CA2900910C - Pyridin-4-yl derivatives - Google Patents
Pyridin-4-yl derivatives Download PDFInfo
- Publication number
- CA2900910C CA2900910C CA2900910A CA2900910A CA2900910C CA 2900910 C CA2900910 C CA 2900910C CA 2900910 A CA2900910 A CA 2900910A CA 2900910 A CA2900910 A CA 2900910A CA 2900910 C CA2900910 C CA 2900910C
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- CA
- Canada
- Prior art keywords
- compound according
- ethyl
- diseases
- hydroxyacetamide
- oxadiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 100
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 10
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
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- GXTJJKTVNPGWLJ-IBGZPJMESA-N n-[(2s)-3-[2-ethyl-4-[5-(2-ethylpyridin-4-yl)-1,2,4-oxadiazol-3-yl]-6-methylphenoxy]-2-hydroxypropyl]-2-hydroxyacetamide Chemical compound C1=NC(CC)=CC(C=2ON=C(N=2)C=2C=C(CC)C(OC[C@@H](O)CNC(=O)CO)=C(C)C=2)=C1 GXTJJKTVNPGWLJ-IBGZPJMESA-N 0.000 claims 1
- BUMUZYJYGCXMOQ-IBGZPJMESA-N n-[(2s)-3-[2-ethyl-6-methyl-4-[5-(2-propan-2-ylpyridin-4-yl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxyacetamide Chemical compound CC1=C(OC[C@@H](O)CNC(=O)CO)C(CC)=CC(C=2N=C(ON=2)C=2C=C(N=CC=2)C(C)C)=C1 BUMUZYJYGCXMOQ-IBGZPJMESA-N 0.000 claims 1
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- FIZLCOHGMMUGTO-NRFANRHFSA-N n-[(2s)-3-[2-ethyl-6-methyl-4-[5-[2-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxyacetamide Chemical compound CC1=C(OC[C@@H](O)CNC(=O)CO)C(CC)=CC(C=2N=C(ON=2)C=2C=C(CC(C)C)N=CC=2)=C1 FIZLCOHGMMUGTO-NRFANRHFSA-N 0.000 claims 1
- PFJWQQDDQKRIRR-QFIPXVFZSA-N n-[(2s)-3-[2-ethyl-6-methyl-4-[5-[2-(3-methylbutyl)pyridin-4-yl]-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydroxyacetamide Chemical compound CC1=C(OC[C@@H](O)CNC(=O)CO)C(CC)=CC(C=2N=C(ON=2)C=2C=C(CCC(C)C)N=CC=2)=C1 PFJWQQDDQKRIRR-QFIPXVFZSA-N 0.000 claims 1
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- XRJPXSNXMMSPIZ-NRFANRHFSA-N n-[(2s)-3-[4-[5-(2-cyclopentylpyridin-4-yl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-2-hydroxypropyl]-2-hydroxyacetamide Chemical compound CC1=C(OC[C@@H](O)CNC(=O)CO)C(CC)=CC(C=2N=C(ON=2)C=2C=C(N=CC=2)C2CCCC2)=C1 XRJPXSNXMMSPIZ-NRFANRHFSA-N 0.000 claims 1
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Landscapes
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP13159482 | 2013-03-15 | ||
| EP13159482.2 | 2013-03-15 | ||
| PCT/IB2014/059794 WO2014141171A1 (en) | 2013-03-15 | 2014-03-14 | Pyridin-4-yl derivatives |
Publications (2)
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| CA2900910A1 CA2900910A1 (en) | 2014-09-18 |
| CA2900910C true CA2900910C (en) | 2021-03-30 |
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| CA2900910A Active CA2900910C (en) | 2013-03-15 | 2014-03-14 | Pyridin-4-yl derivatives |
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| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| US9200004B2 (en) | 2013-01-15 | 2015-12-01 | Incyte Holdings Corporation | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors |
| PE20160532A1 (es) | 2013-08-23 | 2016-05-21 | Incyte Corp | Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| PH12017502097B1 (en) | 2015-05-20 | 2023-05-05 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| WO2017004610A1 (en) * | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Tercyclic s1p3-sparing, s1p1 receptor agonists |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
