WO2012165815A3 - 종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신 - Google Patents
종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신 Download PDFInfo
- Publication number
- WO2012165815A3 WO2012165815A3 PCT/KR2012/004162 KR2012004162W WO2012165815A3 WO 2012165815 A3 WO2012165815 A3 WO 2012165815A3 KR 2012004162 W KR2012004162 W KR 2012004162W WO 2012165815 A3 WO2012165815 A3 WO 2012165815A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nano
- tumor tissue
- vehicle
- cancer vaccine
- same
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 229940022399 cancer vaccine Drugs 0.000 title abstract 3
- 238000009566 cancer vaccine Methods 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/823,315 US9220763B2 (en) | 2011-05-27 | 2012-05-25 | Nano-vehicle derived from tumor tissue, and cancer vaccine using same |
CN2012800037132A CN103221034A (zh) | 2011-05-27 | 2012-05-25 | 来自肿瘤组织的纳米囊泡及使用该纳米囊泡的癌症疫苗 |
EP12793342.2A EP2617413A4 (en) | 2011-05-27 | 2012-05-25 | NANIUM DERIVED FROM A TUMOR TISSUE AND CANCER VACCINE THEREFOR |
JP2013534840A JP2013543519A (ja) | 2011-05-27 | 2012-05-25 | 腫瘍組織に由来するナノベシクル、及びこれを用いた癌ワクチン |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110050854A KR20120132183A (ko) | 2011-05-27 | 2011-05-27 | 종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신 |
KR10-2011-0050854 | 2011-05-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012165815A2 WO2012165815A2 (ko) | 2012-12-06 |
WO2012165815A3 true WO2012165815A3 (ko) | 2013-02-07 |
Family
ID=47260042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2012/004162 WO2012165815A2 (ko) | 2011-05-27 | 2012-05-25 | 종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9220763B2 (ko) |
EP (1) | EP2617413A4 (ko) |
JP (1) | JP2013543519A (ko) |
KR (1) | KR20120132183A (ko) |
CN (1) | CN103221034A (ko) |
WO (1) | WO2012165815A2 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10357538B2 (en) * | 2012-12-24 | 2019-07-23 | Northern Sydney Local Health District | Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy |
KR101473557B1 (ko) | 2013-03-29 | 2014-12-24 | 포항공과대학교 산학협력단 | 원심력을 이용한 세포유래 인공 마이크로베시클 제조 장치 |
KR101745455B1 (ko) * | 2015-03-24 | 2017-06-09 | 포항공과대학교 산학협력단 | 수용액 이상계를 이용한 세포 밖 소포체의 다단계 정제방법 |
KR101761680B1 (ko) * | 2015-03-31 | 2017-08-23 | 포항공과대학교 산학협력단 | 수용액 이상계를 이용한 세포 밖 소포체의 분리방법 |
KR101833502B1 (ko) * | 2016-12-16 | 2018-03-05 | 주식회사 엠디헬스케어 | 세균 메타게놈 분석을 통한 위암 진단방법 |
CN108295250B (zh) * | 2017-01-12 | 2023-07-21 | 湖北盛齐安生物科技股份有限公司 | 一种口服肿瘤疫苗及其用途 |
GB2574785A (en) | 2017-09-15 | 2019-12-25 | Jan Loetvall | Method and system for identifying membrane proteins on extracellular vesicles |
CN108324958B (zh) * | 2018-05-17 | 2021-09-24 | 陕西师范大学 | 一种紫红素18-脂质体纳米囊泡的制备方法以及在制备用于治疗肿瘤药物中的应用 |
CN110628719B (zh) * | 2019-09-23 | 2021-08-24 | 山东省医学科学院基础医学研究所 | 一种诱导细胞快速产生囊泡的方法及其应用 |
CN110974976A (zh) * | 2019-12-16 | 2020-04-10 | 天津市第三中心医院 | 羧甲基壳聚糖修饰载药囊泡及其制备与应用 |
CN111991565A (zh) * | 2019-12-17 | 2020-11-27 | 河南牧业经济学院 | 促吞噬肽修饰阿魏酸生物可降解纳米囊泡的制备方法 |
CN113332312B (zh) * | 2021-02-01 | 2023-02-24 | 浙江大学医学院附属邵逸夫医院 | 一种基于物理整粒的自成形血小板纳米囊泡及其制备方法 |
WO2022245144A1 (ko) * | 2021-05-20 | 2022-11-24 | 주식회사 뉴메이스 | 고압 유체 분산 방법을 이용한 세포 유래 나노소포체의 제조 방법 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100075315A1 (en) * | 2004-06-02 | 2010-03-25 | Zbigniew Pietrzkowski | Microvesicle-Based Compositions and Methods |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6406689B1 (en) * | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
