EA201391488A1 - Композиции со сниженной вязкостью - Google Patents

Композиции со сниженной вязкостью

Info

Publication number
EA201391488A1
EA201391488A1 EA201391488A EA201391488A EA201391488A1 EA 201391488 A1 EA201391488 A1 EA 201391488A1 EA 201391488 A EA201391488 A EA 201391488A EA 201391488 A EA201391488 A EA 201391488A EA 201391488 A1 EA201391488 A1 EA 201391488A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
reduced viscosity
relates
present
viscosity
Prior art date
Application number
EA201391488A
Other languages
English (en)
Inventor
Мирна А. Монк
Мань И. Вон
Кай Чжан
Original Assignee
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ГЛЭКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛЭКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201391488A1 publication Critical patent/EA201391488A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Изобретение относится к способу снижения вязкости композиции, содержащей цитрат и терапевтический белок, а также к композициям, полученным с использованием заявленного способа. Настоящее изобретение также относится к изделию, включающему контейнер, который содержит композицию по настоящему изобретению.
EA201391488A 2011-04-07 2012-04-06 Композиции со сниженной вязкостью EA201391488A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161473121P 2011-04-07 2011-04-07
PCT/US2012/032462 WO2012138958A1 (en) 2011-04-07 2012-04-06 Formulations with reduced viscosity

Publications (1)

Publication Number Publication Date
EA201391488A1 true EA201391488A1 (ru) 2014-01-30

Family

ID=46969561

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391488A EA201391488A1 (ru) 2011-04-07 2012-04-06 Композиции со сниженной вязкостью

Country Status (12)

Country Link
US (1) US20140023655A1 (ru)
EP (2) EP2694100A4 (ru)
JP (1) JP2014516924A (ru)
KR (1) KR20140018966A (ru)
CN (1) CN103596585A (ru)
AU (2) AU2012240050B2 (ru)
BR (1) BR112013025866A2 (ru)
CA (1) CA2832556A1 (ru)
EA (1) EA201391488A1 (ru)
IL (1) IL228591A0 (ru)
SG (1) SG193963A1 (ru)
WO (1) WO2012138958A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA33989B1 (fr) * 2010-01-15 2013-02-01 Kirin Amgen Inc Formulation d'anticorps et régimes thérapeutiques
EP2771033A4 (en) * 2011-10-28 2016-02-17 Integritybio Inc PROTEIN FORMULATIONS CONTAINING AMINO ACIDS
FR2994390B1 (fr) 2012-08-10 2014-08-15 Adocia Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee
WO2014141149A1 (en) * 2013-03-15 2014-09-18 Glaxosmithkline Intellectual Property (No.2) Limited Formulations with reduced viscosity
WO2014169153A1 (en) * 2013-04-10 2014-10-16 Echogen, Inc. Peptide complexes and therapeutic uses
JP6179939B2 (ja) * 2013-07-09 2017-08-16 国立大学法人 筑波大学 高濃度γグロブリン製剤の粘度低下方法
RU2675824C2 (ru) 2013-09-11 2018-12-25 Игл Байолоджикс, Инк. Жидкие белковые составы, содержащие ионные жидкости
KR102497368B1 (ko) 2014-10-01 2023-02-10 이글 바이올로직스 인코포레이티드 점도-저하제를 함유하는 폴리삭카라이드 및 핵산 제형
EP3256147B8 (en) * 2015-01-18 2020-10-21 Gloriana Therapeutics, Inc. Therapeutic protein formulations
EA037487B1 (ru) 2015-08-24 2021-04-02 Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед Биофармацевтические композиции
US11603407B2 (en) * 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
CA3063324A1 (en) 2017-05-16 2018-11-22 Bhami's Research Laboratory, Pvt. Ltd. High concentration protein formulations with reduced viscosity
AU2020251627A1 (en) 2019-03-29 2021-11-11 Jiangsu Hengrui Medicine Co., Ltd. Pharmaceutical composition containing antibody against IL-5 and use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
DE60139944D1 (de) * 2000-10-12 2009-10-29 Genentech Inc Niederviskose konzentrierte proteinformulierungen
ES2337986T3 (es) 2001-08-10 2010-05-03 Aberdeen University Dominios de union de antigenos de peces.
BR0315767A (pt) * 2002-11-01 2005-09-06 Glaxosmithkline Biolog Sa Composição imunogência, método para fabricar uma vacina, kit, vacina, recipiente com uma superfìcie interna repelente à água, e, método para preservar uma composição que compreende ipv e um agente estabilizador
AU2003291527A1 (en) * 2002-12-31 2004-07-29 Nektar Therapeutics Antibody-containing particles and compositions
PT1610820E (pt) * 2003-04-04 2010-12-16 Novartis Ag Formulações de elevada concentração de anticorpos e proteínas
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
BRPI0620316A2 (pt) * 2005-12-21 2011-11-08 Wyeth Corp formulações de proteìnas com viscosidades reduzida e seus usos
EP1977763A4 (en) * 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd STABILIZER PREPARATION CONTAINING ANTIBODIES
CA2790018C (en) * 2006-12-21 2015-02-03 Amgen Inc. Formulations
AU2008304111B2 (en) * 2007-09-27 2014-04-24 Amgen Inc. Pharmaceutical formulations
CN104650235A (zh) * 2007-11-30 2015-05-27 葛兰素集团有限公司 抗原结合构建体
PE20091174A1 (es) * 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
MA33989B1 (fr) * 2010-01-15 2013-02-01 Kirin Amgen Inc Formulation d'anticorps et régimes thérapeutiques
AU2011212440B2 (en) * 2010-02-04 2015-01-22 Csl Behring Ag Immunoglobulin preparation
US20110223208A1 (en) * 2010-03-09 2011-09-15 Beth Hill Non-Aqueous High Concentration Reduced Viscosity Suspension Formulations
KR20140066124A (ko) * 2011-04-07 2014-05-30 글락소스미스클라인 엘엘씨 점도가 감소된 제제