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| AU7686891A (en) | 1990-04-05 | 1991-10-30 | American National Red Cross, The | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
| US6423508B1 (en) | 1998-03-09 | 2002-07-23 | Smithkline Beecham Corporation | Polynucleotide sequences of human EDG-1c |
| AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
| JP5253401B2 (ja) * | 2006-09-07 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−４−イル誘導体 |
| US8288554B2 (en) | 2006-09-08 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | Pyridin-3-yl derivatives as immunomodulating agents |
| WO2008035239A1 (en) | 2006-09-21 | 2008-03-27 | Actelion Pharmaceuticals Ltd | Phenyl derivatives and their use as immunomodulators |
| ES2450750T3 (es) | 2007-03-16 | 2014-03-25 | Actelion Pharmaceuticals Ltd. | Derivados de amino-piridina como agonistas del receptor S1P1/EDG1 |
| ATE502938T1 (de) | 2007-08-17 | 2011-04-15 | Actelion Pharmaceuticals Ltd | Pyridinderivate als s1p1/edg1-rezeptormodulatoren |
| US8202865B2 (en) | 2007-10-04 | 2012-06-19 | Merck Serono Sa | Oxadiazole derivatives |
| AR069146A1 (es) | 2007-11-01 | 2009-12-30 | Actelion Pharmaceuticals Ltd | Derivados de pirimidina, composicion farmaceutica que los comprende y el uso de esta para el tratamiento de enfermedades relacionadas con la activacion del sistema inmunitario. |
| US20110046170A1 (en) | 2008-03-06 | 2011-02-24 | Martin Bolli | Novel pyrimidine-pyridine derivatives |
| JP5411877B2 (ja) | 2008-03-06 | 2014-02-12 | アクテリオン ファーマシューティカルズ リミテッド | ピリジン化合物 |
| AU2009220893A1 (en) | 2008-03-07 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Novel aminomethyl benzene derivatives |
| HRP20130641T1 (en) | 2008-03-07 | 2013-08-31 | Actelion Pharmaceuticals Ltd. | Pyridin-2-yl derivatives as immunomodulating agents |
| ES2549761T3 (es) * | 2008-05-14 | 2015-11-02 | The Scripps Research Institute | Nuevos moduladores de los receptores de esfingosina fosfato |
| ES2517265T3 (es) | 2009-03-03 | 2014-11-03 | Merck Serono S.A. | Derivados de oxadiazol piridina |
| DK2454255T3 (da) | 2009-07-16 | 2013-12-16 | Actelion Pharmaceuticals Ltd | Pyridin-4-ylderivater som s1p1/edg1-agonister |
| TW201120016A (en) | 2009-12-08 | 2011-06-16 | Abbott Lab | Novel oxadiazole compounds |
| TWI546300B (zh) | 2011-01-19 | 2016-08-21 | 艾克泰聯製藥有限公司 | ２－甲氧基－吡啶－４－基衍生物 |
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2014
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- 2014-03-14 ES ES14715427.2T patent/ES2649475T3/es active Active
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- 2014-03-14 MA MA38482A patent/MA38482B1/fr unknown
- 2014-03-14 CA CA2900910A patent/CA2900910C/en active Active
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2015
- 2015-09-09 IL IL241363A patent/IL241363B/en active IP Right Grant
- 2015-09-11 CL CL2015002620A patent/CL2015002620A1/es unknown
- 2015-09-14 SA SA515361104A patent/SA515361104B1/ar unknown
- 2015-09-14 PH PH12015502118A patent/PH12015502118B1/en unknown
- 2015-10-14 ZA ZA2015/07657A patent/ZA201507657B/en unknown
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2017
- 2017-11-24 CY CY20171101239T patent/CY1119619T1/el unknown
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