EA030538B1 - Биарильное соединение, применяемое при лечении заболеваний человека в онкологии, неврологии и иммунологии - Google Patents

Биарильное соединение, применяемое при лечении заболеваний человека в онкологии, неврологии и иммунологии Download PDF

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Publication number
EA030538B1
EA030538B1 EA201691114A EA201691114A EA030538B1 EA 030538 B1 EA030538 B1 EA 030538B1 EA 201691114 A EA201691114 A EA 201691114A EA 201691114 A EA201691114 A EA 201691114A EA 030538 B1 EA030538 B1 EA 030538B1
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Eurasian Patent Office
Prior art keywords
btk
well
compound
dmso
inhibitor
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EA201691114A
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English (en)
Russian (ru)
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EA201691114A1 (ru
Inventor
Брайан Т. Хопкинс
Бинь Ма
Тимоти Рэймонд Чан
Лихун Сунь
Лэй Чжан
Гнанасамбандам Кумаравел
Джозеф П. Лиссикатос
Кевин Кох
Хуа Мяо
Original Assignee
Байоджен Ма Инк.
Сунезис Фармасьютикалз, Инк.
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Publication of EA201691114A1 publication Critical patent/EA201691114A1/ru
Publication of EA030538B1 publication Critical patent/EA030538B1/ru

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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EA201691114A 2013-12-11 2014-12-11 Биарильное соединение, применяемое при лечении заболеваний человека в онкологии, неврологии и иммунологии EA030538B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361914886P 2013-12-11 2013-12-11
PCT/US2014/069853 WO2015089337A1 (en) 2013-12-11 2014-12-11 Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology

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EA201691114A1 EA201691114A1 (ru) 2016-11-30
EA030538B1 true EA030538B1 (ru) 2018-08-31

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EA201691114A EA030538B1 (ru) 2013-12-11 2014-12-11 Биарильное соединение, применяемое при лечении заболеваний человека в онкологии, неврологии и иммунологии
EA201792348A EA037942B1 (ru) 2013-12-11 2014-12-11 Биарильные соединения, применяемые при лечении заболеваний человека в онкологии, неврологии и иммунологии

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US (4) US9809577B2 (https=)
EP (3) EP3080103B9 (https=)
JP (4) JP6431914B2 (https=)
KR (1) KR102413253B1 (https=)
CN (3) CN106459002B (https=)
AR (2) AR098721A1 (https=)
AU (2) AU2014362231B2 (https=)
BR (1) BR112016012860A2 (https=)
CA (1) CA2932608C (https=)
CL (2) CL2016001435A1 (https=)
CY (1) CY1120517T1 (https=)
DK (1) DK3080103T3 (https=)
EA (2) EA030538B1 (https=)
ES (1) ES2678021T3 (https=)
HR (1) HRP20181109T1 (https=)
HU (1) HUE040346T2 (https=)
IL (2) IL246031B (https=)
LT (1) LT3080103T (https=)
MX (2) MX388978B (https=)
MY (1) MY179781A (https=)
NZ (1) NZ721217A (https=)
PH (1) PH12016501107B1 (https=)
PL (1) PL3080103T3 (https=)
PT (1) PT3080103T (https=)
RS (1) RS57662B1 (https=)
SA (1) SA518391170B1 (https=)
SG (2) SG11201604595VA (https=)
SI (1) SI3080103T1 (https=)
SM (1) SMT201800373T1 (https=)
TW (3) TWI608002B (https=)
WO (1) WO2015089337A1 (https=)
ZA (1) ZA201706244B (https=)

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