ECSP056077A - Composición de insulina oral y métodos de fabricación y uso de estos - Google Patents

Composición de insulina oral y métodos de fabricación y uso de estos

Info

Publication number
ECSP056077A
ECSP056077A EC2005006077A ECSP056077A ECSP056077A EC SP056077 A ECSP056077 A EC SP056077A EC 2005006077 A EC2005006077 A EC 2005006077A EC SP056077 A ECSP056077 A EC SP056077A EC SP056077 A ECSP056077 A EC SP056077A
Authority
EC
Ecuador
Prior art keywords
composition
manufacture
methods
mammal
oral insulin
Prior art date
Application number
EC2005006077A
Other languages
English (en)
Inventor
Vladimir Sabetsky
Original Assignee
Technology Dev Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technology Dev Company filed Critical Technology Dev Company
Publication of ECSP056077A publication Critical patent/ECSP056077A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Un método para reducir la glucosa sanguínea en un mamífero incluye administrar oralmente una cantidad terapéuticamente efectiva de micropartículas de dextrán cristalizada e insulina al mamífero para reducir la glucosa sanguínea del mamífero. La composición puede ser una fase o una composición multi-fase estructurada para liberación controlada de insulina.
EC2005006077A 2003-03-04 2005-10-04 Composición de insulina oral y métodos de fabricación y uso de estos ECSP056077A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45124503P 2003-03-04 2003-03-04
US46760103P 2003-05-05 2003-05-05
US46901703P 2003-05-09 2003-05-09
US49509703P 2003-08-15 2003-08-15

Publications (1)

Publication Number Publication Date
ECSP056077A true ECSP056077A (es) 2006-08-30

Family

ID=32831112

Family Applications (3)

Application Number Title Priority Date Filing Date
EC2005006077A ECSP056077A (es) 2003-03-04 2005-10-04 Composición de insulina oral y métodos de fabricación y uso de estos
EC2005006078A ECSP056078A (es) 2003-03-04 2005-10-04 Composición de insulina inyectable de acción prolongada y métodos de fabricación y uso del mismo
EC2005006076A ECSP056076A (es) 2003-03-04 2005-10-04 Sistema de suministro para droga y terapia celular

Family Applications After (2)

Application Number Title Priority Date Filing Date
EC2005006078A ECSP056078A (es) 2003-03-04 2005-10-04 Composición de insulina inyectable de acción prolongada y métodos de fabricación y uso del mismo
EC2005006076A ECSP056076A (es) 2003-03-04 2005-10-04 Sistema de suministro para droga y terapia celular

Country Status (17)

