ECSP066669A - Indoles, 1h-indazoles, 1,2-benzisoxazoles, y 1,2-benzisotiazoles, y preparación y usos de los mismos - Google Patents
Indoles, 1h-indazoles, 1,2-benzisoxazoles, y 1,2-benzisotiazoles, y preparación y usos de los mismosInfo
- Publication number
- ECSP066669A ECSP066669A EC2006006669A ECSP066669A ECSP066669A EC SP066669 A ECSP066669 A EC SP066669A EC 2006006669 A EC2006006669 A EC 2006006669A EC SP066669 A ECSP066669 A EC SP066669A EC SP066669 A ECSP066669 A EC SP066669A
- Authority
- EC
- Ecuador
- Prior art keywords
- benzisoxazoles
- indazoles
- indoles
- benzisotiazoles
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
La presente invención refiere en general al campo de ligandos para receptores nicotínicos de acetilcolina (nAChR), activación de nAChRs, y el tratamiento de estados de enfermedad asociados con receptores nicotínicos de acetilcolina defectuosos o que no funcionan correctamente, especialmente del cerebro. Compuestos novedosos por ejemplo indoles, 1H-indazoles, 1,2-benzisoxazoles, y 1,2-benzisotiazoles, que actúan como ligandos para el subtipo a7 nAChR, métodos para preparar dichos compuestos, composiciones que contienen dichos compuestos, y métodos para su uso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53089103P | 2003-12-22 | 2003-12-22 | |
US60689704P | 2004-09-03 | 2004-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066669A true ECSP066669A (es) | 2006-10-25 |
Family
ID=34742980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006669A ECSP066669A (es) | 2003-12-22 | 2006-06-22 | Indoles, 1h-indazoles, 1,2-benzisoxazoles, y 1,2-benzisotiazoles, y preparación y usos de los mismos |
Country Status (22)
Country | Link |
---|---|
US (4) | US7396833B2 (es) |
EP (1) | EP1697378B1 (es) |
JP (1) | JP4824578B2 (es) |
KR (1) | KR20060120694A (es) |
AU (1) | AU2004309367B2 (es) |
BR (1) | BRPI0417323A (es) |
CA (1) | CA2550689A1 (es) |
CR (1) | CR8472A (es) |
DE (1) | DE602004010299T2 (es) |
DK (1) | DK1697378T3 (es) |
EC (1) | ECSP066669A (es) |
ES (1) | ES2295973T3 (es) |
IL (1) | IL176283A0 (es) |
MA (1) | MA28228A1 (es) |
NO (1) | NO20063392L (es) |
NZ (1) | NZ548228A (es) |
PL (1) | PL1697378T3 (es) |
PT (1) | PT1697378E (es) |
RS (1) | RS20060391A (es) |
RU (1) | RU2389729C2 (es) |
SG (1) | SG149830A1 (es) |
WO (1) | WO2005063767A2 (es) |
Families Citing this family (38)
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ATE487716T1 (de) * | 2004-04-22 | 2010-11-15 | Memory Pharm Corp | Indole, 1h-indazole, 1,2-benzisoxazole, 1,2- benzoisothiazole, deren herstellung und verwendungen |
WO2006089168A2 (en) * | 2005-02-18 | 2006-08-24 | Cornell Research Foundation, Inc. | Methods for modulating ion channels |
US8106066B2 (en) * | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
RU2450003C2 (ru) * | 2005-09-23 | 2012-05-10 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, бензоизоксазолы, пиразолопиридины, изотиазолопиридины, их получение и их применение |
WO2007056582A1 (en) * | 2005-11-09 | 2007-05-18 | Memory Pharmaceuticals Corporation | 1 h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
CA2648168A1 (en) * | 2006-04-11 | 2007-10-18 | F. Hoffmann-La Roche Ag | Heterocyclic gaba alpha subtype selective receptor modulators |
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TW200840569A (en) * | 2007-03-13 | 2008-10-16 | Targacept Inc | Sub-type selective amides of diazabicycloalkanes |
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WO2010043515A1 (en) * | 2008-10-13 | 2010-04-22 | F. Hoffmann-La Roche Ag | Diazonium-free method to make an indazole intermediate in the synthesis of bicyclic 5-(trifluormethoxy)-1h-3-indazolecarboxylic acid amides |
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EP2523562B1 (en) * | 2010-01-11 | 2019-01-02 | Astraea Therapeutics, LLC | Nicotinic acetylcholine receptor modulators |
