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
KR102152809B1 (ko) * 2004-07-28 2020-09-07 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도
CA2575345A1 (fr) * 2004-08-02 2006-02-09 Altana Pharma Ag 1h-pyrrolo[3,2-b]pyridines 5-substituees
KR100958828B1 (ko) * 2004-09-03 2010-05-24 주식회사유한양행 피롤로[3,2-ｂ]피리딘 유도체 및 그의 제조방법
ES2342478T3 (es) * 2004-09-03 2010-07-07 Yuhan Corporation Derivados de pirrolo(3,2-c)piridina y procedimiento para la preparacion de los mismos.
WO2006025714A1 (fr) * 2004-09-03 2006-03-09 Yuhan Corporation Derives pyrrolo[3,2-c]pyridine et procedes de preparation de ces derniers
CA2579087C (fr) 2004-09-03 2012-05-01 Yuhan Corporation Derives de pyrrolo[2,3-c]pyridine et leurs procedes de preparation
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
JP2009507032A (ja) 2005-09-02 2009-02-19 アボット・ラボラトリーズ 新規なイミダゾ系複素環
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
AR061229A1 (es) * 2006-06-06 2008-08-13 Schering Corp Imidazopirazinas como inhibidores de la proteina quinasa
CA2658506C (fr) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Derives d'acrylamide en tant qu'inhibiteurs de fab 1
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
AU2009215191A1 (en) 2008-02-13 2009-08-20 Gilead Connecticut, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
HUE030427T2 (en) 2008-12-08 2017-05-29 Gilead Connecticut Inc Imidazopyrazine Syk inhibitors
ES2744541T3 (es) 2008-12-08 2020-02-25 Gilead Connecticut Inc Inhibidores de imidazopirazina Syk
EP2545052B1 (fr) 2010-03-11 2014-11-12 Gilead Connecticut, Inc. Inhibiteurs de syk à base d'imidazopyridines
NZ702695A (en) 2012-06-19 2015-10-30 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
UA115815C2 (uk) 2013-07-30 2017-12-26 Гіліад Коннектікут, Інк. Склад на основі інгібіторів syk
MD4659B1 (ro) 2013-07-30 2019-11-30 Gilead Connecticut Inc Polimorf al inhibitorilor SYK
PT3076976T (pt) 2013-12-04 2020-12-07 Kronos Bio Inc Métodos para tratar cancros
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
AU2015290000B2 (en) 2014-07-14 2018-05-17 Gilead Sciences, Inc. Combinations for treating cancers
PT3419628T (pt) 2016-02-26 2021-01-05 Debiopharm Int Sa Medicamento para o tratamento de infeções do pé diabético
KR102399996B1 (ko) 2017-08-25 2022-05-20 길리애드 사이언시즈, 인코포레이티드 Syk 억제제의 다형체
KR20210131372A (ko) 2019-02-22 2021-11-02 크로노스 바이오, 인코포레이티드 Syk 억제제로서의 축합된 피라진의 고체 형태

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US4507294A (en) 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
IL97931A0 (en) * 1990-04-27 1992-06-21 Byk Gulden Lomberg Chem Fab Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US5041442A (en) * 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
AU8712191A (en) 1990-10-15 1992-05-20 Byk Gulden Lomberg Chemische Fabrik Gmbh New diazines
ES2133331T3 (es) 1991-10-25 1999-09-16 Byk Gulden Lomberg Chem Fab Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos.
DK0742218T3 (da) 1994-01-19 2003-01-13 Sankyo Co Pyrrolopyridazinderivat
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
AU752187C (en) 2003-09-18
TW515798B (en) 2003-01-01
MY121032A (en) 2005-12-30
EP1042324B1 (fr) 2003-02-26
NZ504355A (en) 2001-12-21
ATE233263T1 (de) 2003-03-15
NO20002721L (no) 2000-07-28
AR016972A1 (es) 2001-08-01
JP2001525322A (ja) 2001-12-11
US6518270B1 (en) 2003-02-11
SK283904B6 (sk) 2004-04-06
IL136145A0 (en) 2001-05-20
HUP0100601A3 (en) 2002-10-28
CN1284078A (zh) 2001-02-14
TR200001530T2 (tr) 2000-11-21
ID24730A (id) 2000-08-03
ZA9810468B (en) 1999-05-21
SE9704404D0 (sv) 1997-11-28
BR9814755A (pt) 2000-10-03
CN1142933C (zh) 2004-03-24
UA70932C2 (uk) 2004-11-15
EE200000315A (et) 2001-10-15
WO1999028322A1 (fr) 1999-06-10
SK6742000A3 (en) 2001-03-12
CZ292349B6 (cs) 2003-09-17
ES2191356T3 (es) 2003-09-01
AU1356599A (en) 1999-06-16
DE69811735T2 (de) 2003-12-18
PT1042324E (pt) 2003-06-30
DK1042324T3 (da) 2003-05-05
AU752187B2 (en) 2002-09-12
DE69811735D1 (de) 2003-04-03
EP1042324A1 (fr) 2000-10-11
NO20002721D0 (no) 2000-05-26
NO315704B1 (no) 2003-10-13
IS5486A (is) 2000-05-10
HUP0100601A2 (hu) 2001-09-28
HK1030216A1 (en) 2001-04-27
PL340920A1 (en) 2001-03-12
RU2241000C2 (ru) 2004-11-27
CA2311798A1 (fr) 1999-06-10
CZ20001947A3 (cs) 2000-11-15
KR20010032559A (ko) 2001-04-25

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

MM4A Lapsed by not paying the annual fees

Effective date: 20061118