EA200602290A1 - Лиганды crth2 рецептора и их применение - Google Patents

Лиганды crth2 рецептора и их применение

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Publication number
EA200602290A1
EA200602290A1 EA200602290A EA200602290A EA200602290A1 EA 200602290 A1 EA200602290 A1 EA 200602290A1 EA 200602290 A EA200602290 A EA 200602290A EA 200602290 A EA200602290 A EA 200602290A EA 200602290 A1 EA200602290 A1 EA 200602290A1
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EA
Eurasian Patent Office
Prior art keywords
ring
monocyclic heteroaryl
membered
application
heteroaryl ring
Prior art date
Application number
EA200602290A
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English (en)
Other versions
EA014729B1 (ru
Inventor
Тронд Ульвен
Томас Фримурер
Эйстейн Рист
Эви Костенис
Томас Хёгберг
Жан - Мари Ресевё
Мари Гримструп
Original Assignee
7ТиЭм ФАРМА А/С
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Priority claimed from GB0412198A external-priority patent/GB0412198D0/en
Priority claimed from GB0414196A external-priority patent/GB0414196D0/en
Priority claimed from GB0424018A external-priority patent/GB0424018D0/en
Application filed by 7ТиЭм ФАРМА А/С filed Critical 7ТиЭм ФАРМА А/С
Publication of EA200602290A1 publication Critical patent/EA200602290A1/ru
Publication of EA014729B1 publication Critical patent/EA014729B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Urology & Nephrology (AREA)
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Abstract

Соединения формулы (I) пригодны для лечения болезни, отвечающей на модулирование активности CRTH2 рецептора, такой как астма, ринит, аллергический синдром дыхательных путей и аллергический ринобронхит, причём А обозначает карбоксильную группу -СООН или биоизостер карбоксила; Aобозначает водород или метил; кольцо Arобозначает возможно замещённое фенильное кольцо, 5- или 6-членное моноциклическое гетероарильное кольцо, в котором AACHO- и L2 соединены со смежными атомами в кольце; кольца Ar, Ar, каждое независимо, обозначает фенил или 5- или 6-членное моноциклическое гетероарильное кольцо или бициклическую кольцевую систему, состоящую из 5- или 6-членного карбоциклического или гетероциклического кольца, которое является бензконденсированным или конденсированным с 5- или 6-членным моноциклическим гетероарильным кольцом, причём указанное кольцо или кольцевая система могут быть замещены; t равен 0 или 1; L2 и L3 обозначают линкеры, определённые в описании.
EA200602290A 2004-05-29 2005-05-30 Лиганды crth2 рецептора и их применение EA014729B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0412198A GB0412198D0 (en) 2004-05-29 2004-05-29 Medicinal use of receptor ligands
GB0414196A GB0414196D0 (en) 2004-06-24 2004-06-24 Medicinal use of receptor ligands
GB0424018A GB0424018D0 (en) 2004-10-29 2004-10-29 Medicinal use of receptor ligands
PCT/EP2005/005884 WO2005115382A1 (en) 2004-05-29 2005-05-30 Crth2 receptor ligands for medicinal uses

Publications (2)

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EA200602290A1 true EA200602290A1 (ru) 2007-06-29
EA014729B1 EA014729B1 (ru) 2011-02-28

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US (2) US8022063B2 (ru)
EP (2) EP2336113A1 (ru)
JP (1) JP2008500991A (ru)
KR (1) KR20070045153A (ru)
AU (1) AU2005247110B2 (ru)
BR (1) BRPI0511676A (ru)
CA (1) CA2568766A1 (ru)
CR (1) CR8838A (ru)
EA (1) EA014729B1 (ru)
HK (1) HK1107763A1 (ru)
IL (1) IL179694A (ru)
MX (1) MXPA06013912A (ru)
NO (1) NO20066048L (ru)
NZ (1) NZ551810A (ru)
WO (1) WO2005115382A1 (ru)

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US20090099189A1 (en) 2009-04-16
CR8838A (es) 2009-01-12
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US8022063B2 (en) 2011-09-20
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