EA029309B1 - Производные пиридин-4-ила в качестве агонистов s1p/edg1 - Google Patents
Производные пиридин-4-ила в качестве агонистов s1p/edg1 Download PDFInfo
- Publication number
- EA029309B1 EA029309B1 EA201500931A EA201500931A EA029309B1 EA 029309 B1 EA029309 B1 EA 029309B1 EA 201500931 A EA201500931 A EA 201500931A EA 201500931 A EA201500931 A EA 201500931A EA 029309 B1 EA029309 B1 EA 029309B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- ethyl
- methylphenoxy
- hydroxyacetamide
- compounds
- oxadiazol
- Prior art date
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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| PCT/IB2014/059794 WO2014141171A1 (en) | 2013-03-15 | 2014-03-14 | Pyridin-4-yl derivatives |
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| CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| ES2770348T3 (es) | 2015-05-20 | 2020-07-01 | Idorsia Pharmaceuticals Ltd | Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| WO2017004610A1 (en) * | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Tercyclic s1p3-sparing, s1p1 receptor agonists |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
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| WO2008029371A1 (en) * | 2006-09-07 | 2008-03-13 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
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| AU7686891A (en) | 1990-04-05 | 1991-10-30 | American National Red Cross, The | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| EP1070080A4 (en) | 1998-03-09 | 2004-12-29 | Smithkline Beecham Corp | HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND THEIR APPLICATIONS |
| AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
| MX2009002234A (es) | 2006-09-08 | 2009-03-16 | Actelion Pharmaceuticals Ltd | Derivados de piridin-3-il como agentes inmunomoduladores. |
| MX2009002915A (es) | 2006-09-21 | 2009-03-31 | Actelion Pharmaceuticals Ltd | Derivados de fenilo y su uso como inmunomoduladores. |
| NZ580454A (en) | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
| PT2195311E (pt) | 2007-08-17 | 2011-05-25 | Actelion Pharmaceuticals Ltd | Derivados de piridina como moduladores do receptor s1p1/edg1 |
| US8202865B2 (en) | 2007-10-04 | 2012-06-19 | Merck Serono Sa | Oxadiazole derivatives |
| CA2700917A1 (en) | 2007-11-01 | 2009-05-07 | Actelion Pharmaceuticals Ltd | Novel pyrimidine derivatives |
| JP2011513385A (ja) | 2008-03-06 | 2011-04-28 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピリミジン−ピリジン誘導体 |
| JP5411877B2 (ja) | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| CN102015695B (zh) | 2008-03-07 | 2014-08-27 | 埃科特莱茵药品有限公司 | 吡啶-2-基衍生物 |
| JP5481395B2 (ja) | 2008-03-07 | 2014-04-23 | アクテリオン ファーマシューティカルズ リミテッド | 新規なアミノメチルベンゼン誘導体 |
| AU2009258242B2 (en) * | 2008-05-14 | 2015-07-16 | The Scripps Research Institute | Novel modulators of sphingosine phosphate receptors |
| EP2403849B1 (en) | 2009-03-03 | 2014-07-16 | Merck Serono S.A. | Oxazole pyridine derivatives useful as S1P1 receptor agonists |
| SI2454255T1 (sl) | 2009-07-16 | 2014-01-31 | Actelion Pharmaceuticals Ltd. | Derivati piridin-4-ila kot agonisti s1p1/edg1 |
| TW201120016A (en) | 2009-12-08 | 2011-06-16 | Abbott Lab | Novel oxadiazole compounds |
| KR101869120B1 (ko) | 2011-01-19 | 2018-06-19 | 이도르시아 파마슈티컬스 리미티드 | 2-메톡시-피리딘-4-일 유도체 |
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| WO2008029371A1 (en) * | 2006-09-07 | 2008-03-13 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
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| Title |
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| HALE J J, DOHERTY G, TOTH L, MILLS S G, HAJDU R, KEOHANE C A, ROSENBACH M, MILLIGAN J, SHEI G J, CHREBET G, BERGSTROM J, CARD D, F: "Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 14, no. 13, 5 July 2004 (2004-07-05), AMSTERDAM, NL, pages 3501 - 3505, XP002718181, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2004.04.070 * |
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