EA201691980A1 - Способы уменьшения побочных эффектов, связанных с химиотерапией - Google Patents

Способы уменьшения побочных эффектов, связанных с химиотерапией

Info

Publication number
EA201691980A1
EA201691980A1 EA201691980A EA201691980A EA201691980A1 EA 201691980 A1 EA201691980 A1 EA 201691980A1 EA 201691980 A EA201691980 A EA 201691980A EA 201691980 A EA201691980 A EA 201691980A EA 201691980 A1 EA201691980 A1 EA 201691980A1
Authority
EA
Eurasian Patent Office
Prior art keywords
chemotherapy
vitamin
ways
bone marrow
side effects
Prior art date
Application number
EA201691980A
Other languages
English (en)
Inventor
Хоакин Дж. Хименес
Джон Патрик Маккук
Найвен Раджин Нэрейн
Original Assignee
БЕРГ ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by БЕРГ ЭлЭлСи filed Critical БЕРГ ЭлЭлСи
Publication of EA201691980A1 publication Critical patent/EA201691980A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Данное изобретение относится к применению соединения витамина D, такого как витамин D3 или его аналоги и/или метаболиты, для модуляции прекурсоров костного мозга и стромальных клеток до введения антинеопластических средств. Способы по данному изобретению могут облегчать миелосупрессию путем увеличения доступности плюрипотентных прекурсоров стволовых клеток и могут применяться в сочетании со стандартной терапией (например, гранулоцитарный стимулирующий фактор) для усиления пролиферации миелоидных клеток и/или улучшения их мобилизации из костного мозга, таким образом уменьшая дозу и частоту введения колониестимулирующих факторов (КСФ), а также время восстановления после химиотерапии.
EA201691980A 2009-01-27 2010-01-27 Способы уменьшения побочных эффектов, связанных с химиотерапией EA201691980A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14754909P 2009-01-27 2009-01-27
US23900309P 2009-09-01 2009-09-01

Publications (1)

Publication Number Publication Date
EA201691980A1 true EA201691980A1 (ru) 2017-07-31

Family

ID=42099048

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691980A EA201691980A1 (ru) 2009-01-27 2010-01-27 Способы уменьшения побочных эффектов, связанных с химиотерапией
EA201101025A EA026334B1 (ru) 2009-01-27 2010-01-27 Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201101025A EA026334B1 (ru) 2009-01-27 2010-01-27 Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении

Country Status (15)

Country Link
US (1) US20100196308A1 (ru)
EP (1) EP2393494A1 (ru)
JP (2) JP5932339B2 (ru)
KR (2) KR20170096238A (ru)
CN (2) CN102341110B (ru)
AU (2) AU2010208323B2 (ru)
BR (1) BRPI1007415A2 (ru)
CA (2) CA2981549A1 (ru)
CO (1) CO6410300A2 (ru)
CR (2) CR20170434A (ru)
EA (2) EA201691980A1 (ru)
IL (2) IL214270A (ru)
MX (1) MX339746B (ru)
SG (2) SG173119A1 (ru)
WO (1) WO2010088304A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2483240B1 (en) * 2009-10-02 2014-09-03 Wisconsin Alumni Research Foundation 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses
WO2014113048A1 (en) * 2013-01-18 2014-07-24 Loma Linda University Compositions and methods for diagnosing and treating sepsis
WO2014113068A1 (en) * 2013-01-18 2014-07-24 Loma Linda University Compositions and methods for diagnosing and treating sepsis
US10391107B2 (en) 2015-03-16 2019-08-27 The Trustees Of The University Of Pennsylvania Compositions and methods for suppressing or reducing systemic immune response in a subject
CN106954857A (zh) * 2017-03-21 2017-07-18 深圳奥萨医疗有限公司 一种有助于减轻肿瘤放化疗后毒副作用的保健食品
WO2023196668A2 (en) * 2022-04-08 2023-10-12 GATC Health Corp Prodrugs for cancer treatment