Country Link
US (5) US20040234615A1 (es)
EP (3) EP1454630B1 (es)
JP (3) JP2006519252A (es)
KR (3) KR20060014027A (es)
AR (1) AR046485A1 (es)
AT (1) ATE485051T1 (es)
AU (3) AU2004216908A1 (es)
BR (3) BRPI0408105A (es)
CA (3) CA2518143A1 (es)
DE (1) DE602004029630D1 (es)
EA (3) EA200501421A1 (es)
EC (3) ECSP056077A (es)
MX (1) MXPA05009493A (es)
NO (3) NO20054539L (es)
PT (1) PT1454630E (es)
TW (1) TW200529869A (es)
WO (3) WO2004078196A1 (es)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7339033B2 (en) * 1998-06-26 2008-03-04 Genentech, Inc. Pro1481
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
CA2479751C (en) 2002-03-20 2008-06-03 Trent Poole Inhalation apparatus
KR20060014027A (ko) * 2003-03-04 2006-02-14 더 테크놀로지 디벨로프먼트 컴퍼니 리미티드 지속성의 주사용 인슐린 조성물 및 그 제조방법 및사용방법
PL2107069T3 (pl) * 2003-08-05 2013-06-28 Novo Nordisk As Nowe pochodne insuliny
TW200603843A (en) * 2004-04-20 2006-02-01 Technology Dev Company Ltd Tissue enhancement implant and method
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
FR2880272A1 (fr) * 2005-01-04 2006-07-07 Jean Marc Ruiz Preparation contenant des microparticules d'un sel de polymere insoluble portant un principe actif, ainsi que son procede de fabrication
US8932633B2 (en) * 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
ES2640282T3 (es) * 2005-09-14 2017-11-02 Mannkind Corporation Método de formulación de fármacos basado en el aumento de la afinidad de superficies de micropartículas cristalinas para agentes activos
WO2007074133A2 (en) * 2005-12-28 2007-07-05 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
SE0600091L (sv) * 2006-01-18 2007-04-17 Bows Pharmaceuticals Ag Förfarande för framställning av en dextranmatris för kontrollerad frisättning av insulin
CN101389348A (zh) 2006-02-22 2009-03-18 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
EP2069062A2 (en) * 2006-10-06 2009-06-17 The President and Fellows of Harvard College Chemically-directed electrostatic self-assembly of materials
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
EP2025334A1 (en) * 2007-07-25 2009-02-18 OctoPlus Sciences B.V. Sustained release drug delivery system for repeated administration
RU2468832C2 (ru) 2008-06-13 2012-12-10 Маннкайнд Корпорейшн Ингалятор для сухого порошка и система для доставки лекарственных средств
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN102065942B (zh) 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
FR2940802A1 (fr) * 2008-10-10 2010-07-09 Adocia Complexe entre l'insuline humaine et un polymere amphiphile et utilisation de ce complexe pour la preparation d'une formulation d'insuline humaine rapide.
PT2349324T (pt) 2008-10-17 2017-12-06 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
US9603904B2 (en) * 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
FR2943538B1 (fr) * 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
JP5859433B2 (ja) 2009-06-12 2016-02-10 マンカインド コーポレイション 規定された比表面積を有するジケトピペラジン微粒子
US9068182B2 (en) * 2009-07-28 2015-06-30 Corning Incorporated Synthetic polysaccharide microcarriers for culturing cells
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
EP2498801B1 (de) 2009-11-13 2018-01-24 Sanofi-Aventis Deutschland GmbH HARMAZEUTISCHE ZUSAMMENSETZUNG UMFASSEND desPro36Exendin-4(1-39)-Lys6-NH2 UND METHIONIN
EP3417871B1 (de) 2009-11-13 2020-12-23 Sanofi-Aventis Deutschland GmbH Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
JP6385673B2 (ja) 2010-06-21 2018-09-05 マンカインド コーポレイション 乾燥粉末薬物送達システム
CA2809321C (en) 2010-08-30 2018-08-14 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
BR122020008875B8 (pt) 2011-04-01 2022-12-06 Mannkind Corp Embalagem de bolha e método de fabricação de uma embalagem de bolhas
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US10143754B2 (en) * 2011-08-07 2018-12-04 Transgene Biotek Limited Method for peroral delivery of insulin and its analogues for therapeutic usage
AU2012300978B2 (en) 2011-08-29 2017-04-27 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9157939B2 (en) * 2012-08-09 2015-10-13 Infineon Technologies Ag System and device for determining electric voltages
