ECSP12011926A - Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa - Google Patents

Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa

Info

Publication number
ECSP12011926A
ECSP12011926A ECSP12011926A ECSP12011926A EC SP12011926 A ECSP12011926 A EC SP12011926A EC SP12011926 A ECSP12011926 A EC SP12011926A EC SP12011926 A ECSP12011926 A EC SP12011926A
Authority
EC
Ecuador
Prior art keywords
hemitartrate
crystalline
formula
glucosilceramide
amorphy
Prior art date
Application number
Other languages
English (en)
Spanish (es)
Inventor
Harlin Liu
Chris Willis
Renu Bhardwaj
Diane P Copeland
Abizer Harianawala
Jeffrey Skell
John Marshall
Jianmei Kochling
Seng Cheng
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43431870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011926(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of ECSP12011926A publication Critical patent/ECSP12011926A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Molecular Biology (AREA)
ECSP12011926 2009-11-27 2012-05-24 Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa ECSP12011926A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26474809P 2009-11-27 2009-11-27
PCT/US2010/057952 WO2011066352A1 (en) 2009-11-27 2010-11-24 An amorphous and a crystalline form of genz 112638 hemitartrat as inhibitor of glucosylceramide synthase

Publications (1)

Publication Number Publication Date
ECSP12011926A true ECSP12011926A (es) 2012-07-31

Family

ID=43431870

Family Applications (2)

Application Number Title Priority Date Filing Date
ECSP12011926 ECSP12011926A (es) 2009-11-27 2012-05-24 Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa
ECSENADI201863798A ECSP18063798A (es) 2009-11-27 2018-08-23 Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
ECSENADI201863798A ECSP18063798A (es) 2009-11-27 2018-08-23 Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa

Country Status (40)

