EA034980B1 - Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот, способы их получения и применения - Google Patents
Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот, способы их получения и применения Download PDFInfo
- Publication number
- EA034980B1 EA034980B1 EA201400151A EA201400151A EA034980B1 EA 034980 B1 EA034980 B1 EA 034980B1 EA 201400151 A EA201400151 A EA 201400151A EA 201400151 A EA201400151 A EA 201400151A EA 034980 B1 EA034980 B1 EA 034980B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- epa
- biomass
- less
- fraction
- fatty acids
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
- C12N1/125—Unicellular algae isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/89—Algae ; Processes using algae
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161510464P | 2011-07-21 | 2011-07-21 | |
| PCT/US2012/047728 WO2013013208A2 (en) | 2011-07-21 | 2012-07-20 | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201400151A1 EA201400151A1 (ru) | 2014-10-30 |
| EA034980B1 true EA034980B1 (ru) | 2020-04-14 |
Family
ID=47558749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201400151A EA034980B1 (ru) | 2011-07-21 | 2012-07-20 | Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции жирных кислот, способы их получения и применения |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9045785B2 (enExample) |
| EP (4) | EP4585049A2 (enExample) |
| JP (3) | JP6338285B2 (enExample) |
| KR (2) | KR102038715B1 (enExample) |
| CN (3) | CN104011217B (enExample) |
| AR (1) | AR087944A1 (enExample) |
| AU (2) | AU2012285803B2 (enExample) |
| BR (2) | BR122015020130A2 (enExample) |
| CA (1) | CA2842374C (enExample) |
| CL (2) | CL2014000156A1 (enExample) |
| DK (1) | DK3050972T3 (enExample) |
| EA (1) | EA034980B1 (enExample) |
| ES (2) | ES2774778T3 (enExample) |
| IL (1) | IL230500B (enExample) |
| MX (2) | MX351174B (enExample) |
| MY (1) | MY169454A (enExample) |
| PH (1) | PH12014500169B1 (enExample) |
| SG (1) | SG10201605966TA (enExample) |
| WO (1) | WO2013013208A2 (enExample) |
| ZA (2) | ZA201400620B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3125443B2 (ja) | 1992-07-02 | 2001-01-15 | 石川島播磨重工業株式会社 | 偏平ブロー成形装置 |
| JP3118954B2 (ja) | 1992-05-14 | 2000-12-18 | 石川島播磨重工業株式会社 | 偏平ブロー成形装置 |
| JP3196326B2 (ja) | 1992-06-22 | 2001-08-06 | 石川島播磨重工業株式会社 | 偏平ブロー成形装置 |
| JP3196316B2 (ja) | 1992-05-20 | 2001-08-06 | 石川島播磨重工業株式会社 | ブロー成形装置 |
| JP3196323B2 (ja) | 1992-06-09 | 2001-08-06 | 石川島播磨重工業株式会社 | 偏平ブロー成形機のパリソン皺矯正装置 |
| WO2011090493A1 (en) | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| HK1198515A1 (en) | 2011-07-21 | 2015-05-15 | Dsm Ip Assets B.V. | Fatty acid compositions |
| US9587215B2 (en) | 2014-08-07 | 2017-03-07 | General Electric Company | Devices, systems and methods for automated transfer of a sample |
| FI3200604T4 (fi) | 2014-10-02 | 2025-07-29 | Evonik Operations Gmbh | Menetelmä rehun valmistamiseksi |
| ES2870093T3 (es) | 2014-10-02 | 2021-10-26 | Evonik Operations Gmbh | Biomasa que contiene PUFA con estabilidad celular elevada y su empleo para la producción de piensos |
| CA2958439C (en) | 2014-10-02 | 2022-09-20 | Evonik Industries Ag | Feedstuff of high abrasion resistance and good stability in water, containing pufas |
