EA028532B1 - Ячмень с уменьшенной липоксигеназной активностью - Google Patents
Ячмень с уменьшенной липоксигеназной активностью Download PDFInfo
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- EA028532B1 EA028532B1 EA201170906A EA201170906A EA028532B1 EA 028532 B1 EA028532 B1 EA 028532B1 EA 201170906 A EA201170906 A EA 201170906A EA 201170906 A EA201170906 A EA 201170906A EA 028532 B1 EA028532 B1 EA 028532B1
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- Prior art keywords
- lox
- barley
- plant
- beverage
- malt
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C12/00—Processes specially adapted for making special kinds of beer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/10—Seeds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/46—Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
- A01H6/4624—Hordeum vulgarus [barley]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C1/00—Preparation of malt
- C12C1/18—Preparation of malt extract or of special kinds of malt, e.g. caramel, black malt
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C2200/00—Special features
- C12C2200/01—Use of specific genetic variants of barley or other sources of fermentable carbohydrates for beer brewing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Physiology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Non-Alcoholic Beverages (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200801851 | 2008-12-30 | ||
| PCT/DK2009/050355 WO2010075860A2 (en) | 2008-12-30 | 2009-12-28 | Barley with reduced lipoxygenase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201170906A1 EA201170906A1 (ru) | 2012-02-28 |
| EA028532B1 true EA028532B1 (ru) | 2017-11-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201170906A EA028532B1 (ru) | 2008-12-30 | 2009-12-28 | Ячмень с уменьшенной липоксигеназной активностью |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9363959B2 (https=) |
| EP (1) | EP2384110B1 (https=) |
| JP (1) | JP5670347B2 (https=) |
| CN (1) | CN102333440B (https=) |
| AR (1) | AR074913A1 (https=) |
| AU (1) | AU2009335397B2 (https=) |
| BR (1) | BRPI0923863A2 (https=) |
| CA (1) | CA2747225A1 (https=) |
| EA (1) | EA028532B1 (https=) |
| MX (1) | MX2011006588A (https=) |
| MY (1) | MY155960A (https=) |
| NZ (1) | NZ593962A (https=) |
| SA (1) | SA109310019B1 (https=) |
| UA (1) | UA106597C2 (https=) |
| UY (1) | UY32372A (https=) |
| WO (1) | WO2010075860A2 (https=) |
| ZA (1) | ZA201105047B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012030806B8 (pt) * | 2010-06-03 | 2022-05-10 | Carlsberg Breweries As | Método para preparar uma bebida à base de cevada e composição de malte moído |
| CN103114129B (zh) * | 2012-11-08 | 2016-08-31 | 中国农业科学院作物科学研究所 | 一种大麦脂肪氧化酶(lox-1)合成缺陷基因的多态性分子标记方法 |
| CN103018388B (zh) * | 2013-01-21 | 2015-01-07 | 江苏省农业科学院 | 一种以己醛含量判别甜玉米烫漂终点的方法 |
| JP6470948B2 (ja) * | 2014-11-17 | 2019-02-13 | アサヒビール株式会社 | コク感が増強された麦芽発酵飲料 |
| JP2017127228A (ja) * | 2016-01-19 | 2017-07-27 | サッポロビール株式会社 | ノンアルコールビールテイスト飲料の製造方法 |
| JP6691826B2 (ja) * | 2016-06-01 | 2020-05-13 | サッポロビール株式会社 | 蒸留酒類 |
| KR102433243B1 (ko) | 2016-07-01 | 2022-08-17 | 칼스버그 브류어리스 에이/에스 | 정제 곡물계 음료 |
| CN106405024B (zh) * | 2016-08-25 | 2018-08-24 | 青岛啤酒股份有限公司 | 一种评价麦芽脂质氧化程度的方法 |
| MA51410A (fr) * | 2017-12-28 | 2021-04-07 | Carlsberg As | Plantes céréalières présentant des propriétés de paroi cellulaire améliorées |
| HUE066457T2 (hu) | 2017-12-28 | 2024-08-28 | Carlsberg As | Gyors módszerek gabona kivonatok készítéséhez |
| CA3086078A1 (en) | 2017-12-28 | 2019-07-04 | Carlsberg A/S | Method for producing an extract of cereal and method for processing this extract into beverage |
| CA3085899A1 (en) | 2017-12-28 | 2019-07-04 | Carlsberg A/S | Barley with increased hydrolytic enzyme activity |
| EP3784058A1 (en) | 2018-04-25 | 2021-03-03 | Carlsberg A/S | Barley based beverages |
