UA115357C2 - Похідні піридин-4-ілу - Google Patents

Похідні піридин-4-ілу

Info

Publication number
UA115357C2
UA115357C2 UAA201510003A UAA201510003A UA115357C2 UA 115357 C2 UA115357 C2 UA 115357C2 UA A201510003 A UAA201510003 A UA A201510003A UA A201510003 A UAA201510003 A UA A201510003A UA 115357 C2 UA115357 C2 UA 115357C2
Authority
UA
Ukraine
Prior art keywords
pyridin
derivatives
compounds
formula
preparation
Prior art date
Application number
UAA201510003A
Other languages
English (en)
Ukrainian (uk)
Inventor
Мартін Боллі
Сірілл Лескоп
Олівер Найлер
Беат ШТАЙНЕР
Original Assignee
Ідорсія Фармасьютікалз Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ідорсія Фармасьютікалз Лтд filed Critical Ідорсія Фармасьютікалз Лтд
Publication of UA115357C2 publication Critical patent/UA115357C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
UAA201510003A 2013-03-15 2014-03-14 Похідні піридин-4-ілу UA115357C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13159482 2013-03-15
PCT/IB2014/059794 WO2014141171A1 (en) 2013-03-15 2014-03-14 Pyridin-4-yl derivatives

Publications (1)

Publication Number Publication Date
UA115357C2 true UA115357C2 (uk) 2017-10-25

Family

ID=47877933

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201510003A UA115357C2 (uk) 2013-03-15 2014-03-14 Похідні піридин-4-ілу

Country Status (33)

Country Link
US (1) US9617250B2 (enExample)
EP (1) EP2970236B1 (enExample)
JP (1) JP6387361B2 (enExample)
KR (1) KR102212975B1 (enExample)
CN (1) CN105189487B (enExample)
AR (1) AR095523A1 (enExample)
AU (1) AU2014229217B2 (enExample)
BR (1) BR112015023161B1 (enExample)
CA (1) CA2900910C (enExample)
CL (1) CL2015002620A1 (enExample)
CY (1) CY1119619T1 (enExample)
DK (1) DK2970236T3 (enExample)
EA (1) EA029309B1 (enExample)
ES (1) ES2649475T3 (enExample)
HR (1) HRP20171763T1 (enExample)
HU (1) HUE035154T2 (enExample)
IL (1) IL241363B (enExample)
LT (1) LT2970236T (enExample)
MA (1) MA38482B1 (enExample)
MX (1) MX363545B (enExample)
MY (1) MY173573A (enExample)
NO (1) NO2970236T3 (enExample)
NZ (1) NZ713080A (enExample)
PH (1) PH12015502118B1 (enExample)
PL (1) PL2970236T3 (enExample)
PT (1) PT2970236T (enExample)
SA (1) SA515361104B1 (enExample)
SG (1) SG11201507227UA (enExample)
SI (1) SI2970236T1 (enExample)
TW (1) TWI623534B (enExample)
UA (1) UA115357C2 (enExample)
WO (1) WO2014141171A1 (enExample)
ZA (1) ZA201507657B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
US9200004B2 (en) 2013-01-15 2015-12-01 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
PE20160532A1 (es) 2013-08-23 2016-05-21 Incyte Corp Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
PH12017502097B1 (en) 2015-05-20 2023-05-05 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
WO2017004610A1 (en) * 2015-07-02 2017-01-05 Exelixis, Inc. Tercyclic s1p3-sparing, s1p1 receptor agonists
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7686891A (en) 1990-04-05 1991-10-30 American National Red Cross, The A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
US6423508B1 (en) 1998-03-09 2002-07-23 Smithkline Beecham Corporation Polynucleotide sequences of human EDG-1c
AU2003279915A1 (en) 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
JP5253401B2 (ja) * 2006-09-07 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−４−イル誘導体
US8288554B2 (en) 2006-09-08 2012-10-16 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
WO2008035239A1 (en) 2006-09-21 2008-03-27 Actelion Pharmaceuticals Ltd Phenyl derivatives and their use as immunomodulators
ES2450750T3 (es) 2007-03-16 2014-03-25 Actelion Pharmaceuticals Ltd. Derivados de amino-piridina como agonistas del receptor S1P1/EDG1
ATE502938T1 (de) 2007-08-17 2011-04-15 Actelion Pharmaceuticals Ltd Pyridinderivate als s1p1/edg1-rezeptormodulatoren
US8202865B2 (en) 2007-10-04 2012-06-19 Merck Serono Sa Oxadiazole derivatives
AR069146A1 (es) 2007-11-01 2009-12-30 Actelion Pharmaceuticals Ltd Derivados de pirimidina, composicion farmaceutica que los comprende y el uso de esta para el tratamiento de enfermedades relacionadas con la activacion del sistema inmunitario.
US20110046170A1 (en) 2008-03-06 2011-02-24 Martin Bolli Novel pyrimidine-pyridine derivatives
JP5411877B2 (ja) 2008-03-06 2014-02-12 アクテリオン ファーマシューティカルズ リミテッド ピリジン化合物
AU2009220893A1 (en) 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
HRP20130641T1 (en) 2008-03-07 2013-08-31 Actelion Pharmaceuticals Ltd. Pyridin-2-yl derivatives as immunomodulating agents
ES2549761T3 (es) * 2008-05-14 2015-11-02 The Scripps Research Institute Nuevos moduladores de los receptores de esfingosina fosfato
ES2517265T3 (es) 2009-03-03 2014-11-03 Merck Serono S.A. Derivados de oxadiazol piridina
DK2454255T3 (da) 2009-07-16 2013-12-16 Actelion Pharmaceuticals Ltd Pyridin-4-ylderivater som s1p1/edg1-agonister
TW201120016A (en) 2009-12-08 2011-06-16 Abbott Lab Novel oxadiazole compounds
TWI546300B (zh) 2011-01-19 2016-08-21 艾克泰聯製藥有限公司 ２－甲氧基－吡啶－４－基衍生物