| ES2873094T3 (es) * | 2014-10-02 | 2021-11-03 | Evonik Operations Gmbh | Procedimiento para la producción de un pienso que contiene PUFAs mediante extrusión de una biomasa que contiene PUFAs de tipo Labyrinthulomycetes |
| CN104962589B (zh) * | 2015-08-05 | 2019-02-26 | 嘉必优生物技术（武汉）股份有限公司 | 一种富含磷脂型多不饱和脂肪酸的微生物油脂及制备方法 |
| US20190300818A1 (en) * | 2016-07-13 | 2019-10-03 | Evonik Degussa Gmbh | Method for isolating lipids from lipid-containing cells |
| KR102405390B1 (ko) | 2016-07-13 | 2022-06-03 | 에보닉 오퍼레이션스 게엠베하 | 용해된 지질을 함유하는 바이오매스로부터 지질을 분리하는 방법 |
| JP2019530577A (ja) | 2016-08-19 | 2019-10-24 | ノーブルジェン・インコーポレーテッド | 金属イオンを結合させるための方法及び溶解有機物画分の使用 |
| CN110462014A (zh) | 2016-12-27 | 2019-11-15 | 赢创德固赛有限公司 | 从含有脂质的生物质中分离脂质的方法 |
| JP2020516768A (ja) | 2017-04-07 | 2020-06-11 | ノーブルジェン・インコーポレーテッド | 金属を結合するための方法並びにカプセル化された滲出物及び乾燥ユーグレナ（ｅｕｇｌｅｎａ）バイオマスの使用 |
| EP3470502A1 (en) | 2017-10-13 | 2019-04-17 | Evonik Degussa GmbH | Method of separating lipids from a lysed lipids containing biomass |
| EP3527664A1 (en) | 2018-02-15 | 2019-08-21 | Evonik Degussa GmbH | Method of isolating lipids from a lipids containing biomass |
| DK3794097T3 (da) | 2018-05-15 | 2024-12-16 | Evonik Operations Gmbh | Fremgangsmåde til isolering af lipider fra en lipid-indeholdende biomasse ved hjælp af hydrofob silica |
| WO2019219396A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion |
| US20210277430A1 (en) * | 2020-03-09 | 2021-09-09 | Lanzatech, Inc. | Fermentation process for the production of lipids |
| WO2023144707A1 (en) | 2022-01-25 | 2023-08-03 | Dsm Ip Assets B.V. | Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production |
| CN115927005B (zh) * | 2022-10-14 | 2024-11-22 | 广西中医药大学 | 两面针内生真菌y118的固体发酵培养基及其制备和培养方法 |
| CN116479063B (zh) * | 2023-05-04 | 2024-02-20 | 厦门汇盛生物有限公司 | 一种ω-3多不饱和脂肪酸的生产方法 |
| WO2025019424A1 (en) * | 2023-07-14 | 2025-01-23 | Dsm Ip Assets B.V. | Microbial oils having high epa content and methods of making the same |
| CN118755584B (zh) * | 2024-08-06 | 2025-04-29 | 杭州合碳创物科技有限公司 | 一种高产epa的裂殖壶菌及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607900B2 (en) * | 2000-01-28 | 2003-08-19 | Martek Biosciences Boulder Corporation | Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors |
| US7005280B2 (en) * | 1988-09-07 | 2006-02-28 | Martek Biosciences Corporation | Method of producing lipids by growing microorganisms of the order thraustochytriales |
| US20100285105A1 (en) * | 2006-08-01 | 2010-11-11 | Helia Radianingtyas | Oil producing microbes adn method of modification thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130242A (en) | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| CA2164291C (en) * | 1993-06-09 | 2007-10-30 | David John Kyle | Methods and pharmaceutical compositions useful for treating neurological disorders |
| AU5346296A (en) | 1995-04-17 | 1996-11-07 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms |
| US6255505B1 (en) * | 1996-03-28 | 2001-07-03 | Gist-Brocades, B.V. | Microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| JP2001512029A (ja) | 1997-08-01 | 2001-08-21 | マーテック・バイオサイエンスィズ・コーポレーション | Ｄｈａ含有栄養組成物およびそれらの製造方法 |