| JP6709301B2 (ja) * | 2019-01-21 | 2020-06-10 | アサヒビール株式会社 | コク感が増強された麦芽発酵飲料 |
| JP7428504B2 (ja) * | 2019-11-15 | 2024-02-06 | サッポロビール株式会社 | 麦芽原料液又はビールテイスト飲料の製造方法、及び、麦芽原料液又はビールテイスト飲料の香味を向上させる方法 |
| MX2022010777A (es) * | 2020-03-02 | 2022-11-30 | Carlsberg As | Plantas de cebada con elevada actividad de dextrinasa limite. |
| AR132565A1 (es) | 2023-05-01 | 2025-07-16 | Carlsberg As | Cebada con propiedades mejoradas |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002053721A1 (en) * | 2000-12-29 | 2002-07-11 | Carlsberg Research Laboratory | Low-lipoxygenase 1 barley |
| US20030167544A1 (en) * | 2000-12-29 | 2003-09-04 | Douma Anna Christina | Low lipoxygenase 1 barley |
| WO2004011591A1 (en) * | 2002-07-25 | 2004-02-05 | Novozymes A/S | Mashing process |
| US20050204437A1 (en) * | 2004-03-11 | 2005-09-15 | Carlsberg A/S | Barley for production of flavor-stable beverage |
| US20060005276A1 (en) * | 2004-03-12 | 2006-01-05 | Falco Saverio C | Transgenic soybean seeds having reduced activity of lipoxygenases |
| US20070067871A1 (en) * | 2005-09-07 | 2007-03-22 | Monsanto Technology, L.L.C. | Agronomically elite soybeans with high beta-conglycinin content |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| DE4428978A1 (de) | 1993-09-29 | 1995-03-30 | Weissheimer Friedr Malzfab | Verfahren zur Herstellung eines Malzproduktes für Lebensmittel, insbesondere für die Bierherstellung, und ein nach diesem Verfahren hergestelltes Malzprodukt |
| US6696294B1 (en) | 1998-06-19 | 2004-02-24 | Northwest Plant Breeding Co. | Methods for generating and identifying mutant polyploid plants, and uses therefor |
| JP4113795B2 (ja) | 2003-03-25 | 2008-07-09 | サッポロビール株式会社 | 大麦リポキシゲナーゼ−１遺伝子、大麦の選抜方法、麦芽アルコール飲料用原料及び麦芽アルコール飲料の製造方法 |
| JP2006034129A (ja) | 2004-07-23 | 2006-02-09 | Asahi Breweries Ltd | 麦芽の製造方法 |
-
2009
- 2009-12-26 SA SA109310019A patent/SA109310019B1/ar unknown
- 2009-12-28 BR BRPI0923863-8A patent/BRPI0923863A2/pt not_active Application Discontinuation
- 2009-12-28 AU AU2009335397A patent/AU2009335397B2/en not_active Ceased
- 2009-12-28 MX MX2011006588A patent/MX2011006588A/es active IP Right Grant
- 2009-12-28 US US13/141,579 patent/US9363959B2/en not_active Expired - Fee Related
- 2009-12-28 AR ARP090105124A patent/AR074913A1/es not_active Application Discontinuation
- 2009-12-28 WO PCT/DK2009/050355 patent/WO2010075860A2/en not_active Ceased
- 2009-12-28 EP EP09801148.9A patent/EP2384110B1/en not_active Revoked
- 2009-12-28 JP JP2011542680A patent/JP5670347B2/ja not_active Expired - Fee Related
- 2009-12-28 NZ NZ593962A patent/NZ593962A/en not_active IP Right Cessation
- 2009-12-28 EA EA201170906A patent/EA028532B1/ru not_active IP Right Cessation
- 2009-12-28 CN CN200980157631.1A patent/CN102333440B/zh not_active Expired - Fee Related
- 2009-12-28 UA UAA201109384A patent/UA106597C2/uk unknown
- 2009-12-28 CA CA2747225A patent/CA2747225A1/en not_active Abandoned
- 2009-12-28 MY MYPI2011003031A patent/MY155960A/en unknown
- 2009-12-29 UY UY0001032372A patent/UY32372A/es not_active Application Discontinuation
-
2011
- 2011-07-08 ZA ZA2011/05047A patent/ZA201105047B/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002053721A1 (en) * | 2000-12-29 | 2002-07-11 | Carlsberg Research Laboratory | Low-lipoxygenase 1 barley |
| US20030167544A1 (en) * | 2000-12-29 | 2003-09-04 | Douma Anna Christina | Low lipoxygenase 1 barley |
| WO2004011591A1 (en) * | 2002-07-25 | 2004-02-05 | Novozymes A/S | Mashing process |
| US20050204437A1 (en) * | 2004-03-11 | 2005-09-15 | Carlsberg A/S | Barley for production of flavor-stable beverage |
| US20060005276A1 (en) * | 2004-03-12 | 2006-01-05 | Falco Saverio C | Transgenic soybean seeds having reduced activity of lipoxygenases |
| US20070067871A1 (en) * | 2005-09-07 | 2007-03-22 | Monsanto Technology, L.L.C. | Agronomically elite soybeans with high beta-conglycinin content |
Non-Patent Citations (9)
| Title |
|---|
