EA201890584A1 - Новые аналоги инсулина и их применение - Google Patents

Новые аналоги инсулина и их применение

Info

Publication number
EA201890584A1
EA201890584A1 EA201890584A EA201890584A EA201890584A1 EA 201890584 A1 EA201890584 A1 EA 201890584A1 EA 201890584 A EA201890584 A EA 201890584A EA 201890584 A EA201890584 A EA 201890584A EA 201890584 A1 EA201890584 A1 EA 201890584A1
Authority
EA
Eurasian Patent Office
Prior art keywords
insulin analogue
application
insulin analogues
new insulin
insulin
Prior art date
Application number
EA201890584A
Other languages
English (en)
Inventor
Джин Ён Ким
Ых Лим О
Джон Су Ли
Хён Гю Лим
Ин Юнг Чхой
Се Чан Квон
Original Assignee
Ханми Фарм. Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ханми Фарм. Ко., Лтд. filed Critical Ханми Фарм. Ко., Лтд.
Publication of EA201890584A1 publication Critical patent/EA201890584A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение относится к новому аналогу инсулина и, более конкретно, к аналогу инсулина с улучшенным in vitro эффектом по сравнению с нативным инсулином, нуклеиновой кислоте, кодирующей указанный аналог, вектору экспрессии, содержащему указанную нуклеиновую кислоту, трансформанту, в которого введен указанный вектор экспрессии, способу получения аналога инсулина из указанного трансформанта, фармацевтической композиции для лечения диабета, содержащей указанный аналог инсулина в качестве активного ингредиента, и способу лечения диабета с использованием указанного аналога инсулина или указанной фармацевтической композиции.
EA201890584A 2015-08-28 2016-08-29 Новые аналоги инсулина и их применение EA201890584A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150121819 2015-08-28
PCT/KR2016/009606 WO2017039267A1 (en) 2015-08-28 2016-08-29 Novel insulin analogs and use thereof

Publications (1)

Publication Number Publication Date
EA201890584A1 true EA201890584A1 (ru) 2018-08-31

Family

ID=58189026

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890584A EA201890584A1 (ru) 2015-08-28 2016-08-29 Новые аналоги инсулина и их применение

Country Status (17)

Country Link
US (2) US10017557B2 (ru)
EP (1) EP3341404B1 (ru)
JP (2) JP6976930B2 (ru)
KR (1) KR20170026284A (ru)
CN (2) CN113637065A (ru)
AR (1) AR105822A1 (ru)
AU (1) AU2016317449B2 (ru)
CA (1) CA2999823A1 (ru)
EA (1) EA201890584A1 (ru)
ES (1) ES2978863T3 (ru)
NZ (1) NZ741060A (ru)
PH (1) PH12018500690A1 (ru)
TW (1) TWI781083B (ru)
UA (1) UA125928C2 (ru)
UY (1) UY36870A (ru)
WO (1) WO2017039267A1 (ru)
ZA (1) ZA201802017B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY36870A (es) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
EP3517544A4 (en) 2016-09-23 2020-06-03 Hanmi Pharm. Co., Ltd. INSULIN ANALOG HAVING REDUCED INSULIN RECEPTOR BINDING FORCE AND USE THEREOF
CN110291103A (zh) 2016-12-05 2019-09-27 韩美药品株式会社 具有弱化的免疫应答的缀合物
KR102645064B1 (ko) 2017-02-03 2024-03-08 한미약품 주식회사 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도
AR111341A1 (es) 2017-03-23 2019-07-03 Hanmi Pharm Ind Co Ltd Un conjugado del análogo de insulina con afinidad reducida para el receptor de insulina y uso del mismo
WO2020130751A1 (ko) 2018-12-21 2020-06-25 한미약품 주식회사 인슐린 및 글루카곤을 포함하는 약학 조성물
CN113453703A (zh) 2018-12-21 2021-09-28 韩美药品株式会社 包括胰岛素和对胰高血糖素和glp-1和gip受体均具有活性的三重激动剂的药物组合物
CN111220604B (zh) * 2019-12-06 2022-03-15 东北农业大学 一种肉制品中总淀粉含量的测定方法
KR102663243B1 (ko) 2021-08-30 2024-05-03 국립순천대학교산학협력단 트립신 특이적 형광 프로브 및 이의 용도
KR102574341B1 (ko) 2021-08-30 2023-09-04 순천대학교 산학협력단 아미노산 특이적 차단제 및 이의 용도
JP2023058903A (ja) * 2021-10-14 2023-04-26 株式会社三共 遊技機
JP2023058900A (ja) * 2021-10-14 2023-04-26 株式会社三共 遊技機
JP2023058901A (ja) * 2021-10-14 2023-04-26 株式会社三共 遊技機
JP2023058902A (ja) * 2021-10-14 2023-04-26 株式会社三共 遊技機
JP2023058899A (ja) * 2021-10-14 2023-04-26 株式会社三共 遊技機
CN114805544B (zh) * 2022-06-23 2022-09-09 北京惠之衡生物科技有限公司 一种赖脯胰岛素前体、其重组基因工程菌及其构建方法