| RU2336307C2 (ru) | 2000-01-19 | 2008-10-20 | Мартек Биосайнсис Корпорейшн | Способ получения липидов (варианты) и липиды, полученные этим способом |
| US6410282B1 (en) * | 2000-03-30 | 2002-06-25 | Council Of Scientific And Industrial Research | Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid fungi |
| DE10102337A1 (de) * | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
| US20040203120A1 (en) * | 2002-03-22 | 2004-10-14 | Council Of Scientific And Industrial Research | Method for enhancing levels of polyunsaturated fatty acids in thraustochytrid protists |
| JP4280158B2 (ja) | 2002-12-27 | 2009-06-17 | 富士フイルム株式会社 | ドコサヘキサエン酸生産能を有する微生物及びその利用 |
| US20050019880A1 (en) * | 2003-03-31 | 2005-01-27 | Council Of Scientific And Industrial Research | Method of enhancing levels of polyunsaturated fatty acids in thraustochytrid protists |
| KR101167331B1 (ko) * | 2003-12-30 | 2012-07-19 | 디에스엠 아이피 어셋츠 비.브이. | 탈기 방법 |
| DK1756280T3 (en) * | 2004-04-22 | 2015-02-02 | Commw Scient Ind Res Org | SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS |
| EA023523B1 (ru) * | 2007-08-31 | 2016-06-30 | Мартек Биосайнсиз Корпорейшн | Твердые жировые композиции, содержащие полиненасыщенные жирные кислоты, и способы их получения и использования |
| CA2698289A1 (en) * | 2007-09-11 | 2009-03-19 | Sapphire Energy, Inc. | Methods of producing organic products with photosynthetic organisms and products and compositions thereof |
| CN101874117A (zh) * | 2007-09-12 | 2010-10-27 | 马太克生物科学公司 | 生物油及其制备与应用 |
| US20090117253A1 (en) * | 2007-10-03 | 2009-05-07 | E. I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| NZ703725A (en) * | 2009-03-19 | 2017-06-30 | Dsm Ip Assets Bv | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| CN103068965A (zh) * | 2009-12-28 | 2013-04-24 | Dsmip资产公司 | 在蔗糖上生长的重组破囊壶菌和其组合物、制备方法及用途 |
| WO2011090493A1 (en) * | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| WO2011133610A1 (en) * | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| US8769868B2 (en) * | 2010-06-09 | 2014-07-08 | Photonz Corporation Limited | Compositions comprising eicosapentaenoic acid suitable for high purification |
| US20140323569A1 (en) * | 2011-07-21 | 2014-10-30 | Krishna Raman | Microbial oils enriched in polyunsaturated fatty acids |
-
2012
- 2012-07-20 CN CN201280035935.2A patent/CN104011217B/zh active Active
- 2012-07-20 PH PH1/2014/500169A patent/PH12014500169B1/en unknown
- 2012-07-20 EP EP25170782.4A patent/EP4585049A2/en active Pending
- 2012-07-20 ES ES12815192T patent/ES2774778T3/es active Active
- 2012-07-20 KR KR1020147004428A patent/KR102038715B1/ko active Active
- 2012-07-20 BR BR122015020130A patent/BR122015020130A2/pt not_active Application Discontinuation
- 2012-07-20 EP EP15171724.6A patent/EP3050972B1/en active Active
- 2012-07-20 DK DK15171724.6T patent/DK3050972T3/da active
- 2012-07-20 WO PCT/US2012/047728 patent/WO2013013208A2/en not_active Ceased
- 2012-07-20 AR ARP120102657A patent/AR087944A1/es unknown
- 2012-07-20 SG SG10201605966TA patent/SG10201605966TA/en unknown
- 2012-07-20 EP EP12815192.5A patent/EP2734630B1/en active Active
- 2012-07-20 MX MX2014000759A patent/MX351174B/es active IP Right Grant
- 2012-07-20 AU AU2012285803A patent/AU2012285803B2/en active Active
- 2012-07-20 MX MX2017012687A patent/MX385408B/es unknown