Country Link
US (6) US11458119B2 (enExample)
EP (5) EP3896069A1 (enExample)
JP (6) JP2013512252A (enExample)
KR (6) KR20220162824A (enExample)
CN (5) CN105777707B (enExample)
AR (3) AR079152A1 (enExample)
AU (3) AU2010324810B2 (enExample)
BR (1) BR112012012947B8 (enExample)
CA (3) CA3075788C (enExample)
CL (2) CL2012001348A1 (enExample)
CR (1) CR20120277A (enExample)
CY (3) CY1115880T1 (enExample)
DK (3) DK3133070T3 (enExample)
DO (2) DOP2012000141A (enExample)
EA (3) EA201890254A3 (enExample)
EC (2) ECSP12011926A (enExample)
ES (4) ES2875382T3 (enExample)
GT (1) GT201200161A (enExample)
HR (3) HRP20140780T4 (enExample)
HU (2) HUE029371T2 (enExample)
IL (4) IL310635A (enExample)
LT (2) LT2796457T (enExample)
MA (1) MA33838B1 (enExample)
ME (1) ME02477B (enExample)
MX (2) MX381242B (enExample)
MY (2) MY160542A (enExample)
NI (1) NI201200096A (enExample)
NZ (3) NZ715108A (enExample)
PE (2) PE20171255A1 (enExample)
PH (2) PH12015502514B1 (enExample)
PL (4) PL3599237T3 (enExample)
PT (4) PT3599237T (enExample)
RS (3) RS59543B1 (enExample)
SG (2) SG10201800136QA (enExample)
SI (3) SI3133070T1 (enExample)
SM (1) SMT201600273B (enExample)
TN (1) TN2012000237A1 (enExample)
TW (3) TWI586663B (enExample)
UA (1) UA113491C2 (enExample)
WO (1) WO2011066352A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889127B2 (en) 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
MY160542A (en) 2009-11-27 2017-03-15 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
EP2721151B1 (en) * 2011-06-20 2017-12-06 Mount Sinai School Of Medicine Anti-tnf-therapy for the mucopolysaccharidoses and other lysosomal disorders
US10350277B2 (en) 2011-09-07 2019-07-16 Icahn School Of Medicine At Mount Sinai Ceramidase and cell differentiation
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
LT2854910T (lt) 2012-06-01 2020-05-25 Icahn School Of Medicine At Mount Sinai Ceramido lygiai infekcijos gydymo ir prevencijos metu
HRP20191361T1 (hr) 2013-03-14 2019-11-01 Icahn School Med Mount Sinai Pripravci ceramidaze terapeutske kiseline i postupci njihove izrade i uporabe
EP3912977A1 (en) * 2013-09-20 2021-11-24 BioMarin Pharmaceutical Inc. Glucosylceramide synthase inhibitors for the treatment of diseases
US20170129869A1 (en) * 2014-07-03 2017-05-11 Dr. Reddy's Laboratories Limited Amorphous form of eliglustat hemitartarate
ES2716420T3 (es) 2015-04-14 2019-06-12 Sandoz Ag Clorhidrato de eliglustat cristalino
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
MX2018006250A (es) 2015-11-18 2018-09-05 Genzyme Corp Biomarcador de enfermedad poliquistica renal y usos del mismo.
CN109071526B (zh) 2016-02-25 2023-02-28 阿森纽荣股份公司 哌嗪衍生物的酸加成盐
CN107445938B (zh) * 2016-05-31 2020-04-03 北京启慧生物医药有限公司 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物
CN106349210A (zh) * 2016-08-24 2017-01-25 北京阳光诺和药物研究有限公司 一种制备酒石酸艾力骨司坦的方法
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
WO2018193090A2 (en) 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Process for preparation of eliglustat hemitartrate and intermediates thereof
WO2018225085A1 (en) 2017-06-05 2018-12-13 Cipla Limited Stable solid dispersions of eliglustat hemitartrate
AU2018283289B2 (en) * 2017-06-16 2021-03-25 Beta Pharma, Inc. Pharmaceutical formulations of N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and salts thereof
EP3664798B1 (en) 2017-08-08 2025-10-29 Amneal Pharmaceuticals LLC Pharmaceutical composition comprising eliglustat
US12472144B2 (en) * 2017-08-08 2025-11-18 Amneal Pharmaceuticals Llc Pharmaceutical composition comprising eliglustat
BR112020011056A2 (pt) * 2017-12-15 2020-11-17 Genzyme Corporation métodos para o tratamento da doença de gaucher
WO2019123476A1 (en) * 2017-12-20 2019-06-27 Sarudbhava Formulations Private Limited Stable amorphous eliglustat premix and process for the preparation thereof
WO2019211778A2 (en) * 2018-05-02 2019-11-07 Kashiv Biosciences, Llc Pro-drugs of eliglustat
AU2019276882A1 (en) * 2018-05-27 2021-01-14 Bioasis Technolgies Inc. Treatment of gaucher disease
CN110878079A (zh) * 2018-12-31 2020-03-13 北京启慧生物医药有限公司 一种高纯度依利格鲁司他的制备方法
IL309862A (en) * 2021-07-05 2024-02-01 Ferrer Int Medicines that include glycosidase inhibitors
CN116120274A (zh) * 2021-11-12 2023-05-16 曙方(上海)医药科技有限公司 依利格鲁司他可药用盐及其晶型

