CN104428677A - 用于识别循环肿瘤细胞的设备、系统和方法 - Google Patents

用于识别循环肿瘤细胞的设备、系统和方法 Download PDF

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Publication number
CN104428677A
CN104428677A CN201280069331.XA CN201280069331A CN104428677A CN 104428677 A CN104428677 A CN 104428677A CN 201280069331 A CN201280069331 A CN 201280069331A CN 104428677 A CN104428677 A CN 104428677A
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hole
cells
cell
methods
ctcs
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格尔德·马林费尔德
P·昆
A·考拉特卡
D·马里努茨
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Scripps Research Institute
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
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  • Pathology (AREA)
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  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Oncology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN201280069331.XA 2011-12-09 2012-12-07 用于识别循环肿瘤细胞的设备、系统和方法 Pending CN104428677A (zh)

Applications Claiming Priority (3)

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US201161568793P 2011-12-09 2011-12-09
US61/568,793 2011-12-09
PCT/US2012/068586 WO2013086428A1 (en) 2011-12-09 2012-12-07 Apparatus, system and method for identifying circulating tumor cells

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US (1) US20140329917A1 (enExample)
EP (1) EP2788773A4 (enExample)
JP (1) JP2015505966A (enExample)
KR (1) KR20150008842A (enExample)
CN (1) CN104428677A (enExample)
AU (1) AU2012347526A1 (enExample)
BR (1) BR112014013956A2 (enExample)
CA (1) CA2858689A1 (enExample)
EA (1) EA201491140A1 (enExample)
HK (1) HK1201916A1 (enExample)
IL (1) IL233007A0 (enExample)
MX (1) MX2014006884A (enExample)
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WO (1) WO2013086428A1 (enExample)

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CN107614674A (zh) * 2015-06-24 2018-01-19 株式会社日立制作所 检查系统、检查装置以及检查方法
CN108693009A (zh) * 2017-03-31 2018-10-23 合度精密生物科技有限公司 使用图像分析识别候选细胞
CN110959110A (zh) * 2017-07-26 2020-04-03 泰希斯有限公司 用于固定生物样品以用于分析和诊断目的的方法
CN111323362A (zh) * 2020-03-17 2020-06-23 宁波江丰生物信息技术有限公司 一种基于荧光切片的循环肿瘤细胞检测系统及检测方法

