EA038695B1 - Способы и композиции для переноса генов по сосудистой сети - Google Patents

Способы и композиции для переноса генов по сосудистой сети Download PDF

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Publication number
EA038695B1
EA038695B1 EA201991911A EA201991911A EA038695B1 EA 038695 B1 EA038695 B1 EA 038695B1 EA 201991911 A EA201991911 A EA 201991911A EA 201991911 A EA201991911 A EA 201991911A EA 038695 B1 EA038695 B1 EA 038695B1
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amino acid
seq
aav
capsid protein
acid sequence
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EA201991911A
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Russian (ru)
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EA201991911A1 (ru
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Аравинд Асокан
Гиридхар Мурлидхаран
Блейк Олбрайт
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Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл
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Publication of EA201991911A1 publication Critical patent/EA201991911A1/ru
Publication of EA038695B1 publication Critical patent/EA038695B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14011Parvoviridae
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145Special targeting system for viral vectors

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
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  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EA201991911A 2017-02-15 2018-02-15 Способы и композиции для переноса генов по сосудистой сети EA038695B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762459286P 2017-02-15 2017-02-15
PCT/US2018/018381 WO2018152333A1 (en) 2017-02-15 2018-02-15 Methods and compositions for gene transfer across the vasculature

Publications (2)

Publication Number Publication Date
EA201991911A1 EA201991911A1 (ru) 2020-02-20
EA038695B1 true EA038695B1 (ru) 2021-10-06

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EA201991911A EA038695B1 (ru) 2017-02-15 2018-02-15 Способы и композиции для переноса генов по сосудистой сети

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US (2) US11905312B2 (https=)
EP (1) EP3583220A4 (https=)
JP (2) JP7291397B2 (https=)
KR (1) KR20190117571A (https=)
CN (2) CN118978574A (https=)
AU (1) AU2018221738B2 (https=)
BR (1) BR112019016769A2 (https=)
CA (1) CA3052829A1 (https=)
EA (1) EA038695B1 (https=)
IL (2) IL312788A (https=)
MX (1) MX2019009720A (https=)
SG (1) SG11201907298WA (https=)
WO (1) WO2018152333A1 (https=)

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WO2004027019A2 (en) * 2002-05-01 2004-04-01 University Of Florida Research Foundation, Inc. Improved raav expression systems for genetic modification of specific capsid proteins

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WO2018152333A9 (en) 2019-01-24
EP3583220A1 (en) 2019-12-25
JP2020505936A (ja) 2020-02-27
IL312788A (en) 2024-07-01
EA201991911A1 (ru) 2020-02-20
JP7574508B2 (ja) 2024-10-29
KR20190117571A (ko) 2019-10-16
BR112019016769A2 (pt) 2020-05-26
US11905312B2 (en) 2024-02-20
IL268534A (en) 2019-09-26
JP7291397B2 (ja) 2023-06-15
CA3052829A1 (en) 2018-08-23
JP2023052541A (ja) 2023-04-11
AU2018221738B2 (en) 2024-06-27
SG11201907298WA (en) 2019-09-27
AU2018221738A1 (en) 2019-08-22
WO2018152333A1 (en) 2018-08-23
MX2019009720A (es) 2019-10-07
CN110520536A (zh) 2019-11-29
CN118978574A (zh) 2024-11-19
IL268534B1 (en) 2024-06-01
US20240209031A1 (en) 2024-06-27
IL268534B2 (en) 2024-10-01
US20190367562A1 (en) 2019-12-05
EP3583220A4 (en) 2021-07-07
CN110520536B (zh) 2024-07-09

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