- 2012-07-20 CN CN202411870122.6A patent/CN119899748A/zh active Pending
- 2012-07-20 JP JP2014521849A patent/JP6338285B2/ja not_active Expired - Fee Related
- 2012-07-20 CN CN201510526715.5A patent/CN105255738B/zh active Active
- 2012-07-20 BR BR112014001443-4A patent/BR112014001443B1/pt active IP Right Grant
- 2012-07-20 EP EP20207686.5A patent/EP3831952A1/en active Pending
- 2012-07-20 CA CA2842374A patent/CA2842374C/en active Active
- 2012-07-20 KR KR1020197019037A patent/KR102158437B1/ko active Active
- 2012-07-20 ES ES15171724T patent/ES2859752T3/es active Active
- 2012-07-20 MY MYPI2014700130A patent/MY169454A/en unknown
- 2012-07-20 EA EA201400151A patent/EA034980B1/ru not_active IP Right Cessation
- 2012-07-20 US US13/554,975 patent/US9045785B2/en active Active
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2014
- 2014-01-16 IL IL230500A patent/IL230500B/en active IP Right Grant
- 2014-01-21 CL CL2014000156A patent/CL2014000156A1/es unknown
- 2014-01-24 ZA ZA2014/00620A patent/ZA201400620B/en unknown
- 2014-12-10 US US14/566,500 patent/US20150094382A1/en not_active Abandoned
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2015
- 2015-04-23 ZA ZA2015/02764A patent/ZA201502764B/en unknown
- 2015-04-28 US US14/698,378 patent/US20150223492A1/en not_active Abandoned
- 2015-05-07 CL CL2015001217A patent/CL2015001217A1/es unknown
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2016
- 2016-11-10 AU AU2016256769A patent/AU2016256769B2/en active Active
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2017
- 2017-05-18 US US15/598,812 patent/US20170245523A1/en not_active Abandoned
- 2017-05-22 JP JP2017100780A patent/JP2017200480A/ja active Pending
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2019
- 2019-11-07 JP JP2019202514A patent/JP7134938B2/ja active Active
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2021
- 2021-11-05 US US17/519,961 patent/US20220322705A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7005280B2 (en) * | 1988-09-07 | 2006-02-28 | Martek Biosciences Corporation | Method of producing lipids by growing microorganisms of the order thraustochytriales |
| US6607900B2 (en) * | 2000-01-28 | 2003-08-19 | Martek Biosciences Boulder Corporation | Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors |
| US20100285105A1 (en) * | 2006-08-01 | 2010-11-11 | Helia Radianingtyas | Oil producing microbes adn method of modification thereof |
Non-Patent Citations (3)
| Title |
|---|
| BARCLAY et al. "Heterotrophic production of long chain omega-3 fatty acids utilizing algae and algae-like microorganisms"; J. Appl. Phycology; April 1994; Vol. 6, No. 2; Pages 123-129, especially pg. 125, col. 1, para 3, pg. 126, col. 2 para 2. * |
| YAZAWA et al. "Production of eicosapentaenoic acid from marine bacteria"; Lipids; March 1996; Vol. 31, Suppl.; pg. S297-300, especially abstract, pg. S299 fig 3. * |
| YONGMANITCHAI et al. "Growth of and Omega-3 Fatty Acid Production by Phaeodactylum tricornutum under Different Culture Conditions"; Appl. Environ. Microbiol.; February 1991; Vol. 57, No. 2; Pages 419-425, especially pg. 421, col. 2, para 3, pg. 422, table 9. * |
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