| DROST B W ET AL: "FLAVOR STABILITY", JOURNAL OF THE AMERICAN SOCIETY OF BREWING CHEMISTS., AMERICAN SOCIETY OF BREWING CHEMISTS, ST PAUL, MN., US, vol. 48, no. 4, 1 January 1990 (1990-01-01), US, pages 124 - 131, XP000926610, ISSN: 0361-0470 * |
| HIROTA N; KURODA H; TAKOI K; KANEKO T; KANEDA H; YOSHIDA I; TAKASHIO M; ITO K; TAKEDA K: "Brewing performance of malted lipoxygenase-1 null barley and effect on the flavor stability of beer", CEREAL CHEMISTRY, AACC INTERNATIONAL INC., US, vol. 83, no. 3, 1 May 2006 (2006-05-01), US, pages 250 - 254, XP009124704, ISSN: 0009-0352, DOI: 10.1094/CC-83-0250 * |
| HOTZEL H, MÜLLER W, SACHSE K: "Recovery and characterization of residual DNA from beer as a prerequisite for the detection of genetically modified ingredients", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 209, no. 3-4, 1 January 1999 (1999-01-01), Berlin/Heidelberg, pages 192 - 196, XP002635202, ISSN: 1438-2377, DOI: 10.1007/s002170050478 * |
| HUGUES M ET AL: "Two Lipoxygenases from Germinated Barley-Heat and Kilning Stability", JOURNAL OF FOOD SCIENCE, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 59, no. 4, 1 January 1994 (1994-01-01), US, pages 885 - 889, XP002552212, ISSN: 0022-1147, DOI: 10.1111/j.1365-2621.1994.tb08150.x * |
| KURODA H, ET AL.: "Characterization of factors that transform linoleic acid into di- and trihydroxyoctadecenoic acids in mash", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 93, no. 1, 1 January 2002 (2002-01-01), NL, pages 73 - 77, XP002980834, ISSN: 1389-1723 * |
| MECHELEN VAN J R, ET AL.: "MOLECULAR CHARACTERIZATION OF TWO LIPOXYGENASES FROM BARLEY", PLANT MOLECULAR BIOLOGY, SPRINGER, DORDRECHT., NL, vol. 39, no. 06, 1 April 1999 (1999-04-01), NL, pages 1283 - 1298, XP001015731, ISSN: 0167-4412, DOI: 10.1023/A:1006118003998 * |
| N. HIROTA ; T. KANEKO ; H. KURODA ; H. KANEDA ; M. TAKASHIO ; K. ITO ; K. TAKEDA: "Characterization of lipoxygenase-1 null mutants in barley", THEORETICAL AND APPLIED GENETICS ; INTERNATIONAL JOURNAL OF PLANT BREEDING RESEARCH, SPRINGER, BERLIN, DE, vol. 111, no. 8, 1 November 2005 (2005-11-01), Berlin, DE, pages 1580 - 1584, XP019322107, ISSN: 1432-2242, DOI: 10.1007/s00122-005-0088-y * |
| RUTGERSSON A., ET AL.: "OPTIMIZATION OF TEMPERATURE, TIME, AND LACTIC ACID CONCENTRATION TOINACTIVATE LIPOXYGENASE AND LIPASE AND PRESERVE PHYTASE ACTIVITY INBARLEY (CV. BLENHEIM) DURING SOAKING.", CEREAL CHEMISTRY, AACC INTERNATIONAL INC., US, vol. 74., no. 06., 1 January 1997 (1997-01-01), US, pages 727 - 732., XP000867116, ISSN: 0009-0352 * |
| WAN HENG WANG ET AL: "Molecular basis of a null mutation in soybean lipoxygenase 2: substitution of glutamine for an iron-ligand histidine.", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, NATIONAL ACADEMY OF SCIENCES, US, vol. 91, no. 13, 1 January 1994 (1994-01-01), US, pages 5828 - 5832, XP002175448, ISSN: 0027-8424, DOI: 10.1073/pnas.91.13.5828 * |
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| ZA201105047B (en) | 2012-10-31 |
| CN102333440A (zh) | 2012-01-25 |
| AR074913A1 (es) | 2011-02-23 |
| SA109310019B1 (ar) | 2014-09-10 |
| JP2012513744A (ja) | 2012-06-21 |
| US9363959B2 (en) | 2016-06-14 |
| UA106597C2 (uk) | 2014-09-25 |
| EP2384110B1 (en) | 2016-04-20 |
| NZ593962A (en) | 2012-04-27 |
| WO2010075860A3 (en) | 2011-07-14 |
| CA2747225A1 (en) | 2010-07-08 |
| UY32372A (es) | 2010-02-26 |
| BRPI0923863A2 (pt) | 2020-08-11 |
| WO2010075860A2 (en) | 2010-07-08 |
| EA201170906A1 (ru) | 2012-02-28 |
| US20110318469A1 (en) | 2011-12-29 |
| MY155960A (en) | 2015-12-31 |
| HK1162851A1 (zh) | 2012-09-07 |
| AU2009335397A1 (en) | 2011-07-28 |
| JP5670347B2 (ja) | 2015-02-18 |
| MX2011006588A (es) | 2011-09-27 |
| AU2009335397A8 (en) | 2011-08-04 |
| CN102333440B (zh) | 2014-07-23 |
| EP2384110A2 (en) | 2011-11-09 |
| AU2009335397B2 (en) | 2014-08-07 |
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