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
DE3522475A1 (de) 1985-06-22 1987-01-02 Kali Chemie Pharma Gmbh Neue aromatische verbindungen, ihre herstellung und verwendung
US5041441A (en) 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
US5302609A (en) 1992-12-16 1994-04-12 The Regents Of The University Of Michigan Treatment of diabetic nephropathy
US5399567A (en) 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
WO1995005177A1 (en) 1993-08-13 1995-02-23 Seikagaku Corporation Remedy for nervous diseases
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
EP0742789B1 (en) 1994-02-02 2000-08-30 The Liposome Company, Inc. Pharmaceutically active compounds and liposomes, and methods of use therof
CN1152907A (zh) 1994-06-10 1997-06-25 生化学工业株式会社 2-酰胺基丙醇化合物及其药物组合物
FR2734819B1 (fr) 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
WO1997010817A1 (en) 1995-09-20 1997-03-27 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
WO2001004108A1 (en) 1999-07-09 2001-01-18 Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US20030073680A1 (en) 1995-09-20 2003-04-17 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US6255336B1 (en) 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US6890949B1 (en) 1999-07-09 2005-05-10 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
JP3993908B2 (ja) 1995-12-08 2007-10-17 生化学工業株式会社 アミノアルコール誘導体及び該誘導体の製造方法
NO965193L (no) 1995-12-08 1997-06-09 Seikagaku Kogyo Kk Seikagaku C Aminalkoholderivat og fremgangsmåte for fremstilling derav
JP4140984B2 (ja) 1995-12-20 2008-08-27 生化学工業株式会社 分化誘導作用を有する薬剤
US5972928A (en) 1997-05-21 1999-10-26 Johns Hopkins University Methods for treatment of conditions associated with lactosylceramide
JP4036500B2 (ja) 1997-05-23 2008-01-23 生化学工業株式会社 アミノアルコール誘導体及びそれを含有する医薬
JP4176170B2 (ja) 1997-06-06 2008-11-05 生化学工業株式会社 アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬
US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
JP2002521435A (ja) 1998-07-27 2002-07-16 ジョンズ・ホプキンス・ユニバーシティ ラクトシルセラミドによって調節される病態を治療する方法
US6610703B1 (en) 1998-12-10 2003-08-26 G.D. Searle & Co. Method for treatment of glycolipid storage diseases
EP1196406A1 (en) * 1999-07-09 2002-04-17 The Regents of the University of Michigan Amino ceramide-like compounds and therapeutic methods of use
EP1248869A2 (en) * 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US20040252299A9 (en) 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
ATE338550T1 (de) 2000-04-24 2006-09-15 Teva Pharma Mikronisierter zolpidem hemitartrat
US6436987B1 (en) 2000-06-08 2002-08-20 Pfizer Inc. Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
BR0206400A (pt) 2001-01-10 2005-01-18 Univ Michigan Compostos de amino ceramidas e seus usos em métodos terapêuticos
US20020198240A1 (en) 2001-01-10 2002-12-26 Shayman James A. Amino ceramide - like compounds and therapeutic methods of use
US7148251B2 (en) 2001-01-10 2006-12-12 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US20040260099A1 (en) 2001-01-10 2004-12-23 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
BR0116803A (pt) * 2001-01-18 2004-02-17 Merck Patent Gmbh Proteìnas de fusão bifuncionais com atividade de glicocerebrosidase
IL159905A0 (en) 2001-07-16 2004-06-20 Genzyme Corp Enantioselective synthesis of ceramide-like compounds, novel intermediates, their preparation and pyrrole derivatives
EP1281755A3 (en) 2001-07-31 2003-06-18 Pfizer Products Inc. Variants of the human cyp2d6 gene
