ECSP014083A - Metodo de cristalizacion reactiva para mejorar el tamaño de particula - Google Patents
Metodo de cristalizacion reactiva para mejorar el tamaño de particulaInfo
- Publication number
- ECSP014083A ECSP014083A EC2001004083A ECSP014083A ECSP014083A EC SP014083 A ECSP014083 A EC SP014083A EC 2001004083 A EC2001004083 A EC 2001004083A EC SP014083 A ECSP014083 A EC SP014083A EC SP014083 A ECSP014083 A EC SP014083A
- Authority
- EC
- Ecuador
- Prior art keywords
- particle size
- improve particle
- reactive crystallization
- product
- crystallization
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/23—Mixing by intersecting jets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1806—Stationary reactors having moving elements inside resulting in a turbulent flow of the reactants, such as in centrifugal-type reactors, or having a high Reynolds-number
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00101—Reflux columns
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00164—Controlling or regulating processes controlling the flow
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
Esta invención proporciona un método para llevar a cabo una reacción química y una cristalización controlada del producto simultáneas, empleando corrientes en chorro de fluido colisionantes, que contienen reaccionantes capaces de producir el producto con características de tamaño de partícula deseada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20762900P | 2000-05-26 | 2000-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP014083A true ECSP014083A (es) | 2003-01-13 |
Family
ID=22771343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2001004083A ECSP014083A (es) | 2000-05-26 | 2001-05-24 | Metodo de cristalizacion reactiva para mejorar el tamaño de particula |
Country Status (38)
Country | Link |
---|---|
US (1) | US6558435B2 (es) |
EP (1) | EP1157726A1 (es) |
JP (1) | JP2002028475A (es) |
KR (1) | KR100408949B1 (es) |
CN (1) | CN1183989C (es) |
AP (1) | AP1321A (es) |
AR (1) | AR029099A1 (es) |
AU (1) | AU775613B2 (es) |
BG (1) | BG105518A (es) |
BR (1) | BR0102129A (es) |
CA (1) | CA2349136A1 (es) |
CZ (1) | CZ20011726A3 (es) |
DZ (1) | DZ3075A1 (es) |
EA (1) | EA003261B1 (es) |
EC (1) | ECSP014083A (es) |
EE (1) | EE200100284A (es) |
GE (1) | GEP20043173B (es) |
GT (1) | GT200100095A (es) |
HK (1) | HK1038896B (es) |
HR (1) | HRP20010399A2 (es) |
ID (1) | ID30368A (es) |
IL (1) | IL143227A (es) |
IS (1) | IS5950A (es) |
MA (1) | MA25321A1 (es) |
NO (1) | NO20012571L (es) |
NZ (1) | NZ511966A (es) |
OA (1) | OA11719A (es) |
PA (1) | PA8517001A1 (es) |
PE (1) | PE20020149A1 (es) |
PL (1) | PL347736A1 (es) |
SG (1) | SG96223A1 (es) |
SK (1) | SK6882001A3 (es) |
SV (1) | SV2001000464A (es) |
TN (1) | TNSN01075A1 (es) |
TR (1) | TR200101453A3 (es) |
TW (1) | TWI236930B (es) |
YU (1) | YU34501A (es) |
ZA (1) | ZA200104207B (es) |
Families Citing this family (55)
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BR0209605A (pt) * | 2001-05-14 | 2004-03-23 | Pfizer Prod Inc | Sais tartarato de 5,8,14-triazatetraciclo[10.3.1.0.²,¹¹.04,9]-hexadeca-2(11), 3,5,7,9-pentaeno |
CA2468705A1 (en) * | 2001-11-29 | 2003-06-05 | Pfizer Products Inc. | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof |
CA2484212A1 (en) * | 2002-04-29 | 2003-11-13 | Chenkou Wei | Crystallization system utilizing atomization |
KR20050007534A (ko) * | 2002-05-10 | 2005-01-19 | 브리스톨-마이어스 스큅 컴퍼니 | 균질화를 이용한 결정화 시스템 |
US20040098839A1 (en) * | 2002-11-27 | 2004-05-27 | Pfizer Inc. | Crystallization method and apparatus using an impinging plate assembly |
US7488729B2 (en) | 2002-12-04 | 2009-02-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof |
WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
WO2005035531A1 (en) | 2003-06-03 | 2005-04-21 | Teva Paharmaceutical Industries Ltd. | POLYMORPHIC FORMS OF ZIPRASIDONE HCl AND PROCESSES FOR THEIR PREPARATION |
TWI371274B (en) * | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
WO2005040160A2 (en) | 2003-10-24 | 2005-05-06 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of ziprasidone |
EP1703898A2 (en) * | 2003-12-31 | 2006-09-27 | Alpharma, Inc. | Ziprasidone formulations |
US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
US7829720B2 (en) | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
US7396932B2 (en) * | 2004-09-28 | 2008-07-08 | Bristol-Myers Squibb Company | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US7314516B2 (en) * | 2004-12-29 | 2008-01-01 | Five Star Technologies, Inc. | Hydrodynamic cavitation crystallization device and process |
