EA201400031A1 - Стабильные составы на основе фермента, разрушающего хиалуронан - Google Patents
Стабильные составы на основе фермента, разрушающего хиалуронанInfo
- Publication number
- EA201400031A1 EA201400031A1 EA201400031A EA201400031A EA201400031A1 EA 201400031 A1 EA201400031 A1 EA 201400031A1 EA 201400031 A EA201400031 A EA 201400031A EA 201400031 A EA201400031 A EA 201400031A EA 201400031 A1 EA201400031 A1 EA 201400031A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- enzyme
- hyaluronane
- destructing
- compositions based
- stable compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 230000000593 degrading effect Effects 0.000 abstract 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 2
- 229940099552 hyaluronan Drugs 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161520962P | 2011-06-17 | 2011-06-17 | |
| PCT/US2012/042816 WO2012174478A2 (en) | 2011-06-17 | 2012-06-15 | Stable formulations of a hyaluronan-degrading enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201400031A1 true EA201400031A1 (ru) | 2014-07-30 |
Family
ID=46513830
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201400031A EA201400031A1 (ru) | 2011-06-17 | 2012-06-15 | Стабильные составы на основе фермента, разрушающего хиалуронан |
| EA201501068A EA033472B1 (ru) | 2011-06-17 | 2012-06-15 | Композиция для стабилизации гиалуронидазы и ее применение |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201501068A EA033472B1 (ru) | 2011-06-17 | 2012-06-15 | Композиция для стабилизации гиалуронидазы и ее применение |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2720712B1 (enExample) |
| JP (3) | JP2014518216A (enExample) |
| KR (2) | KR101874401B1 (enExample) |
| CN (2) | CN103974715A (enExample) |
| AU (2) | AU2012271359B2 (enExample) |
| BR (1) | BR112013032396A2 (enExample) |
| CA (1) | CA2839511C (enExample) |
| EA (2) | EA201400031A1 (enExample) |
| ES (1) | ES2566549T3 (enExample) |
| IL (1) | IL229749A0 (enExample) |
| MX (1) | MX340172B (enExample) |
| NZ (2) | NZ717728A (enExample) |
| WO (1) | WO2012174478A2 (enExample) |
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|---|---|---|---|---|
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| WO2013102144A2 (en) | 2011-12-30 | 2013-07-04 | Halozyme, Inc. | Ph20 polypeptede variants, formulations and uses thereof |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| JP2016506401A (ja) | 2012-12-21 | 2016-03-03 | サノフイ | 二重ｇｌｐ１／ｇｉｐまたは三方ｇｌｐ１／ｇｉｐ／グルカゴンアゴニストとしてのエキセンジン−４誘導体 |
| TWI641381B (zh) * | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| RU2019128331A (ru) * | 2013-02-04 | 2019-12-16 | Санофи | Стабилизированные фармацевтические составы аналогов инсулина и/или производные инсулина |
| AR098168A1 (es) * | 2013-10-25 | 2016-05-04 | Sanofi Sa | Formulación estable de insulina glulisina |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| CN112957455A (zh) | 2014-01-09 | 2021-06-15 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
| JP6562902B2 (ja) * | 2014-03-28 | 2019-08-21 | テルモ株式会社 | 生体血管内血液置換用液体、生体血管内血液置換用液体製剤およびプレフィルドシリンジ |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| CN104095871A (zh) * | 2014-07-10 | 2014-10-15 | 青岛蔚蓝生物股份有限公司 | 一种含盐酸林可霉素与硫酸大观霉素的兽用注射液 |
| CA2958145C (en) * | 2014-07-16 | 2023-09-26 | New York University | Use of hyaluronidase for treatment of muscle stiffness |
| TW201630622A (zh) | 2014-12-16 | 2016-09-01 | 美國禮來大藥廠 | 速效胰島素組合物 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| CN105018457A (zh) * | 2015-07-20 | 2015-11-04 | 宁波美成生物科技有限公司 | 虫荧光素酶稳定剂 |