US20110172428A1 (en) | 2010-01-12 | 2011-07-14 | Shan-Ming Kuang | Methods for the preparation of indazole-3-carboxylic acid and n-(s)-1-azabicyclo[2.2.2]oct-3-yl-1h-indazole-3-carboxamide hydrochloride salt |
US8242276B2 (en) | 2010-06-30 | 2012-08-14 | Hoffmann-La Roche Inc. | Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt |
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JP6058557B2 (ja) | 2011-01-26 | 2017-01-11 | ザフゲン,インコーポレイテッド | テトラゾール化合物ならびにその作製方法および使用方法 |
EA025526B1 (ru) | 2011-05-06 | 2017-01-30 | Зафджен Инк. | Частично насыщенные трициклические соединения и способы их получения и применения |
KR20140053013A (ko) | 2011-05-06 | 2014-05-07 | 자프겐 인크. | 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법 |
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US9365495B2 (en) | 2011-12-23 | 2016-06-14 | Basf Se | Process for manufacturing aryloxyacetamides |
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CA2861381A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
CN104395292B (zh) * | 2012-04-10 | 2017-03-01 | 大日本住友制药株式会社 | 1‑取代的吲唑衍生物 |
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BR112015010225A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos e seus métodos de produção e utilização |
CN104918615B (zh) | 2012-11-05 | 2018-10-12 | 扎夫根股份有限公司 | 治疗肝病的方法 |
JP6064062B2 (ja) | 2013-03-15 | 2017-01-18 | ファイザー・インク | Ampkを活性化させるインダゾール化合物 |
AR099052A1 (es) | 2014-01-09 | 2016-06-29 | Takeda Pharmaceuticals Co | Derivados de azaindol |
KR101532211B1 (ko) * | 2014-04-30 | 2015-06-30 | 세종대학교산학협력단 | Ampk 억제기능에 기반한 뇌졸중 치료용 약학적 조성물 및 방법 |
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-
2004
- 2004-12-22 US US11/018,429 patent/US7396833B2/en not_active Expired - Fee Related
- 2004-12-22 PT PT04814981T patent/PT1697378E/pt unknown
- 2004-12-22 RU RU2006126540/04A patent/RU2389729C2/ru not_active IP Right Cessation
- 2004-12-22 CA CA002550689A patent/CA2550689A1/en not_active Abandoned
- 2004-12-22 RS YUP-2006/0391A patent/RS20060391A/sr unknown
- 2004-12-22 NZ NZ548228A patent/NZ548228A/en not_active IP Right Cessation
- 2004-12-22 WO PCT/US2004/042852 patent/WO2005063767A2/en active IP Right Grant
- 2004-12-22 DE DE602004010299T patent/DE602004010299T2/de active Active
- 2004-12-22 DK DK04814981T patent/DK1697378T3/da active
- 2004-12-22 AU AU2004309367A patent/AU2004309367B2/en not_active Ceased
- 2004-12-22 ES ES04814981T patent/ES2295973T3/es active Active
- 2004-12-22 SG SG200900253-6A patent/SG149830A1/en unknown
- 2004-12-22 PL PL04814981T patent/PL1697378T3/pl unknown
- 2004-12-22 EP EP04814981A patent/EP1697378B1/en active Active
- 2004-12-22 KR KR1020067012319A patent/KR20060120694A/ko not_active Application Discontinuation
- 2004-12-22 BR BRPI0417323-6A patent/BRPI0417323A/pt not_active IP Right Cessation
- 2004-12-22 JP JP2006545564A patent/JP4824578B2/ja not_active Expired - Fee Related
-
2006
- 2006-06-13 IL IL176283A patent/IL176283A0/en unknown
- 2006-06-14 MA MA29103A patent/MA28228A1/fr unknown
- 2006-06-21 CR CR8472A patent/CR8472A/es not_active Application Discontinuation
- 2006-06-22 EC EC2006006669A patent/ECSP066669A/es unknown
- 2006-07-21 NO NO20063392A patent/NO20063392L/no not_active Application Discontinuation
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2008
- 2008-05-29 US US12/128,839 patent/US7790722B2/en not_active Expired - Fee Related
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2010
- 2010-08-17 US US12/857,617 patent/US7964600B2/en not_active Expired - Fee Related
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2011
- 2011-06-17 US US13/162,786 patent/US8158629B2/en not_active Expired - Fee Related
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