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EP3290530B1 (en) 2009-02-18 2020-09-02 Streck Inc. Preservation of cell-free nucleic acids
ES2556639T3 (es) 2009-10-21 2016-01-19 The Scripps Research Institute Método para usar células no raras para detectar células raras
EP2704740B1 (en) 2011-05-04 2016-10-05 Streck, Inc. Inactivated swine flu virus and methods of preparing it
US9396532B2 (en) * 2012-11-15 2016-07-19 Siemens Healthcare Diagnostics, Inc. Cell feature-based automatic circulating tumor cell detection
EP4136972A1 (en) 2013-07-24 2023-02-22 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
US9683938B2 (en) 2013-07-31 2017-06-20 The Regents Of The University Of California Fluorescent imaging using a flatbed scanner
US10053692B2 (en) 2013-10-21 2018-08-21 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
EP3100047B1 (en) 2014-01-27 2021-08-11 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
US20160011198A1 (en) * 2014-01-27 2016-01-14 Epic Sciences, Inc. Detection of prostate specific membrane antigen (psma) expression on circulating tumor cells (ctc)
WO2015116828A1 (en) * 2014-01-30 2015-08-06 Epic Sciences, Inc. Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies
EP3108246B1 (en) 2014-02-21 2019-10-09 Epic Sciences, Inc. Methods for analyzing rare circulating cells
CN104062428B (zh) * 2014-07-09 2016-08-17 郑勤 一种检测循环肿瘤细胞的试剂盒
HK1244848A1 (zh) * 2014-12-10 2018-08-17 得克萨斯州大学系统董事会 使用基因组特异性探针的循环肿瘤和肿瘤干细胞检测
US20160178630A1 (en) * 2014-12-18 2016-06-23 Creatv Microtech, Inc. Methods for predicting overall survival of cancer patients based on numbers of circulating tumor cells
JP6737185B2 (ja) * 2015-01-29 2020-08-05 コニカミノルタ株式会社 相互作用する分子を有する血中細胞の同時検出方法
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
CN108064343B (zh) * 2015-04-21 2021-07-09 基因泰克公司 用于前列腺癌分析的组合物和方法
KR102080107B1 (ko) * 2015-05-14 2020-02-21 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 순환되는 종양세포를 바이오마커로 사용하여 암 치료요법의 효율을 모니터링 하는 방법
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2018020897A1 (ja) * 2016-07-25 2018-02-01 株式会社オプトニクス精密 細胞のスライドグラス標本作製装置、細胞のスライドグラス標本作製方法、及びｄｎａ又はｒｎａの抽出方法
US11506655B2 (en) 2016-07-29 2022-11-22 Streck, Inc. Suspension composition for hematology analysis control
WO2018116465A1 (ja) * 2016-12-22 2018-06-28 日立化成株式会社 Ｈｅｒ２陽性癌細胞の検出方法
ES2991437T3 (es) 2017-10-19 2024-12-03 Streck Llc Composiciones para la regulación de la hemólisis y la coagulación y la estabilización de vesículas extracelulares
JP6485576B2 (ja) * 2018-04-19 2019-03-20 日立化成株式会社 標準細胞液
CN109887542A (zh) * 2019-02-12 2019-06-14 嘉兴海云惠智医疗科技有限公司 一种基于云计算的肿瘤个体化基因检测智能解读系统
CN110146704A (zh) * 2019-03-28 2019-08-20 苏州举健生物科技有限公司 一种基于循环肿瘤细胞的用药及病理检测数据系统
JP2021110664A (ja) * 2020-01-14 2021-08-02 学校法人杏林学園 癌被験体の予後を予測する方法
CN114092934A (zh) * 2020-07-31 2022-02-25 骏实生物科技(上海)有限公司 循环肿瘤细胞的分类方法

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Publication number Priority date Publication date Assignee Title
CN107614674A (zh) * 2015-06-24 2018-01-19 株式会社日立制作所 检查系统、检查装置以及检查方法
US12152269B2 (en) 2015-06-24 2024-11-26 Hitachi, Ltd. Examination system, examination device, and examination method for testing sample quality prior to biomarker detection
CN108693009A (zh) * 2017-03-31 2018-10-23 合度精密生物科技有限公司 使用图像分析识别候选细胞
CN108693009B (zh) * 2017-03-31 2021-02-19 合度精密生物科技有限公司 使用图像分析识别候选细胞
CN112730002A (zh) * 2017-03-31 2021-04-30 合度精密生物科技有限公司 使用图像分析识别候选细胞
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CN110959110A (zh) * 2017-07-26 2020-04-03 泰希斯有限公司 用于固定生物样品以用于分析和诊断目的的方法
CN111323362A (zh) * 2020-03-17 2020-06-23 宁波江丰生物信息技术有限公司 一种基于荧光切片的循环肿瘤细胞检测系统及检测方法

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EP2788773A1 (en) 2014-10-15
CA2858689A1 (en) 2013-06-13
MX2014006884A (es) 2015-06-02
EP2788773A4 (en) 2015-09-09
BR112014013956A2 (pt) 2017-06-13
IL233007A0 (en) 2014-07-31
HK1201916A1 (en) 2015-09-11
WO2013086428A1 (en) 2013-06-13
EA201491140A1 (ru) 2014-11-28
SG11201403041TA (en) 2014-08-28
KR20150008842A (ko) 2015-01-23
US20140329917A1 (en) 2014-11-06
JP2015505966A (ja) 2015-02-26
AU2012347526A1 (en) 2014-07-10

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