US20060160841A1 (en) * | 2005-01-19 | 2006-07-20 | Chenkou Wei | Crystallization via high-shear transformation |
DE102005053862A1 (de) | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
US8143397B2 (en) | 2006-02-01 | 2012-03-27 | Medichem S.A. | Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof |
SG172700A1 (en) * | 2006-04-28 | 2011-07-28 | Schering Corp | Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same |
CN101495095B (zh) * | 2006-04-28 | 2013-05-29 | 默沙东公司 | 通过受控的沉淀来沉淀和分离6,6-二甲基-3-氮杂-双环[3.1.0]己烷-酰胺化合物的方法和含有其的药学制剂 |
US8420122B2 (en) * | 2006-04-28 | 2013-04-16 | Merck Sharp & Dohme Corp. | Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same |
KR100850010B1 (ko) * | 2007-03-19 | 2008-08-04 | 희성금속 주식회사 | 초음파 화학적 반응에 의한 산화 인듐 분말의 제조방법 및ito 타겟재의 제조방법 |
KR100850011B1 (ko) * | 2007-03-19 | 2008-08-04 | 희성금속 주식회사 | 초음파 화학적 반응에 의한 산화 주석 분말의 제조 방법 및ito 타겟재의 제조 방법 |
ES2361796T3 (es) * | 2007-06-22 | 2011-06-22 | Bristol-Myers Squibb Company | Composiciones en comprimidos que contienen atazanavir. |
PL2170292T3 (pl) * | 2007-06-22 | 2014-06-30 | Bristol Myers Squibb Holdings Ireland | Tabletkowane kompozycje zawierające atazanawir |
AU2008268627A1 (en) * | 2007-06-22 | 2008-12-31 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
JP2010530890A (ja) * | 2007-06-22 | 2010-09-16 | ブリストル−マイヤーズ スクイブ カンパニー | アタザナビルを含む錠剤組成物 |
WO2009032558A2 (en) * | 2007-08-31 | 2009-03-12 | Dr. Reddy's Laboratories Ltd. | Preparation of ziprasidone hydrochloride monohydrate |
WO2009101185A2 (en) * | 2008-02-15 | 2009-08-20 | Medichem, S.A. | A NEW POLYMORPHIC FORM OF A PYRAZINO[2,3-h][3] BENZAZEPINE DERIVATIVE |
WO2009111623A2 (en) * | 2008-03-06 | 2009-09-11 | Dr. Reddy's Laboratories Ltd. | Amorphous varenicline tartrate |
US8187554B2 (en) | 2008-04-23 | 2012-05-29 | Microfluidics International Corporation | Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems |
US8039620B2 (en) | 2008-05-22 | 2011-10-18 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate |
US20090318695A1 (en) * | 2008-06-19 | 2009-12-24 | Vinod Kumar Kansal | Processes for the preparation of varenicline and intermediates thereof |
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DE102009008478A1 (de) | 2009-02-11 | 2010-08-19 | PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
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CN104843745B (zh) * | 2015-04-27 | 2016-08-24 | 青海国泰盐湖化肥有限公司 | 一种复分解法硝酸钾产品粒度的控制方法 |
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CN111346397B (zh) * | 2020-03-11 | 2022-03-29 | 天津大学 | 适用于溶析结晶或反应结晶的加料设备 |
CN113980020B (zh) * | 2021-11-22 | 2023-05-09 | 浙江车头制药股份有限公司 | 一种酒石酸伐尼克兰晶型的制备方法 |
CN114130324A (zh) * | 2021-12-01 | 2022-03-04 | 沈阳铝镁设计研究院有限公司 | 一种蛟吸增效分解系统 |
CN115253367A (zh) * | 2022-08-31 | 2022-11-01 | 浙江新和成股份有限公司 | 一种布洛芬微晶的生产装置及结晶方法和产品 |
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DE3330445A1 (de) * | 1983-08-24 | 1985-03-21 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von als feststoffe anfallenden chemischen verbindungen aus fluessigen ausgangsstoffen |
US4675194A (en) * | 1986-03-03 | 1987-06-23 | Reaction Technology, Inc. | Sonic process for converting proteinaceous raw materials in situ into semi-solid food products |
SE8700213L (sv) | 1987-01-21 | 1988-07-22 | Nobel Kemi Ab | Sett att framstella kristallina substanser |
CH671166A5 (en) | 1987-07-01 | 1989-08-15 | Fershan Holding S A | Crystallisation nuclei formation - by turbulising soln. and applying mechanical energy to form nucleation sites |
IE67187B1 (en) * | 1990-06-15 | 1996-03-06 | Merck & Co Inc | A crystallization method to improve crystal structure and size |
US5143965A (en) * | 1990-12-26 | 1992-09-01 | The Dow Chemical Company | Magnesium hydroxide having fine, plate-like crystalline structure and process therefor |
GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
US5853691A (en) * | 1993-08-10 | 1998-12-29 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On The Behalf Of The University Of Oregon | Silver halides of altered crystal habit or morphology and methods for producing same |
GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
DE4431872C1 (de) | 1994-09-07 | 1996-01-11 | Santrade Ltd | Anwendung von Ultraschall bei der Verfestigung von Schmelzen oder übersättigten Lösungen auf Förderbändern oder Aufnahmetrommeln |
SE9501384D0 (sv) | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
GB9624615D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Chrystallisation process |
GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
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