EA201500941A1 - Способы и композиции для модуляции гамма-глутамилового цикла - Google Patents
Способы и композиции для модуляции гамма-глутамилового циклаInfo
- Publication number
- EA201500941A1 EA201500941A1 EA201500941A EA201500941A EA201500941A1 EA 201500941 A1 EA201500941 A1 EA 201500941A1 EA 201500941 A EA201500941 A EA 201500941A EA 201500941 A EA201500941 A EA 201500941A EA 201500941 A1 EA201500941 A1 EA 201500941A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- gamma
- methods
- compositions
- glutamil
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
В описании предлагаются фармацевтические композиции, включающие ингибиторы гамма-глутамилового цикла (GGCI) и их некоторые фармацевтически приемлемые соли, и способы их применения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361801709P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/030053 WO2014145314A2 (en) | 2013-03-15 | 2014-03-15 | Methods and compositions for gamma-glutamyl cycle modulation |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201500941A1 true EA201500941A1 (ru) | 2016-07-29 |
EA030611B1 EA030611B1 (ru) | 2018-08-31 |
Family
ID=51529989
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500941A EA030611B1 (ru) | 2013-03-15 | 2014-03-15 | Способы и композиции для модуляции гамма-глутамилового цикла |
Country Status (12)
Country | Link |
---|---|
US (4) | US9630936B2 (ru) |
EP (1) | EP2968346B1 (ru) |
JP (2) | JP6458000B2 (ru) |
KR (2) | KR20210144942A (ru) |
CN (1) | CN105246483A (ru) |
AU (2) | AU2014233168B2 (ru) |
CA (2) | CA2909510C (ru) |
DK (1) | DK2968346T3 (ru) |
EA (1) | EA030611B1 (ru) |
FI (1) | FI2968346T3 (ru) |
IL (2) | IL283717B (ru) |
WO (1) | WO2014145314A2 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2909510C (en) | 2013-03-15 | 2024-04-02 | Cancer Research Technology, Llc | Methods and compositions for gamma-glutamyl cycle modulation |
JP6570512B2 (ja) * | 2013-03-22 | 2019-09-04 | ユニバーシティ・オブ・ハワイUniversity Of Hawaii | 新規なStat3阻害剤 |
WO2016109002A2 (en) | 2014-10-16 | 2016-07-07 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
CN107382903B (zh) * | 2017-05-22 | 2021-02-26 | 重庆南松凯博生物制药有限公司 | 一种抗癌药物中间体的制备方法 |
Family Cites Families (40)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4011233A (en) * | 1973-06-28 | 1977-03-08 | Givaudan Corporation | 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine |
JPS56133216A (en) * | 1980-03-24 | 1981-10-19 | Senjiyu Seiyaku Kk | Antitumor agent |
JPS57128625A (en) * | 1981-01-30 | 1982-08-10 | Rikagaku Kenkyusho | Carcinostatic |
JPS62501769A (ja) * | 1984-12-18 | 1987-07-16 | デイビツト ラビン | 細胞毒性アルデヒドとベニシラミンとの反応性成物を含有する抗腫瘍組成物及びその使用方法 |
HU200177B (en) * | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
JP2717257B2 (ja) * | 1988-03-19 | 1998-02-18 | 参天製薬株式会社 | 光学活性化合物の製造法 |
US4970221A (en) * | 1989-07-28 | 1990-11-13 | E. R. Squibb & Sons, Inc. | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
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JPH04169858A (ja) | 1990-11-02 | 1992-06-17 | Toyota Motor Corp | 力学量センサ |
US7425635B2 (en) * | 1997-08-07 | 2008-09-16 | University Of Utah Research Foundation | Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof |
US6723711B2 (en) * | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
US20080220441A1 (en) | 2001-05-16 | 2008-09-11 | Birnbaum Eva R | Advanced drug development and manufacturing |
NZ535139A (en) | 2002-03-22 | 2007-07-27 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof in the treatment of cancer |
US7064211B2 (en) * | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
BRPI0415390A (pt) * | 2003-10-14 | 2006-12-12 | Pharmacia Corp | compostos de pirazinona substituìda para o tratamento da inflamação |
DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US20060014740A1 (en) * | 2003-11-18 | 2006-01-19 | Miller Duane D | Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof |
MXPA06005528A (es) * | 2003-11-18 | 2007-01-30 | Univ Tennessee Res Foundation | Tiazolidinona-amidas, amidas de acido tiazolidina-carboxilico, metodos de elaboracion, y uso de las mismas. |
KR100590530B1 (ko) | 2003-12-10 | 2006-06-15 | 삼성전자주식회사 | 수직자기기록매체 |
US20080176923A1 (en) * | 2003-12-18 | 2008-07-24 | Salama Zoser B | Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors |
JP2007522247A (ja) * | 2004-02-11 | 2007-08-09 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | 細胞増殖の阻害を示すアナログ、それを作製する方法およびその使用 |
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WO2009154562A1 (en) * | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity |
JP5030934B2 (ja) | 2008-12-18 | 2012-09-19 | 株式会社ケーヒン | エンジンの吸気制御装置における制御ケースの呼吸構造 |
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KR101395146B1 (ko) * | 2011-02-09 | 2014-05-16 | 부산대학교 산학협력단 | 피부미백, 항산화 및 ppar 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
WO2013168021A1 (en) * | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
CA2909510C (en) | 2013-03-15 | 2024-04-02 | Cancer Research Technology, Llc | Methods and compositions for gamma-glutamyl cycle modulation |
-
2014
- 2014-03-15 CA CA2909510A patent/CA2909510C/en active Active
- 2014-03-15 KR KR1020217038087A patent/KR20210144942A/ko not_active Application Discontinuation
- 2014-03-15 EA EA201500941A patent/EA030611B1/ru unknown
- 2014-03-15 EP EP14763483.6A patent/EP2968346B1/en active Active
- 2014-03-15 US US14/214,888 patent/US9630936B2/en active Active
- 2014-03-15 CA CA3232320A patent/CA3232320A1/en active Pending
- 2014-03-15 JP JP2016503319A patent/JP6458000B2/ja active Active
- 2014-03-15 DK DK14763483.6T patent/DK2968346T3/da active
- 2014-03-15 AU AU2014233168A patent/AU2014233168B2/en active Active
- 2014-03-15 WO PCT/US2014/030053 patent/WO2014145314A2/en active Application Filing
- 2014-03-15 KR KR1020157029230A patent/KR20160003652A/ko active Application Filing
- 2014-03-15 FI FIEP14763483.6T patent/FI2968346T3/fi active
- 2014-03-15 IL IL283717A patent/IL283717B/en unknown
- 2014-03-15 CN CN201480028110.7A patent/CN105246483A/zh active Pending
-
2015
- 2015-09-16 IL IL241620A patent/IL241620B/en active IP Right Grant
-
2017
- 2017-04-24 US US15/495,496 patent/US10323009B2/en active Active
-
2018
- 2018-12-21 JP JP2018239199A patent/JP6739509B2/ja active Active
-
2019
- 2019-02-22 AU AU2019201264A patent/AU2019201264B2/en active Active
- 2019-06-17 US US16/443,795 patent/US11186555B2/en active Active
-
2021
- 2021-11-29 US US17/537,266 patent/US20220324820A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US9630936B2 (en) | 2017-04-25 |
AU2014233168B2 (en) | 2018-11-22 |
US20140275187A1 (en) | 2014-09-18 |
DK2968346T3 (da) | 2024-05-06 |
WO2014145314A2 (en) | 2014-09-18 |
US10323009B2 (en) | 2019-06-18 |
CA2909510A1 (en) | 2014-09-18 |
US20190359580A1 (en) | 2019-11-28 |
EP2968346B1 (en) | 2024-02-07 |
JP2019065031A (ja) | 2019-04-25 |
EP2968346A2 (en) | 2016-01-20 |
CN105246483A (zh) | 2016-01-13 |
AU2014233168A1 (en) | 2015-11-05 |
AU2019201264B2 (en) | 2020-07-16 |
WO2014145314A3 (en) | 2014-11-13 |
KR20160003652A (ko) | 2016-01-11 |
JP2016515531A (ja) | 2016-05-30 |
IL283717A (en) | 2021-07-29 |
CA2909510C (en) | 2024-04-02 |
EA030611B1 (ru) | 2018-08-31 |
EP2968346A4 (en) | 2017-02-08 |
US11186555B2 (en) | 2021-11-30 |
KR20210144942A (ko) | 2021-11-30 |
JP6739509B2 (ja) | 2020-08-12 |
US20170226070A1 (en) | 2017-08-10 |
IL283717B (en) | 2022-09-01 |
US20220324820A1 (en) | 2022-10-13 |
IL241620B (en) | 2021-06-30 |
JP6458000B2 (ja) | 2019-01-23 |
CA3232320A1 (en) | 2014-09-18 |
FI2968346T3 (fi) | 2024-05-06 |
AU2019201264A1 (en) | 2019-03-14 |
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