AU2002328092A1 (en) 2001-08-08 2003-02-24 Takeda Chemical Industries, Ltd. Bicyclic compound, production and use as hiv inhibitors
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US20060217560A1 (en) 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
WO2004004702A2 (en) 2002-07-09 2004-01-15 The Scripps Research Institute Method to inhibit ischemia and reperfusion injury
US20050032070A1 (en) 2003-08-05 2005-02-10 Sebastian Raimundo Polymorphisms in the human gene for CYP2D6 and their use in diagnostic and therapeutic applications
AR047459A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
KR20070054246A (ko) 2004-09-17 2007-05-28 유니버시티 오브 매사추세츠 리소좀성 효소 결핍을 위한 조성물 및 이의 용도
EP1799865B1 (en) 2004-09-30 2012-06-06 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
ES2463681T3 (es) 2004-10-13 2014-05-28 Pharmacia & Upjohn Company Llc Formas cristalinas de 3-[5-cloro-4-[(2,4-difluorobencil)oxi]-6-oxopirimidin-1 (6H)-il]-N-(2-hidroxietil)-4-metilbenzamida
JP2008519840A (ja) * 2004-11-10 2008-06-12 ジェンザイム・コーポレイション 糖尿病の処置方法
WO2007038676A2 (en) * 2005-09-28 2007-04-05 Teva Pharmaceutical Industries Ltd. Polymorphic forms of ladostigil tartrate
CA2624340A1 (en) * 2005-10-03 2007-04-12 Mallinckrodt Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
EP2032134B1 (en) * 2006-05-09 2015-06-24 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
KR101271225B1 (ko) 2006-10-31 2013-06-03 삼성디스플레이 주식회사 발광 다이오드 칩 및 발광 다이오드 광원 모듈의 제조 방법
TWI314226B (en) 2006-12-07 2009-09-01 Ind Tech Res Inst Piezoelectricity-driving optical lens module
EP1961765A1 (en) 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
US20080175908A1 (en) * 2007-01-12 2008-07-24 Wyeth Tablet-in-tablet compositions
JP2010523578A (ja) 2007-03-30 2010-07-15 アミカス セラピューティックス インコーポレイテッド 薬理シャペロンを用いるファブリー病の治療方法
MX2009011473A (es) 2007-04-26 2010-01-18 Amicus Therapeutics Inc Regimenes de dosificacion para el tratamiento de enfermedades por almacenamiento lisosomal que utilizan chaperonas farmacologicas.
EP2594564B1 (en) * 2007-05-31 2016-09-28 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
DE102007029581B4 (de) 2007-06-26 2020-04-09 GM Global Technology Operations LLC (n. d. Ges. d. Staates Delaware) Kraftfahrzeugdach und Kraftfahrzeugkarosserie
US20090307181A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
WO2009117150A2 (en) 2008-03-20 2009-09-24 Genzyme Corporation Method of treating lupus with ceramide derivatives
FR2953139B1 (fr) 2009-11-27 2012-04-13 Servier Lab Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine
KR20120107080A (ko) 2009-11-27 2012-09-28 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
ES2693746T3 (es) 2009-11-27 2018-12-13 Adverio Pharma Gmbh Procedimiento para la preparación de {4,6-diamino-2-[1-(2-fluorobencil)-1H-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}metilcarbamato de metilo para su uso como principio activo farmacéutico
MY160542A (en) 2009-11-27 2017-03-15 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
CN103619840B (zh) 2011-06-21 2016-01-20 诺华股份有限公司 (s)-吡咯烷-1,2-二羧酸2-酰胺1-{4-甲基-5-[2-(2,2,2-三氟-1,1-二甲基-乙基)-吡啶-4-基]噻唑-2-基}酰胺的多晶型物
JO3316B1 (ar) 2013-05-30 2019-03-13 Lilly Co Eli مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
JP6728842B2 (ja) 2016-03-24 2020-07-22 オムロン株式会社 光学計測装置
CN107445938B (zh) 2016-05-31 2020-04-03 北京启慧生物医药有限公司 依利格鲁司他半酒石酸盐的结晶形式、制备方法和含有所述结晶形式的药用组合物
WO2018193090A2 (en) 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Process for preparation of eliglustat hemitartrate and intermediates thereof

