SG10201803845SA - Pyrazole derivatives as modulators of calcium release -activated calcium channel - Google Patents
Pyrazole derivatives as modulators of calcium release -activated calcium channelInfo
- Publication number
- SG10201803845SA SG10201803845SA SG10201803845SA SG10201803845SA SG10201803845SA SG 10201803845S A SG10201803845S A SG 10201803845SA SG 10201803845S A SG10201803845S A SG 10201803845SA SG 10201803845S A SG10201803845S A SG 10201803845SA SG 10201803845S A SG10201803845S A SG 10201803845SA
- Authority
- SG
- Singapore
- Prior art keywords
- calcium
- modulators
- methods
- pyrazole derivatives
- activated
- Prior art date
Links
- 102000020167 Calcium release-activated calcium channel Human genes 0.000 title abstract 2
- 108091022898 Calcium release-activated calcium channel Proteins 0.000 title abstract 2
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001669 calcium Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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Abstract
PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE - ACTIVATED CALCIUM CHANNEL Dislcosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present dislcosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer. (No suitable figure)
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