SA517381713B1 - تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة - Google Patents
تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلةInfo
- Publication number
- SA517381713B1 SA517381713B1 SA517381713A SA517381713A SA517381713B1 SA 517381713 B1 SA517381713 B1 SA 517381713B1 SA 517381713 A SA517381713 A SA 517381713A SA 517381713 A SA517381713 A SA 517381713A SA 517381713 B1 SA517381713 B1 SA 517381713B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- orlistat
- acarbose
- obesity
- treatment
- release composition
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- Chemical & Material Sciences (AREA)
- Public Health (AREA)
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- Diabetes (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة A MODIFIED RELEASE COMPOSITION OF ORLISTAT AND ACARBOSE FOR THE TREATMENT OF OBESITY AND RELATED METABOLIC DISORDERS الملخـــص يتعلق هذا الاختراع بتركيبة الاطلاق مُعدلة modified-release composition تتضمن الأورليستات orlistat والأكارابوز acarbose، بما في ذلك أجزاء منفصلة على حدة مع نماذج اطلاق مختلفة different release patterns. أ) الجزء الأول، G1، يتضمن حوالي 5 إلى حوالي 70% وزن/وزن من الجرعة الكلية total dose للأكارابوز acarbose، ب) الجزء الثاني، G2A، يتضمن حوالي 30 إلى حوالي 95% وزن/وزن من الجرعة الكلية للأكارابوز acarbose، ج) الجزء الثالث، G2B، يتضمن حوالي 10 إلى حوالي 90% وزن/وزن من الجرعة الكلية للأوليستات orlistat ، و د) الجزء الرابع، G3، يتضمن حوالي 10 إلى حوالي 80% وزن/وزن من الجرعة الكلية للأورليستات orlistat ، ويكون التركيز الكلي للأكارابوز acarbose والأورليستات orlistat ، على التوالي، في التركيبة 100% وزن/وزن. الشكل 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14198468 | 2014-12-17 |
Publications (1)
Publication Number | Publication Date |
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SA517381713B1 true SA517381713B1 (ar) | 2022-03-17 |
Family
ID=52146175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SA517381713A SA517381713B1 (ar) | 2014-12-17 | 2017-06-12 | تركيبة أطلاق معدلة من الأورليستات والأكارابوز لعلاج السمنة واضطرابات التمثيل الغذائي ذات الصلة |
Country Status (28)
Country | Link |
---|---|
US (2) | US10561617B2 (ar) |
EP (3) | EP3233066B1 (ar) |
JP (1) | JP6607955B2 (ar) |
KR (2) | KR102094631B1 (ar) |
CN (1) | CN107405309B (ar) |
AU (1) | AU2015367422B2 (ar) |
BR (1) | BR112017012714B1 (ar) |
CA (1) | CA2970991C (ar) |
CL (1) | CL2017001574A1 (ar) |
CO (1) | CO2017005834A2 (ar) |
DK (1) | DK3233066T3 (ar) |
EA (1) | EA033448B1 (ar) |
EC (1) | ECSP17035750A (ar) |
ES (1) | ES2901122T3 (ar) |
HU (1) | HUE057093T2 (ar) |
IL (1) | IL252865B2 (ar) |
MX (3) | MX2017007493A (ar) |
MY (1) | MY195038A (ar) |
NZ (1) | NZ732241A (ar) |
PE (1) | PE20171243A1 (ar) |
PH (1) | PH12017550023A1 (ar) |
PL (1) | PL3233066T3 (ar) |
SA (1) | SA517381713B1 (ar) |
SG (1) | SG11201704470PA (ar) |
SI (1) | SI3233066T1 (ar) |
UA (1) | UA122403C2 (ar) |
WO (1) | WO2016097170A1 (ar) |
ZA (1) | ZA201704590B (ar) |
Families Citing this family (11)
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CA2970991C (en) | 2014-12-17 | 2021-08-03 | Goran Alderborn | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
US20190142808A1 (en) * | 2016-06-09 | 2019-05-16 | Ds Pharma Animal Health Co., Ltd. | Sustained-release preparation composition for animals |
WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
KR102508141B1 (ko) * | 2019-07-01 | 2023-03-10 | 주식회사 연세대학교 바이오헬스기술지주회사 | 하이드로겔 및 egfr 리간드를 유효성분으로 포함하는 당 배출용 조성물 |
IL293648A (en) * | 2019-12-11 | 2022-08-01 | Evonik Operations Gmbh | Dosage form for use in the treatment or prevention of disease |
CN111297826B (zh) * | 2020-04-20 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种稳定的奥利司他胶囊及其制备方法 |
WO2022154687A1 (ru) * | 2021-01-14 | 2022-07-21 | Общество C Ограниченной Ответственностью "Новамедика" | Фармацевтическая композиция, включающая эзомепразол |
WO2022243528A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Use of a composition comprising orlistat and acarbose to obtain a sustained weight loss |
CA3219508A1 (en) | 2021-05-21 | 2022-11-24 | Jan Stefan Persson Gruden | Reduced rebound effects in subjects treated for overweight or obesity |
JP2024519099A (ja) | 2021-05-21 | 2024-05-08 | エンプロス ファーマ エービー | オルリスタット及びアルカボースの組成物での、体重減少、クオリティ・オブ・ライフ改善及び胃腸管副作用の低減に対する相乗効果 |
WO2024102902A1 (en) * | 2022-11-10 | 2024-05-16 | Temple University-Of The Commonwealth System Of Higher Education | Methods of treating or preventing liver diseases or disorders |
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NL8101930A (nl) | 1981-04-21 | 1982-11-16 | Philips Nv | Contactinrichting voor een meeraderige kabel. |
CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
DE19802700A1 (de) * | 1998-01-24 | 1999-07-29 | Bayer Ag | Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält |
US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
US6849609B2 (en) | 2001-04-10 | 2005-02-01 | James U. Morrison | Method and composition for controlled release acarbose formulations |
WO2003009840A1 (en) * | 2001-07-24 | 2003-02-06 | Lonza Ag | Composition comprising at least one lipase inhibitor and carnitine |
CN1296050C (zh) * | 2003-12-10 | 2007-01-24 | 浙江海正药业股份有限公司 | 阿卡波糖肠溶片及制备方法 |
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