EA200601773A1 - Тетраазабензо[е]азуленовые производные и их аналоги - Google Patents

Тетраазабензо[е]азуленовые производные и их аналоги

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Publication number
EA200601773A1
EA200601773A1 EA200601773A EA200601773A EA200601773A1 EA 200601773 A1 EA200601773 A1 EA 200601773A1 EA 200601773 A EA200601773 A EA 200601773A EA 200601773 A EA200601773 A EA 200601773A EA 200601773 A1 EA200601773 A1 EA 200601773A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetraazabenzo
analogues
azulene derivatives
compounds
azulene
Prior art date
Application number
EA200601773A
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English (en)
Other versions
EA010888B1 (ru
Inventor
Кимберли О'Киф Камерон
Ричард Луис Эллиотт
Марлис Хаммонд
Original Assignee
Пфайзер Продактс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Пфайзер Продактс, Инк. filed Critical Пфайзер Продактс, Инк.
Publication of EA200601773A1 publication Critical patent/EA200601773A1/ru
Publication of EA010888B1 publication Critical patent/EA010888B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Это изобретение относится к агонистам рецептора холецистокинина-А (ССК-А) формулы (I)где R-R, А, В, X, D, Е и G являются такими, как определено в описании, а также, между прочим, к фармацевтическим композициям, содержащим соединения, и способам применения соединений и композиций. Соединения являются полезными в лечении ожирения.
EA200601773A 2004-05-25 2005-05-13 Тетраазабензо[е]азуленовые производные и их аналоги EA010888B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57403304P 2004-05-25 2004-05-25
PCT/IB2005/001469 WO2005116034A1 (en) 2004-05-25 2005-05-13 Tetraazabenzo[e]azulene derivatives and analogs thereof

Publications (2)

Publication Number Publication Date
EA200601773A1 true EA200601773A1 (ru) 2007-06-29
EA010888B1 EA010888B1 (ru) 2008-12-30

Family

ID=34967684

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601773A EA010888B1 (ru) 2004-05-25 2005-05-13 Тетраазабензо[е]азуленовые производные и их аналоги

Country Status (26)

Country Link
US (2) US7265104B2 (ru)
EP (1) EP1753766A1 (ru)
JP (1) JP4069159B2 (ru)
CN (1) CN1950374A (ru)
AP (1) AP2006003768A0 (ru)
AR (1) AR049187A1 (ru)
AU (1) AU2005247693A1 (ru)
BR (1) BRPI0510273A (ru)
CA (1) CA2568056A1 (ru)
CR (1) CR8753A (ru)
EA (1) EA010888B1 (ru)
EC (1) ECSP067025A (ru)
GE (1) GEP20094723B (ru)
GT (1) GT200500119A (ru)
IL (1) IL178220A0 (ru)
MA (1) MA28605B1 (ru)
NL (1) NL1029105C2 (ru)
NO (1) NO20064288L (ru)
PA (1) PA8634101A1 (ru)
PE (1) PE20060363A1 (ru)
SV (1) SV2006002127A (ru)
TN (1) TNSN06386A1 (ru)
TW (1) TWI297688B (ru)
UA (1) UA84208C2 (ru)
UY (1) UY28915A1 (ru)
WO (1) WO2005116034A1 (ru)

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AP2006003768A0 (en) 2006-10-31
AU2005247693A1 (en) 2005-12-08
US7265104B2 (en) 2007-09-04
TWI297688B (en) 2008-06-11
JP4069159B2 (ja) 2008-04-02
GT200500119A (es) 2006-01-12
US7358242B2 (en) 2008-04-15
NL1029105A1 (nl) 2005-11-30
SV2006002127A (es) 2006-02-15
US20070265193A1 (en) 2007-11-15
PE20060363A1 (es) 2006-05-08
MA28605B1 (fr) 2007-05-02
UA84208C2 (en) 2008-09-25
JP2008500326A (ja) 2008-01-10
CR8753A (es) 2006-12-13
PA8634101A1 (es) 2006-06-02
WO2005116034A1 (en) 2005-12-08
TW200609235A (en) 2006-03-16
NL1029105C2 (nl) 2006-06-13
ECSP067025A (es) 2006-12-29
IL178220A0 (en) 2006-12-31
TNSN06386A1 (fr) 2008-02-22
CN1950374A (zh) 2007-04-18
BRPI0510273A (pt) 2007-10-30
AR049187A1 (es) 2006-07-05
CA2568056A1 (en) 2005-12-08
US20050267100A1 (en) 2005-12-01
UY28915A1 (es) 2005-12-30
NO20064288L (no) 2006-10-23
EA010888B1 (ru) 2008-12-30
EP1753766A1 (en) 2007-02-21

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