EA201100190A1 - Наночастицы диоксида кремния и их применение для вакцинации - Google Patents

Наночастицы диоксида кремния и их применение для вакцинации

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Publication number
EA201100190A1
EA201100190A1 EA201100190A EA201100190A EA201100190A1 EA 201100190 A1 EA201100190 A1 EA 201100190A1 EA 201100190 A EA201100190 A EA 201100190A EA 201100190 A EA201100190 A EA 201100190A EA 201100190 A1 EA201100190 A1 EA 201100190A1
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EA
Eurasian Patent Office
Prior art keywords
silicon dioxide
vaccination
application
relates
dioxide nanoparticles
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EA201100190A
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English (en)
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EA023047B1 (ru
Inventor
Маркус Вайгандт
Андреа Ханефельд
Армин Кюбельбекк
Грегор Ларбиг
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Мерк Патент Гмбх
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Publication of EA201100190A1 publication Critical patent/EA201100190A1/ru
Publication of EA023047B1 publication Critical patent/EA023047B1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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Abstract

Данное изобретение касается ультрамалых, монодисперсных наночастиц, содержащих диоксид кремния, к поверхности которых присоединен по крайней мере один антиген. Наночастицы могут быть использованы для иммунопрофилактики или иммунотерапии рака. Изобретение также касается способа таргетинга антигенов на антигенпрезентующие клетки и активации иммунной системы, причем эффективность таргетинга и/или иммуноактивации задается через характеристики частиц. Изобретение также касается способа активной и пассивной иммунизации млекопитающих.
EA201100190A 2008-07-15 2009-07-13 Наночастицы диоксида кремния и их применение для вакцинации EA023047B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008033175A DE102008033175A1 (de) 2008-07-15 2008-07-15 Siliciumdioxid-Nanopartikel und deren Verwendung zur Vakzinierung
PCT/EP2009/005078 WO2010006753A2 (de) 2008-07-15 2009-07-13 Siliciumdioxid-nanopartikel und deren verwendung zur vakzinierung

Publications (2)

Publication Number Publication Date
EA201100190A1 true EA201100190A1 (ru) 2011-08-30
EA023047B1 EA023047B1 (ru) 2016-04-29

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US (4) US8980324B2 (ru)
EP (2) EP3241545B1 (ru)
JP (3) JP5726075B2 (ru)
KR (2) KR101694130B1 (ru)
CN (2) CN105126115B (ru)
AU (1) AU2009270468B2 (ru)
BR (2) BRPI0915788B8 (ru)
CA (1) CA2730694C (ru)
DE (1) DE102008033175A1 (ru)
DK (2) DK3241545T3 (ru)
EA (1) EA023047B1 (ru)
ES (2) ES2640012T3 (ru)
HU (2) HUE054973T2 (ru)
MX (1) MX341881B (ru)
PT (2) PT2299980T (ru)
WO (1) WO2010006753A2 (ru)
ZA (1) ZA201101171B (ru)

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CN102099014A (zh) 2011-06-15
JP2015042694A (ja) 2015-03-05
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CA2730694A1 (en) 2010-01-21
DE102008033175A1 (de) 2010-01-21
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BRPI0915788A2 (pt) 2015-11-10
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