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US456444A (en) * 1891-07-21 Air-cooling apparatus
US627656A (en) * 1898-12-27 1899-06-27 Franz Rings Reflecting acetylene-lamp.
US1680818A (en) * 1924-06-30 1928-08-14 Wisconsin Alumni Res Found Antirachitic product and process
US1871136A (en) * 1926-12-27 1932-08-09 Wisconsin Alumni Res Found Antirachitic product essence and process
US1902785A (en) * 1931-09-18 1933-03-21 Winthrop Chem Co Inc Crystalline antirachitically active product and a process of preparing the same
US2030792A (en) * 1935-02-25 1936-02-11 Winthrop Chem Co Inc Water-miscible vitamin preparations containing vitamin d
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4307231A (en) 1980-07-18 1981-12-22 Wisconsin Alumni Research Foundation Vitamin D-lactone derivative and process for preparing same
US4336193A (en) 1980-08-04 1982-06-22 Wisconsin Alumni Research Foundation Process for preparing vitamin D-lactones
US4367177A (en) 1981-04-15 1983-01-04 Wisconsin Alumni Research Foundation Process for preparing 23,25-dihydroxyvitamin D3
US4305880A (en) 1980-09-22 1981-12-15 Wisconsin Alumni Research Foundation Process for preparing 24-fluoro-25-hydroxycholecalciferol
US4279826A (en) * 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4307025A (en) 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
JPS57149224A (en) * 1981-03-13 1982-09-14 Chugai Pharmaceut Co Ltd Tumor-suppressing agent
US4358406A (en) 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4360472A (en) 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation Trihydroxyvitamin D3 compounds
US4411833A (en) 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4428946A (en) 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US5036061A (en) 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4564474A (en) 1983-08-18 1986-01-14 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4502991A (en) 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4769181A (en) 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
US5120722A (en) * 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4481198A (en) 1984-02-13 1984-11-06 Wisconsin Alumni Research Foundation Vitamin D metabolism inhibitor
US4719204A (en) 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US4588716A (en) 1984-05-04 1986-05-13 Wisconsin Alumni Research Foundation Method for treating metabolic bone disease in mammals
US4588528A (en) 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4857518A (en) * 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
JPS62501505A (ja) 1985-01-17 1987-06-18 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン ビタミンｄ誘導体
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
US4594192A (en) 1985-03-20 1986-06-10 Wisconsin Alumni Research Foundation 2α-fluorovitamin D3
JPS62502545A (ja) 1985-04-23 1987-10-01 ウイスコンシン　アラムナイ　リサ−チ　フオンデ−シヨン セコステロール化合物
US4755329A (en) * 1985-06-10 1988-07-05 Wisconsin Alumni Research Foundation Process and intermediates for preparing 1α-hydroxyvitamin D compounds
JPH07100685B2 (ja) 1985-08-02 1995-11-01 レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ） 新規ビタミンｄ類似体
US4619920A (en) 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
US5145846A (en) 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5250523A (en) 1988-04-29 1993-10-05 Wisconsin Alumni Research Foundation Side chain unsaturated 1α-hydroxyvitanim D homologs
US4927815A (en) 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5354744A (en) 1988-04-29 1994-10-11 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin D analogs
US4847012A (en) * 1988-04-29 1989-07-11 Wisconsin Alumni Research Foundation Vitamin D related compounds and processes for their preparation
US5232836A (en) * 1988-05-04 1993-08-03 Ire-Medgenix S.A. Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5321018A (en) * 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US4973584A (en) 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
DE3933034A1 (de) 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5254538A (en) 1989-10-04 1993-10-19 Trustees Of Boston University Method of treating periodontal disease
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
GB9007236D0 (en) 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9017890D0 (en) 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5185150A (en) * 1990-08-24 1993-02-09 Wisconsin Alumni Research Fdn. Cosmetic compositions containing 19-nor-vitamin D compounds
DE4101953A1 (de) 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
US5086191A (en) * 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
AU650751B2 (en) 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
EP0521550B1 (en) 1991-07-05 1996-09-18 Duphar International Research B.V Vitamin D compound, method of preparing this compound and intermediate therefor
DE4141746A1 (de) 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
IL104201A0 (en) * 1991-12-26 1993-05-13 Wisconsin Alumni Res Found 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
GB9206648D0 (en) * 1992-03-26 1992-05-06 Leo Pharm Prod Ltd Chemical compounds
AU666529B2 (en) 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
KR960013798B1 (ko) 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
JP2876547B2 (ja) 1992-06-23 1999-03-31 呉羽化学工業株式会社 抗クル病剤
DE4220757A1 (de) 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
GB9214202D0 (en) 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
US5194431A (en) 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
AU666563B2 (en) 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL103224A (en) 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
GB9220272D0 (en) 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US5247104A (en) 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
JPH08505147A (ja) * 1992-12-29 1996-06-04 エフ． ホリック、マイケル 骨粗鬆症の治療又は予防に関するビタミンｄグリコシドの用途
US5547947A (en) 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9309422D0 (en) 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
US5371249A (en) 1993-05-11 1994-12-06 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
RU2153491C2 (ru) 1993-07-09 2000-07-27 Лаборатуар Терамекс С.А. Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция
GB9314400D0 (en) 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
GB9315253D0 (en) 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5565589A (en) 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5552392A (en) 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5384313A (en) 1993-11-24 1995-01-24 Wisconsin Alumni Research Foundation 21-norvitamin D compounds
US5373004A (en) 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
GB9325415D0 (en) * 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
US6103709A (en) 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
GB9405715D0 (en) 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
AU2148295A (en) 1994-04-11 1995-10-30 Chugai Seiyaku Kabushiki Kaisha 22-thiavitamin d3 derivative
BR9509739A (pt) 1994-11-21 1997-10-21 Wisconsin Alumni Res Found Compostos 18,19-dinor-vitamina d
US5661140A (en) 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
DK0717034T3 (da) * 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
ES2169220T3 (es) 1995-01-23 2002-07-01 Chugai Pharmaceutical Co Ltd Derivados de vitamina d3 con sustituyentes en la posicion 2.
US5877168A (en) * 1995-02-10 1999-03-02 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivative with substituent at the 2β-position
EP0832063B1 (de) * 1995-06-14 2000-02-23 Schering Aktiengesellschaft Vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln
ATE189812T1 (de) * 1995-10-30 2000-03-15 Hoffmann La Roche 1-alpha, 26-dihydroxy-d-homo-vitamin d3
GB9524812D0 (en) 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
GB9526208D0 (en) 1995-12-21 1996-02-21 Res Inst Medicine Chem Chemical compounds
GB9607034D0 (en) 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
AU2953697A (en) 1996-05-02 1997-11-26 Duphar International Research B.V. Vitamin d analogs and methods of preparing these compounds
GB9611603D0 (en) 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
US5976784A (en) 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
KR100573234B1 (ko) 1996-12-20 2006-04-24 쥬가이 세이야쿠 가부시키가이샤 16-엔-비타민 ｄ 유도체
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US5945410A (en) 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US6392071B1 (en) * 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
EP0884308B1 (en) 1997-05-02 2003-04-16 Duphar International Research B.V A method of preparing 16-dehydro vitamin D compounds
EP0981514B1 (en) 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
CA2290772A1 (en) 1997-05-22 1998-11-26 Cephalon, Inc. Vitamin d analogues and their neuronal effects
US5936105A (en) 1997-06-13 1999-08-10 Tetrionics, Inc. 14-EPI-19-nor-vitamin D compounds and methods
JPH1112175A (ja) * 1997-06-27 1999-01-19 Nisshin Flour Milling Co Ltd 白血病治療剤
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5939406A (en) 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
GB9721156D0 (en) * 1997-10-06 1997-12-03 Leo Pharm Prod Ltd Novel vitamin d analogues
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
US6043385A (en) 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
US6184422B1 (en) 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
ATE515265T1 (de) * 1998-03-27 2011-07-15 Univ Oregon Health & Science Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen
EP1070704A4 (en) 1998-04-10 2001-11-07 Chugai Pharmaceutical Co Ltd VITAMIN D DERIVATIVES SUBSTITUTED IN THE 2 BETA POSITION
US6114317A (en) 1998-05-21 2000-09-05 Wisconsin Alumni Research Foundation Method of locking 1α-OH of vitamin D compounds in axial orientation
US5972917A (en) 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
IL139354A (en) 1998-05-29 2005-08-31 Bone Care Internat Inc Method for making hydroxy-25 ene-vitamin d compounds
US6218430B1 (en) * 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
FR2785284B1 (fr) * 1998-11-02 2000-12-01 Galderma Res & Dev Analogues de la vitamine d
FR2801305B1 (fr) 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
FR2801307B1 (fr) * 1999-11-24 2002-12-06 Galderma Res & Dev Analogues de la vitamine d
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
WO2001056981A1 (en) * 2000-01-31 2001-08-09 Leo Pharma A/S Use of vitamin d-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin d3-derivatives
AU2001243385B2 (en) * 2000-03-02 2006-11-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education Combination chemotherapy
US20010036937A1 (en) * 2000-04-07 2001-11-01 Leticia Delgado-Herrera Treatment of ICU-associated hypocalcemia with vitamin D compounds
US20020165178A1 (en) * 2000-06-28 2002-11-07 Christian Schetter Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
AU2002341566A1 (en) * 2001-08-16 2003-04-01 Mucosal Therapeutics, Inc. Treatment and prevention of mucositis in cancer patients
JP2004026811A (ja) * 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンｄ３誘導体を含有する抗癌作用を増強させるための薬剤
AR041696A1 (es) * 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
AU2003291294A1 (en) * 2002-11-06 2004-06-03 Novacea, Inc. Methods of using vitamin d compounds in the treatment of myelodysplastic syndromes
US20050101576A1 (en) * 2003-11-06 2005-05-12 Novacea, Inc. Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes
CN1845937A (zh) * 2003-03-24 2006-10-11 津莫吉尼蒂克斯公司 抗il－20抗体和结合伴侣以及在炎症中的使用方法
JP2007501865A (ja) 2003-06-11 2007-02-01 ノバセア インコーポレイティッド 放射線治療薬および放射線治療と併用した、活性ビタミンｄ化合物による癌の治療法
DE602004025261D1 (de) 2003-10-14 2010-03-11 X Ceptor Therapeutics Inc Verbindungen mit verbrückten ringen als pharmazeutische mittel
AU2005228447A1 (en) * 2004-03-29 2005-10-13 Roswell Park Cancer Institute Method of treating solid tumors and leukemias using combination therapy of vitamin D and anti-metabolic nucleoside analogs
TW200714289A (en) * 2005-02-28 2007-04-16 Genentech Inc Treatment of bone disorders
AU2006239883A1 (en) * 2005-04-22 2006-11-02 Novacea, Inc. Treatment, prevention and amelioration of pulmonary disorders associated with chemotherapy or radiotherapy with active vitamin D compounds or mimics thereof
CA2838089A1 (en) * 2006-08-25 2008-02-28 Cougar Biotechnology, Inc. Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20100075933A1 (en) * 2008-07-28 2010-03-25 Sunita Vijay Shelke Injectable compositions of vitamin d compounds
CN105663146B (zh) * 2009-08-14 2020-09-11 博格有限责任公司 用于治疗脱发的维生素d3及其类似物