WO1999058645A1 (en) * | 1998-05-11 | 1999-11-18 | I.N.S.E.R.M. (Institut National de la Santé et de la Recherche Médicale) | New apoptotic bodies, monocyte derived cells containing the same, a process for their preparation and their uses as vaccines |
US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
KR100796220B1 (ko) | 1998-06-29 | 2008-01-21 | 넥타르 테라퓨틱스 | 미립자 전달 시스템 및 사용 방법 |
JP2005281266A (ja) | 2004-03-31 | 2005-10-13 | Takeshi Kobayashi | 温熱細胞ワクチンとサイトカインを含む医薬用組成物およびその調製方法 |
CA2609260A1 (en) * | 2004-06-02 | 2005-12-22 | Sourcepharm, Inc. | Rna-containing microvesicles and methods therefor |
CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
CA2723918C (en) * | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
DE102008033175A1 (de) | 2008-07-15 | 2010-01-21 | Merck Patent Gmbh | Siliciumdioxid-Nanopartikel und deren Verwendung zur Vakzinierung |
EP2355797A1 (en) * | 2008-10-21 | 2011-08-17 | Domantis Limited | Composition for targeting dendritic cells |
CN107617110A (zh) | 2009-08-26 | 2018-01-23 | 西莱克塔生物科技公司 | 诱导t细胞辅助的组合物 |
WO2012002759A2 (ko) * | 2010-07-01 | 2012-01-05 | 포항공과대학교 산학협력단 | 세포의 원형질체에서 유래한 마이크로베시클 및 이의 용도 |
-
2011
- 2011-05-27 KR KR1020110050854A patent/KR20120132183A/ko active Search and Examination
-
2012
- 2012-05-25 WO PCT/KR2012/004162 patent/WO2012165815A2/ko active Application Filing
- 2012-05-25 CN CN2012800037132A patent/CN103221034A/zh active Pending
- 2012-05-25 JP JP2013534840A patent/JP2013543519A/ja active Pending
- 2012-05-25 US US13/823,315 patent/US9220763B2/en active Active
- 2012-05-25 EP EP12793342.2A patent/EP2617413A4/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100075315A1 (en) * | 2004-06-02 | 2010-03-25 | Zbigniew Pietrzkowski | Microvesicle-Based Compositions and Methods |
Non-Patent Citations (6)
Title |
---|
K. AL-NEDAWI ET AL.: "Microvescicles: Messengers and mediators of tumor progression", CELL CYCLE, vol. 8, no. 13, 1 July 2009 (2009-07-01), pages 2014 - 2018, XP008161991 * |
M. BAJ-KRZYWORZEKA ET AL.: "Tumor-derived microvesicles carry several surface determinants and mRNA of tumor cells and transfer some of these determinants to monocytes", CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 55, 2006, pages 808 - 818, XP019333260 * |
M. SZAJNIK ET AL.: "Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T-cells (Treg)", PLOS ONE, vol. 5, no. 7, July 2010 (2010-07-01), pages 1 - 13, XP002697141 * |
M. WYSOCZYNSKI ET AL.: "Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors", INTERNATIONAL JOURNAL OF CANCER, vol. 125, no. 7, 1 October 2009 (2009-10-01), pages 1595 - 1603, XP002592725 * |
R. VALENTI ET AL.: "Tumor-released microvesicles as vehicles of immunosuppression", CANCER RESEARCH, vol. 67, no. 7, 1 April 2007 (2007-04-01), pages 2912 - 2915, XP002523308 * |
X. LI ET AL.: "Nanovesicular vaccines: exosomes", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMANTALIS, vol. 53, no. 4, 2005, pages 329 - 335, XP009149577 * |
Also Published As
Publication number | Publication date |
---|---|
EP2617413A2 (en) | 2013-07-24 |
US20130177595A1 (en) | 2013-07-11 |
KR20120132183A (ko) | 2012-12-05 |
WO2012165815A2 (ko) | 2012-12-06 |
JP2013543519A (ja) | 2013-12-05 |
US9220763B2 (en) | 2015-12-29 |
CN103221034A (zh) | 2013-07-24 |
EP2617413A4 (en) | 2014-03-19 |
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