Also Published As

Publication number Publication date
IL241363A0 (en) 2015-11-30
HUE035154T2 (en) 2018-05-02
PH12015502118A1 (en) 2016-01-25
HK1220454A1 (en) 2017-05-05
SI2970236T1 (sl) 2017-11-30
IL241363B (en) 2018-11-29
KR20150128947A (ko) 2015-11-18
HRP20171763T1 (hr) 2017-12-29
EA029309B1 (ru) 2018-03-30
MA38482A1 (fr) 2017-12-29
DK2970236T3 (en) 2017-10-16
EP2970236A1 (en) 2016-01-20
MY173573A (en) 2020-02-04
WO2014141171A1 (en) 2014-09-18
SG11201507227UA (en) 2015-10-29
EP2970236B1 (en) 2017-08-30
CA2900910A1 (en) 2014-09-18
AR095523A1 (es) 2015-10-21
AU2014229217B2 (en) 2017-12-14
TWI623534B (zh) 2018-05-11
AU2014229217A1 (en) 2015-11-05
JP6387361B2 (ja) 2018-09-05
BR112015023161A8 (pt) 2021-06-22
PL2970236T3 (pl) 2018-01-31
TW201443044A (zh) 2014-11-16
CN105189487A (zh) 2015-12-23
ZA201507657B (en) 2022-08-31
NZ713080A (en) 2020-06-26
BR112015023161A2 (pt) 2017-07-18
MX363545B (es) 2019-03-27
CY1119619T1 (el) 2018-04-04
LT2970236T (lt) 2017-11-10
MA38482B1 (fr) 2018-11-30
ES2649475T3 (es) 2018-01-12
BR112015023161B1 (pt) 2022-11-16
MX2015012293A (es) 2015-12-16
CL2015002620A1 (es) 2016-03-18
PT2970236T (pt) 2017-11-30
CA2900910C (en) 2021-03-30
JP2016512227A (ja) 2016-04-25
KR102212975B1 (ko) 2021-02-05
PH12015502118B1 (en) 2016-01-25
US20160031866A1 (en) 2016-02-04
NO2970236T3 (enExample) 2018-01-27
SA515361104B1 (ar) 2016-06-28
US9617250B2 (en) 2017-04-11
CN105189487B (zh) 2017-12-26
EA201500931A1 (ru) 2016-03-31

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