DE69739733D1 - 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors - Google Patents

1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors

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Publication number
DE69739733D1
DE69739733D1 DE69739733T DE69739733T DE69739733D1 DE 69739733 D1 DE69739733 D1 DE 69739733D1 DE 69739733 T DE69739733 T DE 69739733T DE 69739733 T DE69739733 T DE 69739733T DE 69739733 D1 DE69739733 D1 DE 69739733D1
Authority
DE
Germany
Prior art keywords
group
alkyl
disorders
general formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739733T
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English (en)
Inventor
Lene Teuber
Frank Waetjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
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Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE69739733D1 publication Critical patent/DE69739733D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69739733T 1996-10-21 1997-10-21 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors Expired - Lifetime DE69739733D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115796 1996-10-21
PCT/DK1997/000462 WO1998017651A1 (en) 1996-10-21 1997-10-21 1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators

Publications (1)

Publication Number Publication Date
DE69739733D1 true DE69739733D1 (de) 2010-02-25

Family

ID=8101649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739733T Expired - Lifetime DE69739733D1 (de) 1996-10-21 1997-10-21 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors

Country Status (13)

Country Link
US (3) US6218547B1 (de)
EP (1) EP0934281B1 (de)
JP (1) JP2001502675A (de)
CN (1) CN1115336C (de)
AT (1) ATE454375T1 (de)
AU (1) AU726447B2 (de)
CA (1) CA2267114A1 (de)
CZ (1) CZ127299A3 (de)
DE (1) DE69739733D1 (de)
NZ (1) NZ334868A (de)
RU (1) RU2194699C2 (de)
SK (1) SK42499A3 (de)
WO (1) WO1998017651A1 (de)

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AU726447B2 (en) * 1996-10-21 2000-11-09 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
EP1017682A4 (de) * 1997-09-26 2000-11-08 Merck & Co Inc Neue angiogenese-inhibitoren
AU1224499A (en) * 1997-12-09 1999-06-28 Neurosearch A/S Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds
EP1097918A4 (de) * 1998-07-15 2003-04-02 Meiji Seika Kaisha Verfahren zur herstellung 4-substituierter-2-nitro-fluorbenzole
AU764479B2 (en) * 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
US6358949B1 (en) 1999-04-02 2002-03-19 Neurogen Corporation Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors
US6627624B1 (en) 1999-04-02 2003-09-30 Neurogen Corporation Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6281237B1 (en) 1999-04-02 2001-08-28 Neurogen Corporation N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
US6380210B1 (en) 1999-04-02 2002-04-30 Neurogen Corporation Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
MXPA01009949A (es) * 1999-04-02 2003-07-14 Neurogen Corp Derivados aminoalquil-imidazol arilo y heteroarilo fusionados, moduladores selectivos de los receptores gaba a.
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
WO2000078728A1 (en) 1999-06-22 2000-12-28 Neurosearch A/S Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
AU2002221566A1 (en) * 2000-12-20 2002-07-01 Neurosearch A/S Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders
EA007475B1 (ru) * 2001-12-20 2006-10-27 Х. Лундбекк А/С Производные арилоксифенила и арилсульфанилфенила
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
AU2004226179A1 (en) 2003-04-03 2004-10-14 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABA-a receptor complex
DE602004011914T2 (de) * 2003-04-03 2008-06-12 Neurosearch A/S Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
DE602004013299T2 (de) * 2003-04-10 2009-06-25 Neurosearch A/S Neue benzimidazolderivative und ihre pharmazeutische zusammensetzungen
BRPI0413746A (pt) * 2003-08-21 2006-10-24 Osi Pharm Inc composto ou um seu n-óxido ou seu sal farmaceuticamente aceitável, composição, e, método de tratamento de distúrbio hiperproliferativo
JP2007509108A (ja) * 2003-10-23 2007-04-12 アクゾ ノベル ナムローゼ フェンノートシャップ １，５，７−三置換ベンズイミダゾール誘導体及びｇａｂａａ受容体複合体を調節するためのその使用
EP1680120A2 (de) * 2003-11-03 2006-07-19 Probiodrug AG Zusammenstellungen zur behandlung von neuronalen erkrankungen
WO2005121132A1 (ja) * 2004-06-11 2005-12-22 Shionogi & Co., Ltd. 抗ｈｃｖ作用を有する縮合ヘテロ環化合物
EP1877052B1 (de) * 2005-04-13 2009-07-22 Neurosearch A/S Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes
WO2006111517A1 (en) * 2005-04-19 2006-10-26 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US20090062304A1 (en) * 2005-04-19 2009-03-05 Lene Teuber Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex
EP1874758A1 (de) * 2005-04-19 2008-01-09 Neurosearch A/S Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes
EP1937265A2 (de) * 2005-08-19 2008-07-02 Aventis Pharmaceuticals Inc. Kombination aus einem hypnotischen mittel und r(+)-alpha-(2,3-dimethoxy-phenyl)-1-[2-(4-fluorphenl)ethyl]-4-piperidinmethanol und ihre therapeutische anwendung
CA2617980A1 (en) * 2005-08-19 2007-03-01 Aventis Pharmaceuticals Inc. Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
DE602006010602D1 (de) * 2005-12-05 2009-12-31 Neurosearch As Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes
AU2007223036A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TWI391381B (zh) 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
RU2451017C2 (ru) * 2007-03-01 2012-05-20 Мицубиси Танабе Фарма Корпорейшн Бензимидазольное соединение и его фармацевтическое применение
EP2172454A4 (de) 2007-07-24 2010-12-08 Astellas Pharma Inc Benzimidazolderivat
US20110282066A1 (en) 2009-01-27 2011-11-17 Takashi Furutani Screening method for substance useful as agent for treating prostate cancer
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8222246B2 (en) * 2009-04-02 2012-07-17 Hoffmann-La Roche Inc. Substituted isoxazoles
WO2020065642A1 (en) 2018-09-25 2020-04-02 Pepticom Ltd. Positive allosteric modulators of gabaa receptor

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DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation
US5554630A (en) * 1993-03-24 1996-09-10 Neurosearch A/S Benzimidazole compounds
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AU726447B2 (en) * 1996-10-21 2000-11-09 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators

Also Published As

Publication number Publication date
US6710044B2 (en) 2004-03-23
EP0934281B1 (de) 2010-01-06
AU726447B2 (en) 2000-11-09
SK42499A3 (en) 2000-05-16
AU4616197A (en) 1998-05-15
EP0934281A1 (de) 1999-08-11
US20030166638A1 (en) 2003-09-04
ATE454375T1 (de) 2010-01-15
RU2194699C2 (ru) 2002-12-20
CN1234025A (zh) 1999-11-03
CZ127299A3 (cs) 1999-09-15
WO1998017651A1 (en) 1998-04-30
NZ334868A (en) 2001-02-23
CA2267114A1 (en) 1998-04-30
US6218547B1 (en) 2001-04-17
CN1115336C (zh) 2003-07-23
JP2001502675A (ja) 2001-02-27
US6503925B1 (en) 2003-01-07

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