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
ES2670969T3 (es) 2012-11-13 2018-06-04 Adocia Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido
KR102391750B1 (ko) 2013-03-15 2022-04-28 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
KR102180215B1 (ko) 2013-04-03 2020-11-18 사노피 장시간-작용 제형의 인슐린에 의한 당뇨병의 치료
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
JP6200698B2 (ja) * 2013-06-18 2017-09-20 ニュートリー株式会社 嚥下造影検査食
JP6491658B2 (ja) 2013-07-18 2019-03-27 マンカインド コーポレイション 熱安定性乾燥粉末医薬組成物及び方法
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
RU2014120626A (ru) * 2014-05-22 2015-11-27 Владимир Андреевич Сабецкий Инсулинсодержащий препарат пролонгированного действия
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN105617362B (zh) * 2014-10-27 2021-05-11 中国医学科学院药物研究所 一种新型的胰岛素－磷脂－壳聚糖自组装微粒载体及其制剂
LT3229828T (lt) 2014-12-12 2023-06-12 Sanofi-Aventis Deutschland Gmbh Insulino glargino/liksisenatido fiksuoto santykio kompozicija
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
US10660941B2 (en) 2016-02-19 2020-05-26 Indian Institute Of Technology, Bombay Orally administrable pharmaceutical preparation containing protein
RU2647466C1 (ru) * 2016-12-01 2018-03-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) Способ получения нативного белка пролонгирующего действия в составе полимерных наносфер и резорбируемых микросфер для доставки
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
KR20200056359A (ko) 2020-04-29 2020-05-22 김용원 퀵보드 등 승용기구바퀴(회전자)에 설치되는 바퀴덮개(고정자)에 설치하는 발전기
KR20200056360A (ko) 2020-04-29 2020-05-22 김용원 자전거바퀴(회전자)와 바퀴덮개(고정자)에 설치하는 발전기
KR20200056361A (ko) 2020-05-04 2020-05-22 김용원 발판보드에 설치하는 발전기
KR20200060307A (ko) 2020-05-06 2020-05-29 김용원 자전거와 리어 캐리어에 설치하는 발전장치들
KR20200060308A (ko) 2020-05-07 2020-05-29 김용원 수상보드에 설치하는 발전기
KR20200060309A (ko) 2020-05-08 2020-05-29 김용원 헬스차량에 설치하는 발전기
KR20200061324A (ko) 2020-05-11 2020-06-02 김용원 보트에 설치하는 발전기
KR20200062092A (ko) 2020-05-11 2020-06-03 김용원 수차와 공기 컴프레서를 이용한 공기 터빈구조 발전기와 바퀴구조 발전기를 합한 발전기
KR20200068614A (ko) 2020-05-26 2020-06-15 김용원 펠티어소자를 이용한 공기, 물 컨디션너 조절장치 내에 설치한 발전기
KR20200083393A (ko) 2020-06-16 2020-07-08 김용원 "공기 터빈구조 발전기"와 "바퀴구조를 합한 발전기"를 "발열소자를 이용한 발전기"와 적용 양방향 모터(양방향 프로펠러)를 양방향공기추진기(Propullor)와 결합 장착한 드론
KR20200088241A (ko) 2020-06-30 2020-07-22 김용원 역방향 모터(양방향 프로펠러)의 추진에 맞는 관성을 이기는 팬이 없는 양방향공기추진기(Propullor)를 장착한 드론
KR20200108392A (ko) 2020-08-31 2020-09-18 김용원 전동 오토바이 모터의 정격에 맞는 오토바이바퀴에 회전자와 물받이 고정자 발전기를 설치한 오토바이에 모터가 장착된 항공기 공기추진기(Propulsor)와 장착한 드론의 프로퓰러(Propullor)를 장착하는 제조기술)
KR20210018367A (ko) 2021-01-26 2021-02-17 김용원 전동 오토바이에 설치한 모터가 장착된 항공기 공기추진기와 장착한 프로퓰러(Propullor)로 구성한 오토에어크라프트(Autoaircraft)
KR20210029730A (ko) 2021-02-22 2021-03-16 김용원 산사태에 대비, 대응하는 에어 레이어들 블록들이 형성된 거대장비들(에어 레이어들 블록들)
KR20210040852A (ko) 2021-03-24 2021-04-14 김용원 전동에어버스
KR20210043513A (ko) 2021-03-26 2021-04-21 김용원 전동에어버스에 설치하는 연기(분연), 재 포집장치
KR20210045369A (ko) 2021-03-31 2021-04-26 김용원 전기 에어 카
KR20210049046A (ko) 2021-04-13 2021-05-04 김용원 전기에어버스를 강풍, 태풍에 구조하는 보조날개와 보조출입문 장치
KR20210055643A (ko) 2021-04-27 2021-05-17 김용원 모터가 장착된 회전축에 다량의 회전자바퀴와 다량의 고정자바퀴발전기를 설치한 전동보드
KR20210072739A (ko) 2021-05-27 2021-06-17 김용원 의료용 전동보드
KR20210080293A (ko) 2021-06-11 2021-06-30 김용원 바퀴 사이 발전기 케이스
CN115702880B (zh) * 2021-08-12 2023-11-03 山东新时代药业有限公司 一种重组甘精胰岛素注射液及其制备工艺
KR20220016234A (ko) 2022-01-14 2022-02-08 김용원 공기추진기(공기펌프와 공기터빈)를 장착한 3륜 자전거
KR20220038026A (ko) 2022-02-24 2022-03-25 김용원 4합 공기터빈 : 공기터빈 축에 1. 인너 팬들의 인너 실린더와 2. 아웃터 팬들의 아웃터 실린더와 3. 양쪽 1. 인너 실린더들과 2. 아웃터 실린더들의 사이에 아웃터 팬들에 덕트팬들과 덕트흡입구와 4 1. 인너 실린더들과 2. 아웃터 실린더들의 사이에 아웃터 팬들의 3. 덕트팬들에 블레이드와 블레이드 외부 형틀
KR20220056159A (ko) 2022-04-04 2022-05-04 김용원 물탱크 내의 스팀집 슈퍼히터에 전력공급한 스팀공급으로 스팀터빈을 구동하는 것과 슈퍼히터로 스팀을 공급하는 스팀청소기에 발전기들을 설치하는 것과 공기터빈의 흡입구들의 공기필터들 설치와 펠티에소자를 이용한 냉온 공기배출과 얼음제조기 시스템
KR20220056835A (ko) 2022-04-18 2022-05-06 김용원 공기추진기(공기펌프와 여러 공기터빈들)들을 장착한 수상 자전거
KR20220076421A (ko) 2022-05-11 2022-06-08 김용원 공기추진기(공기펌프와 공기터빈들)들을 장착한 페달자전차
KR20220080053A (ko) 2022-05-27 2022-06-14 김용원 다중 에어 레이어 튜브보트
KR20240124228A (ko) * 2023-02-08 2024-08-16 주식회사 인벤테라 정맥오염 없는 림프관 조영제

