EA201491081A1 - Композиции и способы для лечения заболеваний и расстройств печени - Google Patents

Композиции и способы для лечения заболеваний и расстройств печени

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Publication number
EA201491081A1
EA201491081A1 EA201491081A EA201491081A EA201491081A1 EA 201491081 A1 EA201491081 A1 EA 201491081A1 EA 201491081 A EA201491081 A EA 201491081A EA 201491081 A EA201491081 A EA 201491081A EA 201491081 A1 EA201491081 A1 EA 201491081A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
liver
diseases
disorders
Prior art date
Application number
EA201491081A
Other languages
English (en)
Inventor
Элизабет Маккенна
Original Assignee
Элизабет Маккенна
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элизабет Маккенна filed Critical Элизабет Маккенна
Publication of EA201491081A1 publication Critical patent/EA201491081A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21043—Classical-complement-pathway C3/C5 convertase (3.4.21.43)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Согласно изобретению предложены композиции для перорального введения и способы применения указанных композиций для лечения субъектов, страдающих одним или более расстройствами печени. Указанные композиции содержат лизаты или экстракты клеточных стенок одной или более грамм-положительных бактерий и проявляют особую активность в отношении вируса гепатита С (HCV) и могут применяться для лечения субъектов, инфицированных HCV, а также страдающих другими заболеваниями или расстройствами печени. Также описаны способы лечения заболевания или расстройства печени путем введения терапевтически эффективного количества по меньшей мере одного терапевтически активного агента, способного положительно или отрицательно регулировать путь системы активации комплемента, где указанный терапевтически активный агент усиливает образование одного или более ферментов конвертаз.
EA201491081A 2012-01-16 2013-01-16 Композиции и способы для лечения заболеваний и расстройств печени EA201491081A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261586975P 2012-01-16 2012-01-16
PCT/US2013/021752 WO2013109635A1 (en) 2012-01-16 2013-01-16 Compositions and methods for the treatment of hepatic diseases and disorders

Publications (1)

Publication Number Publication Date
EA201491081A1 true EA201491081A1 (ru) 2016-11-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491081A EA201491081A1 (ru) 2012-01-16 2013-01-16 Композиции и способы для лечения заболеваний и расстройств печени

Country Status (19)

Country Link
US (4) US9713630B2 (ru)
EP (1) EP2804613A4 (ru)
JP (1) JP6632802B2 (ru)
KR (3) KR20140121818A (ru)
CN (2) CN104144693A (ru)
AP (1) AP2014007804A0 (ru)
AU (2) AU2013209887B2 (ru)
BR (1) BR112014016389A8 (ru)
CA (2) CA2860311A1 (ru)
CR (1) CR20140342A (ru)
EA (1) EA201491081A1 (ru)
HK (1) HK1198909A1 (ru)
IL (1) IL233639B (ru)
NI (1) NI201400076A (ru)
NZ (1) NZ625592A (ru)
PE (1) PE20142295A1 (ru)
PH (1) PH12014501620A1 (ru)
SG (3) SG10201605350UA (ru)
WO (1) WO2013109635A1 (ru)

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Also Published As

Publication number Publication date
CA2860311A1 (en) 2013-07-25
EP2804613A4 (en) 2015-12-09
US20170348358A1 (en) 2017-12-07
AP2014007804A0 (en) 2014-07-31
AU2021203147A1 (en) 2021-06-10
BR112014016389A2 (pt) 2017-06-13
HK1198909A1 (en) 2015-06-19
NI201400076A (es) 2015-04-13
SG10201605350UA (en) 2016-08-30
NZ625592A (en) 2016-09-30
PE20142295A1 (es) 2014-12-19
CA3208225A1 (en) 2013-07-25
KR20200106088A (ko) 2020-09-10
BR112014016389A8 (pt) 2021-06-08
IL233639A0 (en) 2014-08-31
JP2015503628A (ja) 2015-02-02
EP2804613A1 (en) 2014-11-26
SG11201402650RA (en) 2014-06-27
KR20140121818A (ko) 2014-10-16
US10149869B2 (en) 2018-12-11
KR20220042485A (ko) 2022-04-05
WO2013109635A1 (en) 2013-07-25
CN104144693A (zh) 2014-11-12
US11857577B2 (en) 2024-01-02
AU2013209887B2 (en) 2021-02-18
US20190290703A1 (en) 2019-09-26
CN113813294A (zh) 2021-12-21
US20140030194A1 (en) 2014-01-30
US9713630B2 (en) 2017-07-25
JP6632802B2 (ja) 2020-01-22
PH12014501620A1 (en) 2014-10-13
IL233639B (en) 2021-03-25
CR20140342A (es) 2014-12-03
SG10202013014RA (en) 2021-02-25
US20230372410A1 (en) 2023-11-23
AU2013209887A1 (en) 2019-08-08

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