Also Published As

Publication number Publication date
EP2504332B1 (en) 2014-06-04
RS59543B1 (sr) 2019-12-31
CL2012001348A1 (es) 2012-08-24
ES2875382T3 (es) 2021-11-10
NZ600155A (en) 2014-10-31
US20230172903A1 (en) 2023-06-08
HUE029371T2 (en) 2017-02-28
AU2010324810B2 (en) 2016-05-12
CN105753846A (zh) 2016-07-13
ES2493940T3 (es) 2014-09-12
PL2504332T3 (pl) 2014-10-31
CA2781676C (en) 2020-05-05
ES2493940T5 (es) 2021-11-23
CN112521366A (zh) 2021-03-19
US12465586B2 (en) 2025-11-11
KR20120115972A (ko) 2012-10-19
EP2504332B2 (en) 2021-03-17
KR20250005503A (ko) 2025-01-09
SI2504332T1 (sl) 2014-09-30
HRP20161038T1 (hr) 2016-10-21
HRP20140780T1 (en) 2014-11-07
EP3133070A1 (en) 2017-02-22
HUE045784T2 (hu) 2020-01-28
EP3599237B1 (en) 2021-03-24
GT201200161A (es) 2014-01-27
DOP2016000250A (es) 2017-02-15
MY192644A (en) 2022-08-29
PH12015502514B1 (en) 2022-07-29
ECSP18063798A (es) 2020-02-28
CY1122698T1 (el) 2021-03-12
SG10201800136QA (en) 2018-02-27
TW201130822A (en) 2011-09-16
EP3896069A1 (en) 2021-10-20
EP3599237A1 (en) 2020-01-29
JP7150528B2 (ja) 2022-10-11
PL3599237T3 (pl) 2021-09-27
US20160166542A1 (en) 2016-06-16
KR20200013105A (ko) 2020-02-05
PH12015502514A1 (en) 2016-08-15
IL260299A (en) 2018-08-30
PT3599237T (pt) 2021-04-28
CA3075788A1 (en) 2011-06-03
CA3075788C (en) 2021-12-21
US11458119B2 (en) 2022-10-04
ES2586947T3 (es) 2016-10-19
AR121612A2 (es) 2022-06-22
CN112521367A (zh) 2021-03-19
IL310635A (en) 2024-04-01
DK2504332T4 (da) 2021-06-07
TWI606827B (zh) 2017-12-01
US20210393590A1 (en) 2021-12-23
TWI656873B (zh) 2019-04-21
TWI586663B (zh) 2017-06-11
RS53503B2 (sr) 2021-07-30
EA201890254A2 (ru) 2018-10-31
JP6452635B2 (ja) 2019-01-16
MX381242B (es) 2025-03-12
SG10201407881WA (en) 2015-01-29
CN112521367B (zh) 2024-01-02
US20130137743A1 (en) 2013-05-30
US10888547B2 (en) 2021-01-12
UA113491C2 (xx) 2017-02-10
PL3133070T3 (pl) 2020-01-31
EP2796457A1 (en) 2014-10-29
CN102712629A (zh) 2012-10-03
NZ715108A (en) 2017-06-30
AR121611A2 (es) 2022-06-22
CN105777707A (zh) 2016-07-20
KR20180049255A (ko) 2018-05-10
RS54978B1 (sr) 2016-11-30
AU2017265180A1 (en) 2017-12-14
PL2796457T3 (pl) 2017-04-28
EA201270646A1 (ru) 2013-01-30
JP2016138124A (ja) 2016-08-04
HRP20191647T1 (hr) 2019-12-13
CN102712629B (zh) 2016-10-12
SI2796457T1 (sl) 2016-10-28
KR20150125734A (ko) 2015-11-09
CN105777707B (zh) 2020-10-13
PH12012501048A1 (en) 2013-02-04
IL219892A0 (en) 2012-07-31
IL283935A (en) 2021-07-29
EP2504332A1 (en) 2012-10-03
CN105753846B (zh) 2019-11-15
CA3140959A1 (en) 2011-06-03
US20160120842A1 (en) 2016-05-05
SI3133070T1 (sl) 2019-11-29
DK2504332T3 (da) 2014-08-25
SMT201600273B (it) 2016-08-31
MA33838B1 (fr) 2012-12-03