Also Published As

Publication number Publication date
IL250751A0 (en) 2017-04-30
EP2393494A1 (en) 2011-12-14
CN102341110B (zh) 2017-04-12
JP2012516343A (ja) 2012-07-19
IL214270A (en) 2017-03-30
EA201101025A1 (ru) 2012-03-30
MX2011007849A (es) 2011-11-29
CR20170434A (es) 2017-11-21
SG2014006324A (en) 2014-03-28
CA2750659C (en) 2017-11-21
AU2016203858A1 (en) 2016-06-30
JP6091548B2 (ja) 2017-03-08
SG173119A1 (en) 2011-08-29
CN107019795A (zh) 2017-08-08
AU2010208323A1 (en) 2011-08-25
JP5932339B2 (ja) 2016-06-08
CA2750659A1 (en) 2010-08-05
AU2010208323B2 (en) 2016-03-10
KR101991692B1 (ko) 2019-06-21
KR20110113639A (ko) 2011-10-17
US20100196308A1 (en) 2010-08-05
JP2015227335A (ja) 2015-12-17
IL214270A0 (en) 2011-09-27
EA026334B1 (ru) 2017-03-31
KR20170096238A (ko) 2017-08-23
CR20110445A (es) 2011-11-03
CA2981549A1 (en) 2010-08-05
CN102341110A (zh) 2012-02-01
BRPI1007415A2 (pt) 2016-02-16
WO2010088304A1 (en) 2010-08-05
CO6410300A2 (es) 2012-03-30
MX339746B (es) 2016-06-08

Similar Documents

Publication Publication Date Title
EA201691980A1 (ru) Способы уменьшения побочных эффектов, связанных с химиотерапией
EA201390010A1 (ru) Замещенные триазолопиридины
PH12015502839A1 (en) Antiviral compounds
SG10201803845SA (en) Pyrazole derivatives as modulators of calcium release -activated calcium channel
PH12013502565A1 (en) Substituted imidazopyridinyl-aminopyridine compounds
MY188139A (en) Sodium channel modulators for the treatment of pain
JO3438B1 (ar) مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
MX364155B (es) Sulfonamidas como moduladores de canales de sodio.
GEP201706616B (en) Hydrazide containing nuclear transport modulators and usage thereof
EA201490707A1 (ru) Макроциклические ингибиторы flt3-киназы
MX2011007930A (es) Conjugados de insulina cristalina.
MX2014002990A (es) Tratamientos combinados que comprenden antagonistas de c-met y antagonistas de b-raf.
GB2502032A (en) Vitamin D composition
MX360774B (es) Antagonistas de progesterona.
WO2014134084A3 (en) Phf20 and jmjd3 compositions and methods of use in cancer immunotherapy
PH12016500136A1 (en) Positive allosteric modulators of nicotinic acetylcholine receptor
MX356317B (es) Tratamiento de síntomas asociados a gastroparesia femenina.
NZ713129A (en) Oxprenolol compositions for treating cancer
MX2018004296A (es) Combinacion de un agonista selectivo de il-2rbeta y un agonista il-15 de accion prolongada.
MX2013011694A (es) Analogos de taxano y abeo-taxanos.
MX347541B (es) Analogos de acido sialico.
IN2014DN03010A (ru)
AR085105A1 (es) Dosificacion para tratamiento con anticuerpos anti-dominio 7 de tipo de factor de crecimiento epidermico (anti-egfl7)
EA201490231A1 (ru) Позитивные аллостерические модуляторы никотинового рецептора ацетилхолина
PH12015501980A1 (en) Pyrroloquinolinyl-pyrrolidine-2,5-dione formulations and methods for preparing and using same