EA201491140A1 - Устройство, система и способ для идентификации циркулирующих опухолевых клеток - Google Patents
Устройство, система и способ для идентификации циркулирующих опухолевых клетокInfo
- Publication number
- EA201491140A1 EA201491140A1 EA201491140A EA201491140A EA201491140A1 EA 201491140 A1 EA201491140 A1 EA 201491140A1 EA 201491140 A EA201491140 A EA 201491140A EA 201491140 A EA201491140 A EA 201491140A EA 201491140 A1 EA201491140 A1 EA 201491140A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- well
- cells
- circulating tumor
- tumor cells
- objects
- Prior art date
Links
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 102000011782 Keratins Human genes 0.000 abstract 1
- 108010076876 Keratins Proteins 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Cell Biology (AREA)
- Multimedia (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Oncology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568793P | 2011-12-09 | 2011-12-09 | |
| PCT/US2012/068586 WO2013086428A1 (en) | 2011-12-09 | 2012-12-07 | Apparatus, system and method for identifying circulating tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201491140A1 true EA201491140A1 (ru) | 2014-11-28 |
Family
ID=48574948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491140A EA201491140A1 (ru) | 2011-12-09 | 2012-12-07 | Устройство, система и способ для идентификации циркулирующих опухолевых клеток |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140329917A1 (enExample) |
| EP (1) | EP2788773A4 (enExample) |
| JP (1) | JP2015505966A (enExample) |
| KR (1) | KR20150008842A (enExample) |
| CN (1) | CN104428677A (enExample) |
| AU (1) | AU2012347526A1 (enExample) |
| BR (1) | BR112014013956A2 (enExample) |
| CA (1) | CA2858689A1 (enExample) |
| EA (1) | EA201491140A1 (enExample) |
| HK (1) | HK1201916A1 (enExample) |
| IL (1) | IL233007A0 (enExample) |
| MX (1) | MX2014006884A (enExample) |
| SG (1) | SG11201403041TA (enExample) |
| WO (1) | WO2013086428A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2445204C (en) | 2002-10-16 | 2014-08-12 | Streck Laboratories, Inc. | Method and device for collecting and preserving cells for analysis |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| EP3290530B1 (en) | 2009-02-18 | 2020-09-02 | Streck Inc. | Preservation of cell-free nucleic acids |
| ES2556639T3 (es) | 2009-10-21 | 2016-01-19 | The Scripps Research Institute | Método para usar células no raras para detectar células raras |
| EP2704740B1 (en) | 2011-05-04 | 2016-10-05 | Streck, Inc. | Inactivated swine flu virus and methods of preparing it |
| US9396532B2 (en) * | 2012-11-15 | 2016-07-19 | Siemens Healthcare Diagnostics, Inc. | Cell feature-based automatic circulating tumor cell detection |
| EP4136972A1 (en) | 2013-07-24 | 2023-02-22 | Streck, Inc. | Compositions and methods for stabilizing circulating tumor cells |
| US9683938B2 (en) | 2013-07-31 | 2017-06-20 | The Regents Of The University Of California | Fluorescent imaging using a flatbed scanner |