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2536040A1 (de) * 1975-08-13 1977-02-24 Hoechst Ag Insulin-analoga mit biologischer wirkung
US5175145A (en) 1988-08-26 1992-12-29 Amylin Pharmaceuticals, Inc. Treatment of diabetes mellitus with amylin agonists
WO1990007522A1 (en) * 1988-12-23 1990-07-12 Novo Nordisk A/S Human insulin analogues
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
US5422339A (en) 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
WO1997034631A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
IL143866A0 (en) * 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
US7238663B2 (en) 2001-08-28 2007-07-03 Eli Lilly And Company Pre-mixes of GLP-1 and basal insulin
AR036711A1 (es) 2001-10-05 2004-09-29 Bayer Corp Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
MXPA04003569A (es) 2001-10-19 2004-07-23 Lilly Co Eli Mezclas bifasicas de glp-1 e insulina.
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
CA2518776A1 (en) 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
CA2526957C (en) 2003-07-25 2011-07-12 Conjuchem Inc. Long lasting insulin derivatives and methods thereof
WO2005047334A1 (en) 2003-11-13 2005-05-26 Hanmi Pharmaceutical. Co., Ltd. Igg fc fragment for a drug carrier and method for the preparation thereof
EP1917363B1 (en) 2005-08-16 2011-06-22 Novo Nordisk A/S Method for making mature insulin polypeptides
CA2663074A1 (en) * 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
EP2017288A1 (en) 2007-07-16 2009-01-21 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
JP2009019027A (ja) 2007-07-16 2009-01-29 Hanmi Pharmaceutical Co Ltd アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体
CN101743252A (zh) 2007-07-16 2010-06-16 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、peg化的胰岛素类似物
CN101778862B (zh) * 2007-08-13 2014-12-17 诺沃-诺迪斯克有限公司 快速作用的胰岛素类似物
CA2695970A1 (en) 2007-08-15 2009-02-19 Novo Nordisk A\S Insulin analogues with an acyl and aklylene glycol moiety
CN101157725B (zh) * 2007-10-24 2012-07-25 中国药科大学 人胰岛素类似物的制备方法及用途
EP2209800B1 (en) 2007-11-16 2013-07-24 Novo Nordisk A/S Stable pharmaceutical compositions comprising liraglutide and degludec
NZ586589A (en) 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
US9260502B2 (en) * 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
WO2009129250A2 (en) 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
CA2722168A1 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
BR122013025625B1 (pt) 2008-10-17 2021-08-03 Sanofi-Aventis Deutschland Gmbh Composição farmacêutica, seu uso e método de preparação da mesma, kit e dispositivo
CN102245624B (zh) 2008-12-19 2016-08-10 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
CN102256992B (zh) 2008-12-19 2015-04-22 印第安纳大学研究及科技有限公司 胰岛素类似物
PE20120514A1 (es) 2009-03-27 2012-05-14 Glaxo Group Ltd Fusiones y conjugados de agentes insulinotropicos o farmacos incretina con anticuerpos dab anti-albumina serica
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
ES2676373T3 (es) 2009-11-13 2018-07-19 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
KR101058209B1 (ko) 2009-12-30 2011-08-22 전자부품연구원 Ｏｆｄｍ 방식의 디지털 방송 시스템의 빠른 동기 방법
AR081066A1 (es) 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
KR101324828B1 (ko) * 2010-06-08 2013-11-01 한미사이언스 주식회사 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체
KR101330868B1 (ko) 2010-06-08 2013-11-18 한미사이언스 주식회사 면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체
AU2011268327B2 (en) * 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
KR101382593B1 (ko) 2010-07-21 2014-04-10 한미사이언스 주식회사 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물
CA2806399A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
KR20120013727A (ko) 2010-08-06 2012-02-15 삼성전자주식회사 디스플레이장치 및 그 제어방법
JP2014504597A (ja) 2011-01-20 2014-02-24 ジーランド ファーマ アクティーゼルスカブ アシル化グルカゴン類似体とインスリン類似体の組合せ物
WO2012116818A1 (en) 2011-03-02 2012-09-07 Oerlikon Trading Ag, Trübbach Sliding component coated with metal-comprising carbon layer for improving wear and friction behavior by tribological applications under lubricated conditions
CN102675452B (zh) 2011-03-17 2015-09-16 重庆富进生物医药有限公司 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
MX337474B (es) 2011-05-03 2016-03-04 Barrday Inc Panel antibalistico.
UA113626C2 (xx) 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
JP6182134B2 (ja) 2011-06-02 2017-08-16 オプコ バイオロジクス リミテッド 長時間作用型ｇｌｐ−１／グルカゴン受容体アゴニスト
DK2718318T3 (en) 2011-06-10 2018-11-05 Hanmi Science Co Ltd New oxyntomodulin derivatives and pharmaceutical compositions for the treatment of obesity comprising these
SG10201605006XA (en) 2011-06-17 2016-08-30 Hanmi Science Co Ltd A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof
US9165768B2 (en) 2011-12-16 2015-10-20 Lg Innotek Co., Ltd. Method for deposition of silicon carbide and silicon carbide epitaxial wafer
JP2015507916A (ja) 2012-01-20 2015-03-16 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ グルタミン酸安定化インスリン類似体
EP2820150A1 (en) * 2012-03-01 2015-01-07 Novo Nordisk A/S N-terminally modified oligopeptides and uses thereof
KR101665009B1 (ko) 2012-03-09 2016-10-11 한미사이언스 주식회사 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
AR092862A1 (es) 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
AR091902A1 (es) 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
SG11201503370WA (en) 2012-11-06 2015-05-28 Hanmi Pharm Ind Co Ltd Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
PE20191481A1 (es) 2013-02-26 2019-10-18 Hanmi Pharm Ind Co Ltd Analogo de insulina novedoso y su uso
WO2014133327A1 (ko) * 2013-02-26 2014-09-04 한미약품 주식회사 인슐린 위치 특이적 결합체
CA2937168A1 (en) * 2014-01-20 2015-07-23 Hanmi Pharm. Co., Ltd. Long-acting insulin and use thereof
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
KR101676542B1 (ko) * 2014-12-30 2016-11-16 건국대학교 산학협력단 프로인슐린의 면역학적 용도
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos

