EA201490279A1 - Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения - Google Patents

Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения

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Publication number
EA201490279A1
EA201490279A1 EA201490279A EA201490279A EA201490279A1 EA 201490279 A1 EA201490279 A1 EA 201490279A1 EA 201490279 A EA201490279 A EA 201490279A EA 201490279 A EA201490279 A EA 201490279A EA 201490279 A1 EA201490279 A1 EA 201490279A1
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EA
Eurasian Patent Office
Prior art keywords
methods
chemical compound
pharmaceutical compositions
kinurenin
monoxygenase
Prior art date
Application number
EA201490279A
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English (en)
Inventor
Стефен Мартин Кортни
Майкл Прайм
Уильям Митчелл
Кристофер Джон Браун
Паула С. Де Агуиар Пена
Питер Джонсон
Селия Домингез
Летиция М. Толедо-Шерман
Игнасио Мунос
Original Assignee
Схди Фаундейшн, Инк.
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Application filed by Схди Фаундейшн, Инк. filed Critical Схди Фаундейшн, Инк.
Publication of EA201490279A1 publication Critical patent/EA201490279A1/ru

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/04—Ortho-condensed systems
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

Предусмотрены некоторые химические соединения. Также предусмотрены фармацевтические композиции, содержащие по меньшей мере одно химическое соединение и один или более фармацевтически приемлемых носителей. Описаны способы лечения пациентов, страдающих от некоторых заболеваний или нарушений, восприимчивых к ингибированию активности KMO, которые включают введение таким пациентам количества по меньшей мере одного химического соединения, эффективного для уменьшения признаков или симптомов такого заболевания или нарушения. Такие заболевания включают нейродегенеративные заболевания, такие как болезнь Хантингтона. Также описаны способы лечения, включающие введение по меньшей мере одного химического соединения в виде единственного активного агента или введение по меньшей мере одного химического соединения в комбинации с одним или более другими терапевтическими агентами. Также предусмотрены способы скрининга соединений, способных ингибировать активность KMO.
EA201490279A 2011-08-30 2012-08-28 Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения EA201490279A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161529003P 2011-08-30 2011-08-30
PCT/US2012/052617 WO2013033068A1 (en) 2011-08-30 2012-08-28 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof

Publications (1)

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EA201490279A1 true EA201490279A1 (ru) 2014-08-29

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Country Link
US (1) US9428464B2 (ru)
EP (1) EP2751086A4 (ru)
JP (1) JP2014525443A (ru)
KR (1) KR20140072037A (ru)
CN (1) CN103827095A (ru)
AR (1) AR087711A1 (ru)
AU (1) AU2012300246A1 (ru)
BR (1) BR112014004845A2 (ru)
CA (1) CA2844521A1 (ru)
EA (1) EA201490279A1 (ru)
HK (1) HK1199726A1 (ru)
IL (1) IL231271A0 (ru)
MX (1) MX2014002459A (ru)
SG (1) SG2014011654A (ru)
TW (1) TW201326138A (ru)
WO (1) WO2013033068A1 (ru)
ZA (1) ZA201401117B (ru)

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