EA200870593A1 - Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения - Google Patents

Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения

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Publication number
EA200870593A1
EA200870593A1 EA200870593A EA200870593A EA200870593A1 EA 200870593 A1 EA200870593 A1 EA 200870593A1 EA 200870593 A EA200870593 A EA 200870593A EA 200870593 A EA200870593 A EA 200870593A EA 200870593 A1 EA200870593 A1 EA 200870593A1
Authority
EA
Eurasian Patent Office
Prior art keywords
binding molecules
human binding
activity against
killing activity
stafiloccus
Prior art date
Application number
EA200870593A
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English (en)
Other versions
EA018030B1 (ru
Inventor
Марк Тросби
Сесилия А.В Геэйен
Корнелис Адриан Де Крэйф
Original Assignee
Круселл Холланд Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Круселл Холланд Б.В. filed Critical Круселл Холланд Б.В.
Publication of EA200870593A1 publication Critical patent/EA200870593A1/ru
Publication of EA018030B1 publication Critical patent/EA018030B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение обеспечивает связывающие молекулы человека, специфически связывающиеся со стафилококками и имеющие убивающую активность против стафилококков, молекулы нуклеиновых кислот, кодирующие эти связывающие молекулы человека, композиции, содержащие связывающие молекулы человека, и способы идентификации или получения связывающих молекул человека. Эти связывающие молекулы человека могут быть использованы в диагностике, профилактике и/или лечении состояния, вызываемого Staphylococcus.
EA200870593A 2006-06-06 2007-06-05 Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения EA018030B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81147706P 2006-06-06 2006-06-06
EP06124231 2006-11-16
EP07103584 2007-03-06
PCT/EP2007/055527 WO2007141274A2 (en) 2006-06-06 2007-06-05 Human binding molecules having killing activity against staphylococci and uses thereof

Publications (2)

Publication Number Publication Date
EA200870593A1 true EA200870593A1 (ru) 2009-06-30
EA018030B1 EA018030B1 (ru) 2013-05-30

Family

ID=44951549

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201201650A EA031202B1 (ru) 2006-06-06 2007-06-05 Антитело человека, обладающее фагоцитарной активностью против стафилококков, и его применение
EA200870593A EA018030B1 (ru) 2006-06-06 2007-06-05 Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения

Family Applications Before (1)

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EA201201650A EA031202B1 (ru) 2006-06-06 2007-06-05 Антитело человека, обладающее фагоцитарной активностью против стафилококков, и его применение

Country Status (15)

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US (2) US8211431B2 (ru)
EP (3) EP2027155B1 (ru)
JP (2) JP5574706B2 (ru)
KR (1) KR101508390B1 (ru)
CN (2) CN103351435B (ru)
AU (1) AU2007255384B2 (ru)
CA (2) CA2881717C (ru)
DK (2) DK2027155T3 (ru)
EA (2) EA031202B1 (ru)
HU (1) HUE027099T2 (ru)
IL (1) IL195675A (ru)
MX (1) MX2008014977A (ru)
NZ (1) NZ572773A (ru)
SI (1) SI2395018T1 (ru)
WO (1) WO2007141274A2 (ru)

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MX2008014977A (es) 2008-12-05
US8211431B2 (en) 2012-07-03
EP2027155A2 (en) 2009-02-25
JP5959576B2 (ja) 2016-08-02
US20120141493A1 (en) 2012-06-07
AU2007255384B2 (en) 2012-09-27
SI2395018T1 (sl) 2016-06-30
WO2007141274A2 (en) 2007-12-13
IL195675A (en) 2015-04-30
EA201201650A1 (ru) 2013-09-30
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EP2395018A1 (en) 2011-12-14
IL195675A0 (en) 2011-08-01
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US20090104204A1 (en) 2009-04-23
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CA2654712A1 (en) 2007-12-13
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