EA202092904A1 - Способы получения рекомбинантных белков - Google Patents
Способы получения рекомбинантных белковInfo
- Publication number
- EA202092904A1 EA202092904A1 EA202092904A EA202092904A EA202092904A1 EA 202092904 A1 EA202092904 A1 EA 202092904A1 EA 202092904 A EA202092904 A EA 202092904A EA 202092904 A EA202092904 A EA 202092904A EA 202092904 A1 EA202092904 A1 EA 202092904A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- density
- culturing
- interest
- cell culture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862693606P | 2018-07-03 | 2018-07-03 | |
| PCT/US2019/040298 WO2020010080A1 (en) | 2018-07-03 | 2019-07-02 | Methods of producing recombinant proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092904A1 true EA202092904A1 (ru) | 2021-04-22 |
Family
ID=67470657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092904A EA202092904A1 (ru) | 2018-07-03 | 2019-07-02 | Способы получения рекомбинантных белков |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20210253996A1 (https=) |
| EP (2) | EP3818078B1 (https=) |
| JP (3) | JP7419273B2 (https=) |
| KR (2) | KR20250153311A (https=) |
| CN (1) | CN112839954A (https=) |
| AU (1) | AU2019299358B2 (https=) |
| CA (1) | CA3104684A1 (https=) |
| DK (1) | DK3818078T3 (https=) |
| EA (1) | EA202092904A1 (https=) |
| ES (1) | ES2976708T3 (https=) |
| FI (1) | FI3818078T3 (https=) |
| HR (1) | HRP20240584T1 (https=) |
| HU (1) | HUE066560T2 (https=) |
| IL (2) | IL324666A (https=) |
| LT (1) | LT3818078T (https=) |
| MX (1) | MX2020013633A (https=) |
| PL (1) | PL3818078T3 (https=) |
| PT (1) | PT3818078T (https=) |
| RS (1) | RS65472B1 (https=) |
| SG (1) | SG11202012582QA (https=) |
| SI (1) | SI3818078T1 (https=) |
| SM (1) | SMT202400173T1 (https=) |
| WO (1) | WO2020010080A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK181991B1 (en) * | 2021-11-11 | 2025-05-15 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) in escherichia coli |
| WO2023242238A1 (en) * | 2022-06-15 | 2023-12-21 | UCB Biopharma SRL | Cell culture processes |
| EP4339274B1 (en) | 2022-09-13 | 2025-03-26 | Sartorius Stedim Biotech GmbH | Method for operating a bioprocess installation for production of a bioproduct |
| KR20240172522A (ko) * | 2023-06-01 | 2024-12-10 | (주)알테오젠 | 지속형 호르몬 수용체 길항제의 생산 방법 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515893A (en) | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5091313A (en) | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| DE68919361T2 (de) | 1988-06-21 | 1995-05-24 | Genentech Inc | Therapeutische zusammensetzungen für die behandlung von myocard-infarkten. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ES2193136T3 (es) | 1991-08-14 | 2003-11-01 | Genentech Inc | Variantes de inmunoglubina para receptores especificos de fc epsilon. |
| AU687755B2 (en) | 1992-08-21 | 1998-03-05 | Genentech Inc. | Method for treating an LFA-1-mediated disorder |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| ES2108566T3 (es) | 1993-12-10 | 1997-12-16 | Genentech Inc | Procedimientos para diagnosticar alergias y para seleccionar agentes terapeuticos antialergicos. |
| WO1995019181A1 (en) | 1994-01-18 | 1995-07-20 | Genentech, Inc. | A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS |
| US5707622A (en) | 1994-03-03 | 1998-01-13 | Genentech, Inc. | Methods for treating ulcerative colitis |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| CA2242414C (en) | 1996-01-23 | 2012-01-03 | Genentech, Inc. | Anti-cd18 antibodies for use against stroke |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| EP0941344B1 (en) | 1996-11-27 | 2004-05-19 | Genentech, Inc. | HUMANIZED ANTI-CD11a ANTIBODIES |
| KR100816621B1 (ko) | 1997-04-07 | 2008-03-24 | 제넨테크, 인크. | 항-ｖｅｇｆ 항체 |
| ES2293682T5 (es) | 1997-05-15 | 2011-11-17 | Genentech, Inc. | Anticuerpo anti-apo2. |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| ES2309012T3 (es) | 1999-10-29 | 2008-12-16 | Genentech, Inc. | Composiciones del anticuerpo anti-psca y a sus procedimientos contra celulas cancerigenas que expresen psca. |
| US7335491B2 (en) * | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| AU2007294731B2 (en) * | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| HUE042314T2 (hu) | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| PT2837680T (pt) * | 2011-07-01 | 2020-04-17 | Amgen Inc | Cultura celular de mamífero |
| WO2015095809A1 (en) * | 2013-12-20 | 2015-06-25 | Biogen Idec Ma Inc. | Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality |
| MA40021A (fr) * | 2014-06-03 | 2015-12-10 | Lupin Ltd | Processus de culture cellulaire destiné à produire une protéine |
| AU2015269365A1 (en) * | 2014-06-04 | 2016-12-15 | Amgen Inc. | Methods for harvesting mammalian cell cultures |
| US9813410B2 (en) | 2014-06-26 | 2017-11-07 | Rakuten, Inc. | Information processing apparatus, information processing method, and information processing program |
-
2019
- 2019-07-02 HR HRP20240584TT patent/HRP20240584T1/hr unknown
- 2019-07-02 AU AU2019299358A patent/AU2019299358B2/en active Active
- 2019-07-02 KR KR1020257033442A patent/KR20250153311A/ko active Pending
- 2019-07-02 HU HUE19745845A patent/HUE066560T2/hu unknown
- 2019-07-02 US US17/252,163 patent/US20210253996A1/en active Pending
- 2019-07-02 CA CA3104684A patent/CA3104684A1/en active Pending
- 2019-07-02 ES ES19745845T patent/ES2976708T3/es active Active
- 2019-07-02 WO PCT/US2019/040298 patent/WO2020010080A1/en not_active Ceased
- 2019-07-02 JP JP2020573229A patent/JP7419273B2/ja active Active
- 2019-07-02 MX MX2020013633A patent/MX2020013633A/es unknown
- 2019-07-02 FI FIEP19745845.8T patent/FI3818078T3/fi active
- 2019-07-02 EA EA202092904A patent/EA202092904A1/ru unknown
- 2019-07-02 CN CN201980044908.3A patent/CN112839954A/zh active Pending
- 2019-07-02 IL IL324666A patent/IL324666A/en unknown
- 2019-07-02 LT LTEPPCT/US2019/040298T patent/LT3818078T/lt unknown
- 2019-07-02 PL PL19745845.8T patent/PL3818078T3/pl unknown
- 2019-07-02 EP EP19745845.8A patent/EP3818078B1/en active Active
- 2019-07-02 SG SG11202012582QA patent/SG11202012582QA/en unknown
- 2019-07-02 PT PT197458458T patent/PT3818078T/pt unknown
- 2019-07-02 DK DK19745845.8T patent/DK3818078T3/da active
- 2019-07-02 SM SM20240173T patent/SMT202400173T1/it unknown
- 2019-07-02 KR KR1020217003056A patent/KR102870511B1/ko active Active
- 2019-07-02 SI SI201930722T patent/SI3818078T1/sl unknown
- 2019-07-02 EP EP24153543.4A patent/EP4368699A3/en active Pending
- 2019-07-02 RS RS20240475A patent/RS65472B1/sr unknown
-
2020
- 2020-12-25 IL IL279782A patent/IL279782B1/en unknown
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2024
- 2024-01-10 JP JP2024001657A patent/JP2024050590A/ja active Pending
-
2025
- 2025-01-17 US US19/030,272 patent/US20250171732A1/en active Pending
- 2025-12-12 JP JP2025247705A patent/JP2026048825A/ja active Pending
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