EA201201047A1 - Способы и композиции, в которых применяют слитые полипептиды fgf 23 - Google Patents

Способы и композиции, в которых применяют слитые полипептиды fgf 23

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Publication number
EA201201047A1
EA201201047A1 EA201201047A EA201201047A EA201201047A1 EA 201201047 A1 EA201201047 A1 EA 201201047A1 EA 201201047 A EA201201047 A EA 201201047A EA 201201047 A EA201201047 A EA 201201047A EA 201201047 A1 EA201201047 A1 EA 201201047A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fgf23
derivative
functionally active
active variant
fragment
Prior art date
Application number
EA201201047A
Other languages
English (en)
Russian (ru)
Inventor
Дейвид Гласс
Шоуи Сюй
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201201047A1 publication Critical patent/EA201201047A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/14—Hydrolases (3)
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2445—Beta-glucosidase (3.2.1.21)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12Y—ENZYMES
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01021—Beta-glucosidase (3.2.1.21)
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    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
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    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003—Long-chain-fatty-acid-CoA ligase (6.2.1.3)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Biochemistry (AREA)
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  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
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EA201201047A 2010-01-29 2011-01-27 Способы и композиции, в которых применяют слитые полипептиды fgf 23 EA201201047A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/696,693 US8420088B2 (en) 2008-01-28 2010-01-29 Methods and compositions using FGF23 fusion polypeptides
PCT/EP2011/051112 WO2011092234A1 (en) 2010-01-29 2011-01-27 Methods and compositions using fgf23 fusion polypeptides

Publications (1)

Publication Number Publication Date
EA201201047A1 true EA201201047A1 (ru) 2013-02-28

Family

ID=43828141

Family Applications (1)

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EA201201047A EA201201047A1 (ru) 2010-01-29 2011-01-27 Способы и композиции, в которых применяют слитые полипептиды fgf 23

Country Status (16)

Country Link
US (3) US8420088B2 (enExample)
EP (2) EP3124612A1 (enExample)
JP (2) JP5964243B2 (enExample)
KR (1) KR20130032296A (enExample)
CN (3) CN102725413B (enExample)
AR (1) AR080043A1 (enExample)
AU (1) AU2011209380B2 (enExample)
CA (1) CA2787285A1 (enExample)
EA (1) EA201201047A1 (enExample)
ES (1) ES2605302T3 (enExample)
MX (1) MX336391B (enExample)
PL (1) PL2529016T3 (enExample)
PT (1) PT2529016T (enExample)
TW (2) TWI430805B (enExample)
UY (1) UY33204A (enExample)
WO (1) WO2011092234A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
CA2835607C (en) 2011-07-01 2021-07-20 Ngm Biopharmaceuticals, Inc. Compositions, uses and methods for treatment of metabolic disorders and diseases
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
AU2013352363B2 (en) 2012-11-28 2018-04-12 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
CN102961739A (zh) * 2012-12-12 2013-03-13 黄曙 Klotho蛋白的用途
US9925242B2 (en) 2012-12-27 2018-03-27 Ngm Biopharmaceuticals, Inc. Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of nonalcoholic steatohepatitis
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US20160120959A1 (en) * 2013-03-14 2016-05-05 The Board Of Regents Of The University Of Oklahoma Use of Klotho Nucleic Acids or Proteins for Treatment of Diabetes and Diabetes-Related Conditions
KR101492710B1 (ko) * 2013-04-03 2015-02-13 중앙대학교 산학협력단 Fgf23 유전자를 이용한 전립선암 진단용 마커 및 이를 이용한 전립선암 예측 및 진단 방법
JP6159930B2 (ja) 2013-10-24 2017-07-12 地方独立行政法人東京都健康長寿医療センター 筋幹細胞又は筋芽細胞、及びそれを用いた代謝変換に関与する物質のスクリーニング方法、並びにスクリーニング方法によって得られた物質を含む医薬組成物
JP6560202B2 (ja) 2013-10-28 2019-08-21 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド 癌モデル及び関連方法
AU2014348657A1 (en) 2013-11-13 2016-05-19 Novartis Ag mTOR inhibitors for enhancing the immune response
EP3738981A1 (en) 2014-01-24 2020-11-18 NGM Biopharmaceuticals, Inc. Antibodies binding beta klotho domain 2 and methods of use thereof
JP6370577B2 (ja) * 2014-03-26 2018-08-08 国立大学法人京都工芸繊維大学 抗老化物質のスクリーニング方法
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
AU2015277438B2 (en) 2014-06-16 2020-02-27 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
SG11201702757YA (en) 2014-10-23 2017-05-30 Ngm Biopharmaceuticals Inc Pharmaceutical compositions comprising peptide variants and methods of use thereof
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