MY160542A (en) 2017-03-15
JP6370264B2 (ja) 2018-08-08
PT2796457T (pt) 2016-07-14
EA023923B1 (ru) 2016-07-29
TN2012000237A1 (en) 2013-12-12
RS53503B1 (sr) 2015-02-27
EP3133070B1 (en) 2019-08-14
WO2011066352A8 (en) 2011-08-11
DK2796457T3 (en) 2016-08-29
DK3133070T3 (da) 2019-11-11
NZ625712A (en) 2016-02-26
PE20121337A1 (es) 2012-10-12
ES2754398T3 (es) 2020-04-17
HK1203485A1 (en) 2015-10-30
HRP20140780T4 (hr) 2021-08-06
TW201737910A (zh) 2017-11-01
BR112012012947A2 (pt) 2017-03-01
PE20171255A1 (es) 2017-08-28
CY1117996T1 (el) 2017-05-17
EA201592195A1 (ru) 2016-04-29
BR112012012947B8 (pt) 2021-05-25
PT2504332E (pt) 2014-09-02
WO2011066352A1 (en) 2011-06-03
HK1172031A1 (en) 2013-04-12
KR20220162824A (ko) 2022-12-08
US20210369672A1 (en) 2021-12-02
AU2016202591B2 (en) 2017-11-30
CL2016002589A1 (es) 2017-05-19
AR079152A1 (es) 2011-12-28
PL2504332T5 (pl) 2021-08-23
AU2017265180B2 (en) 2019-08-01
AU2016202591A1 (en) 2016-05-19
CR20120277A (es) 2012-09-05
JP2020189873A (ja) 2020-11-26
PT3133070T (pt) 2019-11-11
SI2504332T2 (sl) 2021-08-31
MX2012006083A (es) 2012-06-19
JP2015212291A (ja) 2015-11-26
CA2781676A1 (en) 2011-06-03
BR112012012947B1 (pt) 2021-04-06
JP2023116764A (ja) 2023-08-22
AU2010324810A1 (en) 2012-06-07
ME02477B (me) 2017-02-20
JP2019001809A (ja) 2019-01-10
EA201890254A3 (ru) 2019-02-28
EA029990B1 (ru) 2018-06-29
LT2796457T (lt) 2016-09-12
TW201639562A (zh) 2016-11-16
CY1115880T1 (el) 2017-01-25
EP2796457B1 (en) 2016-05-18
DOP2012000141A (es) 2012-09-30
NI201200096A (es) 2012-10-30
LT3133070T (lt) 2019-11-11
KR102073207B1 (ko) 2020-02-05
MX358345B (es) 2018-08-14
JP2013512252A (ja) 2013-04-11

Similar Documents

Publication Publication Date Title
ECSP18063798A (es) Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa
ECSP14004812A (es) Triazolopiridinas sustituidas
BR112013023876A2 (pt) derivados de pirroltriazinona como inibidores de pi3k
UY32096A (es) Derivados de 2-carboxamida - cicloamino - urea especìficos, sus sales farmacèuticamente aceptables, composiciones contenièndolos, pro-farmacos de los mismos, procesos para su produciòn y aplicaciones
CO6480931A2 (es) Sulfonamidas heterocíclicas, usos y composiciones farmacéuticas de las mismas.
ECSP12011935A (es) Triazolopiridinas
ECSP13013011A (es) Triazolopiridinas
DOP2009000287A (es) Oxazolidinonas sustituidas y su uso
DOP2012000312A (es) Triazolopiridinas sustituidas
CO6680645A2 (es) Inhibidores de oxadiazol de la producción de leucotrieno
UY33584A (es) Nuevos compuestos benzamida de inhibidores lrrk2
CU20100127A7 (es) Derivados de tiazol usados como inhibidores de pi 3-cinasa
CU24174B1 (es) Triazolopiridinas como inhibidores de quinasa mps-1