EE02979B1 - Formoterool ja tema ühendid ning nende valmistamise meetod - Google Patents
Formoterool ja tema ühendid ning nende valmistamise meetodInfo
- Publication number
- EE02979B1 EE02979B1 EE9400425A EE9400425A EE02979B1 EE 02979 B1 EE02979 B1 EE 02979B1 EE 9400425 A EE9400425 A EE 9400425A EE 9400425 A EE9400425 A EE 9400425A EE 02979 B1 EE02979 B1 EE 02979B1
- Authority
- EE
- Estonia
- Prior art keywords
- formoterol
- compounds
- preparation
- directed
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002848 formoterol Drugs 0.000 title abstract 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9003057A SE9003057D0 (sv) | 1990-09-26 | 1990-09-26 | New process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE02979B1 true EE02979B1 (et) | 1997-04-15 |
Family
ID=20380456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400425A EE02979B1 (et) | 1990-09-26 | 1994-11-23 | Formoterool ja tema ühendid ning nende valmistamise meetod |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0550612B1 (cs) |
| JP (1) | JP2801401B2 (cs) |
| KR (1) | KR0179639B1 (cs) |
| AT (1) | ATE134990T1 (cs) |
| AU (1) | AU652386B2 (cs) |
| BG (1) | BG61605B1 (cs) |
| CA (1) | CA2091343C (cs) |
| CZ (1) | CZ284256B6 (cs) |
| DE (1) | DE69117768T2 (cs) |
| DK (1) | DK0550612T3 (cs) |
| EE (1) | EE02979B1 (cs) |
| ES (1) | ES2084831T3 (cs) |
| FI (1) | FI111714B (cs) |
| GR (1) | GR3020134T3 (cs) |
| HK (1) | HK52297A (cs) |
| HU (1) | HU214054B (cs) |
| IE (1) | IE74387B1 (cs) |
| IS (1) | IS1684B (cs) |
| LT (1) | LT3813B (cs) |
| LV (1) | LV10770B (cs) |
| NO (1) | NO301709B1 (cs) |
| PL (1) | PL166434B1 (cs) |
| PT (1) | PT99051B (cs) |
| RU (1) | RU2079486C1 (cs) |
| SE (1) | SE9003057D0 (cs) |
| SG (1) | SG43150A1 (cs) |
| SK (1) | SK22793A3 (cs) |
| WO (1) | WO1992005147A1 (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6299863B1 (en) | 1992-04-03 | 2001-10-09 | Sepracor Inc. | Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy |
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| US6866839B2 (en) | 1991-04-05 | 2005-03-15 | Sepracor Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| US5629200A (en) * | 1993-11-18 | 1997-05-13 | Daicel Chemical Industries, Ltd. | Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation |
| SE9404080L (sv) * | 1993-12-28 | 1995-06-29 | Ciba Geigy Ag | Förfarande för framställning av en optiskt ren enantiomer av formoterol |
| PT938467E (pt) * | 1996-11-11 | 2002-11-29 | Sepracor Inc | Processo para a preparacao de isomeros opticamente puros de formoterol |
| US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6303145B2 (en) | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| DE10290562D2 (de) * | 2001-02-22 | 2004-04-29 | Universitaetsklinikum Charite | Zielkomplex als Mittel zur Hemmung von Tumorzellen und zur Stimulierung der Angiogenese |
| US6472563B1 (en) | 2001-11-09 | 2002-10-29 | Sepracor Inc. | Formoterol tartrate process and polymorph |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| TW200738634A (en) | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
| WO2008035380A2 (en) * | 2006-09-19 | 2008-03-27 | Natco Pharma Limited | An improved process for the preparation of high purity formoterol and its pharmaceutically acceptable salts |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| WO2009056872A2 (en) * | 2007-10-29 | 2009-05-07 | Generics [Uk] Limited | Novel chromatography methods |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| CN101921200B (zh) * | 2009-06-16 | 2014-01-15 | 上海医药工业研究院 | 一种n-苄基-1-(4-甲氧基苯基)-2-丙胺的制备方法 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| CN115368250B (zh) * | 2022-09-02 | 2024-07-26 | 博诺康源(北京)药业科技有限公司 | 拆分福莫特罗手性中间体的方法 |
| CN117682969A (zh) * | 2023-07-31 | 2024-03-12 | 浙江理工大学 | 一种福莫特罗中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2305092A1 (de) | 1972-02-05 | 1973-08-16 | Yamanouchi Pharma Co Ltd | Alpha-aminomethylbenzylalkoholderivate |
| GB1468156A (en) * | 1973-07-19 | 1977-03-23 | Ici Ltd | Phenylethylamine derivatives |
| JPS643121A (en) | 1987-06-25 | 1989-01-06 | Mitsubishi Kasei Corp | Remedy for endometriosis |
| ES2005492A6 (es) | 1987-12-23 | 1989-03-01 | Lasa Lab | Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). |
-
1990
- 1990-09-26 SE SE9003057A patent/SE9003057D0/xx unknown
-
1991
- 1991-09-25 RU RU9193005269A patent/RU2079486C1/ru active
- 1991-09-25 ES ES91917624T patent/ES2084831T3/es not_active Expired - Lifetime
- 1991-09-25 DK DK91917624.8T patent/DK0550612T3/da active
