EA200501421A1 - Пероральная композиция инсулина и способы её изготовления и применения - Google Patents

Пероральная композиция инсулина и способы её изготовления и применения

Info

Publication number
EA200501421A1
EA200501421A1 EA200501421A EA200501421A EA200501421A1 EA 200501421 A1 EA200501421 A1 EA 200501421A1 EA 200501421 A EA200501421 A EA 200501421A EA 200501421 A EA200501421 A EA 200501421A EA 200501421 A1 EA200501421 A1 EA 200501421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
insulin
manufacture
methods
application
oral composition
Prior art date
Application number
EA200501421A
Other languages
English (en)
Inventor
Владимир Андреевич САБЕЦКИЙ
Original Assignee
Дзе Текнолоджи Девелопмент Компани Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Текнолоджи Девелопмент Компани Лтд. filed Critical Дзе Текнолоджи Девелопмент Компани Лтд.
Publication of EA200501421A1 publication Critical patent/EA200501421A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Способ снижения уровня глюкозы крови у млекопитающего включает пероральное введение терапевтически эффективного количества кристаллизованных микрочастиц декстрана и инсулина млекопитающему для снижения уровня глюкозы в крови млекопитающего. Композиция может представлять собой однофазную или структурированную многофазную композицию для регулируемого высвобождения инсулина.
EA200501421A 2003-03-04 2004-03-04 Пероральная композиция инсулина и способы её изготовления и применения EA200501421A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45124503P 2003-03-04 2003-03-04
US46760103P 2003-05-05 2003-05-05
US46901703P 2003-05-09 2003-05-09
US49509703P 2003-08-15 2003-08-15
PCT/IB2004/000933 WO2004078196A1 (en) 2003-03-04 2004-03-04 Oral insulin composition and methods of making and using thereof

Publications (1)

Publication Number Publication Date
EA200501421A1 true EA200501421A1 (ru) 2006-04-28

Family

ID=32831112

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200501421A EA200501421A1 (ru) 2003-03-04 2004-03-04 Пероральная композиция инсулина и способы её изготовления и применения
EA200501422A EA200501422A1 (ru) 2003-03-04 2004-03-04 Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения
EA200501420A EA200501420A1 (ru) 2003-03-04 2004-03-04 Устройство доставки для лекарственной и клеточной терапии

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA200501422A EA200501422A1 (ru) 2003-03-04 2004-03-04 Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения
EA200501420A EA200501420A1 (ru) 2003-03-04 2004-03-04 Устройство доставки для лекарственной и клеточной терапии

Country Status (17)

Country Link
US (5) US20040234615A1 (ru)
EP (3) EP1454630B1 (ru)
JP (3) JP2006519252A (ru)
KR (3) KR20060014027A (ru)
AR (1) AR046485A1 (ru)
AT (1) ATE485051T1 (ru)
AU (3) AU2004216908A1 (ru)
BR (3) BRPI0408105A (ru)
CA (3) CA2518143A1 (ru)
DE (1) DE602004029630D1 (ru)
EA (3) EA200501421A1 (ru)
EC (3) ECSP056077A (ru)
MX (1) MXPA05009493A (ru)
NO (3) NO20054539L (ru)
PT (1) PT1454630E (ru)
TW (1) TW200529869A (ru)
WO (3) WO2004078196A1 (ru)

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KR20200062092A (ko) 2020-05-11 2020-06-03 김용원 수차와 공기 컴프레서를 이용한 공기 터빈구조 발전기와 바퀴구조 발전기를 합한 발전기
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KR20210055643A (ko) 2021-04-27 2021-05-17 김용원 모터가 장착된 회전축에 다량의 회전자바퀴와 다량의 고정자바퀴발전기를 설치한 전동보드
KR20210072739A (ko) 2021-05-27 2021-06-17 김용원 의료용 전동보드
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CN115702880B (zh) * 2021-08-12 2023-11-03 山东新时代药业有限公司 一种重组甘精胰岛素注射液及其制备工艺
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KR20220056159A (ko) 2022-04-04 2022-05-04 김용원 물탱크 내의 스팀집 슈퍼히터에 전력공급한 스팀공급으로 스팀터빈을 구동하는 것과 슈퍼히터로 스팀을 공급하는 스팀청소기에 발전기들을 설치하는 것과 공기터빈의 흡입구들의 공기필터들 설치와 펠티에소자를 이용한 냉온 공기배출과 얼음제조기 시스템
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