EA200970707A1 - Вещества, связывающие ядерные рецепторы - Google Patents
Вещества, связывающие ядерные рецепторыInfo
- Publication number
- EA200970707A1 EA200970707A1 EA200970707A EA200970707A EA200970707A1 EA 200970707 A1 EA200970707 A1 EA 200970707A1 EA 200970707 A EA200970707 A EA 200970707A EA 200970707 A EA200970707 A EA 200970707A EA 200970707 A1 EA200970707 A1 EA 200970707A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- nuclear
- nuclear receptor
- prevention
- treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Настоящее изобретение относится к новому классу веществ, связывающих ядерные рецепторы (NRBA). Вещества, связывающие ядерные рецепторы, можно применять для использования в предотвращении и/или лечении ряда заболеваний и состояний, включая предотвращение и лечение рака, такого как рак простаты и рак молочной железы, остеопороз, гормональные заболевания, воспалительные заболевания, связанные с окислительным стрессом заболевания, такие как болезнь Паркинсона и инсульт, неврологические расстройства, заболевания глаз, сердечно-сосудистые заболевания и ожирение.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88147607P | 2007-01-22 | 2007-01-22 | |
US90775407P | 2007-04-16 | 2007-04-16 | |
PCT/US2008/000736 WO2008091555A2 (en) | 2007-01-22 | 2008-01-22 | Nuclear receptor binding agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970707A1 true EA200970707A1 (ru) | 2010-02-26 |
EA019833B1 EA019833B1 (ru) | 2014-06-30 |
Family
ID=39645049
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400056A EA026578B1 (ru) | 2007-01-22 | 2008-01-22 | Вещества, связывающие ядерные рецепторы |
EA201692214A EA201692214A1 (ru) | 2007-01-22 | 2008-01-22 | Вещества, связывающие ядерные рецепторы |
EA200970707A EA019833B1 (ru) | 2007-01-22 | 2008-01-22 | Вещества, связывающие ядерные рецепторы |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400056A EA026578B1 (ru) | 2007-01-22 | 2008-01-22 | Вещества, связывающие ядерные рецепторы |
EA201692214A EA201692214A1 (ru) | 2007-01-22 | 2008-01-22 | Вещества, связывающие ядерные рецепторы |
Country Status (15)
Country | Link |
---|---|
US (1) | US9078888B2 (ru) |
EP (2) | EP2647376A1 (ru) |
JP (4) | JP5484914B2 (ru) |
KR (3) | KR20160020584A (ru) |
CN (2) | CN103432133B (ru) |
AU (1) | AU2008209581B2 (ru) |
BR (1) | BRPI0806371A2 (ru) |
CA (1) | CA2676066C (ru) |
EA (3) | EA026578B1 (ru) |
ES (1) | ES2475193T3 (ru) |
IL (2) | IL199996A (ru) |
IS (1) | IS8842A (ru) |
MX (1) | MX2009007831A (ru) |
NO (1) | NO20092822L (ru) |
WO (1) | WO2008091555A2 (ru) |
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KR20160020584A (ko) * | 2007-01-22 | 2016-02-23 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
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KR20110102468A (ko) * | 2008-12-16 | 2011-09-16 | 서트리스 파마슈티컬즈, 인코포레이티드 | 시르투인 조절제로서의 프탈라지논 및 관련 유사체 |
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CN101928245A (zh) * | 2010-09-02 | 2010-12-29 | 西安交通大学 | 8-羟基或甲氧基-2-芳基-1-异喹啉酮及其合成方法和用途 |
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CN102875466A (zh) * | 2012-04-23 | 2013-01-16 | 中国药科大学 | 异喹啉酮衍生物,其制备方法及其医药用途 |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
LT2872482T (lt) | 2012-07-13 | 2020-12-28 | Oncternal Therapeutics, Inc. | Krūties vėžių gydymo būdas selektyviu androgeno receptoriaus moduliatoriumi |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
WO2014037811A2 (en) | 2012-09-07 | 2014-03-13 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
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CN105530924A (zh) | 2013-09-06 | 2016-04-27 | 蒙大拿大学 | 用卤代烷基胺减少神经元细胞死亡的方法 |
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