- 1991-09-25 PT PT99051A patent/PT99051B/pt not_active IP Right Cessation
- 1991-09-25 WO PCT/SE1991/000643 patent/WO1992005147A1/en active IP Right Grant
- 1991-09-25 EP EP91917624A patent/EP0550612B1/en not_active Expired - Lifetime
- 1991-09-25 HU HU9300867A patent/HU214054B/hu unknown
- 1991-09-25 CZ CZ93442A patent/CZ284256B6/cs not_active IP Right Cessation
- 1991-09-25 CA CA002091343A patent/CA2091343C/en not_active Expired - Lifetime
- 1991-09-25 PL PL91298237A patent/PL166434B1/pl unknown
- 1991-09-25 DE DE69117768T patent/DE69117768T2/de not_active Expired - Lifetime
- 1991-09-25 SK SK22793A patent/SK22793A3/sk unknown
- 1991-09-25 KR KR1019930700901A patent/KR0179639B1/ko not_active Expired - Lifetime
- 1991-09-25 AU AU86520/91A patent/AU652386B2/en not_active Expired
- 1991-09-25 SG SG1996004479A patent/SG43150A1/en unknown
- 1991-09-25 IS IS3756A patent/IS1684B/is unknown
- 1991-09-25 JP JP3516242A patent/JP2801401B2/ja not_active Expired - Lifetime
- 1991-09-25 AT AT91917624T patent/ATE134990T1/de not_active IP Right Cessation
- 1991-09-26 IE IE337391A patent/IE74387B1/en not_active IP Right Cessation
-
1993
- 1993-03-23 NO NO931058A patent/NO301709B1/no not_active IP Right Cessation
- 1993-03-24 BG BG97576A patent/BG61605B1/bg unknown
- 1993-03-25 FI FI931333A patent/FI111714B/fi not_active IP Right Cessation
- 1993-08-10 LV LVP-93-1025A patent/LV10770B/en unknown
- 1993-12-30 LT LTIP1715A patent/LT3813B/lt not_active IP Right Cessation
-
1994
- 1994-11-23 EE EE9400425A patent/EE02979B1/xx unknown
-
1996
- 1996-05-31 GR GR960401514T patent/GR3020134T3/el unknown
-
1997
- 1997-04-24 HK HK52297A patent/HK52297A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE02979B1 (et) | Formoterool ja tema ühendid ning nende valmistamise meetod | |
| FI914905L (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi | |
| FI925737A7 (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten indol-3-yylialkyylipiperatsiinijohdannaisten valmistamiseksi | |
| FI914174A7 (fi) | Menetelmä piperidyylialkyyliamiinien valmistamiseksi | |
| RU93005269A (ru) | Способ получения формотерола и родственных соединений | |
| FI102756B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten 6H-bentsfuro[3a,3,3-ef][2]bentsatsepiinijohdannaisten valmistamiseksi | |
| FI923527L (fi) | Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi | |
| FI915741A7 (fi) | Parannettu menetelmä substituoitujen isoflavonijohdannaisten valmistam iseksi | |
| FI911083A7 (fi) | Menetelmä kolinergisina aineina käyttökelpoisten 1-atsabisyklo/2.2.1/heptaani- tai -/2.2.2/oktaani-3-oni-O-oksiimien valmistamiseksi | |
| FI924838A7 (fi) | Menetelmä uusien farmakologisesti aktiivisten katekolijohdannaisten valmistamiseksi | |
| FI915231A7 (fi) | Mikrobiologinen menetelmä hydroksyloitujen pyratsiinijohdannaisten valmistamiseksi | |
| FI906408L (fi) | Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi | |
| ES2071303T3 (es) | Compuestos homologados de vitamina d2 y los derivados hidroxilados en 1alfa correspondientes. | |
| ES488708A0 (es) | Un procedimiento para preparar derivados de fenilpiperidina | |
| NO972845L (no) | FremgangsmÕte for fremstilling av et polyoksyalkylenderivat substituert med suksinimidylgruppe | |
| NO179205C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 1-piperidinylalkanoylarylsulfonamidderivater | |
| FI922835L (fi) | Menetelmä terapeuttisesti aktiivisten piperidiinijohdannaisten valmistamiseksi | |
| FI905930A7 (fi) | Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi | |
| FI910159A7 (fi) | Menetelmä uusien, terapeuttisesti käyttökelpoisten 9a-hydroksi-3-okso- 4,24(25)-stigmastadieeni-26-happojohdannaisten valmistamiseksi | |
| FI910448A7 (fi) | Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3b/indolijohdannaisten valmistamiseksi | |
| FI910816L (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten 3H-6H-1,4,5a,8a,-tetra-atsa-asenaftyleeni-3,5(4H)-dionijohdannaisten valmistamiseksi | |
| NO179909C (no) | Analogifremgangsmåte for fremstilling av terapeutisk avtive 6-substituerte purinylpiperazinderivater | |
| FI912733L (fi) | Menetelmä terapeuttisesti käyttökelpoisten /(1-aryylipyrrolidin-2-yyli)metyyli/piperatsiinijohdannaisten valmistamiseksi | |
| GB2066256A (en) | Intermediate compounds for preparation of morphine derivatives | |
| FI914874A0 (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten C-3-ditioasetaalisubstituoitujen karbapeneemiyhdisteiden valmistamiseksi |