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204244L (sv) * 1982-07-09 1984-01-10 Ulf Schroder Kristalliserad kolhydratsmatris for biologiskt aktiva substanser
US4713249A (en) * 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
US4963526A (en) * 1984-05-09 1990-10-16 Synthetic Blood Corporation Oral insulin and a method of making the same
WO1987002704A1 (en) 1985-10-22 1987-05-07 Eric Robinson Process for cell immobilisation
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
USRE37950E1 (en) * 1990-04-24 2002-12-31 Atrix Laboratories Biogradable in-situ forming implants and methods of producing the same
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5840290A (en) * 1996-05-30 1998-11-24 University Of Florida Research Foundation Injectable bio-active glass in a dextran suspension
US5783556A (en) * 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
US6395302B1 (en) * 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
SI0941068T1 (en) * 1996-11-19 2004-10-31 Octoplus B.V. Controlled release microspheres
EP0842657A1 (en) * 1996-11-19 1998-05-20 OctoPlus B.V. Microspheres for controlled release and processes to prepare these microspheres
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
JP2001509419A (ja) * 1997-07-10 2001-07-24 ユーエスバイオマテリアルズ コーポレイション 成形可能な生物活性組成物
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US20020054914A1 (en) * 1999-02-03 2002-05-09 Tulin Morcol Compositions and methods for therapuetic agents complexed with calcium phosphate and encased by casein
JP4865947B2 (ja) * 1999-02-19 2012-02-01 ウニフェルシテイト ユトレヒト ステレオコンプレックスヒドロゲル
FR2794649B1 (fr) * 1999-06-11 2003-04-11 Solutions Biomateriau a base d'un derive de dextrane insolubilise et d'un facteur de croissance, son procede de preparation et ses applications
AU773990B2 (en) * 1999-09-27 2004-06-10 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins, hormones and hormone receptors
EP1184032A1 (en) * 2000-08-31 2002-03-06 OctoPlus B.V. Dextran hydrogels
FR2814951B1 (fr) * 2000-10-06 2003-01-17 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
CA2429100A1 (en) 2000-11-16 2002-05-23 Jagotec Ag Parenterally administrable microparticles
GB2374010B (en) * 2001-02-26 2004-12-29 Council Scient Ind Res Novel vitamin B12 - biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines
NZ519403A (en) * 2001-06-21 2005-03-24 Pfizer Prod Inc Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels
KR20060014027A (ko) * 2003-03-04 2006-02-14 더 테크놀로지 디벨로프먼트 컴퍼니 리미티드 지속성의 주사용 인슐린 조성물 및 그 제조방법 및사용방법
SE0600091L (sv) * 2006-01-18 2007-04-17 Bows Pharmaceuticals Ag Förfarande för framställning av en dextranmatris för kontrollerad frisättning av insulin

