EA201791348A1 - Композиция орлистата и акарбозы с модифицированным высвобождением для лечения ожирения и связанных метаболических нарушений - Google Patents

Композиция орлистата и акарбозы с модифицированным высвобождением для лечения ожирения и связанных метаболических нарушений

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EA201791348A1
EA201791348A1 EA201791348A EA201791348A EA201791348A1 EA 201791348 A1 EA201791348 A1 EA 201791348A1 EA 201791348 A EA201791348 A EA 201791348A EA 201791348 A EA201791348 A EA 201791348A EA 201791348 A1 EA201791348 A1 EA 201791348A1
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Prior art keywords
acarbose
orlistat
composition
obesity
treatment
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EA201791348A
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English (en)
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EA033448B1 (ru
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Йеран Альдерборн
Андерс Форслунд
Ульф Холмбек
Ханс Леннернес
Ян Стефан Перссон Груден
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Эмпрос Фарма Аб
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Application filed by Эмпрос Фарма Аб filed Critical Эмпрос Фарма Аб
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Abstract

Настоящее изобретение относится к композиции с модифицированным высвобождением, содержей орлистат и акарбозу, которая содержит индивидуальные отдельные части с различными паттернами высвобождения: a) первую часть, G1, которая содержит приблизительно от 5 приблизительно до 70% мас./мас. суммарной дозы акарбозы, b) вторую часть, G2A, которая содержит приблизительно от 30 приблизительно до 95% мас./мас. суммарной дозы акарбозы, c) третью часть, G2B, которая содержит приблизительно от 10 приблизительно до 90% мас./мас. суммарной дозы орлистата, и d) четвертую часть, G3, которая содержит приблизительно от 10 приблизительно до 80% мас./мас. суммарной дозы орлистата, и общая концентрация акарбозы и орлистата, соответственно, в композиции составляет 100% мас./мас.
EA201791348A 2014-12-17 2015-12-17 Композиция орлистата и акарбозы с модифицированным высвобождением для лечения ожирения и связанных метаболических нарушений EA033448B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14198468 2014-12-17
PCT/EP2015/080265 WO2016097170A1 (en) 2014-12-17 2015-12-17 A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders

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EA201791348A1 true EA201791348A1 (ru) 2017-09-29
EA033448B1 EA033448B1 (ru) 2019-10-31

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US (2) US10561617B2 (ru)
EP (3) EP3943076A3 (ru)
JP (1) JP6607955B2 (ru)
KR (2) KR101937069B1 (ru)
CN (1) CN107405309B (ru)
AU (1) AU2015367422B2 (ru)
BR (1) BR112017012714B1 (ru)
CA (1) CA2970991C (ru)
CL (1) CL2017001574A1 (ru)
CO (1) CO2017005834A2 (ru)
DK (1) DK3233066T3 (ru)
EA (1) EA033448B1 (ru)
EC (1) ECSP17035750A (ru)
ES (1) ES2901122T3 (ru)
HU (1) HUE057093T2 (ru)
IL (1) IL252865B2 (ru)
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PE (1) PE20171243A1 (ru)
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PL (1) PL3233066T3 (ru)
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SI (1) SI3233066T1 (ru)
UA (1) UA122403C2 (ru)
WO (1) WO2016097170A1 (ru)
ZA (1) ZA201704590B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3943076A3 (en) 2014-12-17 2022-04-13 Empros Pharma AB A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders
JP6359234B2 (ja) * 2016-06-09 2018-07-18 Ｄｓファーマアニマルヘルス株式会社 動物用徐放性製剤組成物
WO2020227437A1 (en) 2019-05-06 2020-11-12 Axial Biotherapeutics, Inc. Sustained release solid dosage forms for modulating the colonic microbiome
WO2021002645A1 (ko) * 2019-07-01 2021-01-07 연세대학교 산학협력단 하이드로겔 및 egfr 리간드를 유효성분으로 포함하는 당 배출용 조성물
EP4072532B1 (en) * 2019-12-11 2024-01-24 Evonik Operations GmbH Dosage form for use in treating or preventing of a disease
CN111297826B (zh) * 2020-04-20 2021-08-03 鲁南制药集团股份有限公司 一种稳定的奥利司他胶囊及其制备方法
WO2022154687A1 (ru) * 2021-01-14 2022-07-21 Общество C Ограниченной Ответственностью "Новамедика" Фармацевтическая композиция, включающая эзомепразол
WO2022243528A1 (en) 2021-05-21 2022-11-24 Empros Pharma Ab Use of a composition comprising orlistat and acarbose to obtain a sustained weight loss
JP2024519099A (ja) 2021-05-21 2024-05-08 エンプロス ファーマ エービー オルリスタット及びアルカボースの組成物での、体重減少、クオリティ・オブ・ライフ改善及び胃腸管副作用の低減に対する相乗効果
CA3219508A1 (en) 2021-05-21 2022-11-24 Jan Stefan Persson Gruden Reduced rebound effects in subjects treated for overweight or obesity

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8101930A (nl) 1981-04-21 1982-11-16 Philips Nv Contactinrichting voor een meeraderige kabel.
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
DE19802700A1 (de) * 1998-01-24 1999-07-29 Bayer Ag Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält
US20060240105A1 (en) * 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
US6419954B1 (en) * 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
US6849609B2 (en) 2001-04-10 2005-02-01 James U. Morrison Method and composition for controlled release acarbose formulations
WO2003009840A1 (en) * 2001-07-24 2003-02-06 Lonza Ag Composition comprising at least one lipase inhibitor and carnitine
CN1296050C (zh) * 2003-12-10 2007-01-24 浙江海正药业股份有限公司 阿卡波糖肠溶片及制备方法
US20060229261A1 (en) * 2005-04-12 2006-10-12 John Devane Acarbose methods and formulations for treating chronic constipation
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
EP1872777A1 (en) * 2006-06-27 2008-01-02 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising tetrahydrolipstatin
KR100857411B1 (ko) * 2006-07-21 2008-09-08 한올제약주식회사 리파아제 저해제의 경구 투여용 방출조절 약학 제제 및이의 제조 방법
US8110186B2 (en) * 2006-09-18 2012-02-07 Chelatexx, LLC Method to maintain the efficacy of orlistat
TW200841876A (en) * 2007-04-18 2008-11-01 Anchen Pharmaceuticals Taiwan Inc Pharmaceutical composition containing orlistat
BRPI0817053A2 (pt) 2007-09-17 2015-03-24 Reddys Lab Ltd Dr Formulações farmacêuticas de orlistat
US20110256130A1 (en) * 2008-12-01 2011-10-20 Joshua Robert Schultz Methods of treating inflammatory disorders
SG184851A1 (en) * 2010-04-27 2012-11-29 Bayer Ip Gmbh Orally disintegrating tablet containing acarbose
EP2590633B1 (en) * 2010-07-05 2017-10-11 Jagotec AG Dosage form
CN102872062A (zh) 2011-07-13 2013-01-16 鲁南制药集团股份有限公司 一种治疗或预防肥胖症以及代谢综合症的药物组合物
EP3943076A3 (en) 2014-12-17 2022-04-13 Empros Pharma AB A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders

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