Also Published As

Publication number Publication date
BR112013025866A2 (pt) 2016-12-20
CN103596585A (zh) 2014-02-19
JP2014516924A (ja) 2014-07-17
CA2832556A1 (en) 2012-10-11
KR20140018966A (ko) 2014-02-13
AU2012240050A1 (en) 2013-10-17
US20140023655A1 (en) 2014-01-23
AU2016202355A1 (en) 2016-05-05
SG193963A1 (en) 2013-11-29
EP2694100A1 (en) 2014-02-12
AU2012240050B2 (en) 2016-01-21
WO2012138958A1 (en) 2012-10-11
IL228591A0 (en) 2013-12-31
EP2694100A4 (en) 2014-10-01
EP3058952A1 (en) 2016-08-24

Similar Documents

Publication Publication Date Title
EA201391488A1 (ru) Композиции со сниженной вязкостью
EA201391489A1 (ru) Композиции со сниженной вязкостью
EA202190619A1 (ru) Противовирусные соединения
EA202100040A2 (ru) Применение композиции, содержащей akkermansia muciniphila или её фрагменты, в форме пищевой добавки и для уменьшения тяжести метаболического нарушения
EA201690930A1 (ru) Композиции и способы модуляции фарнезоидных х-рецепторов
EA201590868A1 (ru) Противовирусные соединения
EA201391561A1 (ru) Новые соединения-модуляторы gpr-119
EA201790963A1 (ru) Противовирусные соединения
EA202193044A2 (ru) Способы лечения таупатии
EA201590887A1 (ru) Композиция
EA028156B9 (ru) Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов
EA201590731A1 (ru) Антитела к гемагглютинину и способы применения
MX356337B (es) Anticuerpos contra csf-1r humano y sus usos.
EA201492216A1 (ru) Ингибиторы бромодомена и их применение
UA114289C2 (uk) Неводні концентровані суспензійні композиції зі зниженою в'язкістю на основі антитіл
EA201301019A1 (ru) Бензодиоксановые ингибиторы продуцирования лейкотриена
EA201391274A1 (ru) Аминохинолины в качестве ингибиторов киназ
EA201690520A1 (ru) Способ получения замещенных 5-фтор-1h-пиразолопиридинов
EA201490037A1 (ru) Антагонисты trpv4
EA201500627A1 (ru) Приготовление стабильного напитка
EA201391371A1 (ru) Фармацевтическая композиция ситаглиптина
UA116889C2 (uk) Фармацевтична композиція, що містить суміш ізоформ apg101 (cd95-fc)
EA201390467A1 (ru) Композиции антител и способы применения
EA201592085A1 (ru) Применение жирной кислоты таллового масла
EA201690793A1 (ru) Способ получения лиофилизированной фармацевтической композиции, содержащей митомицин c