Also Published As

Publication number Publication date
EA200501422A1 (ru) 2006-04-28
JP2006519253A (ja) 2006-08-24
ECSP056076A (es) 2006-08-30
KR20060015472A (ko) 2006-02-17
EP1454630B1 (en) 2010-10-20
US20040234615A1 (en) 2004-11-25
KR20060015469A (ko) 2006-02-17
NO20054539D0 (no) 2005-10-03
US20110097385A1 (en) 2011-04-28
CA2518143A1 (en) 2004-09-16
EP1603589A1 (en) 2005-12-14
WO2004078198A1 (en) 2004-09-16
EA200501421A1 (ru) 2006-04-28
US7544656B2 (en) 2009-06-09
WO2004078196A1 (en) 2004-09-16
BRPI0408100A (pt) 2006-03-01
EP1454631A1 (en) 2004-09-08
PT1454630E (pt) 2010-12-15
US20100166855A1 (en) 2010-07-01
TW200529869A (en) 2005-09-16
AU2004216911A1 (en) 2004-09-16
DE602004029630D1 (de) 2010-12-02
BRPI0408105A (pt) 2006-03-01
KR20060014027A (ko) 2006-02-14
AU2004216909A1 (en) 2004-09-16
JP2006519252A (ja) 2006-08-24
CA2518148A1 (en) 2004-09-16
US20100167985A1 (en) 2010-07-01
WO2004078197A1 (en) 2004-09-16
EP1454630A1 (en) 2004-09-08
ATE485051T1 (de) 2010-11-15
US20040234616A1 (en) 2004-11-25
AU2004216908A1 (en) 2004-09-16
NO20054534D0 (no) 2005-10-03
NO20054534L (no) 2005-11-29
NO20054539L (no) 2005-12-01
AR046485A1 (es) 2005-12-14
MXPA05009493A (es) 2006-08-11
NO20054533D0 (no) 2005-10-03
BRPI0408097A (pt) 2006-02-14
EA200501420A1 (ru) 2006-04-28
CA2518136A1 (en) 2004-09-16
NO20054533L (no) 2005-12-02
JP2006519840A (ja) 2006-08-31
ECSP056078A (es) 2006-08-30

Similar Documents

Publication Publication Date Title
ECSP056077A (es) Composición de insulina oral y métodos de fabricación y uso de estos
CY2016031I2 (el) Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων
CL2007003609A1 (es) Compuestos derivados de dihidropiridinas sustituidas; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; proceso para producir la composicion farmaceutica; y uso en el tratamiento de una enfermedad mejorada con la inhibicion
AR034900A1 (es) Uso de una cantidad eficaz de un inhibidor de pde4 y un agente anticolinergico, bien en forma combinada sola o por separado, composiciones farmaceuticas que los comprenden, metodo para prepararlas, y uso de una composicion que comprende una cantidad eficaz de un inhibidor de pde4, una cantidad efica
AR068185A1 (es) Composiciones de tabletas de desintegracion oral de lamotrigina
AR047779A1 (es) Composiciones y metodos para tratar diabetes
EE200400029A (et) Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks
AR052854A1 (es) Metodo para reducir la inflamacion del tejido oral utilizando extracto de magnolia
NI200800169A (es) Uso de derivados de sulfamidas heterocíclicas benzo-fusionadas para el tratamiento del dolor
CO6270217A2 (es) Formulaciones galenicas de alisquireno y valsartan
EA200702102A1 (ru) Пластинки, содержащие стероидные гормоны
AR065581A1 (es) Mejoras en composiciones medicinales o relativas a las mismas
UY29445A1 (es) Composiciones para la transmisión transmucosa oral de la metformina
HUP0300709A2 (hu) Pemetrexedet monotioglikollal, L-ciszteinnel vagy tioglikolsavval együtt tartalmazó gyógyászati készítmény
AR022621A1 (es) Composicion farmaceutica que contiene desoxipeganina para el tratamiento de la dependencia de la nicotina
ITMI20021866A1 (it) Preparazione farmaceutica in forma colloidale utile nella cura delle affezioni cutanee.
CR8059A (es) Composicion farmaceutica en forma de hidrogel para administracion transdermica de sustancias activas
PA8800601A1 (es) Productos quimioterapeuticos cristalinos
ATE466574T1 (de) Verfahren und zusammensetzungen zur oralen fts- abgabe
CO6410284A2 (es) Composición farmacéutica oral para uso en enfermedades respiratorias
WO2002053099A3 (en) Methods and compositions for treating periodontal disease
BR0313305A (pt) Agente analgésico para indivìduos recém-nascidos ou fetais
AR030660A1 (es) Composicion farmaceutica para la prevencion o el tratamiento de una enfermedad asociada con un exceso de la produccion de il-12
WO2004069272A3 (en) Adjuvant combination for use in the immunization of a mamal comprising il2 and il12
ATE477021T1 (de) 1,3,5-triazepin-dionen zur behandlung von malaria