CL2017001574A1 - Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionados - Google Patents
Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionadosInfo
- Publication number
- CL2017001574A1 CL2017001574A1 CL2017001574A CL2017001574A CL2017001574A1 CL 2017001574 A1 CL2017001574 A1 CL 2017001574A1 CL 2017001574 A CL2017001574 A CL 2017001574A CL 2017001574 A CL2017001574 A CL 2017001574A CL 2017001574 A1 CL2017001574 A1 CL 2017001574A1
- Authority
- CL
- Chile
- Prior art keywords
- orlistat
- approximately
- composition
- acarbose
- obesity
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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Abstract
<p>LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN DE LIBERACIÓN MODIFICADA QUE COMPRENDE ORLISTAT Y ACARBOSA, QUE COMPRENDE PARTES INDIVIDUALMENTE DISTINTAS CON DIFERENTES PATRONES DE LIBERACIÓN: A) UNA PRIMERA PARTE, G1, QUE COMPRENDE DE APROXIMADAMENTE 5 A APROXIMADAMENTE 70% P/P DE LA DOSIS TOTAL DE ACARBOSA, B) UNA SEGUNDA PARTE, G2A, QUE COMPRENDE DE APROXIMADAMENTE 30 A APROXIMADAMENTE 95% P/P DE LA DOSIS TOTAL DE ACARBOSA, C) UNA TERCERA PARTE, G2B, QUE COMPRENDE DE APROXIMADAMENTE 10 A APROXIMADAMENTE 90% P/P DE LA DOSIS TOTAL DE ORLISTAT, Y D) UNA CUARTA PARTE, G3, QUE COMPRENDE DE APROXIMADAMENTE 10 A APROXIMADAMENTE 80% P/P DE LA DOSIS TOTAL DE ORLISTAT, Y LA CONCENTRACIÓN TOTAL DE ACARBOSA Y ORLISTAT, RESPECTIVAMENTE, EN LA COMPOSICIÓN ES DE 100% P/P.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14198468 | 2014-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017001574A1 true CL2017001574A1 (es) | 2018-01-26 |
Family
ID=52146175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017001574A CL2017001574A1 (es) | 2014-12-17 | 2017-06-16 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionados |
Country Status (28)
Country | Link |
---|---|
US (2) | US10561617B2 (es) |
EP (3) | EP3943076A3 (es) |
JP (1) | JP6607955B2 (es) |
KR (2) | KR101937069B1 (es) |
CN (1) | CN107405309B (es) |
AU (1) | AU2015367422B2 (es) |
BR (1) | BR112017012714B1 (es) |
CA (1) | CA2970991C (es) |
CL (1) | CL2017001574A1 (es) |
CO (1) | CO2017005834A2 (es) |
DK (1) | DK3233066T3 (es) |
EA (1) | EA033448B1 (es) |
EC (1) | ECSP17035750A (es) |
ES (1) | ES2901122T3 (es) |
HU (1) | HUE057093T2 (es) |
IL (1) | IL252865B2 (es) |
MX (3) | MX2017007493A (es) |
MY (1) | MY195038A (es) |
NZ (1) | NZ732241A (es) |
PE (1) | PE20171243A1 (es) |
PH (1) | PH12017550023A1 (es) |
PL (1) | PL3233066T3 (es) |
SA (1) | SA517381713B1 (es) |
SG (1) | SG11201704470PA (es) |
SI (1) | SI3233066T1 (es) |
UA (1) | UA122403C2 (es) |
WO (1) | WO2016097170A1 (es) |
ZA (1) | ZA201704590B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3943076A3 (en) | 2014-12-17 | 2022-04-13 | Empros Pharma AB | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
JP6359234B2 (ja) * | 2016-06-09 | 2018-07-18 | Dsファーマアニマルヘルス株式会社 | 動物用徐放性製剤組成物 |
WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
WO2021002645A1 (ko) * | 2019-07-01 | 2021-01-07 | 연세대학교 산학협력단 | 하이드로겔 및 egfr 리간드를 유효성분으로 포함하는 당 배출용 조성물 |
EP4072532B1 (en) * | 2019-12-11 | 2024-01-24 | Evonik Operations GmbH | Dosage form for use in treating or preventing of a disease |
CN111297826B (zh) * | 2020-04-20 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种稳定的奥利司他胶囊及其制备方法 |
WO2022154687A1 (ru) * | 2021-01-14 | 2022-07-21 | Общество C Ограниченной Ответственностью "Новамедика" | Фармацевтическая композиция, включающая эзомепразол |
WO2022243528A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Use of a composition comprising orlistat and acarbose to obtain a sustained weight loss |
JP2024519099A (ja) | 2021-05-21 | 2024-05-08 | エンプロス ファーマ エービー | オルリスタット及びアルカボースの組成物での、体重減少、クオリティ・オブ・ライフ改善及び胃腸管副作用の低減に対する相乗効果 |
CA3219508A1 (en) | 2021-05-21 | 2022-11-24 | Jan Stefan Persson Gruden | Reduced rebound effects in subjects treated for overweight or obesity |
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NL8101930A (nl) | 1981-04-21 | 1982-11-16 | Philips Nv | Contactinrichting voor een meeraderige kabel. |
TW381025B (en) * | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
DE19802700A1 (de) * | 1998-01-24 | 1999-07-29 | Bayer Ag | Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält |
US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
US6849609B2 (en) | 2001-04-10 | 2005-02-01 | James U. Morrison | Method and composition for controlled release acarbose formulations |
WO2003009840A1 (en) * | 2001-07-24 | 2003-02-06 | Lonza Ag | Composition comprising at least one lipase inhibitor and carnitine |
CN1296050C (zh) * | 2003-12-10 | 2007-01-24 | 浙江海正药业股份有限公司 | 阿卡波糖肠溶片及制备方法 |
US20060229261A1 (en) * | 2005-04-12 | 2006-10-12 | John Devane | Acarbose methods and formulations for treating chronic constipation |
FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
EP1872777A1 (en) * | 2006-06-27 | 2008-01-02 | LEK Pharmaceuticals D.D. | Pharmaceutical composition comprising tetrahydrolipstatin |
KR100857411B1 (ko) * | 2006-07-21 | 2008-09-08 | 한올제약주식회사 | 리파아제 저해제의 경구 투여용 방출조절 약학 제제 및이의 제조 방법 |
US8110186B2 (en) * | 2006-09-18 | 2012-02-07 | Chelatexx, LLC | Method to maintain the efficacy of orlistat |
TW200841876A (en) * | 2007-04-18 | 2008-11-01 | Anchen Pharmaceuticals Taiwan Inc | Pharmaceutical composition containing orlistat |
BRPI0817053A2 (pt) | 2007-09-17 | 2015-03-24 | Reddys Lab Ltd Dr | Formulações farmacêuticas de orlistat |
US20110256130A1 (en) * | 2008-12-01 | 2011-10-20 | Joshua Robert Schultz | Methods of treating inflammatory disorders |
SG184851A1 (en) * | 2010-04-27 | 2012-11-29 | Bayer Ip Gmbh | Orally disintegrating tablet containing acarbose |
EP2590633B1 (en) * | 2010-07-05 | 2017-10-11 | Jagotec AG | Dosage form |
CN102872062A (zh) | 2011-07-13 | 2013-01-16 | 鲁南制药集团股份有限公司 | 一种治疗或预防肥胖症以及代谢综合症的药物组合物 |
EP3943076A3 (en) | 2014-12-17 | 2022-04-13 | Empros Pharma AB | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
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2015
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