| US10053692B2 (en) | 2013-10-21 | 2018-08-21 | The General Hospital Corporation | Methods relating to circulating tumor cell clusters and the treatment of cancer |
| EP3100047B1 (en) | 2014-01-27 | 2021-08-11 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for prostate cancer biomarkers |
| US20160011198A1 (en) * | 2014-01-27 | 2016-01-14 | Epic Sciences, Inc. | Detection of prostate specific membrane antigen (psma) expression on circulating tumor cells (ctc) |
| WO2015116828A1 (en) * | 2014-01-30 | 2015-08-06 | Epic Sciences, Inc. | Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies |
| EP3108246B1 (en) | 2014-02-21 | 2019-10-09 | Epic Sciences, Inc. | Methods for analyzing rare circulating cells |
| CN104062428B (zh) * | 2014-07-09 | 2016-08-17 | 郑勤 | 一种检测循环肿瘤细胞的试剂盒 |
| HK1244848A1 (zh) * | 2014-12-10 | 2018-08-17 | 得克萨斯州大学系统董事会 | 使用基因组特异性探针的循环肿瘤和肿瘤干细胞检测 |
| US20160178630A1 (en) * | 2014-12-18 | 2016-06-23 | Creatv Microtech, Inc. | Methods for predicting overall survival of cancer patients based on numbers of circulating tumor cells |
| JP6737185B2 (ja) * | 2015-01-29 | 2020-08-05 | コニカミノルタ株式会社 | 相互作用する分子を有する血中細胞の同時検出方法 |
| US11168351B2 (en) | 2015-03-05 | 2021-11-09 | Streck, Inc. | Stabilization of nucleic acids in urine |
| CN108064343B (zh) * | 2015-04-21 | 2021-07-09 | 基因泰克公司 | 用于前列腺癌分析的组合物和方法 |
| KR102080107B1 (ko) * | 2015-05-14 | 2020-02-21 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 순환되는 종양세포를 바이오마커로 사용하여 암 치료요법의 효율을 모니터링 하는 방법 |
| WO2016207986A1 (ja) | 2015-06-24 | 2016-12-29 | 株式会社日立製作所 | 検査システム、検査装置、及び検査方法 |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| WO2018020897A1 (ja) * | 2016-07-25 | 2018-02-01 | 株式会社オプトニクス精密 | 細胞のスライドグラス標本作製装置、細胞のスライドグラス標本作製方法、及びｄｎａ又はｒｎａの抽出方法 |
| US11506655B2 (en) | 2016-07-29 | 2022-11-22 | Streck, Inc. | Suspension composition for hematology analysis control |
| WO2018116465A1 (ja) * | 2016-12-22 | 2018-06-28 | 日立化成株式会社 | Ｈｅｒ２陽性癌細胞の検出方法 |
| US9738937B1 (en) | 2017-03-31 | 2017-08-22 | Cellmax, Ltd. | Identifying candidate cells using image analysis |
| IT201700085439A1 (it) * | 2017-07-26 | 2019-01-26 | Tethis S P A | Metodo di immobilizzazione di campioni biologici a scopo analitico e diagnostico |
| ES2991437T3 (es) | 2017-10-19 | 2024-12-03 | Streck Llc | Composiciones para la regulación de la hemólisis y la coagulación y la estabilización de vesículas extracelulares |
| JP6485576B2 (ja) * | 2018-04-19 | 2019-03-20 | 日立化成株式会社 | 標準細胞液 |
| CN109887542A (zh) * | 2019-02-12 | 2019-06-14 | 嘉兴海云惠智医疗科技有限公司 | 一种基于云计算的肿瘤个体化基因检测智能解读系统 |
| CN110146704A (zh) * | 2019-03-28 | 2019-08-20 | 苏州举健生物科技有限公司 | 一种基于循环肿瘤细胞的用药及病理检测数据系统 |
| JP2021110664A (ja) * | 2020-01-14 | 2021-08-02 | 学校法人杏林学園 | 癌被験体の予後を予測する方法 |
| CN111323362A (zh) * | 2020-03-17 | 2020-06-23 | 宁波江丰生物信息技术有限公司 | 一种基于荧光切片的循环肿瘤细胞检测系统及检测方法 |
| CN114092934A (zh) * | 2020-07-31 | 2022-02-25 | 骏实生物科技(上海)有限公司 | 循环肿瘤细胞的分类方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3830721A1 (de) * | 1988-09-09 | 1990-03-22 | Michael Dr Menton | In labors, insbesondere in medizinischen labors, zu verwendender objekttraeger |
| CN2265982Y (zh) * | 1996-05-20 | 1997-10-29 | 中国农业大学 | 平底方槽型细胞显微操作载片 |
| US8192994B2 (en) * | 1998-02-10 | 2012-06-05 | Angros Lee H | Method of applying a biological specimen to an analytic plate |
| EP1101143A1 (en) * | 1998-08-07 | 2001-05-23 | Biogenex Laboratories | Slides with reaction zones defined by hydrophobic barriers |
| CN2377532Y (zh) * | 1999-06-10 | 2000-05-10 | 中国人民解放军第二军医大学 | 微量荧光细胞计数板 |
| AU2002249481A1 (en) * | 2000-10-25 | 2002-08-12 | Exiqon A/S | Open substrate platforms suitable for analysis of biomolecules |
| US7943093B2 (en) * | 2001-12-12 | 2011-05-17 | Erie Scientific Company | Cover slip |
| US20070009389A1 (en) * | 2005-07-08 | 2007-01-11 | Antti Seppo | Slide deposition chamber |
| ES2420834T3 (es) * | 2006-01-30 | 2013-08-27 | The Scripps Research Institute | Métodos de detección de células tumorales circulantes y métodos de diagnóstico del cáncer en un sujeto mamífero |
| US8244021B2 (en) * | 2006-12-20 | 2012-08-14 | Ventana Medical Systems, Inc. | Quantitative, multispectral image analysis of tissue specimens stained with quantum dots |
| EP2155856A4 (en) * | 2007-06-05 | 2013-06-26 | Nanopoint Inc | SYSTEMS AND METHODS OF CELL TRAY |
| CN201184866Y (zh) * | 2008-02-26 | 2009-01-21 | 强实贸易(上海)有限公司 | 定量细胞计数系统装置 |
| WO2010045949A2 (en) * | 2008-10-21 | 2010-04-29 | Chemometec A/S | A method and apparatus for analysis of a particle |
| EP3029460A1 (en) * | 2010-01-27 | 2016-06-08 | Duke University | O-cadherin as a biomarker for circulating tumor cells |
-
2012
- 2012-12-07 EP EP12855719.6A patent/EP2788773A4/en not_active Withdrawn
- 2012-12-07 KR KR20147018924A patent/KR20150008842A/ko not_active Withdrawn
- 2012-12-07 SG SG11201403041TA patent/SG11201403041TA/en unknown
- 2012-12-07 US US14/363,290 patent/US20140329917A1/en not_active Abandoned
- 2012-12-07 HK HK15102251.3A patent/HK1201916A1/xx unknown
- 2012-12-07 WO PCT/US2012/068586 patent/WO2013086428A1/en not_active Ceased
- 2012-12-07 CN CN201280069331.XA patent/CN104428677A/zh active Pending
- 2012-12-07 CA CA2858689A patent/CA2858689A1/en not_active Abandoned
- 2012-12-07 AU AU2012347526A patent/AU2012347526A1/en not_active Abandoned
- 2012-12-07 JP JP2014546147A patent/JP2015505966A/ja active Pending
- 2012-12-07 MX MX2014006884A patent/MX2014006884A/es unknown
- 2012-12-07 EA EA201491140A patent/EA201491140A1/ru unknown
- 2012-12-07 BR BR112014013956A patent/BR112014013956A2/pt not_active Application Discontinuation
-
2014
- 2014-06-08 IL IL233007A patent/IL233007A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2788773A1 (en) | 2014-10-15 |
| CA2858689A1 (en) | 2013-06-13 |
| MX2014006884A (es) | 2015-06-02 |
| EP2788773A4 (en) | 2015-09-09 |
| BR112014013956A2 (pt) | 2017-06-13 |
| IL233007A0 (en) | 2014-07-31 |
| HK1201916A1 (en) | 2015-09-11 |
| WO2013086428A1 (en) | 2013-06-13 |
| CN104428677A (zh) | 2015-03-18 |
| SG11201403041TA (en) | 2014-08-28 |
| KR20150008842A (ko) | 2015-01-23 |
| US20140329917A1 (en) | 2014-11-06 |
| JP2015505966A (ja) | 2015-02-26 |
| AU2012347526A1 (en) | 2014-07-10 |
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