EA199800278A1 - Пентациклические соединения, промежуточные соединения, способы, композиции и методы - Google Patents

Пентациклические соединения, промежуточные соединения, способы, композиции и методы

Info

Publication number
EA199800278A1
EA199800278A1 EA199800278A EA199800278A EA199800278A1 EA 199800278 A1 EA199800278 A1 EA 199800278A1 EA 199800278 A EA199800278 A EA 199800278A EA 199800278 A EA199800278 A EA 199800278A EA 199800278 A1 EA199800278 A1 EA 199800278A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
methods
pyrrolidinyl
compounds
formula
Prior art date
Application number
EA199800278A
Other languages
English (en)
Other versions
EA001649B1 (ru
Inventor
Тимоти А. Гриз
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199800278A1 publication Critical patent/EA199800278A1/ru
Publication of EA001649B1 publication Critical patent/EA001649B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)

Abstract

Данное изобретение относится к соединениям формулы (I) и (II), где Х обозначает -O-, -S- или -NR-; Y обозначает -O-, -S-, -CH-, -CHCH-, -CH=CH- или -NR-; B обозначает -CH- или -CO-; R, Rи Rобозначают, каждый независимо, -H, -OH, -O(C-Cалкил), -OCOCH, -OCO(C-Cалкил), -OSO(C-Cалкил), -OSOF, Cl или F; n равно 1 или 2; W обозначает CHили C=O; Rобозначает 1-пиперидинил, 2-оксо-1-пиперидинил, 1-пирролидинил, метил-1-пирролидинил, диметил-1-пирролидинил, 2-оксо-1-пирролидинил, 4-морфолино, диметиламино, диэтиламино или 1-гексаметиленимино; Rобозначает C-Cалкил, -COCH, -CO(C-Cалкил), -C(O)OCH, -C(O)O(C-Cалкил), -SO(C-Cалкил), -SOCHили -SOCF; или их фармацевтически приемлемые соли. Данное изобретение также представляет промежуточные соединения, способы получения соединений формулы (I) и (II) и фармацевтические способы и лекарственные формы с использованием соединений формулы (I) и (II).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800278A 1995-09-08 1996-08-26 Четырехциклические конденсированные соединения с гетероатомами, замещенные арилом, промежуточные соединения, способы получения, композиции и методы лечения EA001649B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US349695P 1995-09-08 1995-09-08
PCT/US1996/013778 WO1997009044A1 (en) 1995-09-08 1996-08-26 Pentacyclic compounds, intermediates, processes, compositions, and methods

Publications (2)

Publication Number Publication Date
EA199800278A1 true EA199800278A1 (ru) 1998-08-27
EA001649B1 EA001649B1 (ru) 2001-06-25

Family

ID=21706148

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800278A EA001649B1 (ru) 1995-09-08 1996-08-26 Четырехциклические конденсированные соединения с гетероатомами, замещенные арилом, промежуточные соединения, способы получения, композиции и методы лечения

Country Status (25)

Country Link
US (3) US5726186A (ru)
EP (1) EP0761669B1 (ru)
JP (1) JP3688299B2 (ru)
KR (1) KR19990044422A (ru)
CN (1) CN1201392A (ru)
AT (1) ATE197712T1 (ru)
AU (1) AU705454B2 (ru)
BR (1) BR9610356A (ru)
CA (1) CA2230974A1 (ru)
CZ (1) CZ286236B6 (ru)
DE (1) DE69611015T2 (ru)
DK (1) DK0761669T3 (ru)
EA (1) EA001649B1 (ru)
ES (1) ES2152496T3 (ru)
GR (1) GR3035253T3 (ru)
HU (1) HUP9802213A3 (ru)
IL (1) IL123560A (ru)
MX (1) MX9801734A (ru)
NO (1) NO980936L (ru)
NZ (1) NZ318183A (ru)
PL (1) PL325479A1 (ru)
PT (1) PT761669E (ru)
SI (1) SI0761669T1 (ru)
TR (1) TR199800387T1 (ru)
WO (1) WO1997009044A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU6277396A (en) * 1995-06-07 1996-12-30 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
AR021719A1 (es) * 1998-12-18 2002-07-31 Schering Corp Composicion farmaceutica oral antiestrogenica.
US7105679B2 (en) 2001-12-19 2006-09-12 Kanojia Ramesh M Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
US7329654B2 (en) * 2001-12-19 2008-02-12 Janssen Pharmaceutica N.V. Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
JP2005538091A (ja) 2002-07-24 2005-12-15 イーライ・リリー・アンド・カンパニー ジヒドロ−ベンゾ［ｂ，ｅ］オキセピンに基づく選択的エストロゲン受容体調節物質、組成物および方法
EP1551822B1 (en) 2002-07-24 2006-12-20 Eli Lilly And Company Pentacyclic oxepines and derivatives thereof, process for their preparation and pharmaceutical compositions containing them
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク Ｘ線回折による応力測定法
US7119206B2 (en) 2002-09-25 2006-10-10 Eli Lilly And Company Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
US7074779B2 (en) * 2003-07-02 2006-07-11 Ortho-Mcneil Pharmaceutical, Inc. Estrieno[3,2-b]/[3,4-c]pyrrole derivatives useful as modulators of the estrogen receptors
WO2005073244A1 (en) * 2004-01-22 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
JP4909086B2 (ja) * 2004-01-22 2012-04-04 イーライ リリー アンド カンパニー 血管運動性症候の治療のための選択的エストロゲン受容体モジュレーター
CN1910167B (zh) * 2004-01-22 2011-08-10 伊莱利利公司 用于治疗血管舒缩症状的选择性雌激素受体调节剂
MX2012014579A (es) 2010-06-16 2013-05-22 Endorech Inc Procedimientos de tratamiento o pevencion de enfermedades relacionadas con estrogenos.
KR102021162B1 (ko) 2011-11-01 2019-09-11 메르크 파텐트 게엠베하 유기 전계발광 소자
US8829993B2 (en) 2012-10-30 2014-09-09 Eta Devices, Inc. Linearization circuits and methods for multilevel power amplifier systems
CN109678878A (zh) * 2019-02-27 2019-04-26 陕西科技大学 一种苯并噻吩并香豆素类化合物及其合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2884427A (en) * 1958-01-22 1959-04-28 Oliver H Emerson Synthesis of coumestrol and its esters
US2987398A (en) * 1958-05-12 1961-06-06 Emanuel M Bickoff Coumestrol ethers and use thereof
US3912740A (en) * 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4659671A (en) * 1983-07-01 1987-04-21 Massachusetts Institute Of Technology Enzymatic separation of racemic mixtures of hydroxy compounds
CA2054569A1 (en) * 1990-11-07 1992-05-08 Masanobu Suzuki Process for preparing benzo¬c|phenanthridinium derivatives, and novel compounds prepared by said process
US5147880A (en) * 1991-07-22 1992-09-15 Eli Lilly And Company Benzo[a]fluorene compounds
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5336687A (en) * 1993-08-04 1994-08-09 American Home Products Corporation Inhibition of bone loss by 4-aryloxy-5-hydroxy-2(5H)-furanones