| CN114835795A (zh) * | 2015-11-16 | 2022-08-02 | Ubi蛋白公司 | 用于延长蛋白质半衰期的方法 |
| WO2018045943A1 (zh) | 2016-09-06 | 2018-03-15 | 杏辉天力（杭州）药业有限公司 | 茯苓萃取物及其活性成分于保养肌肤及/或促进伤口愈合的用途 |
| IL265109B2 (en) | 2016-09-13 | 2024-05-01 | Allergan Inc | Stabilized non-protein clostridial toxin compositions |
| CN108070532A (zh) * | 2016-11-16 | 2018-05-25 | 福建力多利生物科技有限公司 | 一种生产葡萄糖氧化酶的方法 |
| WO2019050749A1 (en) * | 2017-09-08 | 2019-03-14 | Eli Lilly And Company | PHARMACEUTICAL COMBINATIONS COMPRISING INSULIN AND AT LEAST ONE AGENT SELECTED AMONG MELOXICAM, BROMFENAC SODIUM, ACETYLSALICYLIC ACID, SALICYLIC ACID AND PARACETAMOL |
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| WO2022141232A1 (zh) * | 2020-12-30 | 2022-07-07 | 上海宝济药业有限公司 | 一种重组人透明质酸酶制剂及其应用 |
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-
2012
- 2012-06-15 WO PCT/US2012/042816 patent/WO2012174478A2/en not_active Ceased
- 2012-06-15 KR KR1020177027130A patent/KR101874401B1/ko not_active Expired - Fee Related
- 2012-06-15 EP EP12735366.2A patent/EP2720712B1/en active Active
- 2012-06-15 BR BR112013032396A patent/BR112013032396A2/pt not_active IP Right Cessation
- 2012-06-15 NZ NZ717728A patent/NZ717728A/en not_active IP Right Cessation
- 2012-06-15 NZ NZ618331A patent/NZ618331A/en not_active IP Right Cessation
- 2012-06-15 JP JP2014516067A patent/JP2014518216A/ja active Pending
- 2012-06-15 MX MX2013014923A patent/MX340172B/es active IP Right Grant
- 2012-06-15 EA EA201400031A patent/EA201400031A1/ru unknown
- 2012-06-15 AU AU2012271359A patent/AU2012271359B2/en not_active Ceased
- 2012-06-15 CN CN201280039713.8A patent/CN103974715A/zh active Pending
- 2012-06-15 CA CA2839511A patent/CA2839511C/en active Active
- 2012-06-15 ES ES12735366.2T patent/ES2566549T3/es active Active
- 2012-06-15 CN CN201610243096.3A patent/CN105797140B/zh active Active
- 2012-06-15 EA EA201501068A patent/EA033472B1/ru not_active IP Right Cessation
- 2012-06-15 KR KR1020147001375A patent/KR20140043438A/ko not_active Ceased
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2013
- 2013-12-02 IL IL229749A patent/IL229749A0/en unknown
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2016
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- 2016-10-12 JP JP2016200761A patent/JP6224802B2/ja active Active
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2017
- 2017-06-06 JP JP2017111643A patent/JP2017197556A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EA201501068A1 (ru) | 2016-07-29 |
| NZ618331A (en) | 2016-04-29 |
| AU2012271359B2 (en) | 2016-05-19 |
| JP2017036313A (ja) | 2017-02-16 |
| EP2720712A2 (en) | 2014-04-23 |
| AU2012271359A1 (en) | 2014-01-09 |
| CN105797140A (zh) | 2016-07-27 |
| JP2014518216A (ja) | 2014-07-28 |
| MX2013014923A (es) | 2014-02-11 |
| WO2012174478A3 (en) | 2013-04-11 |
| NZ717728A (en) | 2016-04-29 |
| WO2012174478A9 (en) | 2013-05-30 |
| CN105797140B (zh) | 2020-08-11 |
| KR20170116173A (ko) | 2017-10-18 |
| CA2839511A1 (en) | 2012-12-20 |
| BR112013032396A2 (pt) | 2016-11-22 |
| CN103974715A (zh) | 2014-08-06 |
| CA2839511C (en) | 2018-07-31 |
| WO2012174478A2 (en) | 2012-12-20 |
| IL229749A0 (en) | 2014-01-30 |
| JP2017197556A (ja) | 2017-11-02 |
| KR20140043438A (ko) | 2014-04-09 |
| EA033472B1 (ru) | 2019-10-31 |
| KR101874401B1 (ko) | 2018-07-04 |
| EP2720712B1 (en) | 2016-03-02 |
| ES2566549T3 (es) | 2016-04-13 |
| MX340172B (es) | 2016-06-28 |
| AU2016202472B2 (en) | 2017-02-02 |
| JP6224802B2 (ja) | 2017-11-01 |
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