Also Published As

Publication number Publication date
NZ741060A (en) 2024-05-31
CN108350056B (zh) 2021-09-21
EP3341404A4 (en) 2019-08-21
US10017557B2 (en) 2018-07-10
CN113637065A (zh) 2021-11-12
JP2021168687A (ja) 2021-10-28
WO2017039267A1 (en) 2017-03-09
EP3341404C0 (en) 2024-04-03
TW201710288A (zh) 2017-03-16
EP3341404B1 (en) 2024-04-03
CN108350056A (zh) 2018-07-31
AU2016317449B2 (en) 2021-01-07
UA125928C2 (uk) 2022-07-13
KR20170026284A (ko) 2017-03-08
ZA201802017B (en) 2019-01-30
AU2016317449A1 (en) 2018-04-19
JP7252280B2 (ja) 2023-04-04
PH12018500690A1 (en) 2018-10-15
ES2978863T3 (es) 2024-09-23
CA2999823A1 (en) 2017-03-09
UY36870A (es) 2017-03-31
TWI781083B (zh) 2022-10-21
US10647753B2 (en) 2020-05-12
AR105822A1 (es) 2017-11-15
EP3341404A1 (en) 2018-07-04
JP6976930B2 (ja) 2021-12-08
JP2018526001A (ja) 2018-09-13
US20170066811A1 (en) 2017-03-09
US20180282388A1 (en) 2018-10-04

Similar Documents

Publication Publication Date Title
EA201890584A1 (ru) Новые аналоги инсулина и их применение
MX2024001192A (es) Anticuerpos anti gen 3 de activacion linfocitica (lag-3) y metodos para usarlos.
EA201890343A1 (ru) Быстродействующие инсулиновые композиции
MY161773A (en) Amylin analogues and pharmaceutical compositions thereof
EA201890630A1 (ru) Антитела против pd-1 и способы их применения
EA201890725A1 (ru) Агонисты фарнезоидного х-рецептора и их применение
CL2016000873A1 (es) Analogos de glucagon acilado, una composicion que lo comprende; su uso para la fabricacion de un medicamento util para impedir el aumento de peso; un kit y un procedimiento.
EA201492053A1 (ru) Белки фактора роста фибробластов 21
BR112017027567A2 (pt) proteínas de fusão para inibir a angiogênese
EA033399B1 (ru) Аналоги глюкагона с повышенной растворимостью и/или стабильностью и их применение
EA201691754A1 (ru) Рекомбинантный микроорганизм, экспрессирующий аналог авермектина, и его применение
PH12017501486A1 (en) Nasal powder formulation for treatment of hypoglycemia
EA201691374A1 (ru) Инсулин длительного действия и его применение
EA201890776A1 (ru) Агонисты ppar, соединения, фармацевтические композиции и способы их применения
EA201791537A1 (ru) Фармацевтическая композиция на основе наночастиц доцетаксела-альбумина, способ ее получения и ее применение
EA201391488A1 (ru) Композиции со сниженной вязкостью
EA202090014A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA201790699A1 (ru) Стабилизированные производные адреномедуллина и их применение
BR112017014552A2 (pt) ?análogo de calcitonina, e, método para produzir uma diminuição nos triglicerídeos no fígado/redução de acúmulo de gordura no fígado?
EA201992168A1 (ru) Аналоги деутетрабеназина, их получение и применение
MX2018009676A (es) Proceso.
MX2016012314A (es) Analagos de apelina ciclicos.
EA202090788A1 (ru) Жидкая композиция для использования в качестве противовоспалительного средства
EA201700097A1 (ru) Пептид для лечения сахарного диабета 2-го типа и его осложнений
BR112017022656A2 (pt) conservação in vitro de células terapêuticas