Also Published As

Publication number Publication date
AU6959096A (en) 1997-03-27
MX9801734A (es) 1998-08-30
KR19990044422A (ko) 1999-06-25
EA001649B1 (ru) 2001-06-25
TR199800387T1 (xx) 1998-05-21
SI0761669T1 (en) 2001-04-30
ES2152496T3 (es) 2001-02-01
EP0761669B1 (en) 2000-11-22
CN1201392A (zh) 1998-12-09
CA2230974A1 (en) 1997-03-13
DE69611015D1 (de) 2000-12-28
WO1997009044A1 (en) 1997-03-13
AU705454B2 (en) 1999-05-20
EP0761669A2 (en) 1997-03-12
JP3688299B2 (ja) 2005-08-24
NZ318183A (en) 1998-09-24
BR9610356A (pt) 1999-07-06
CZ286236B6 (cs) 2000-02-16
US6133288A (en) 2000-10-17
DK0761669T3 (da) 2000-12-11
IL123560A (en) 2002-02-10
CZ67898A3 (cs) 1998-06-17
PT761669E (pt) 2001-04-30
JPH11514347A (ja) 1999-12-07
US6004971A (en) 1999-12-21
GR3035253T3 (en) 2001-04-30
DE69611015T2 (de) 2001-05-10
IL123560A0 (en) 1998-10-30
HUP9802213A2 (hu) 1999-02-01
NO980936L (no) 1998-05-07
NO980936D0 (no) 1998-03-04
EP0761669A3 (en) 1997-10-29
ATE197712T1 (de) 2000-12-15
US5726186A (en) 1998-03-10
HUP9802213A3 (en) 2000-03-28
PL325479A1 (en) 1998-07-20

Similar Documents

Publication Publication Date Title
EA199800278A1 (ru) Пентациклические соединения, промежуточные соединения, способы, композиции и методы
KR890016046A (ko) 2-치환-4-치환-1,3-디옥솔란, 이의 합성 및 이의 용도
YU61595A (sh) Nova naftilna jedinjenja, njihovi intermedijeri farmaceutske kompozicije, i postupci za dobijanje tih jedinjenja
SE8301412L (sv) Substituerade 1h-pyrazolo(1,5)pyrimidiner och forfarande for deras framstellning
KR900018064A (ko) 피라닐 시아노구아니딘 유도체
SE8307133L (sv) Karboxamidoderivat av 5h-1,3,4-tiadiazolo/3,2-a/pyrimider och forfarande for deras framstellning
SE8403801D0 (sv) Nya bensotiazepiner med kardiovaskuler anvendbarhet, forfarande for framstellning derav och farmaceutiska kompositioner som innehaller dem
SE7606847L (sv) 10-/3(4-(p-fluorobenzoyl)piperidinyl)propyl/fenotiaziner
EA199900238A1 (ru) Нафтильные соединения, промежуточные соединения, препараты и способы применения
DK37580A (da) 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater samt deres fremstilling og anvendelse
NO159379C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye bicyklo (4.2.0)1,3,5-oktatrienderivater.
NO164017C (no) Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive bicyclo-(4.2.0)-octanderivater.
PT88338A (pt) Process for the manufacture of imidazo-benzodiazepines and of pharmaceutical compositions containing the same
SE8103983L (sv) Heterocykliska foreningar, deras framstellning och farmaceutiska kompositioner innehallande dessa
YU34296A (en) Use a compounds for medicament obtaining and pharmaceutical composition thereof
DK534280A (da) Fremgangsmaade til fremstilling af tyrosinderivater
FI912733A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten /(1-aryylipyrrolidin-2-yyli)metyyli/piperatsiinijohdannaisten valmistamiseksi
FI841408A0 (fi) Foerfarande foer framstaellning av 4- acetyl-2-substituerade-imidazoler och i foerfarandet anvaenda mellanproduk mellanprodukter.
AU547599B2 (en) Tricyclic compounds
FI864248A (fi) Kinazolinderivat och foerfarande foer deras framstaellning.
RS49886B (sr) Benzotiofenska jedinjenja, intermedijari, kompozicije i metode
SE8306048L (sv) Nya heterocykliska ettiksyror och forfarande for framstellning derav
FI933205A (fi) Tiatsolietanolijohdannaisia, menetelmä niiden valmistamiseksi ja niiden välituotteet
RU96104250A (ru) Бензопираны

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU