EE04060B1 - Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised - Google Patents

Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Info

Publication number
EE04060B1
EE04060B1 EEP200000315A EEP200000315A EE04060B1 EE 04060 B1 EE04060 B1 EE 04060B1 EE P200000315 A EEP200000315 A EE P200000315A EE P200000315 A EEP200000315 A EE P200000315A EE 04060 B1 EE04060 B1 EE 04060B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
heterocyclic compounds
gastric acid
acid secretion
Prior art date
Application number
EEP200000315A
Other languages
English (en)
Estonian (et)
Inventor
Amin Kosrat
Dahlstr�m Mikael
Nordberg Peter
Starke Ingemar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200000315A publication Critical patent/EE200000315A/xx
Publication of EE04060B1 publication Critical patent/EE04060B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000315A 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised EE04060B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (en) 1997-11-28 1998-11-18 Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EE200000315A EE200000315A (et) 2001-10-15
EE04060B1 true EE04060B1 (et) 2003-06-16

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000315A EE04060B1 (et) 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Country Status (32)

Country Link
US (1) US6518270B1 (cs)
EP (1) EP1042324B1 (cs)
JP (1) JP2001525322A (cs)
KR (1) KR20010032559A (cs)
CN (1) CN1142933C (cs)
AR (1) AR016972A1 (cs)
AT (1) ATE233263T1 (cs)
AU (1) AU752187C (cs)
BR (1) BR9814755A (cs)
CA (1) CA2311798A1 (cs)
CZ (1) CZ292349B6 (cs)
DE (1) DE69811735T2 (cs)
DK (1) DK1042324T3 (cs)
EE (1) EE04060B1 (cs)
ES (1) ES2191356T3 (cs)
HU (1) HUP0100601A3 (cs)
ID (1) ID24730A (cs)
IL (1) IL136145A0 (cs)
IS (1) IS5486A (cs)
MY (1) MY121032A (cs)
NO (1) NO315704B1 (cs)
NZ (1) NZ504355A (cs)
PL (1) PL340920A1 (cs)
PT (1) PT1042324E (cs)
RU (1) RU2241000C2 (cs)
SE (1) SE9704404D0 (cs)
SK (1) SK283904B6 (cs)
TR (1) TR200001530T2 (cs)
TW (1) TW515798B (cs)
UA (1) UA70932C2 (cs)
WO (1) WO1999028322A1 (cs)
ZA (1) ZA9810468B (cs)

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SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
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ES2320984T3 (es) * 2001-04-06 2009-06-01 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
CN100537571C (zh) * 2002-04-19 2009-09-09 细胞基因组公司 咪唑并[1,2-а]吡嗪-8-基胺,其制备方法及使用方法
US7312341B2 (en) 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
WO2004029057A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 内臓痛の治療または予防のための医薬組成物
WO2004029058A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 血中ガストリン濃度上昇の抑制のための医薬組成物
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
WO2004072081A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
WO2005019220A2 (en) 2003-08-11 2005-03-03 Cellular Genomics Inc. Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
CN1874772A (zh) 2003-11-03 2006-12-06 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物
CA2568914C (en) 2004-06-04 2013-09-24 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
KR20070053231A (ko) * 2004-07-28 2007-05-23 다케다 야쿠힌 고교 가부시키가이샤 피롤로[2,3-ｃ]피리딘 화합물, 그 제조 방법 및 용도
CA2575345A1 (en) * 2004-08-02 2006-02-09 Altana Pharma Ag 5-substituted 1h-pyrrolo[3,2-b]pyridines
US7662832B2 (en) * 2004-09-03 2010-02-16 Yuhan Corporation Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof
JP4989477B2 (ja) * 2004-09-03 2012-08-01 ユーハン・コーポレイション ピロロ［３，２−ｃ］ピリジン誘導体及びその製造方法
EP1784402B1 (en) 2004-09-03 2011-08-03 Yuhan Corporation PYRROLO[3,2-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
ES2426920T3 (es) * 2004-09-03 2013-10-25 Yuhan Corporation Derivados de pirrolo[3,2-B]piridina y procesos para su preparación
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
CA2620223A1 (en) 2005-09-02 2007-03-08 Abbott Laboratories Novel imidazo based heterocycles
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
AR061229A1 (es) 2006-06-06 2008-08-13 Schering Corp Imidazopirazinas como inhibidores de la proteina quinasa
US8318720B2 (en) * 2006-07-20 2012-11-27 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as Fab I inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
WO2009102468A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
ES2744541T3 (es) 2008-12-08 2020-02-25 Gilead Connecticut Inc Inhibidores de imidazopirazina Syk
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
KR101748925B1 (ko) 2008-12-08 2017-06-19 질레드 코네티컷 인코포레이티드 이미다조피라진 ｓｙｋ 억제제
ES2530449T3 (es) 2010-03-11 2015-03-02 Gilead Connecticut Inc Inhibidores de Syk de imidazopiridinas
JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ （ｅ）−ｎ−メチル−ｎ−（（３−メチルベンゾフラン−２−イル）メチル）−３−（７−オキソ−５，６，７，８−テトラヒドロ−１，８−ナフチリジン−３−イル）アクリルアミドのプロドラッグ誘導体
AP2016009007A0 (en) 2013-07-30 2016-01-31 Gilead Connecticut Inc Formulation of syk inhibitors
DK3027618T3 (da) 2013-07-30 2020-10-12 Kronos Bio Inc Polymorf af syk-hæmmere
KR20180002888A (ko) 2013-12-04 2018-01-08 길리애드 사이언시즈, 인코포레이티드 암을 치료하는 방법
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
SG11201610551TA (en) 2014-07-14 2017-01-27 Gilead Sciences Inc Combinations for treating cancers
EP3419628B1 (en) 2016-02-26 2020-10-14 Debiopharm International SA Medicament for treatment of diabetic foot infections
AU2018321264A1 (en) 2017-08-25 2020-02-27 Kronos Bio, Inc. Polymorphs of Syk inhibitors
WO2020165407A1 (en) 2019-02-14 2020-08-20 Debiopharm International S.A. Afabicin formulation, method for making the same
MX2021010131A (es) 2019-02-22 2021-11-18 Kronos Bio Inc Formas sólidas de pirazinas condensadas a manera de inhibidores de syk.
JP7418475B2 (ja) 2019-06-14 2024-01-19 デバイオファーム インターナショナル エス．エー． バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用

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DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
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DK0609328T3 (da) * 1991-10-25 1999-10-25 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridaziner med gastro-intestinal beskyttelsesvirkning
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Also Published As

Publication number Publication date
KR20010032559A (ko) 2001-04-25
NO315704B1 (no) 2003-10-13
AU752187B2 (en) 2002-09-12
CA2311798A1 (en) 1999-06-10
MY121032A (en) 2005-12-30
CZ20001947A3 (cs) 2000-11-15
WO1999028322A1 (en) 1999-06-10
BR9814755A (pt) 2000-10-03
DE69811735D1 (de) 2003-04-03
EP1042324B1 (en) 2003-02-26
IS5486A (is) 2000-05-10
PT1042324E (pt) 2003-06-30
TW515798B (en) 2003-01-01
JP2001525322A (ja) 2001-12-11
AU752187C (en) 2003-09-18
HUP0100601A2 (hu) 2001-09-28
EE200000315A (et) 2001-10-15
HUP0100601A3 (en) 2002-10-28
NZ504355A (en) 2001-12-21
SE9704404D0 (sv) 1997-11-28
TR200001530T2 (tr) 2000-11-21
PL340920A1 (en) 2001-03-12
NO20002721D0 (no) 2000-05-26
EP1042324A1 (en) 2000-10-11
ZA9810468B (en) 1999-05-21
RU2241000C2 (ru) 2004-11-27
DK1042324T3 (da) 2003-05-05
DE69811735T2 (de) 2003-12-18
AU1356599A (en) 1999-06-16
AR016972A1 (es) 2001-08-01
SK6742000A3 (en) 2001-03-12
CN1142933C (zh) 2004-03-24
NO20002721L (no) 2000-07-28
ID24730A (id) 2000-08-03
UA70932C2 (uk) 2004-11-15
ES2191356T3 (es) 2003-09-01
CN1284078A (zh) 2001-02-14
US6518270B1 (en) 2003-02-11
CZ292349B6 (cs) 2003-09-17
SK283904B6 (sk) 2004-04-06
IL136145A0 (en) 2001-05-20
HK1030216A1 (en) 2001-04-27
ATE233263T1 (de) 2003-03-15

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KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

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Effective date: 20051231

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Effective date: 20061118